BacMap

Definition	Caulobacter crescentus CB15 chromosome, complete genome.
Accession	NC_002696
Length	4,016,947

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The map label for this gene is linX [H]

Identifier: 16124501

GI number: 16124501

Start: 257952

End: 258737

Strand: Direct

Name: linX [H]

Synonym: CC_0246

Alternate gene names: 16124501

Gene position: 257952-258737 (Clockwise)

Preceding gene: 16124500

Following gene: 16124504

Centisome position: 6.42

GC content: 66.79

Gene sequence:

>786_bases
ATGGCGCAGAGCACGGGCCGGGTCGCCGGCAAGAAGGCCTTCATCACCGGCGGCGCCCAGGGCCTCGGCGCGGCGGCGGG
TCGCATGCTGGCCAAGGAGGGCGCCAAGGTCGCCCTGGCCGACATCAATCTGGCCGGCGCCCAAGCCGTGGCCGACGAGA
TCAACGCCGCTCACGGCGCGGGCACGGCCTTCGCCTTCGAGCTGGACGTCACCCAGGAAGACCAGTGGATCGACGTGCTG
GAAAAGGCGACGGCGGCCATGGGCGGCCTGTCGGTGCTGGTCAATAACGCCGGCATCGGCGGCGATGGTCCCATCGAGAG
CCTCGACTTCGGGCTCTGGAAGAAGGTCATGTCGGTCAATGTCGACTCGGTGTTCCTGGGCGCCAAGCACGCCCTGACCC
ACATGCGCGCCCACCAGCCGGGCTCGATCATCAACCTGTCCTCGATCGCCGGCCTGATCGCCAACGGCAACTCGCCCGCC
TATAACGCCTCCAAGGCGGCGGTCTGGCTGCTGAGCAAGAACATCGCGCTGTACTGCGCCAAGATGAAGCTCGACATCCG
CTCGAACTCCATCCACCCGACCTTCATCGACACCCCGATCCTGGACGGCTTCTCGGCTCGGTTCGGCAAGGAAGAGGCCT
TCGCCAAGCTGGCCCGTCAGGTGCCGCTGGGCCGGATCGGCGAGCCGACCGACATCGCCAATGCGGTGCTCTATCTGGCC
AGCGACGAGAGCAAGTTCATGACCGGCGCCGAGATCAAGGTCGACGGCGGCATTTCGGCGATGTGA

Upstream 100 bases:

>100_bases
ACGGCGTCACCGATCTGGACCTCACGCTCGCGAAGTTCATGGACAGCGCCGCCTGAAGAATTCAAACTGCTGTTTGAATT
ATAATCGGGAGGACGCCGAA

Downstream 100 bases:

>100_bases
TCGAGTTAGAAGTTCCTCCCCCGCGATGCGGGGGAGGTGGCCCAGAGGGCCCGAGGGGGTTAGCTGCACGTTGGCGGAGA
AGGCCCCCTCAGTCACTCCG

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: 2,5-DDOL dehydrogenase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MAQSTGRVAGKKAFITGGAQGLGAAAGRMLAKEGAKVALADINLAGAQAVADEINAAHGAGTAFAFELDVTQEDQWIDVL
EKATAAMGGLSVLVNNAGIGGDGPIESLDFGLWKKVMSVNVDSVFLGAKHALTHMRAHQPGSIINLSSIAGLIANGNSPA
YNASKAAVWLLSKNIALYCAKMKLDIRSNSIHPTFIDTPILDGFSARFGKEEAFAKLARQVPLGRIGEPTDIANAVLYLA
SDESKFMTGAEIKVDGGISAM

Sequences:

>Translated_261_residues
MAQSTGRVAGKKAFITGGAQGLGAAAGRMLAKEGAKVALADINLAGAQAVADEINAAHGAGTAFAFELDVTQEDQWIDVL
EKATAAMGGLSVLVNNAGIGGDGPIESLDFGLWKKVMSVNVDSVFLGAKHALTHMRAHQPGSIINLSSIAGLIANGNSPA
YNASKAAVWLLSKNIALYCAKMKLDIRSNSIHPTFIDTPILDGFSARFGKEEAFAKLARQVPLGRIGEPTDIANAVLYLA
SDESKFMTGAEIKVDGGISAM
>Mature_260_residues
AQSTGRVAGKKAFITGGAQGLGAAAGRMLAKEGAKVALADINLAGAQAVADEINAAHGAGTAFAFELDVTQEDQWIDVLE
KATAAMGGLSVLVNNAGIGGDGPIESLDFGLWKKVMSVNVDSVFLGAKHALTHMRAHQPGSIINLSSIAGLIANGNSPAY
NASKAAVWLLSKNIALYCAKMKLDIRSNSIHPTFIDTPILDGFSARFGKEEAFAKLARQVPLGRIGEPTDIANAVLYLAS
DESKFMTGAEIKVDGGISAM

Specific function: Catalyzes the degradation of 2,5-dichloro-2,5- cyclohexadiene-1,4-diol (2,5-DDOL) into 2,5-dichlorohydroquinone (2,5-DCHQ). LinX appears not to be involved in gamma-HCH degradation pathway [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=32.9317269076305, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=32.5757575757576, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI31542939, Length=259, Percent_Identity=33.2046332046332, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI66933014, Length=259, Percent_Identity=36.6795366795367, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI59889578, Length=235, Percent_Identity=32.3404255319149, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=28.968253968254, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI5031737, Length=260, Percent_Identity=31.9230769230769, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI224922801, Length=166, Percent_Identity=37.3493975903614, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=27.4131274131274, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4758504, Length=271, Percent_Identity=31.7343173431734, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=26.7716535433071, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI109715829, Length=247, Percent_Identity=25.1012145748988, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI10190704, Length=247, Percent_Identity=26.3157894736842, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI83715985, Length=271, Percent_Identity=30.6273062730627, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503301, Length=250, Percent_Identity=27.6, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI40254986, Length=219, Percent_Identity=29.2237442922374, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI310128830, Length=216, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI310115468, Length=216, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4503817, Length=197, Percent_Identity=26.3959390862944, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI40807363, Length=206, Percent_Identity=29.126213592233, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=31.8407960199005, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI142976729, Length=242, Percent_Identity=25.2066115702479, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=249, Percent_Identity=35.7429718875502, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=30.078125, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=31.2252964426877, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=32.6693227091633, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787905, Length=251, Percent_Identity=33.4661354581673, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=31.9838056680162, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1789208, Length=261, Percent_Identity=30.2681992337165, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1789057, Length=253, Percent_Identity=29.2490118577075, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=29.8804780876494, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786812, Length=264, Percent_Identity=30.6818181818182, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789378, Length=257, Percent_Identity=29.5719844357977, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI2367365, Length=256, Percent_Identity=29.296875, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787526, Length=246, Percent_Identity=26.0162601626016, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=35.7142857142857, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=36.3636363636364, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17562910, Length=274, Percent_Identity=30.6569343065693, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17559104, Length=276, Percent_Identity=32.2463768115942, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=29.1497975708502, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17560332, Length=274, Percent_Identity=33.9416058394161, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=264, Percent_Identity=30.3030303030303, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17538480, Length=271, Percent_Identity=31.7343173431734, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=30.4182509505703, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560150, Length=269, Percent_Identity=30.8550185873606, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17538182, Length=259, Percent_Identity=31.6602316602317, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=28.9156626506024, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=29.5454545454545, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=28.7822878228782, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=29.6, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17562908, Length=270, Percent_Identity=28.8888888888889, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=29.6577946768061, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17564282, Length=201, Percent_Identity=29.8507462686567, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=273, Percent_Identity=30.4029304029304, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=268, Percent_Identity=29.8507462686567, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=270, Percent_Identity=28.8888888888889, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=275, Percent_Identity=29.0909090909091, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=271, Percent_Identity=28.7822878228782, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17508651, Length=260, Percent_Identity=30.3846153846154, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17536025, Length=265, Percent_Identity=29.811320754717, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193203117, Length=202, Percent_Identity=27.2277227722772, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=271, Percent_Identity=28.0442804428044, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=201, Percent_Identity=27.363184079602, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=277, Percent_Identity=29.6028880866426, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=266, Percent_Identity=28.1954887218045, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=281, Percent_Identity=29.8932384341637, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=201, Percent_Identity=27.363184079602, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17561272, Length=265, Percent_Identity=31.3207547169811, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=252, Percent_Identity=28.1746031746032, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=188, Percent_Identity=31.3829787234043, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639444, Length=262, Percent_Identity=33.587786259542, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=34.3873517786561, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=35.9375, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21357041, Length=257, Percent_Identity=35.0194552529183, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=32.5581395348837, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355319, Length=260, Percent_Identity=32.3076923076923, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24644337, Length=259, Percent_Identity=35.1351351351351, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17737361, Length=264, Percent_Identity=30.3030303030303, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24643142, Length=257, Percent_Identity=33.4630350194552, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24649181, Length=193, Percent_Identity=30.5699481865285, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281364892, Length=207, Percent_Identity=30.4347826086957, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24640492, Length=203, Percent_Identity=29.5566502463054, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24584744, Length=202, Percent_Identity=29.7029702970297, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574402, Length=202, Percent_Identity=29.7029702970297, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640442, Length=194, Percent_Identity=29.8969072164948, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859837, Length=205, Percent_Identity=30.2439024390244, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24663911, Length=243, Percent_Identity=25.1028806584362, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355631, Length=161, Percent_Identity=27.3291925465839, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27011; Mature: 26880

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQSTGRVAGKKAFITGGAQGLGAAAGRMLAKEGAKVALADINLAGAQAVADEINAAHGA
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCC
GTAFAFELDVTQEDQWIDVLEKATAAMGGLSVLVNNAGIGGDGPIESLDFGLWKKVMSVN
CEEEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
VDSVFLGAKHALTHMRAHQPGSIINLSSIAGLIANGNSPAYNASKAAVWLLSKNIALYCA
CCCEEECHHHHHHHHHCCCCCCEEEHHHHHHEEECCCCCCCCCCCEEEEEEECCEEEEEE
KMKLDIRSNSIHPTFIDTPILDGFSARFGKEEAFAKLARQVPLGRIGEPTDIANAVLYLA
EEEEEECCCCCCCEECCCCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEE
SDESKFMTGAEIKVDGGISAM
CCCCCEEECCEEEECCCCCCC
>Mature Secondary Structure 
AQSTGRVAGKKAFITGGAQGLGAAAGRMLAKEGAKVALADINLAGAQAVADEINAAHGA
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCC
GTAFAFELDVTQEDQWIDVLEKATAAMGGLSVLVNNAGIGGDGPIESLDFGLWKKVMSVN
CEEEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
VDSVFLGAKHALTHMRAHQPGSIINLSSIAGLIANGNSPAYNASKAAVWLLSKNIALYCA
CCCEEECHHHHHHHHHCCCCCCEEEHHHHHHEEECCCCCCCCCCCEEEEEEECCEEEEEE
KMKLDIRSNSIHPTFIDTPILDGFSARFGKEEAFAKLARQVPLGRIGEPTDIANAVLYLA
EEEEEECCCCCCCEECCCCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEE
SDESKFMTGAEIKVDGGISAM
CCCCCEEECCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7515041; 12450824 [H]