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The map label for this gene is tbpB_2

Identifier: 16120342

GI number: 16120342

Start: 357029

End: 357589

Strand: Direct

Name: tbpB_2

Synonym: VNG6476G

Alternate gene names: 16120342

Gene position: 357029-357589 (Clockwise)

Preceding gene: 16120341

Following gene: 16120344

Centisome position: 97.7

GC content: 59.0

Gene sequence:

>561_bases
ATGAGCACGCTGGCGGACACGATCCATATCGAGAACGTTGTTGCATCCAGTGATCTCGGCCAAGAACTCGCCCTCGACCA
ACTCTCCACAGACCTCCCCGGCGCCGAGTACAACCCAGAGGACTTCCCTGGGGTCGTCTACCGCTTGCAGGAGCCGAAGT
CAGCCACGCTGATCTTCCGATCGGGCAAAGTCGTCTGCACCGGCGCCAAAAGCGTCGATGACGTTCACGAAGCTCTCGGC
ATCGTTTTCGGTGACATTCGCGAGTTAGGCATCGATGTCACGAGTAATCCGCCCATCGAGGTGCAAAACATCGTCTCCAG
CGCAAGTCTCGAGCAGTCGCTGAACTTGAACGCGATTGCGATCGGCCTGGGGCTGGAGCAAATCGAGTACGAACCCGAAC
AGTTCCCCGGGCTCGTCTACCGCCTTGACGATCCCGATGTCGTCGTCCTCCTCTTCGGCAGTGGCAAACTCGTGATTACC
GGCGGGCAAAACCCAGACGAAGCCGAGCAAGCACTCGCTCACGTCCAAGACCGACTCACCGAACTCGGCCTGCTTGACTG
A

Upstream 100 bases:

>100_bases
TACTAATCTACGCTCGAATCTAGTAGCCGTTGAGAGTTTCAACAGAGCCCCAAATTTTCACCCGCCGTACTTTAAGTGAG
TTGTCCGACGAATACCCCGT

Downstream 100 bases:

>100_bases
GCCCATGGTCTCTAAACCGATAGCTGTCCGAAGGGAGTCATATTGTTGGAGTGAGTGACAGCCACCCGTCCCTGATCGCT
GAAAACCGGGAAGTTACTCG

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein B; BAP B; TATA sequence-binding protein B; TBP B; TATA-box factor B

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MSTLADTIHIENVVASSDLGQELALDQLSTDLPGAEYNPEDFPGVVYRLQEPKSATLIFRSGKVVCTGAKSVDDVHEALG
IVFGDIRELGIDVTSNPPIEVQNIVSSASLEQSLNLNAIAIGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVIT
GGQNPDEAEQALAHVQDRLTELGLLD

Sequences:

>Translated_186_residues
MSTLADTIHIENVVASSDLGQELALDQLSTDLPGAEYNPEDFPGVVYRLQEPKSATLIFRSGKVVCTGAKSVDDVHEALG
IVFGDIRELGIDVTSNPPIEVQNIVSSASLEQSLNLNAIAIGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVIT
GGQNPDEAEQALAHVQDRLTELGLLD
>Mature_185_residues
STLADTIHIENVVASSDLGQELALDQLSTDLPGAEYNPEDFPGVVYRLQEPKSATLIFRSGKVVCTGAKSVDDVHEALGI
VFGDIRELGIDVTSNPPIEVQNIVSSASLEQSLNLNAIAIGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVITG
GQNPDEAEQALAHVQDRLTELGLLD

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family

Homologues:

Organism=Homo sapiens, GI285026520, Length=168, Percent_Identity=36.3095238095238, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI4507379, Length=168, Percent_Identity=36.3095238095238, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI39930602, Length=168, Percent_Identity=35.7142857142857, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17555358, Length=166, Percent_Identity=37.3493975903614, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320996, Length=173, Percent_Identity=39.3063583815029, Blast_Score=122, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17647997, Length=158, Percent_Identity=39.2405063291139, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17136834, Length=159, Percent_Identity=36.4779874213836, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TBPB_HALSA (Q48325)

Other databases:

- EMBL:   X93206
- EMBL:   AF016485
- EMBL:   AF016485
- EMBL:   AE004438
- EMBL:   AE004438
- PIR:   T08255
- PIR:   T44922
- RefSeq:   NP_045983.1
- RefSeq:   NP_046116.1
- RefSeq:   NP_395608.1
- RefSeq:   NP_395930.1
- ProteinModelPortal:   Q48325
- SMR:   Q48325
- GeneID:   1446790
- GeneID:   1446945
- GeneID:   1449212
- GeneID:   1449440
- GenomeReviews:   AE004438_GR
- GenomeReviews:   AE004438_GR
- GenomeReviews:   AF016485_GR
- GenomeReviews:   AF016485_GR
- KEGG:   hal:VNG6050G
- KEGG:   hal:VNG6476G
- HOGENOM:   HBG499930
- OMA:   FGDIREL
- ProtClustDB:   PRK00394
- BioCyc:   HSP64091:MONOMER9OR-9307
- BioCyc:   HSP64091:TBPB-MONOMER
- BioCyc:   HSP64091:VNG6050G-MONOMER
- BioCyc:   HSP64091:VNG6476G-MONOMER
- HAMAP:   MF_00408
- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294
- Gene3D:   G3DSA:3.30.310.10
- PANTHER:   PTHR10126
- PRINTS:   PR00686

Pfam domain/function: PF00352 TBP; SSF55945 TFIID_C/glycos_N

EC number: NA

Molecular weight: Translated: 19939; Mature: 19807

Theoretical pI: Translated: 3.82; Mature: 3.82

Prosite motif: PS00351 TFIID

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLADTIHIENVVASSDLGQELALDQLSTDLPGAEYNPEDFPGVVYRLQEPKSATLIFR
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEE
SGKVVCTGAKSVDDVHEALGIVFGDIRELGIDVTSNPPIEVQNIVSSASLEQSLNLNAIA
CCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
IGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVITGGQNPDEAEQALAHVQDRLT
EECCHHHHCCCCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHH
ELGLLD
HCCCCC
>Mature Secondary Structure 
STLADTIHIENVVASSDLGQELALDQLSTDLPGAEYNPEDFPGVVYRLQEPKSATLIFR
CCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEE
SGKVVCTGAKSVDDVHEALGIVFGDIRELGIDVTSNPPIEVQNIVSSASLEQSLNLNAIA
CCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
IGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVITGGQNPDEAEQALAHVQDRLT
EECCHHHHCCCCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHH
ELGLLD
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9363785; 9847077; 11016950