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The map label for this gene is gltP

Identifier: 16120218

GI number: 16120218

Start: 237796

End: 239271

Strand: Reverse

Name: gltP

Synonym: VNG6308G

Alternate gene names: 16120218

Gene position: 239271-237796 (Counterclockwise)

Preceding gene: 16120222

Following gene: 16120217

Centisome position: 65.48

GC content: 62.67

Gene sequence:

>1476_bases
ATGGCGCGTTTTTCCGGAATATCCAAACAGGAGCTTTATTCGTGGGAGTTCAAACGCGTGTTGAGTTCCCGACGATCCCA
TAGCGAATGTGACGAGAACGCCACGGATACGAAGCAGTCGTCATGTGTTTTTGAAACGACGCCAGCATATGGTATCGTTA
GCTTTACAGCCAGCATTTCGGAATGCTGTGCTATGTTGAACCGCCTTCGAGACGCATGGGCTGCGTATCGATCCGTTGCG
ATCATCTACCGGATCGCGGTCGCGTTCGTTCTCGGCTCGGTCTGTGGGCTCGCGGTCGGCGCGCCAGCCGCACAGCTTGA
GCCGCTCGGAACGCTGTTCGTTCGGTTGCTCAAAATGATCATCATTCCTGTCGTCGTGTTCACGCTGCTCATGGGAGCGC
GGCAGCTTTCGCCGACCCGCATCGGCAAGATCGGCGGCGAGGTGATCGCGCTCTACCTGGGGACGACGGCGGTCGCGATC
GCCATCGGGCTGTTGGCGGGCAACCTCATCAACCCGGGAGTCGGGCTTGAGGTGGCTGATGCCGCCGTGGAGACGACGCA
AGCCCCGGATCTGGGGACGGTGCTGATGAACGTCGTTCCGACGAACCCGATCGGTGCGATGGCCAACGGGGACGTGTTGC
CGACGATCTTTTTCACGATCGCGCTCGGCATTTCGTTCGCGATCCTGCAGGACGAGTTCGAGCCCGGCACACCGGTGCAC
GACGGTGCACAGGCCGTGTTCAAGATCGCAGAGGCGGGCTCGGAGGCGATGTTCAACGTCGTCTGGGGCGTCATGGAGTA
CGGCGTGATCGGCGTGTTCGCGTTGATGGCGACGACGTTCGGGGAGGCAGGCGTCGACGCCATCCTGCCGTTCGCAAAAC
TCATCGGTGCGCTGGCGCTCGCCGTGGTCCTCCACATCGGGGTCACGTATCTGTTCGTCATTCAGTGGGGGCTGCTGCGT
GAATCGCCGCGGGCGTTCCTCGCCGGCGCCAAAGAAGCGATGGTGACGGCGCTGAGCATCCGTTCCAGCAGCGGGACGCT
GCCCGTCACGATGAACAACGCCGACGAGAACTTCGGGATCGACGAGGAGGTGTACAGCTTCTCGCTGCCGCTCGGTGCGA
CGATCAACATGGACGGAACGGCGATGTATCAGGGCGTGGCGGCCATCTTTGCGGCCAATCTGGTGGGGCAAACGCTCACG
CTCGCCGAACAGGCGACAGTCATCGTGACCGCCCTGCTCGCGAGCGTCGGCACTGCGGGTGTCCCGGGCAGCGGGCTGAT
CATGCTCACGCTGGTGCTCACGCAGCTCGGGTTGCCGCTTGAGGTCGTCGGCATGGTCGCCGGTGTCGACCCGATCCTCG
ACCGGCTTCGGACCATGAACAACGTGACCGGTGATCTGGCGGTCACGACGCTCGTCGCGGACTGGAACGACCGGATCGAC
CGCGAGAACACGGTCTGGGAACGCACCGACGACTGA

Upstream 100 bases:

>100_bases
TGACTTGAATCTTCCTTTCTATCATGAACAACTAACTGATCGAACGTTTCAACGGCATCCGTCGACAGCATCCGCCGATC
CCGCTGTGGTCTCGCTAGCT

Downstream 100 bases:

>100_bases
GCCGGTGTGGCGGGCAACGATGCCCGGACGGGCGCGGCCGCCCGTGACGTGTCCCGGATCGTGGGTCGGCGACGGCAGAG
CATCGTGGATATGACTTCGA

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MARFSGISKQELYSWEFKRVLSSRRSHSECDENATDTKQSSCVFETTPAYGIVSFTASISECCAMLNRLRDAWAAYRSVA
IIYRIAVAFVLGSVCGLAVGAPAAQLEPLGTLFVRLLKMIIIPVVVFTLLMGARQLSPTRIGKIGGEVIALYLGTTAVAI
AIGLLAGNLINPGVGLEVADAAVETTQAPDLGTVLMNVVPTNPIGAMANGDVLPTIFFTIALGISFAILQDEFEPGTPVH
DGAQAVFKIAEAGSEAMFNVVWGVMEYGVIGVFALMATTFGEAGVDAILPFAKLIGALALAVVLHIGVTYLFVIQWGLLR
ESPRAFLAGAKEAMVTALSIRSSSGTLPVTMNNADENFGIDEEVYSFSLPLGATINMDGTAMYQGVAAIFAANLVGQTLT
LAEQATVIVTALLASVGTAGVPGSGLIMLTLVLTQLGLPLEVVGMVAGVDPILDRLRTMNNVTGDLAVTTLVADWNDRID
RENTVWERTDD

Sequences:

>Translated_491_residues
MARFSGISKQELYSWEFKRVLSSRRSHSECDENATDTKQSSCVFETTPAYGIVSFTASISECCAMLNRLRDAWAAYRSVA
IIYRIAVAFVLGSVCGLAVGAPAAQLEPLGTLFVRLLKMIIIPVVVFTLLMGARQLSPTRIGKIGGEVIALYLGTTAVAI
AIGLLAGNLINPGVGLEVADAAVETTQAPDLGTVLMNVVPTNPIGAMANGDVLPTIFFTIALGISFAILQDEFEPGTPVH
DGAQAVFKIAEAGSEAMFNVVWGVMEYGVIGVFALMATTFGEAGVDAILPFAKLIGALALAVVLHIGVTYLFVIQWGLLR
ESPRAFLAGAKEAMVTALSIRSSSGTLPVTMNNADENFGIDEEVYSFSLPLGATINMDGTAMYQGVAAIFAANLVGQTLT
LAEQATVIVTALLASVGTAGVPGSGLIMLTLVLTQLGLPLEVVGMVAGVDPILDRLRTMNNVTGDLAVTTLVADWNDRID
RENTVWERTDD
>Mature_490_residues
ARFSGISKQELYSWEFKRVLSSRRSHSECDENATDTKQSSCVFETTPAYGIVSFTASISECCAMLNRLRDAWAAYRSVAI
IYRIAVAFVLGSVCGLAVGAPAAQLEPLGTLFVRLLKMIIIPVVVFTLLMGARQLSPTRIGKIGGEVIALYLGTTAVAIA
IGLLAGNLINPGVGLEVADAAVETTQAPDLGTVLMNVVPTNPIGAMANGDVLPTIFFTIALGISFAILQDEFEPGTPVHD
GAQAVFKIAEAGSEAMFNVVWGVMEYGVIGVFALMATTFGEAGVDAILPFAKLIGALALAVVLHIGVTYLFVIQWGLLRE
SPRAFLAGAKEAMVTALSIRSSSGTLPVTMNNADENFGIDEEVYSFSLPLGATINMDGTAMYQGVAAIFAANLVGQTLTL
AEQATVIVTALLASVGTAGVPGSGLIMLTLVLTQLGLPLEVVGMVAGVDPILDRLRTMNNVTGDLAVTTLVADWNDRIDR
ENTVWERTDD

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=424, Percent_Identity=31.1320754716981, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI169790839, Length=419, Percent_Identity=29.1169451073986, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI66773030, Length=463, Percent_Identity=32.6133909287257, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI21314632, Length=417, Percent_Identity=29.7362110311751, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI40254478, Length=284, Percent_Identity=36.6197183098592, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI5032093, Length=403, Percent_Identity=30.0248138957816, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI194239697, Length=295, Percent_Identity=34.2372881355932, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI223468566, Length=285, Percent_Identity=32.280701754386, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI223468564, Length=277, Percent_Identity=32.8519855595668, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI301601644, Length=190, Percent_Identity=34.7368421052632, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI262359914, Length=381, Percent_Identity=26.246719160105, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1790514, Length=407, Percent_Identity=32.4324324324324, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789947, Length=419, Percent_Identity=28.6396181384248, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI1789473, Length=398, Percent_Identity=27.6381909547739, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788024, Length=414, Percent_Identity=24.3961352657005, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71983099, Length=436, Percent_Identity=32.3394495412844, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71983106, Length=436, Percent_Identity=32.3394495412844, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17537407, Length=393, Percent_Identity=30.5343511450382, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71996953, Length=429, Percent_Identity=29.1375291375291, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI193206505, Length=411, Percent_Identity=29.683698296837, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17541374, Length=416, Percent_Identity=29.3269230769231, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=191, Percent_Identity=35.0785340314136, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583025, Length=419, Percent_Identity=29.3556085918854, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI17137668, Length=419, Percent_Identity=29.3556085918854, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24583023, Length=419, Percent_Identity=29.3556085918854, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI281360481, Length=421, Percent_Identity=29.9287410926366, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281360483, Length=421, Percent_Identity=29.9287410926366, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17137666, Length=421, Percent_Identity=29.9287410926366, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 51774; Mature: 51643

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARFSGISKQELYSWEFKRVLSSRRSHSECDENATDTKQSSCVFETTPAYGIVSFTASIS
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
ECCAMLNRLRDAWAAYRSVAIIYRIAVAFVLGSVCGLAVGAPAAQLEPLGTLFVRLLKMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHH
IIPVVVFTLLMGARQLSPTRIGKIGGEVIALYLGTTAVAIAIGLLAGNLINPGVGLEVAD
HHHHHHHHHHHCCHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
AAVETTQAPDLGTVLMNVVPTNPIGAMANGDVLPTIFFTIALGISFAILQDEFEPGTPVH
HHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DGAQAVFKIAEAGSEAMFNVVWGVMEYGVIGVFALMATTFGEAGVDAILPFAKLIGALAL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AVVLHIGVTYLFVIQWGLLRESPRAFLAGAKEAMVTALSIRSSSGTLPVTMNNADENFGI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHEECCCCCEEEEECCCCCCCCC
DEEVYSFSLPLGATINMDGTAMYQGVAAIFAANLVGQTLTLAEQATVIVTALLASVGTAG
CHHHHEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VPGSGLIMLTLVLTQLGLPLEVVGMVAGVDPILDRLRTMNNVTGDLAVTTLVADWNDRID
CCCCHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHCC
RENTVWERTDD
CCCCCCCCCCC
>Mature Secondary Structure 
ARFSGISKQELYSWEFKRVLSSRRSHSECDENATDTKQSSCVFETTPAYGIVSFTASIS
CCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH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CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]