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The map label for this gene is hyuA

Identifier: 16119834

GI number: 16119834

Start: 31704

End: 33740

Strand: Direct

Name: hyuA

Synonym: Atu6022

Alternate gene names: NA

Gene position: 31704-33740 (Clockwise)

Preceding gene: 16119825

Following gene: 16119835

Centisome position: 14.8

GC content: 61.51

Gene sequence:

>2037_bases
ATGCTTAGAATCGGCGTTGATATCGGTGGGACGTTCACAGATTTTTGCGGGTGGCGTGAAGGAGAGGACAGGATCGTCAC
TCTGAAGGTACCTTCGACTCCTCCCGCTTTCGAAAACGGTTTCCGCGAGGGATTCGAAAAACTACTGGAACGGCTCGCGC
CCGAGCCGGGCGAGGCAGCCTTCCTCATGCACGGCACCACGGTCAGCACGAATGCCGTAATCGAGCGAAAAGGCCCGAAG
ATCGCGTTCTTCGTAACGAAGGGATACAGGGATCTGCTCGAACTGCAGCGGATCGGCGTCCGCAACCCTCTGAACCTGTT
CGAGACCCGAACCAGGCCGCTGATCGATCGCGAGATGGTTTTCGAGGTTGAGGAACGCCTGCTGCGCGGCGGCTTGGTTC
GAACCTCGATCGACGAGGCCGCAGTCGAGGCACTTGCCCGTCGTGCAGCCGACGCAGGTGCTGCCGGCTATGCGGTCGCG
CTGCTTCACAGCTACGCCAACCCGCAGCATGAACAAGCGGTCGCGCGGGCTATCCGTAAAGCGGTCGGCGAAGATGCCGA
GGTCAGCCTGTCCAGCGAGATCTGGCCGCGGATCGGAGAATACGAAAGAGCGATCGTCAGTGTGCTCAACGCTTTCGTGA
AGCGCCGGATGAACGAGTATATCGGTGCGGTCGAAACTTATGTGGCTGAACGGTTGCCAGGGTCGCAACTTTTCGTCACA
CGCTCGAACGGTGGTGCGATGGCCGCCAGTGAGGCGCGCAACTTCCCCGTCCATACGCTTCTGTCGGGTCCGGCGTCTGG
CGTGACGGCTGTGCAATATCTCGGCCGCGCCTTGGGCGAACACAACATCCTCACCATGGACATGGGTGGCACCAGCACTG
ACATCTCGCTCGTGCGCGATGGCGAAGCTCTGACCTCGACTTCGGCCGAGGTGGGTGAGTTTCCGGTTGTCATGCCAGTT
ACCAGCATCGAGGCGATCGGCGCAGGCGGCGGTTCGGTCGTCACGATTGATGGCGGGGTGTTGCGTATCGGCCCGCGCAG
TGCTGGGTCCTATCCTGGTCCTGCCTGCTTCAGCCGAGGCGGCACGGAACCCACGCTGACCGATGCCTTTTTACTTGCGG
GCTATTTGCCTGAAGCCCTTCTTGGCGGCGATATGCAGCTCGATCGTCATGCCGCCGAACGCGCTATGGCGCCGATTGCG
GAGACTCTCAAGACGGACGTGCTCAGCGCCGCGGAAATGTGCGTCACCGTCGCAAGCTCGAACATGGTGGCCGGTGTCTT
GCCCTATCTCGCACGCCAGGGCGTCGATCCCGAAGATCTGACGGTGCTCGTTTACGGCGGAGCTGGCGCGATCCAGGGGC
CGCTCCTTGCGGCCGAGATCGGCGTGAACCGCGTTCTTGTGCCGGCGACACCTTCCGTATTCTGTGCCCTCGGGGGCCTT
GTCTCTGATTTGAGCAACGACGCGCTCGAAACCGTCCACGGCCTTGATATCGATGGTTCTCTCATCGCGAAGAAGTTTCA
GGTCCTTCGCGAGCAGGGAGCCGAATGGTTATCGCGACAGGCACCGCCGGAGCGTCTCGTGTCGAAAACGTTCGAGTGCT
GGGCCGAGATGCGCTACGTCGGGCAGTCCTTCCAGGTTGACGTGCGGCTGCCGGATACGGCGATCGAAGCGCACGACATT
GCCGCAATGCATGCCGCCTTCCACCAAGAGCACGAACGCATCTACAGCCATGCCGACAAAGCGGCGCCAGTCGAATTCGT
CGACCTGCGCATGCGCGTGCGTGGATCGATGTCGATACCTCAGCCCTCTACACCTGAAACGTCCGGGGCTGGCGGTGCGC
TCAAAACGGTGCGTTCGATGCGCTTCCACAACAAACTCATTCCTGAGGTACGCGTCTTTGATCGCGCATCTCTCACCCCC
AACGATGCGATCCAGGGGCCGGCCGTCATCGAGCAGCGTGATGCGACGATCGTCGTTCCGCCAGAGTTCGTTGCCCGCGT
CGGAGCCTTTGGCGCAATCCTCATGACCCGGAGCTGA

Upstream 100 bases:

>100_bases
ATCGCGAATCATTCCAGGACGGAGACAGGTTTCATGAAGATCAGAGTAGATCGAAATATCCCGCAGGCCGACCAACTGAA
GAAGCGAGGGTAAGTGGCAG

Downstream 100 bases:

>100_bases
TCAATGGATGCCGTTCGTACTGCCGTCATGAACAATCGCTTCAACGCGATTGTCGAAGAAGCCTCTGCCGCGATCTACCG
CACCGCCCATACGACTTTTG

Product: N-methylhydantoinase A/acetone carboxylase, beta subunit

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 678; Mature: 678

Protein sequence:

>678_residues
MLRIGVDIGGTFTDFCGWREGEDRIVTLKVPSTPPAFENGFREGFEKLLERLAPEPGEAAFLMHGTTVSTNAVIERKGPK
IAFFVTKGYRDLLELQRIGVRNPLNLFETRTRPLIDREMVFEVEERLLRGGLVRTSIDEAAVEALARRAADAGAAGYAVA
LLHSYANPQHEQAVARAIRKAVGEDAEVSLSSEIWPRIGEYERAIVSVLNAFVKRRMNEYIGAVETYVAERLPGSQLFVT
RSNGGAMAASEARNFPVHTLLSGPASGVTAVQYLGRALGEHNILTMDMGGTSTDISLVRDGEALTSTSAEVGEFPVVMPV
TSIEAIGAGGGSVVTIDGGVLRIGPRSAGSYPGPACFSRGGTEPTLTDAFLLAGYLPEALLGGDMQLDRHAAERAMAPIA
ETLKTDVLSAAEMCVTVASSNMVAGVLPYLARQGVDPEDLTVLVYGGAGAIQGPLLAAEIGVNRVLVPATPSVFCALGGL
VSDLSNDALETVHGLDIDGSLIAKKFQVLREQGAEWLSRQAPPERLVSKTFECWAEMRYVGQSFQVDVRLPDTAIEAHDI
AAMHAAFHQEHERIYSHADKAAPVEFVDLRMRVRGSMSIPQPSTPETSGAGGALKTVRSMRFHNKLIPEVRVFDRASLTP
NDAIQGPAVIEQRDATIVVPPEFVARVGAFGAILMTRS

Sequences:

>Translated_678_residues
MLRIGVDIGGTFTDFCGWREGEDRIVTLKVPSTPPAFENGFREGFEKLLERLAPEPGEAAFLMHGTTVSTNAVIERKGPK
IAFFVTKGYRDLLELQRIGVRNPLNLFETRTRPLIDREMVFEVEERLLRGGLVRTSIDEAAVEALARRAADAGAAGYAVA
LLHSYANPQHEQAVARAIRKAVGEDAEVSLSSEIWPRIGEYERAIVSVLNAFVKRRMNEYIGAVETYVAERLPGSQLFVT
RSNGGAMAASEARNFPVHTLLSGPASGVTAVQYLGRALGEHNILTMDMGGTSTDISLVRDGEALTSTSAEVGEFPVVMPV
TSIEAIGAGGGSVVTIDGGVLRIGPRSAGSYPGPACFSRGGTEPTLTDAFLLAGYLPEALLGGDMQLDRHAAERAMAPIA
ETLKTDVLSAAEMCVTVASSNMVAGVLPYLARQGVDPEDLTVLVYGGAGAIQGPLLAAEIGVNRVLVPATPSVFCALGGL
VSDLSNDALETVHGLDIDGSLIAKKFQVLREQGAEWLSRQAPPERLVSKTFECWAEMRYVGQSFQVDVRLPDTAIEAHDI
AAMHAAFHQEHERIYSHADKAAPVEFVDLRMRVRGSMSIPQPSTPETSGAGGALKTVRSMRFHNKLIPEVRVFDRASLTP
NDAIQGPAVIEQRDATIVVPPEFVARVGAFGAILMTRS
>Mature_678_residues
MLRIGVDIGGTFTDFCGWREGEDRIVTLKVPSTPPAFENGFREGFEKLLERLAPEPGEAAFLMHGTTVSTNAVIERKGPK
IAFFVTKGYRDLLELQRIGVRNPLNLFETRTRPLIDREMVFEVEERLLRGGLVRTSIDEAAVEALARRAADAGAAGYAVA
LLHSYANPQHEQAVARAIRKAVGEDAEVSLSSEIWPRIGEYERAIVSVLNAFVKRRMNEYIGAVETYVAERLPGSQLFVT
RSNGGAMAASEARNFPVHTLLSGPASGVTAVQYLGRALGEHNILTMDMGGTSTDISLVRDGEALTSTSAEVGEFPVVMPV
TSIEAIGAGGGSVVTIDGGVLRIGPRSAGSYPGPACFSRGGTEPTLTDAFLLAGYLPEALLGGDMQLDRHAAERAMAPIA
ETLKTDVLSAAEMCVTVASSNMVAGVLPYLARQGVDPEDLTVLVYGGAGAIQGPLLAAEIGVNRVLVPATPSVFCALGGL
VSDLSNDALETVHGLDIDGSLIAKKFQVLREQGAEWLSRQAPPERLVSKTFECWAEMRYVGQSFQVDVRLPDTAIEAHDI
AAMHAAFHQEHERIYSHADKAAPVEFVDLRMRVRGSMSIPQPSTPETSGAGGALKTVRSMRFHNKLIPEVRVFDRASLTP
NDAIQGPAVIEQRDATIVVPPEFVARVGAFGAILMTRS

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=734, Percent_Identity=28.0653950953678, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI133901900, Length=719, Percent_Identity=23.9221140472879, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322634, Length=538, Percent_Identity=28.0669144981413, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI45550492, Length=731, Percent_Identity=27.2229822161423, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 72697; Mature: 72697

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIGVDIGGTFTDFCGWREGEDRIVTLKVPSTPPAFENGFREGFEKLLERLAPEPGEAA
CEEEEEECCCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
FLMHGTTVSTNAVIERKGPKIAFFVTKGYRDLLELQRIGVRNPLNLFETRTRPLIDREMV
EEEECCEEECCEEEECCCCEEEEEEECCHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHH
FEVEERLLRGGLVRTSIDEAAVEALARRAADAGAAGYAVALLHSYANPQHEQAVARAIRK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
AVGEDAEVSLSSEIWPRIGEYERAIVSVLNAFVKRRMNEYIGAVETYVAERLPGSQLFVT
HHCCCCCEEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
RSNGGAMAASEARNFPVHTLLSGPASGVTAVQYLGRALGEHNILTMDMGGTSTDISLVRD
ECCCCCEEHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEC
GEALTSTSAEVGEFPVVMPVTSIEAIGAGGGSVVTIDGGVLRIGPRSAGSYPGPACFSRG
CCHHHCCCCHHCCCCEEEEECCHHHCCCCCCEEEEECCCEEEECCCCCCCCCCCHHHCCC
GTEPTLTDAFLLAGYLPEALLGGDMQLDRHAAERAMAPIAETLKTDVLSAAEMCVTVASS
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NMVAGVLPYLARQGVDPEDLTVLVYGGAGAIQGPLLAAEIGVNRVLVPATPSVFCALGGL
CHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHH
VSDLSNDALETVHGLDIDGSLIAKKFQVLREQGAEWLSRQAPPERLVSKTFECWAEMRYV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GQSFQVDVRLPDTAIEAHDIAAMHAAFHQEHERIYSHADKAAPVEFVDLRMRVRGSMSIP
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCC
QPSTPETSGAGGALKTVRSMRFHNKLIPEVRVFDRASLTPNDAIQGPAVIEQRDATIVVP
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCEECCCCEEEEC
PEFVARVGAFGAILMTRS
HHHHHHHHHHHEEEEECC
>Mature Secondary Structure
MLRIGVDIGGTFTDFCGWREGEDRIVTLKVPSTPPAFENGFREGFEKLLERLAPEPGEAA
CEEEEEECCCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
FLMHGTTVSTNAVIERKGPKIAFFVTKGYRDLLELQRIGVRNPLNLFETRTRPLIDREMV
EEEECCEEECCEEEECCCCEEEEEEECCHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHH
FEVEERLLRGGLVRTSIDEAAVEALARRAADAGAAGYAVALLHSYANPQHEQAVARAIRK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
AVGEDAEVSLSSEIWPRIGEYERAIVSVLNAFVKRRMNEYIGAVETYVAERLPGSQLFVT
HHCCCCCEEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
RSNGGAMAASEARNFPVHTLLSGPASGVTAVQYLGRALGEHNILTMDMGGTSTDISLVRD
ECCCCCEEHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEC
GEALTSTSAEVGEFPVVMPVTSIEAIGAGGGSVVTIDGGVLRIGPRSAGSYPGPACFSRG
CCHHHCCCCHHCCCCEEEEECCHHHCCCCCCEEEEECCCEEEECCCCCCCCCCCHHHCCC
GTEPTLTDAFLLAGYLPEALLGGDMQLDRHAAERAMAPIAETLKTDVLSAAEMCVTVASS
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NMVAGVLPYLARQGVDPEDLTVLVYGGAGAIQGPLLAAEIGVNRVLVPATPSVFCALGGL
CHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHH
VSDLSNDALETVHGLDIDGSLIAKKFQVLREQGAEWLSRQAPPERLVSKTFECWAEMRYV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GQSFQVDVRLPDTAIEAHDIAAMHAAFHQEHERIYSHADKAAPVEFVDLRMRVRGSMSIP
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCC
QPSTPETSGAGGALKTVRSMRFHNKLIPEVRVFDRASLTPNDAIQGPAVIEQRDATIVVP
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCEECCCCEEEEC
PEFVARVGAFGAILMTRS
HHHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]