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The map label for this gene is rnc [H]

Identifier: 160903376

GI number: 160903376

Start: 2157542

End: 2158303

Strand: Direct

Name: rnc [H]

Synonym: Pmob_1947

Alternate gene names: 160903376

Gene position: 2157542-2158303 (Clockwise)

Preceding gene: 160903375

Following gene: 160903377

Centisome position: 99.45

GC content: 34.65

Gene sequence:

>762_bases
ATGAAGCATGAGGATGATTTAAAATTAACCTTGCAAGAGGAACAAAATGTAAAAAAAGCAAAAAAGGAGCTCCTATTGCC
ACCATGCGTGAAAGAGAGCGTGTTGTTCGAAGCGTTGTGTCATAAATCATACGTTTTTGACAACGAAAATATTCAAAGAA
AACTTGATTCTAATGAAAGGTTAGAATTTCTCGGAGATGCCGTTTTAGAGTTAGTTATCTCCGAGTTTCTTTACAATAAT
TATCACCTTTCTGAGGGAGAAATGTCAAAGGCGAGGGCTATAATAGGAAGCGAAATTATTTTAGCAGAAGTTGCTTTAAA
GTTGAGGTTAGACGACTTTATTTTTTTAAGTAAAGGTGAAGACAAACAAGGTGGGCGAACGAAAAAGTCAATTTTATCTG
ACACTATGGAGGCTTTGTTTGCTTGTATTTATCTTAGCTGCGGTTATGAAAAGGCAAAGAAGTATATTATAAAAAACATG
AAGGAGTACATCGAGAACGCTGTTGAAGGGAATATTTTTCTCGATTATAAGACGAAGTTACAAGAATTAACTCAAGAAAA
AACAAAAAAATTGCCTGAATATGTGTTATTGAGTGCTTCTGGGCCCTCACATATGAAAAGATACAAGGTAGCAGTAAAAT
TAGATGATGAGATACTAGGAATAGGCGAAGGCTTTTCAAAAAAATTTGCGGAACAATTAGCAGCAAAAATTGCTTGTGAG
AAGTTTTTGGATTCTATTGGTGGAAATGATGTCGTTGATTAA

Upstream 100 bases:

>100_bases
AAGAATATGCACCGTCTGGAACAATCAAAGATTTGCTAAGGGTTCATGGATTTGATGTAGAATCGCTAGTAAAAAAGATG
AAAGGATTAATTGAGAGCAA

Downstream 100 bases:

>100_bases
AGAAATTGAATTCGTTATTTTAAAGAACACATCTTCAGTTTCACTAACAGGGAATTATTGCTACCTGAACTGCAAACATT
GTGGCCGCCATTATCTAAAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MKHEDDLKLTLQEEQNVKKAKKELLLPPCVKESVLFEALCHKSYVFDNENIQRKLDSNERLEFLGDAVLELVISEFLYNN
YHLSEGEMSKARAIIGSEIILAEVALKLRLDDFIFLSKGEDKQGGRTKKSILSDTMEALFACIYLSCGYEKAKKYIIKNM
KEYIENAVEGNIFLDYKTKLQELTQEKTKKLPEYVLLSASGPSHMKRYKVAVKLDDEILGIGEGFSKKFAEQLAAKIACE
KFLDSIGGNDVVD

Sequences:

>Translated_253_residues
MKHEDDLKLTLQEEQNVKKAKKELLLPPCVKESVLFEALCHKSYVFDNENIQRKLDSNERLEFLGDAVLELVISEFLYNN
YHLSEGEMSKARAIIGSEIILAEVALKLRLDDFIFLSKGEDKQGGRTKKSILSDTMEALFACIYLSCGYEKAKKYIIKNM
KEYIENAVEGNIFLDYKTKLQELTQEKTKKLPEYVLLSASGPSHMKRYKVAVKLDDEILGIGEGFSKKFAEQLAAKIACE
KFLDSIGGNDVVD
>Mature_253_residues
MKHEDDLKLTLQEEQNVKKAKKELLLPPCVKESVLFEALCHKSYVFDNENIQRKLDSNERLEFLGDAVLELVISEFLYNN
YHLSEGEMSKARAIIGSEIILAEVALKLRLDDFIFLSKGEDKQGGRTKKSILSDTMEALFACIYLSCGYEKAKKYIIKNM
KEYIENAVEGNIFLDYKTKLQELTQEKTKKLPEYVLLSASGPSHMKRYKVAVKLDDEILGIGEGFSKKFAEQLAAKIACE
KFLDSIGGNDVVD

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=198, Percent_Identity=29.7979797979798, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI155030236, Length=198, Percent_Identity=29.7979797979798, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI1788920, Length=200, Percent_Identity=32, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17506883, Length=163, Percent_Identity=29.4478527607362, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193202651, Length=163, Percent_Identity=29.4478527607362, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17137682, Length=197, Percent_Identity=30.9644670050761, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28750; Mature: 28750

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHEDDLKLTLQEEQNVKKAKKELLLPPCVKESVLFEALCHKSYVFDNENIQRKLDSNER
CCCCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHH
LEFLGDAVLELVISEFLYNNYHLSEGEMSKARAIIGSEIILAEVALKLRLDDFIFLSKGE
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
DKQGGRTKKSILSDTMEALFACIYLSCGYEKAKKYIIKNMKEYIENAVEGNIFLDYKTKL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHH
QELTQEKTKKLPEYVLLSASGPSHMKRYKVAVKLDDEILGIGEGFSKKFAEQLAAKIACE
HHHHHHHHHCCCCEEEEECCCHHHHHHEEEEEEECCHHEECCCCHHHHHHHHHHHHHHHH
KFLDSIGGNDVVD
HHHHHCCCCCCCC
>Mature Secondary Structure
MKHEDDLKLTLQEEQNVKKAKKELLLPPCVKESVLFEALCHKSYVFDNENIQRKLDSNER
CCCCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHH
LEFLGDAVLELVISEFLYNNYHLSEGEMSKARAIIGSEIILAEVALKLRLDDFIFLSKGE
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
DKQGGRTKKSILSDTMEALFACIYLSCGYEKAKKYIIKNMKEYIENAVEGNIFLDYKTKL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHH
QELTQEKTKKLPEYVLLSASGPSHMKRYKVAVKLDDEILGIGEGFSKKFAEQLAAKIACE
HHHHHHHHHCCCCEEEEECCCHHHHHHEEEEEEECCHHEECCCCHHHHHHHHHHHHHHHH
KFLDSIGGNDVVD
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA