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The map label for this gene is gdh [H]

Identifier: 160903244

GI number: 160903244

Start: 1996123

End: 1997487

Strand: Direct

Name: gdh [H]

Synonym: Pmob_1813

Alternate gene names: 160903244

Gene position: 1996123-1997487 (Clockwise)

Preceding gene: 160903243

Following gene: 160903254

Centisome position: 92.01

GC content: 39.19

Gene sequence:

>1365_bases
GTGAGTAACTCAATTGAATTAACCCAAGAAAGTTATGTTGACAGCATAATTGAAAGGGTAGTTGTAAGGAATCCTGGAGA
AACCGAGTTTCACCAGGCGGTACGTGAGGTGCTTGAAAGTATCAAACCGGTTGTTGAACTGTATCCTGAATTTGAAGAAA
ACGGGATTTTAGAAAGGTTAACTGAGCCTGAAAGGCAGATTATCTTTCGCGTTCCATGGGTAGATGATCAAGGGAACGTT
CATGTTAATAGGGGATACAGAATAGAATTTAACTCCGCATTAGGGCCTTATAAAGGGGGATTGCGTTTTCATCCCACCGT
ATACCCTGGAATTATGAAGTTTCTTGCATTTGAACAAACTTTCAAAAATGCTTTAACTGGAAGGCCTATAGGTGGAGCAA
AAGGTGGCAGTGACTTCGATCCAAAGGGGAAGTCAGATTCCGAAGTTATGAGATTTTGTCAAAGTTTTATGACTGAACTA
TATAGACATATAGGGGCACAAACGGATATTCCAGCAGGAGATATAGGTGTTGGAAATAGAGAAATTGGGTATCTCTTTGG
TCAATACAAAAGAATTACCAACCGTTTTGAAGCTGGCACCCTTACTGGAAAAGGTGTAGATTGGGGTGGAAGTTTAGCAA
GAACAGAAGCAACAGGGTATGGATTGGTGTATTTTGTTGATGAAATGCTAAAAGATATTGGTGAAACATTTGAAGGCAAG
AAGGTGATAGTTTCTGGATCTGGAAACGTGGCTATTTACACGGTTCAAAAAGTTATAGAACTCGGTGGAAAGGTTATAGC
CCTTAGTGATTCAGATGGAATGGTATACGATCCAGAAGGAATAGATTTAAATTCTGTAATTGAGATAAAAGAAAAAAGAA
GAGGAAGAATAGTTGAGTATCTCAAAACTCATCCATCAGCAGAGTATAACGATAATAGTAAAAATATTTGGAAAATTGAA
TGTGATATTGCCTTCCCATGTGCCACTCAAAACGAAATTGATATGGAAGAAGCAAAAACACTTGTAAATAACGGTGTTTT
AGTGGTAGCAGAAGGCGCTAATATGCCCTGCACGCCAGAAGCTATTGAATGTTTCCAAAAAAACAACGTTTTGTTTGCCC
CAGCTAAAGCTGCCAACGCTGGCGGTGTTGCTACCTCTGCCTTAGAAATGACTCAAAATAGTATGTGGGAGTCTTGGAGT
TTTGAAGAGGTAGATAAAAAACTACGAGAGGTCATGAAGAATATATACAGTAGTATAAAGACGACAGCTGAAGAGTACAA
GAAAGACGGAGACCTTGTTTTTGGGGCTAATGTGACGGCTTTTCTAAAGGTAGCAAGAGCAATGATGGATCAAGGGATTG
TTTAA

Upstream 100 bases:

>100_bases
ATGAAATATATTTCATTGAATTATTTGTTATGAAAATAATTTCTTGTTTTTTGATCTTTTTTAGGTATACCGGGGAAAAA
CCAAAAAGGAGGAGGTAACA

Downstream 100 bases:

>100_bases
AAATACCCCCTGATAGGGGTATTTTTAAAGCTTTCCTAATTCCTTGAAGATTTCTTTTACTACTTTTATGTCTTGGCTAT
GCTCTGGATCATCTCCAGGG

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSNSIELTQESYVDSIIERVVVRNPGETEFHQAVREVLESIKPVVELYPEFEENGILERLTEPERQIIFRVPWVDDQGNV
HVNRGYRIEFNSALGPYKGGLRFHPTVYPGIMKFLAFEQTFKNALTGRPIGGAKGGSDFDPKGKSDSEVMRFCQSFMTEL
YRHIGAQTDIPAGDIGVGNREIGYLFGQYKRITNRFEAGTLTGKGVDWGGSLARTEATGYGLVYFVDEMLKDIGETFEGK
KVIVSGSGNVAIYTVQKVIELGGKVIALSDSDGMVYDPEGIDLNSVIEIKEKRRGRIVEYLKTHPSAEYNDNSKNIWKIE
CDIAFPCATQNEIDMEEAKTLVNNGVLVVAEGANMPCTPEAIECFQKNNVLFAPAKAANAGGVATSALEMTQNSMWESWS
FEEVDKKLREVMKNIYSSIKTTAEEYKKDGDLVFGANVTAFLKVARAMMDQGIV

Sequences:

>Translated_454_residues
MSNSIELTQESYVDSIIERVVVRNPGETEFHQAVREVLESIKPVVELYPEFEENGILERLTEPERQIIFRVPWVDDQGNV
HVNRGYRIEFNSALGPYKGGLRFHPTVYPGIMKFLAFEQTFKNALTGRPIGGAKGGSDFDPKGKSDSEVMRFCQSFMTEL
YRHIGAQTDIPAGDIGVGNREIGYLFGQYKRITNRFEAGTLTGKGVDWGGSLARTEATGYGLVYFVDEMLKDIGETFEGK
KVIVSGSGNVAIYTVQKVIELGGKVIALSDSDGMVYDPEGIDLNSVIEIKEKRRGRIVEYLKTHPSAEYNDNSKNIWKIE
CDIAFPCATQNEIDMEEAKTLVNNGVLVVAEGANMPCTPEAIECFQKNNVLFAPAKAANAGGVATSALEMTQNSMWESWS
FEEVDKKLREVMKNIYSSIKTTAEEYKKDGDLVFGANVTAFLKVARAMMDQGIV
>Mature_453_residues
SNSIELTQESYVDSIIERVVVRNPGETEFHQAVREVLESIKPVVELYPEFEENGILERLTEPERQIIFRVPWVDDQGNVH
VNRGYRIEFNSALGPYKGGLRFHPTVYPGIMKFLAFEQTFKNALTGRPIGGAKGGSDFDPKGKSDSEVMRFCQSFMTELY
RHIGAQTDIPAGDIGVGNREIGYLFGQYKRITNRFEAGTLTGKGVDWGGSLARTEATGYGLVYFVDEMLKDIGETFEGKK
VIVSGSGNVAIYTVQKVIELGGKVIALSDSDGMVYDPEGIDLNSVIEIKEKRRGRIVEYLKTHPSAEYNDNSKNIWKIEC
DIAFPCATQNEIDMEEAKTLVNNGVLVVAEGANMPCTPEAIECFQKNNVLFAPAKAANAGGVATSALEMTQNSMWESWSF
EEVDKKLREVMKNIYSSIKTTAEEYKKDGDLVFGANVTAFLKVARAMMDQGIV

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=353, Percent_Identity=31.4447592067989, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4885281, Length=353, Percent_Identity=31.1614730878187, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1788059, Length=451, Percent_Identity=53.880266075388, Blast_Score=488, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17544676, Length=354, Percent_Identity=30.5084745762712, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319256, Length=456, Percent_Identity=49.780701754386, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324951, Length=454, Percent_Identity=49.5594713656388, Blast_Score=391, Evalue=1e-110,
Organism=Drosophila melanogaster, GI45549226, Length=388, Percent_Identity=31.9587628865979, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45553475, Length=352, Percent_Identity=33.2386363636364, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24649283, Length=384, Percent_Identity=30.9895833333333, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24649460, Length=323, Percent_Identity=32.1981424148607, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 50426; Mature: 50295

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSIELTQESYVDSIIERVVVRNPGETEFHQAVREVLESIKPVVELYPEFEENGILERL
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
TEPERQIIFRVPWVDDQGNVHVNRGYRIEFNSALGPYKGGLRFHPTVYPGIMKFLAFEQT
CCCCCEEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCCEECCCHHHHHHHHHHHHHH
FKNALTGRPIGGAKGGSDFDPKGKSDSEVMRFCQSFMTELYRHIGAQTDIPAGDIGVGNR
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
EIGYLFGQYKRITNRFEAGTLTGKGVDWGGSLARTEATGYGLVYFVDEMLKDIGETFEGK
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
KVIVSGSGNVAIYTVQKVIELGGKVIALSDSDGMVYDPEGIDLNSVIEIKEKRRGRIVEY
EEEEECCCCEEEEEHHHHHHHCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
LKTHPSAEYNDNSKNIWKIECDIAFPCATQNEIDMEEAKTLVNNGVLVVAEGANMPCTPE
HHCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCHH
AIECFQKNNVLFAPAKAANAGGVATSALEMTQNSMWESWSFEEVDKKLREVMKNIYSSIK
HHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
TTAEEYKKDGDLVFGANVTAFLKVARAMMDQGIV
HHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNSIELTQESYVDSIIERVVVRNPGETEFHQAVREVLESIKPVVELYPEFEENGILERL
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
TEPERQIIFRVPWVDDQGNVHVNRGYRIEFNSALGPYKGGLRFHPTVYPGIMKFLAFEQT
CCCCCEEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCCEECCCHHHHHHHHHHHHHH
FKNALTGRPIGGAKGGSDFDPKGKSDSEVMRFCQSFMTELYRHIGAQTDIPAGDIGVGNR
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
EIGYLFGQYKRITNRFEAGTLTGKGVDWGGSLARTEATGYGLVYFVDEMLKDIGETFEGK
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
KVIVSGSGNVAIYTVQKVIELGGKVIALSDSDGMVYDPEGIDLNSVIEIKEKRRGRIVEY
EEEEECCCCEEEEEHHHHHHHCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
LKTHPSAEYNDNSKNIWKIECDIAFPCATQNEIDMEEAKTLVNNGVLVVAEGANMPCTPE
HHCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCHH
AIECFQKNNVLFAPAKAANAGGVATSALEMTQNSMWESWSFEEVDKKLREVMKNIYSSIK
HHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
TTAEEYKKDGDLVFGANVTAFLKVARAMMDQGIV
HHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]