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The map label for this gene is xanP [H]

Identifier: 160903161

GI number: 160903161

Start: 1888906

End: 1890264

Strand: Direct

Name: xanP [H]

Synonym: Pmob_1726

Alternate gene names: 160903161

Gene position: 1888906-1890264 (Clockwise)

Preceding gene: 160903157

Following gene: 160903162

Centisome position: 87.06

GC content: 38.48

Gene sequence:

>1359_bases
ATGGGAGATAGCACAGAAAAGACTACGGAAGAAGAAAAAGGAACAGAAGTTTTATACAAACTTGAAGACAAACCTCCGTT
TTATGCAACGGTTGTTCTGAGTATTCAGCACATGTTAGCTATGTTCGTTGGTATCATTACTCCACCTTTGATAATCGCGG
GGGTAGTGGGCTTGGATCCTCTAGAAACGGGATATTTCGTCAGCATGGCTTTGATTATTTCCGGGGTAACTACTTTTTTT
CAAGTAAAACAATTAGGACCTTTTGGTAGCGGTCTATTAGCAGTACAAGGGACAAGTTTTACATTTGTTCCTATGGCGAT
TGTCGCTGCAAACTTAGGGGGGTTACCTTTAGTCTTAGGTATGGCACTTATTACGTCCCCGGTTGAGATGATTTTGAGTC
GGTTTTTAGCTCAAACTCGCAAGATATTCCCTCCTGTAGTTTCTGGTACAGTTGTAATGTTAATAGGTTTAGGGTTGATA
GAAACAGCCATAACCGACATTGGTGGAGGAGTTGGAGCTATTGATTTTGGGAATGTGCAAAATTTAGCCATAGCTTTGTT
CGTATTAATAATCATAGTGATTGCAAATATATATGGCAAAGGCATCATAAAAGCTGGGGCGGTGGCTATTGGTTTAGTTG
CAGGATATCTGGTTGCAATACCGTTGGGTATGGTGGATTTTGCTCCGATTGTAGAAGCTGGATGGGTAACAGTCCCTATC
CCATTTAAATATGGGCTATCATTTAATTGGGCACTTATCATTCCTTGGATTTTAGCATATATTATTACTACAATTGAAAC
AGTAGGTGATTTGACAGCTATTGCTGAAGTTAGTGGCGAACCAATTGAAGGCAAAATTCACGATGAAAGATTAAAAAGAG
GAGTTTTATTGGACGGTGTAGGGAGTGCTTTAGCAGCTGTTTTTAATACTCTTCCTAACACAACTTTCAGTCAAAATACT
GGAGTTATTCAATTTAGTAAAATTTCTAGTCGAGTCGTTGGCTACGGTGTGGCAATTGTTTTGATACTATTAGGTGTCTT
TCCTAAAATTGGTGCTTTAGTAAGCGTTATGCCTAAACCTGTTTTAGGAGGTGCTACTATAGCTCTCTTTGGAATGGTAG
CGATGGCAGGTATGAAAATTGCAACAAAAGGTGGACTAAGCGATAAAAAAATGTTTATATTAGCTTTTTCTTTAGCTTTG
GGATTGGGAGTTACATTTAGGCCCGACATAGTGAACCAATTACCAGAATGGATGGCTGTTGTCTTTTCTTCTAACATTAC
TGTTGGATTTTTAACCGCTTTTATTTTAAACCTTTTGATACCAGAACCAAAAAAGGAAAAGAATGGATATAAAGCCTAA

Upstream 100 bases:

>100_bases
ATCTATAAAAAACTTTACTTGCGAATAAAGCAAAACTAAAGTATAATTAAAGTTAATGTTTAAGTAAAAATCCTATTCAT
TTTCAAAGGGGTGATTATTA

Downstream 100 bases:

>100_bases
GTTTACTTATTGCCACTTATGAATAAAGTTGATTATTCATGATTATTCCCGTTTATTGTTCTTTATAGACAACTAAAAAA
GATTAATTTGATTTATCAAT

Product: uracil-xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MGDSTEKTTEEEKGTEVLYKLEDKPPFYATVVLSIQHMLAMFVGIITPPLIIAGVVGLDPLETGYFVSMALIISGVTTFF
QVKQLGPFGSGLLAVQGTSFTFVPMAIVAANLGGLPLVLGMALITSPVEMILSRFLAQTRKIFPPVVSGTVVMLIGLGLI
ETAITDIGGGVGAIDFGNVQNLAIALFVLIIIVIANIYGKGIIKAGAVAIGLVAGYLVAIPLGMVDFAPIVEAGWVTVPI
PFKYGLSFNWALIIPWILAYIITTIETVGDLTAIAEVSGEPIEGKIHDERLKRGVLLDGVGSALAAVFNTLPNTTFSQNT
GVIQFSKISSRVVGYGVAIVLILLGVFPKIGALVSVMPKPVLGGATIALFGMVAMAGMKIATKGGLSDKKMFILAFSLAL
GLGVTFRPDIVNQLPEWMAVVFSSNITVGFLTAFILNLLIPEPKKEKNGYKA

Sequences:

>Translated_452_residues
MGDSTEKTTEEEKGTEVLYKLEDKPPFYATVVLSIQHMLAMFVGIITPPLIIAGVVGLDPLETGYFVSMALIISGVTTFF
QVKQLGPFGSGLLAVQGTSFTFVPMAIVAANLGGLPLVLGMALITSPVEMILSRFLAQTRKIFPPVVSGTVVMLIGLGLI
ETAITDIGGGVGAIDFGNVQNLAIALFVLIIIVIANIYGKGIIKAGAVAIGLVAGYLVAIPLGMVDFAPIVEAGWVTVPI
PFKYGLSFNWALIIPWILAYIITTIETVGDLTAIAEVSGEPIEGKIHDERLKRGVLLDGVGSALAAVFNTLPNTTFSQNT
GVIQFSKISSRVVGYGVAIVLILLGVFPKIGALVSVMPKPVLGGATIALFGMVAMAGMKIATKGGLSDKKMFILAFSLAL
GLGVTFRPDIVNQLPEWMAVVFSSNITVGFLTAFILNLLIPEPKKEKNGYKA
>Mature_451_residues
GDSTEKTTEEEKGTEVLYKLEDKPPFYATVVLSIQHMLAMFVGIITPPLIIAGVVGLDPLETGYFVSMALIISGVTTFFQ
VKQLGPFGSGLLAVQGTSFTFVPMAIVAANLGGLPLVLGMALITSPVEMILSRFLAQTRKIFPPVVSGTVVMLIGLGLIE
TAITDIGGGVGAIDFGNVQNLAIALFVLIIIVIANIYGKGIIKAGAVAIGLVAGYLVAIPLGMVDFAPIVEAGWVTVPIP
FKYGLSFNWALIIPWILAYIITTIETVGDLTAIAEVSGEPIEGKIHDERLKRGVLLDGVGSALAAVFNTLPNTTFSQNTG
VIQFSKISSRVVGYGVAIVLILLGVFPKIGALVSVMPKPVLGGATIALFGMVAMAGMKIATKGGLSDKKMFILAFSLALG
LGVTFRPDIVNQLPEWMAVVFSSNITVGFLTAFILNLLIPEPKKEKNGYKA

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=530, Percent_Identity=26.0377358490566, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI44680143, Length=533, Percent_Identity=26.078799249531, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI44680148, Length=227, Percent_Identity=32.15859030837, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI40316845, Length=227, Percent_Identity=32.15859030837, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1790087, Length=458, Percent_Identity=41.4847161572052, Blast_Score=349, Evalue=3e-97,
Organism=Escherichia coli, GI87082178, Length=450, Percent_Identity=39.5555555555556, Blast_Score=314, Evalue=8e-87,
Organism=Escherichia coli, GI87082181, Length=427, Percent_Identity=31.1475409836066, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1788843, Length=379, Percent_Identity=26.1213720316623, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI87081818, Length=420, Percent_Identity=25.952380952381, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17558856, Length=522, Percent_Identity=25.095785440613, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17541904, Length=502, Percent_Identity=21.5139442231076, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71993493, Length=228, Percent_Identity=24.5614035087719, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17542260, Length=228, Percent_Identity=22.8070175438596, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17542262, Length=230, Percent_Identity=24.3478260869565, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 47571; Mature: 47439

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDSTEKTTEEEKGTEVLYKLEDKPPFYATVVLSIQHMLAMFVGIITPPLIIAGVVGLDP
CCCCCCCCCHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCC
LETGYFVSMALIISGVTTFFQVKQLGPFGSGLLAVQGTSFTFVPMAIVAANLGGLPLVLG
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHH
MALITSPVEMILSRFLAQTRKIFPPVVSGTVVMLIGLGLIETAITDIGGGVGAIDFGNVQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
NLAIALFVLIIIVIANIYGKGIIKAGAVAIGLVAGYLVAIPLGMVDFAPIVEAGWVTVPI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
PFKYGLSFNWALIIPWILAYIITTIETVGDLTAIAEVSGEPIEGKIHDERLKRGVLLDGV
CEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHH
GSALAAVFNTLPNTTFSQNTGVIQFSKISSRVVGYGVAIVLILLGVFPKIGALVSVMPKP
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VLGGATIALFGMVAMAGMKIATKGGLSDKKMFILAFSLALGLGVTFRPDIVNQLPEWMAV
CCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VFSSNITVGFLTAFILNLLIPEPKKEKNGYKA
HHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
GDSTEKTTEEEKGTEVLYKLEDKPPFYATVVLSIQHMLAMFVGIITPPLIIAGVVGLDP
CCCCCCCCHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCC
LETGYFVSMALIISGVTTFFQVKQLGPFGSGLLAVQGTSFTFVPMAIVAANLGGLPLVLG
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHH
MALITSPVEMILSRFLAQTRKIFPPVVSGTVVMLIGLGLIETAITDIGGGVGAIDFGNVQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
NLAIALFVLIIIVIANIYGKGIIKAGAVAIGLVAGYLVAIPLGMVDFAPIVEAGWVTVPI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
PFKYGLSFNWALIIPWILAYIITTIETVGDLTAIAEVSGEPIEGKIHDERLKRGVLLDGV
CEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHH
GSALAAVFNTLPNTTFSQNTGVIQFSKISSRVVGYGVAIVLILLGVFPKIGALVSVMPKP
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VLGGATIALFGMVAMAGMKIATKGGLSDKKMFILAFSLALGLGVTFRPDIVNQLPEWMAV
CCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VFSSNITVGFLTAFILNLLIPEPKKEKNGYKA
HHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]