BacMap

Definition	Petrotoga mobilis SJ95 chromosome, complete genome.
Accession	NC_010003
Length	2,169,548

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The map label for this gene is yvgN [H]

Identifier: 160902946

GI number: 160902946

Start: 1618553

End: 1619377

Strand: Direct

Name: yvgN [H]

Synonym: Pmob_1501

Alternate gene names: 160902946

Gene position: 1618553-1619377 (Clockwise)

Preceding gene: 160902945

Following gene: 160902947

Centisome position: 74.6

GC content: 34.3

Gene sequence:

>825_bases
ATGAGAATTACAAGCATCTATGATAACACAGAATTAGCCAATAAAGTGAAAATCCCTTGGTTGGGCTATGGGACGTACAA
AGCCCATGGAGATGAGTTGATAGAGGGTGTAAAGTACGCTTTAAATATAGGATACAGATTGATAGATACTGCAGAAATGT
ACGAAAACGAAGAAGAGATAGGTAAAGCAATCAGGCAAAGTAAAATACCGAGAGATGAAATTTTTATAACCTCCAAAGTA
TGGAATACGAACCAAGGTTTTGAAAGTACTTTAAACTCTTTTGAAAATTCATTAAAAAGATTGGGAACAGATTATTTAGA
CTTATACTTAATTCATTGGCCTGTAAGTGGAAGATATATAGAAACCTGGAAAGCTCTTGAAAAGCTGTATAAGGAAGGTA
GAGTAAGGGCTATTGGTGTGAGTAACTTTTTAATTCATCATCTCCAAGATATAATAAACAACTGTGAAATTACCCCTATG
GTGAATCAAGTAGAATTTCATCCATACTTACTGCAAAGAGATCTTTTGGATTTCTGTCAAAGAAATAAGATACAGCTAGA
GGCTTGGAGTCCATTAATGAGAGGAAGAGTTCAAAACATACCTCAGATAGTTGATATAGCAAATAAGTATAAAAAAACTC
CCGCACAAATAGTATTGAGATGGGACTTGCAACATGGGGTGGTAACCATTCCAAAATCTGTGCACAAGGAAAGGATAAAA
GAAAATGCTGATATTTTCGACTTTGAACTAACAGAGGAAGAAATGAAGATAATAGACAATTTAGATCAAAGTAAAAGATT
TGGGGCAAATCCCGATGATTTTTAA

Upstream 100 bases:

>100_bases
GGGATTTGAAAAATATATCGCCGTCTGTAGAGATTGCTACTTGAAGTTGAATGAAAAAAAACAAAATCAAGATAAAAAAC
TGAAACAAGGGGGTTGATCT

Downstream 100 bases:

>100_bases
GGTTAACATAGCTTTTAACAAGATTAATTGATTTTTCAACAATGAAATGATATAATATGAAAGCGTCATTACAGGAGGCT
GGGTCCTGCGCAATAGGAAC

Product: 2,5-didehydrogluconate reductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MRITSIYDNTELANKVKIPWLGYGTYKAHGDELIEGVKYALNIGYRLIDTAEMYENEEEIGKAIRQSKIPRDEIFITSKV
WNTNQGFESTLNSFENSLKRLGTDYLDLYLIHWPVSGRYIETWKALEKLYKEGRVRAIGVSNFLIHHLQDIINNCEITPM
VNQVEFHPYLLQRDLLDFCQRNKIQLEAWSPLMRGRVQNIPQIVDIANKYKKTPAQIVLRWDLQHGVVTIPKSVHKERIK
ENADIFDFELTEEEMKIIDNLDQSKRFGANPDDF

Sequences:

>Translated_274_residues
MRITSIYDNTELANKVKIPWLGYGTYKAHGDELIEGVKYALNIGYRLIDTAEMYENEEEIGKAIRQSKIPRDEIFITSKV
WNTNQGFESTLNSFENSLKRLGTDYLDLYLIHWPVSGRYIETWKALEKLYKEGRVRAIGVSNFLIHHLQDIINNCEITPM
VNQVEFHPYLLQRDLLDFCQRNKIQLEAWSPLMRGRVQNIPQIVDIANKYKKTPAQIVLRWDLQHGVVTIPKSVHKERIK
ENADIFDFELTEEEMKIIDNLDQSKRFGANPDDF
>Mature_274_residues
MRITSIYDNTELANKVKIPWLGYGTYKAHGDELIEGVKYALNIGYRLIDTAEMYENEEEIGKAIRQSKIPRDEIFITSKV
WNTNQGFESTLNSFENSLKRLGTDYLDLYLIHWPVSGRYIETWKALEKLYKEGRVRAIGVSNFLIHHLQDIINNCEITPM
VNQVEFHPYLLQRDLLDFCQRNKIQLEAWSPLMRGRVQNIPQIVDIANKYKKTPAQIVLRWDLQHGVVTIPKSVHKERIK
ENADIFDFELTEEEMKIIDNLDQSKRFGANPDDF

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=286, Percent_Identity=38.8111888111888, Blast_Score=211, Evalue=4e-55,
Organism=Homo sapiens, GI5174391, Length=286, Percent_Identity=38.8111888111888, Blast_Score=211, Evalue=4e-55,
Organism=Homo sapiens, GI310109922, Length=285, Percent_Identity=40.7017543859649, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI5453543, Length=305, Percent_Identity=38.6885245901639, Blast_Score=197, Evalue=6e-51,
Organism=Homo sapiens, GI310109920, Length=305, Percent_Identity=38.6885245901639, Blast_Score=197, Evalue=7e-51,
Organism=Homo sapiens, GI223468663, Length=295, Percent_Identity=38.3050847457627, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI45446745, Length=305, Percent_Identity=38.6885245901639, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI4503285, Length=305, Percent_Identity=38.6885245901639, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI5174695, Length=308, Percent_Identity=38.961038961039, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI24497583, Length=301, Percent_Identity=38.5382059800665, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI24497585, Length=301, Percent_Identity=37.8737541528239, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI93277124, Length=304, Percent_Identity=33.8815789473684, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI4502049, Length=294, Percent_Identity=38.7755102040816, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI291291012, Length=270, Percent_Identity=38.1481481481481, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI300116273, Length=286, Percent_Identity=36.7132867132867, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI300116271, Length=286, Percent_Identity=37.0629370629371, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI310109924, Length=155, Percent_Identity=41.9354838709677, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI310109926, Length=136, Percent_Identity=39.7058823529412, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI207028673, Length=136, Percent_Identity=39.7058823529412, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI87082198, Length=261, Percent_Identity=47.8927203065134, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1786400, Length=256, Percent_Identity=35.546875, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1788081, Length=270, Percent_Identity=33.7037037037037, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1788070, Length=310, Percent_Identity=22.5806451612903, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081735, Length=269, Percent_Identity=26.0223048327138, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI48994888, Length=187, Percent_Identity=30.4812834224599, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71998625, Length=268, Percent_Identity=39.1791044776119, Blast_Score=210, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17564128, Length=300, Percent_Identity=37.3333333333333, Blast_Score=190, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17537077, Length=306, Percent_Identity=37.9084967320261, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17537075, Length=295, Percent_Identity=37.2881355932203, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17550248, Length=299, Percent_Identity=34.4481605351171, Blast_Score=177, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17561298, Length=268, Percent_Identity=33.5820895522388, Blast_Score=170, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=36.0294117647059, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17566692, Length=290, Percent_Identity=33.448275862069, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17552492, Length=260, Percent_Identity=33.0769230769231, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562292, Length=281, Percent_Identity=34.5195729537367, Blast_Score=152, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17561300, Length=268, Percent_Identity=35.0746268656716, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17537079, Length=299, Percent_Identity=30.7692307692308, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320576, Length=286, Percent_Identity=38.8111888111888, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324694, Length=297, Percent_Identity=37.3737373737374, Blast_Score=199, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322556, Length=263, Percent_Identity=34.6007604562738, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6320079, Length=278, Percent_Identity=37.0503597122302, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319625, Length=302, Percent_Identity=36.0927152317881, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6321896, Length=306, Percent_Identity=33.3333333333333, Blast_Score=164, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24663317, Length=290, Percent_Identity=41.0344827586207, Blast_Score=214, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24662789, Length=296, Percent_Identity=36.1486486486487, Blast_Score=197, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24644950, Length=295, Percent_Identity=37.2881355932203, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI221378297, Length=315, Percent_Identity=34.9206349206349, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24657054, Length=282, Percent_Identity=36.8794326241135, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI20129731, Length=292, Percent_Identity=35.6164383561644, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI21356425, Length=287, Percent_Identity=35.5400696864112, Blast_Score=183, Evalue=9e-47,
Organism=Drosophila melanogaster, GI45553081, Length=291, Percent_Identity=35.3951890034364, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24662781, Length=277, Percent_Identity=38.9891696750903, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24662785, Length=269, Percent_Identity=39.7769516728625, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=35.9375, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 32092; Mature: 32092

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITSIYDNTELANKVKIPWLGYGTYKAHGDELIEGVKYALNIGYRLIDTAEMYENEEEI
CEEECCCCCCHHHCEEECCEEECCCCCCCHHHHHHHHHHHHHCCHHEEEHHHHHCCHHHH
GKAIRQSKIPRDEIFITSKVWNTNQGFESTLNSFENSLKRLGTDYLDLYLIHWPVSGRYI
HHHHHHHCCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHEEEEEEEECCCCCHH
ETWKALEKLYKEGRVRAIGVSNFLIHHLQDIINNCEITPMVNQVEFHPYLLQRDLLDFCQ
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHH
RNKIQLEAWSPLMRGRVQNIPQIVDIANKYKKTPAQIVLRWDLQHGVVTIPKSVHKERIK
CCCEEEEHHCHHHHHHHHCCHHHHHHHHHHCCCHHHEEEEEECCCCEEECCHHHHHHHHH
ENADIFDFELTEEEMKIIDNLDQSKRFGANPDDF
CCCCEEEEEECHHHHHHHHCCCHHHCCCCCCCCC
>Mature Secondary Structure
MRITSIYDNTELANKVKIPWLGYGTYKAHGDELIEGVKYALNIGYRLIDTAEMYENEEEI
CEEECCCCCCHHHCEEECCEEECCCCCCCHHHHHHHHHHHHHCCHHEEEHHHHHCCHHHH
GKAIRQSKIPRDEIFITSKVWNTNQGFESTLNSFENSLKRLGTDYLDLYLIHWPVSGRYI
HHHHHHHCCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHEEEEEEEECCCCCHH
ETWKALEKLYKEGRVRAIGVSNFLIHHLQDIINNCEITPMVNQVEFHPYLLQRDLLDFCQ
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHH
RNKIQLEAWSPLMRGRVQNIPQIVDIANKYKKTPAQIVLRWDLQHGVVTIPKSVHKERIK
CCCEEEEHHCHHHHHHHHCCHHHHHHHHHHCCCHHHEEEEEECCCCEEECCHHHHHHHHH
ENADIFDFELTEEEMKIIDNLDQSKRFGANPDDF
CCCCEEEEEECHHHHHHHHCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]