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The map label for this gene is ahcY [H]

Identifier: 160902912

GI number: 160902912

Start: 1580904

End: 1582130

Strand: Direct

Name: ahcY [H]

Synonym: Pmob_1467

Alternate gene names: 160902912

Gene position: 1580904-1582130 (Clockwise)

Preceding gene: 160902911

Following gene: 160902914

Centisome position: 72.87

GC content: 36.27

Gene sequence:

>1227_bases
ATGACTTCACTAGCAGAAAGCGGCAAAAAGAAAATAGAATGGGTAAAAAAGCACATGAAAGTTTTAAACTATTTAAAAGA
TCTATACCAAACAGAAAAACCCTTTGAAGGGGTAAATGTAGCTGTAAGCATCCATTTAGAGGCGAAAACAGCCTATTTAG
GAATAGTATTACACGAATTAGGTGCCAACGTTGCTATAACAGGGAGTAACCCCTTATCCACACAAGAAGATGTCGTAGAA
GCTCTGAAAGAATATGGACTCAATGTACATGCAGAAAGAACTTTAGATGAATCAGTCTACTGGAAAAATATCGATAAAAT
ATTAGAAACTAATCCTAACATAATTTTAGACGACGGAGCAGATTTGGGAATAACCTTGATAGAGAAACACCCTGAAAAAG
TAAGCAATCTCTGGGGAATCTGTGAAGAAACCACCACAGGTGTAAAAAGATACAAATCCCTCTTCAAAGAAAATAAATTA
CCTGTACCTGTGATTTTAATAAACGACTCTTACATGAAATATTTGTTCGACAACAGATACGGTACAGGCCAATCAACGTG
GGACGGGATTATGAGATCAACTAACCTTTCTGTTTCTGGTAAAATAGTAGTTGTAGCAGGGTACGGTTGGTGTGGTAAAG
GTGTTGCCATGAGAGCAAAGGGATTAGGCGCCAACGTTATAATAACCGAAGTTGATCCAATAAAAGCTAACGAAGCGATA
ATGGATGGATTTAGAGTTATGAAAATGGATGAAGCAGTAAAATACGGGGATTTTTTTGTAACGGTAACAGGTGACATCGA
TGTAATAACGAAGAGGCACTTTTTAGAAATGAAAGAAGGTGCGATTCTTTCCAATGCCGGACATTTTGACGTTGAAGTAA
AGGTAAAAGATTTGGAAGAAGTTGCGGTAGACAAAATCAACGTAAGAAACGGAGTAGAAGAATACAAATTACCAAACGGG
AAAAGCGTATTTTTATTAGGACAAGGAAGACTGGTTAATCTTGTTAACGGCGATGGTCATCCCGCAGAAATAATGGATCT
CTCCTTTAGTTTACAGTTAGAGGGTGCAAAATATATAAAAGAAAACCACCAAAATATGAAAGTAAATCTTTCCCCAGTAC
CTTATGAAATAGACGAAAAAATAGCACAAATTAACCTAAAAACATTAGGAATTGAGATAGACACCCTATCTGAAGAGCAA
AAAGATTATTTGAATAGTTGGAAATAA

Upstream 100 bases:

>100_bases
AGGGACCGCAGGTCCCTTCCATAGAAGGGTGGGGAGCGGGGAATGGGCGCTATATACAATGTTTTAGAGTATAATTTTTA
AAAATAAGGGGAGGACTACT

Downstream 100 bases:

>100_bases
TATAAAAGGGGCACCAGTAGGCGCCCCTTTCACTCAATCAAATCTGCATACATTGGAAAACGTTGACAGAGAGAAACAAC
ATCTTTTTTAATTTCTTGTG

Product: adenosylhomocysteinase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MTSLAESGKKKIEWVKKHMKVLNYLKDLYQTEKPFEGVNVAVSIHLEAKTAYLGIVLHELGANVAITGSNPLSTQEDVVE
ALKEYGLNVHAERTLDESVYWKNIDKILETNPNIILDDGADLGITLIEKHPEKVSNLWGICEETTTGVKRYKSLFKENKL
PVPVILINDSYMKYLFDNRYGTGQSTWDGIMRSTNLSVSGKIVVVAGYGWCGKGVAMRAKGLGANVIITEVDPIKANEAI
MDGFRVMKMDEAVKYGDFFVTVTGDIDVITKRHFLEMKEGAILSNAGHFDVEVKVKDLEEVAVDKINVRNGVEEYKLPNG
KSVFLLGQGRLVNLVNGDGHPAEIMDLSFSLQLEGAKYIKENHQNMKVNLSPVPYEIDEKIAQINLKTLGIEIDTLSEEQ
KDYLNSWK

Sequences:

>Translated_408_residues
MTSLAESGKKKIEWVKKHMKVLNYLKDLYQTEKPFEGVNVAVSIHLEAKTAYLGIVLHELGANVAITGSNPLSTQEDVVE
ALKEYGLNVHAERTLDESVYWKNIDKILETNPNIILDDGADLGITLIEKHPEKVSNLWGICEETTTGVKRYKSLFKENKL
PVPVILINDSYMKYLFDNRYGTGQSTWDGIMRSTNLSVSGKIVVVAGYGWCGKGVAMRAKGLGANVIITEVDPIKANEAI
MDGFRVMKMDEAVKYGDFFVTVTGDIDVITKRHFLEMKEGAILSNAGHFDVEVKVKDLEEVAVDKINVRNGVEEYKLPNG
KSVFLLGQGRLVNLVNGDGHPAEIMDLSFSLQLEGAKYIKENHQNMKVNLSPVPYEIDEKIAQINLKTLGIEIDTLSEEQ
KDYLNSWK
>Mature_407_residues
TSLAESGKKKIEWVKKHMKVLNYLKDLYQTEKPFEGVNVAVSIHLEAKTAYLGIVLHELGANVAITGSNPLSTQEDVVEA
LKEYGLNVHAERTLDESVYWKNIDKILETNPNIILDDGADLGITLIEKHPEKVSNLWGICEETTTGVKRYKSLFKENKLP
VPVILINDSYMKYLFDNRYGTGQSTWDGIMRSTNLSVSGKIVVVAGYGWCGKGVAMRAKGLGANVIITEVDPIKANEAIM
DGFRVMKMDEAVKYGDFFVTVTGDIDVITKRHFLEMKEGAILSNAGHFDVEVKVKDLEEVAVDKINVRNGVEEYKLPNGK
SVFLLGQGRLVNLVNGDGHPAEIMDLSFSLQLEGAKYIKENHQNMKVNLSPVPYEIDEKIAQINLKTLGIEIDTLSEEQK
DYLNSWK

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=404, Percent_Identity=40.8415841584158, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI239937451, Length=389, Percent_Identity=41.3881748071979, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI298286489, Length=404, Percent_Identity=36.1386138613861, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI195539349, Length=404, Percent_Identity=36.1386138613861, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI195539337, Length=404, Percent_Identity=36.1386138613861, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI24308043, Length=404, Percent_Identity=36.1386138613861, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI21361647, Length=404, Percent_Identity=36.8811881188119, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17506425, Length=408, Percent_Identity=38.2352941176471, Blast_Score=266, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6320882, Length=421, Percent_Identity=39.4299287410926, Blast_Score=280, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24642172, Length=406, Percent_Identity=40.3940886699507, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24656245, Length=400, Percent_Identity=37, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI45553385, Length=400, Percent_Identity=36, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI45553387, Length=400, Percent_Identity=36, Blast_Score=231, Evalue=6e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 45569; Mature: 45438

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLAESGKKKIEWVKKHMKVLNYLKDLYQTEKPFEGVNVAVSIHLEAKTAYLGIVLHEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCHHHHHHHHHHH
GANVAITGSNPLSTQEDVVEALKEYGLNVHAERTLDESVYWKNIDKILETNPNIILDDGA
CCCEEEECCCCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEECCC
DLGITLIEKHPEKVSNLWGICEETTTGVKRYKSLFKENKLPVPVILINDSYMKYLFDNRY
CCCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCC
GTGQSTWDGIMRSTNLSVSGKIVVVAGYGWCGKGVAMRAKGLGANVIITEVDPIKANEAI
CCCCCHHHHHHHCCCCEECCEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCCHHH
MDGFRVMKMDEAVKYGDFFVTVTGDIDVITKRHFLEMKEGAILSNAGHFDVEVKVKDLEE
HCCHHEEEHHHHEEECCEEEEEECCEEEEHHHHHHHHCCCEEEECCCCEEEEEEECCHHH
VAVDKINVRNGVEEYKLPNGKSVFLLGQGRLVNLVNGDGHPAEIMDLSFSLQLEGAKYIK
HHHHHHHHHCCHHHHCCCCCCEEEEEECCCEEEEECCCCCCCEEEEEEEEEEECCHHHHH
ENHQNMKVNLSPVPYEIDEKIAQINLKTLGIEIDTLSEEQKDYLNSWK
CCCCCEEEEECCCCCHHHHHHHEEEEEEEEEEEECCCHHHHHHHHCCC
>Mature Secondary Structure 
TSLAESGKKKIEWVKKHMKVLNYLKDLYQTEKPFEGVNVAVSIHLEAKTAYLGIVLHEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCHHHHHHHHHHH
GANVAITGSNPLSTQEDVVEALKEYGLNVHAERTLDESVYWKNIDKILETNPNIILDDGA
CCCEEEECCCCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEECCC
DLGITLIEKHPEKVSNLWGICEETTTGVKRYKSLFKENKLPVPVILINDSYMKYLFDNRY
CCCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCC
GTGQSTWDGIMRSTNLSVSGKIVVVAGYGWCGKGVAMRAKGLGANVIITEVDPIKANEAI
CCCCCHHHHHHHCCCCEECCEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCCHHH
MDGFRVMKMDEAVKYGDFFVTVTGDIDVITKRHFLEMKEGAILSNAGHFDVEVKVKDLEE
HCCHHEEEHHHHEEECCEEEEEECCEEEEHHHHHHHHCCCEEEECCCCEEEEEEECCHHH
VAVDKINVRNGVEEYKLPNGKSVFLLGQGRLVNLVNGDGHPAEIMDLSFSLQLEGAKYIK
HHHHHHHHHCCHHHHCCCCCCEEEEEECCCEEEEECCCCCCCEEEEEEEEEEECCHHHHH
ENHQNMKVNLSPVPYEIDEKIAQINLKTLGIEIDTLSEEQKDYLNSWK
CCCCCEEEEECCCCCHHHHHHHEEEEEEEEEEEECCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9440516; 10360571 [H]