Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 160902816

GI number: 160902816

Start: 1476238

End: 1476750

Strand: Direct

Name: hpt [H]

Synonym: Pmob_1370

Alternate gene names: 160902816

Gene position: 1476238-1476750 (Clockwise)

Preceding gene: 160902815

Following gene: 160902817

Centisome position: 68.04

GC content: 29.43

Gene sequence:

>513_bases
ATGTCATTAAAAGTCCTTATTTCAGAGGAGGAAATTCAAAAAAAGGTCGAAGATTTGGCTAAGCAAATAGATGATTATTA
TAAAAATATAACGGATGAAATTGTCGCGGTATGTGTCTTAAAAGGATCCGTCAATTTCTTTAGTGATTTGGTAAAAAAGA
TACATTTGAACGTTAATTATAATTTTATACAGGTATCTAGTTATTCTGGGGATATAACCACGGGAAAAGTAAAGGTAAAA
AGTTGGCTTGATGAGCCCCTTGAAAATAAACATGTTTTAATAGTCGAAGACATCGTGGATACTGGGAATACATTAAAATA
TATAGTAAAATATTTAGAGATGCAAAATCCTTCCTCTTTAGAAATTACATCTATTGTTTTAAAAACAATTCACGAGCATG
GAATTCAAGTAAGATTTCCTGGTTTTGAAATTGGAGATAAATTTATAGTAGGGTACGGATTGGATTACAATGAAAAATAT
AGAAATTTACCTTACATTGGATATATAGAATAA

Upstream 100 bases:

>100_bases
TTATAATATTTCTTAGAATGAATTTTTTGGGGGAAGTTTTGGTTTTTAAAAGAATAAGATATAAAGAGAGTAATTTTTTA
TTTCTATGGGGAGGTATATA

Downstream 100 bases:

>100_bases
GGAGGCTAATATTACATGGATATTGAACAGTACGTATCAAAAGTGAGAGAAGCAGCTAAGTATATTCAAGAAAAAACCAC
GAAAAAGCCCAGAATTGCGA

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MSLKVLISEEEIQKKVEDLAKQIDDYYKNITDEIVAVCVLKGSVNFFSDLVKKIHLNVNYNFIQVSSYSGDITTGKVKVK
SWLDEPLENKHVLIVEDIVDTGNTLKYIVKYLEMQNPSSLEITSIVLKTIHEHGIQVRFPGFEIGDKFIVGYGLDYNEKY
RNLPYIGYIE

Sequences:

>Translated_170_residues
MSLKVLISEEEIQKKVEDLAKQIDDYYKNITDEIVAVCVLKGSVNFFSDLVKKIHLNVNYNFIQVSSYSGDITTGKVKVK
SWLDEPLENKHVLIVEDIVDTGNTLKYIVKYLEMQNPSSLEITSIVLKTIHEHGIQVRFPGFEIGDKFIVGYGLDYNEKY
RNLPYIGYIE
>Mature_169_residues
SLKVLISEEEIQKKVEDLAKQIDDYYKNITDEIVAVCVLKGSVNFFSDLVKKIHLNVNYNFIQVSSYSGDITTGKVKVKS
WLDEPLENKHVLIVEDIVDTGNTLKYIVKYLEMQNPSSLEITSIVLKTIHEHGIQVRFPGFEIGDKFIVGYGLDYNEKYR
NLPYIGYIE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=179, Percent_Identity=40.2234636871508, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI9910262, Length=174, Percent_Identity=36.2068965517241, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI87081689, Length=170, Percent_Identity=41.7647058823529, Blast_Score=139, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17510817, Length=175, Percent_Identity=39.4285714285714, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19542; Mature: 19411

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKVLISEEEIQKKVEDLAKQIDDYYKNITDEIVAVCVLKGSVNFFSDLVKKIHLNVNY
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCC
NFIQVSSYSGDITTGKVKVKSWLDEPLENKHVLIVEDIVDTGNTLKYIVKYLEMQNPSSL
EEEEEECCCCCEEECEEEEHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHCCCCCCH
EITSIVLKTIHEHGIQVRFPGFEIGDKFIVGYGLDYNEKYRNLPYIGYIE
HHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCHHHCCCCEEEEEC
>Mature Secondary Structure 
SLKVLISEEEIQKKVEDLAKQIDDYYKNITDEIVAVCVLKGSVNFFSDLVKKIHLNVNY
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCC
NFIQVSSYSGDITTGKVKVKSWLDEPLENKHVLIVEDIVDTGNTLKYIVKYLEMQNPSSL
EEEEEECCCCCEEECEEEEHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHCCCCCCH
EITSIVLKTIHEHGIQVRFPGFEIGDKFIVGYGLDYNEKYRNLPYIGYIE
HHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]