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The map label for this gene is appC [H]

Identifier: 160902775

GI number: 160902775

Start: 1421589

End: 1423265

Strand: Direct

Name: appC [H]

Synonym: Pmob_1328

Alternate gene names: 160902775

Gene position: 1421589-1423265 (Clockwise)

Preceding gene: 160902774

Following gene: 160902776

Centisome position: 65.52

GC content: 36.2

Gene sequence:

>1677_bases
GTGAGAAAAAAGCAGAAGGACAATTTGAAGAACACACCCCAAAACACACAAAACGATGAAGAACTTTTTGAGCGAGAATT
CATGTCAACCCCTGCACTTATTTGGAGGGCATTAAGAAGGCACAAATTGGGAATGATATCACTTGTTGTGTTGATCATTT
TATATTTACTTGCTATATTTGCAGATTTCGTCTCTCCAATGAATCCATTTAATAACCATATTCAGTATAGATTTGCTCCT
CCGTCTACGATTTATAGAAAGGATTTATTCACAGGAGATAGAGTTGGACCTCACACTTATCTGTATATGAGTGAAAGAGA
TCCAATAACATACCAGAGTGATTATGTAGAAGCAACCCATTTGGATGTAATTAGGGCAAGGGATCCCGAAACAGGTGATT
TAATAACCTTTGAATTAGGTGCATACAATCCAACCTACAATGCAACAGTTTCAGACATTACATATACCTTTAAGAATACT
ATCATGGCTAAAACTGCAGATGGGGAGTACATTGAATTATCAACCAATCGTAAATACGATCAGACCCTGATACCTTTATC
TTATTTTACAAAAGAAGAAAACTTAAATGGTCCAGCTTCATATGAAGATGGTCTTTATGACGTTAATTTTTCAAAGCTTT
TGATGGGAGAAGATATTGTTGTCAAAGAAGATAACAGAAGTATGGCAATTAATACTTACAAAAGTGATTATAGATACGCT
CCTAAAATAATGAATCAAGAAATTATCAGCATAGATACTTTTGCTACTTTGGAAGAAATATATGTTTATTTTGACTTTTT
ACCAGTTGTATTAACCCCTTCAGATTTACAAGCGGTTAATTTAAAGAATTATCCTATTGAATTTTTCATTCATTCTTGGG
ATTACAAGCTTTTAGGCCTTTTCCCTAGCAATTTACATTTATTTGGAGTCGAAAAACCAAAATTACCTTCATTATCTGAT
TATTTTTCAAACGATGGGATACTGTATGTATGGGGATCAGACCAATATGGAAGGGATATTTTCAGTAGGATATTCTTTGC
TTCCCGAATTTCCCTTTCTATAGGGTTGATTGGAATATTATTAACTTTTACAATAGGTATTTTTTTAGGCGGTTTGGCTG
GATATTTTGGAGGATGGGTAGACGAAGTGACTATGAGGTTTACGGAAATATTGATGTCCATTCCTAGCCTTTATTTGATA
TTAACTTTAAGTGCTGTTTTGCCTACAGGTATATCGCCAGAGATTAGGTATCTTCTGATAGTTGTGATTTTGTCTTTTAT
TGGCTGGCCCGGAATGACAAGGGTCATAAGAGGGATGACTATGGGATTGAAACAAACAGAGTTTGTTCAAGCTGCTATAG
CCCTAGGATATCCTCCAAGAAAAGTGATCTGGAACCATTTGTTACCGAACACTTATACTTACGTAATCGTTTCCGCTACG
TTATCTATACCGGGATATATTTTAGGTGAGGCTAGTCTCAGTTTCTTGGGTGTGGGAGTAACTGAACCTGGAGCCTCGTG
GGGCTTGATGCTTTCCCAGGCTCAAGATATACAAGTTTTAACCAGTTACCCTTGGGTACTTTTACCAGGATTGTTTATCA
TTATAACGGTTCTTGCCTTCAATTTGTTTGGAGATGCCATAAGGGATGCATTGGATCCACGAGCTTTAGGCTTGTAA

Upstream 100 bases:

>100_bases
TTCTATTAATTACTGGTAATTTGATCGCTGATATCTTACTTGCTGCATCTGATCCTCGTGTCAGATTAAGAATGAGTGCT
TAAATTGGAGGGATTTTTAA

Downstream 100 bases:

>100_bases
TTCTATAATTAATATAAACCCCACGTATTTTGTGGGGCTTTTTATTATGGTATTTGGTTTATATTTTTGTAAAAGCCAAG
AAATTTAGTGAAAATTTGAA

Product: binding-protein-dependent transport systems inner membrane component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MRKKQKDNLKNTPQNTQNDEELFEREFMSTPALIWRALRRHKLGMISLVVLIILYLLAIFADFVSPMNPFNNHIQYRFAP
PSTIYRKDLFTGDRVGPHTYLYMSERDPITYQSDYVEATHLDVIRARDPETGDLITFELGAYNPTYNATVSDITYTFKNT
IMAKTADGEYIELSTNRKYDQTLIPLSYFTKEENLNGPASYEDGLYDVNFSKLLMGEDIVVKEDNRSMAINTYKSDYRYA
PKIMNQEIISIDTFATLEEIYVYFDFLPVVLTPSDLQAVNLKNYPIEFFIHSWDYKLLGLFPSNLHLFGVEKPKLPSLSD
YFSNDGILYVWGSDQYGRDIFSRIFFASRISLSIGLIGILLTFTIGIFLGGLAGYFGGWVDEVTMRFTEILMSIPSLYLI
LTLSAVLPTGISPEIRYLLIVVILSFIGWPGMTRVIRGMTMGLKQTEFVQAAIALGYPPRKVIWNHLLPNTYTYVIVSAT
LSIPGYILGEASLSFLGVGVTEPGASWGLMLSQAQDIQVLTSYPWVLLPGLFIIITVLAFNLFGDAIRDALDPRALGL

Sequences:

>Translated_558_residues
MRKKQKDNLKNTPQNTQNDEELFEREFMSTPALIWRALRRHKLGMISLVVLIILYLLAIFADFVSPMNPFNNHIQYRFAP
PSTIYRKDLFTGDRVGPHTYLYMSERDPITYQSDYVEATHLDVIRARDPETGDLITFELGAYNPTYNATVSDITYTFKNT
IMAKTADGEYIELSTNRKYDQTLIPLSYFTKEENLNGPASYEDGLYDVNFSKLLMGEDIVVKEDNRSMAINTYKSDYRYA
PKIMNQEIISIDTFATLEEIYVYFDFLPVVLTPSDLQAVNLKNYPIEFFIHSWDYKLLGLFPSNLHLFGVEKPKLPSLSD
YFSNDGILYVWGSDQYGRDIFSRIFFASRISLSIGLIGILLTFTIGIFLGGLAGYFGGWVDEVTMRFTEILMSIPSLYLI
LTLSAVLPTGISPEIRYLLIVVILSFIGWPGMTRVIRGMTMGLKQTEFVQAAIALGYPPRKVIWNHLLPNTYTYVIVSAT
LSIPGYILGEASLSFLGVGVTEPGASWGLMLSQAQDIQVLTSYPWVLLPGLFIIITVLAFNLFGDAIRDALDPRALGL
>Mature_558_residues
MRKKQKDNLKNTPQNTQNDEELFEREFMSTPALIWRALRRHKLGMISLVVLIILYLLAIFADFVSPMNPFNNHIQYRFAP
PSTIYRKDLFTGDRVGPHTYLYMSERDPITYQSDYVEATHLDVIRARDPETGDLITFELGAYNPTYNATVSDITYTFKNT
IMAKTADGEYIELSTNRKYDQTLIPLSYFTKEENLNGPASYEDGLYDVNFSKLLMGEDIVVKEDNRSMAINTYKSDYRYA
PKIMNQEIISIDTFATLEEIYVYFDFLPVVLTPSDLQAVNLKNYPIEFFIHSWDYKLLGLFPSNLHLFGVEKPKLPSLSD
YFSNDGILYVWGSDQYGRDIFSRIFFASRISLSIGLIGILLTFTIGIFLGGLAGYFGGWVDEVTMRFTEILMSIPSLYLI
LTLSAVLPTGISPEIRYLLIVVILSFIGWPGMTRVIRGMTMGLKQTEFVQAAIALGYPPRKVIWNHLLPNTYTYVIVSAT
LSIPGYILGEASLSFLGVGVTEPGASWGLMLSQAQDIQVLTSYPWVLLPGLFIIITVLAFNLFGDAIRDALDPRALGL

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787054, Length=242, Percent_Identity=38.0165289256198, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787760, Length=242, Percent_Identity=37.1900826446281, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787498, Length=227, Percent_Identity=39.2070484581498, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1789889, Length=224, Percent_Identity=38.8392857142857, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789964, Length=227, Percent_Identity=37.4449339207048, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788505, Length=229, Percent_Identity=33.6244541484716, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787549, Length=221, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 63270; Mature: 63270

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKQKDNLKNTPQNTQNDEELFEREFMSTPALIWRALRRHKLGMISLVVLIILYLLAIF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ADFVSPMNPFNNHIQYRFAPPSTIYRKDLFTGDRVGPHTYLYMSERDPITYQSDYVEATH
HHHHCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHH
LDVIRARDPETGDLITFELGAYNPTYNATVSDITYTFKNTIMAKTADGEYIELSTNRKYD
EEEEECCCCCCCCEEEEEECCCCCCCCCCHHHEEEEEHHEEEEEECCCCEEEEECCCCCC
QTLIPLSYFTKEENLNGPASYEDGLYDVNFSKLLMGEDIVVKEDNRSMAINTYKSDYRYA
CEEECHHHHCCCCCCCCCCCCCCCEEECCHHHHEECCCEEEEECCCEEEEEEECCCCHHC
PKIMNQEIISIDTFATLEEIYVYFDFLPVVLTPSDLQAVNLKNYPIEFFIHSWDYKLLGL
HHHHCCHHEEHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCEEEEEEECCEEEEEE
FPSNLHLFGVEKPKLPSLSDYFSNDGILYVWGSDQYGRDIFSRIFFASRISLSIGLIGIL
CCCCEEEEECCCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LTFTIGIFLGGLAGYFGGWVDEVTMRFTEILMSIPSLYLILTLSAVLPTGISPEIRYLLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VVILSFIGWPGMTRVIRGMTMGLKQTEFVQAAIALGYPPRKVIWNHLLPNTYTYVIVSAT
HHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEEE
LSIPGYILGEASLSFLGVGVTEPGASWGLMLSQAQDIQVLTSYPWVLLPGLFIIITVLAF
ECCCCEEEECCCEEEEEECCCCCCCCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHH
NLFGDAIRDALDPRALGL
HHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MRKKQKDNLKNTPQNTQNDEELFEREFMSTPALIWRALRRHKLGMISLVVLIILYLLAIF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ADFVSPMNPFNNHIQYRFAPPSTIYRKDLFTGDRVGPHTYLYMSERDPITYQSDYVEATH
HHHHCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHH
LDVIRARDPETGDLITFELGAYNPTYNATVSDITYTFKNTIMAKTADGEYIELSTNRKYD
EEEEECCCCCCCCEEEEEECCCCCCCCCCHHHEEEEEHHEEEEEECCCCEEEEECCCCCC
QTLIPLSYFTKEENLNGPASYEDGLYDVNFSKLLMGEDIVVKEDNRSMAINTYKSDYRYA
CEEECHHHHCCCCCCCCCCCCCCCEEECCHHHHEECCCEEEEECCCEEEEEEECCCCHHC
PKIMNQEIISIDTFATLEEIYVYFDFLPVVLTPSDLQAVNLKNYPIEFFIHSWDYKLLGL
HHHHCCHHEEHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCEEEEEEECCEEEEEE
FPSNLHLFGVEKPKLPSLSDYFSNDGILYVWGSDQYGRDIFSRIFFASRISLSIGLIGIL
CCCCEEEEECCCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LTFTIGIFLGGLAGYFGGWVDEVTMRFTEILMSIPSLYLILTLSAVLPTGISPEIRYLLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VVILSFIGWPGMTRVIRGMTMGLKQTEFVQAAIALGYPPRKVIWNHLLPNTYTYVIVSAT
HHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEEE
LSIPGYILGEASLSFLGVGVTEPGASWGLMLSQAQDIQVLTSYPWVLLPGLFIIITVLAF
ECCCCEEEECCCEEEEEECCCCCCCCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHH
NLFGDAIRDALDPRALGL
HHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]