Click here to switch to the map view.

The map label for this gene is phoQ [H]

Identifier: 160876980

GI number: 160876980

Start: 4567684

End: 4569012

Strand: Direct

Name: phoQ [H]

Synonym: Sbal195_3876

Alternate gene names: 160876980

Gene position: 4567684-4569012 (Clockwise)

Preceding gene: 160876979

Following gene: 160877005

Centisome position: 85.42

GC content: 49.44

Gene sequence:

>1329_bases
ATGATCTCAATCCGCACTAAGCTCAGTTTATGGTTAACGGGCTTACTGGTAATAGGCACAGTCATTGGGCTCATCTTGTT
TGAGTCCATGCTGCGTCAGGCGTTTCATGATTCTATTATCAATCGCTTAGAAGAAGATCTCGAACATATTATGTTGGCAA
CCCATATCCACGATGGGGACATCAGCATAGATCAAAGCCAGCTTTCCAGTTTCTACAAGCCCGCCTATTCAGGCCGCTAT
TTCCAGCTTAACCTGCCCAATGAAGTCATTCGCTCCCGCTCCCTGTGGGATATGCAGTTAGATATCGAGCCACTCGCGCC
AAATCAAACCCGTGTCTGGCAAGCTAAAGGCCCTAAAAATAACGATATGCAGCTGTTATCACTGGGGCTAAATTCCAGTA
GCGCCAATGTCAGCGCCACCTTAACTGTTGCCCAAGATTTGAGTATCGGCAGACGCGTGTTTAGCGAAGTCTATGGCACT
AAGCTGGGGATCAATCTGGCGATGTTGGTGGCTATGATCGCGGGGATCTTCCTCATCCTGCGTCAATCCTTTAAGCCAGT
TAAGCATATTCAGCACGCGCTTTCGCGGCTAAGAGAAGGCGAGATTAACGCGCTGGAGCTGAATAATATCCCCCCAGAAG
TGCAGCCACTCGCTAAGACTTACAACGAGTTACTCGAGTACACCGCCAAGCAAATTGAGCGTAGCCGCAATAACTTAGGC
AACTTAAGCCATGGGCTTAAAACCCCGCTGGCTGTGATGCAGCAACAGGTCGAAGCCCTTGGTCTTAAAGATCCCGAAAC
CGCCATTGCCTTGCAGCAACAGCTGGATTCTATCCACAAGATGGTCGAGCGCAAACTGGCGGCGGCAAGGATCACAGGCG
ATATGCTTCCTGCGGCGCAATTGGTTATCCCAAGGGATTTACACAGCCTAGCCAACACCTTAAACAAGGTTCACCGCAAT
AAAACCATCGAATGTGATTTCGAACTCGACCCTAATATTCTCAGGCTGCCGATCCACAGGGAAGATGGCATGGAGCTCCT
AGGCAATCTGCTGGACAACGCCTTTAAATGGGCCCAGAGCCGAGTCAGCATTCAGTTATCACGCCAACAGGAGCGTCTCT
GCCTTTGTATCGATGATGATGGTCCTGGGGTTGCCGATGATGAACTAGATAAACTCACCCAAAGAGGCACTCGATTAGAT
GAGTCTGTCATGGGGCACGGTTTAGGTTTGTCGATAGTGAAGGAAATTGCTGAACAGTATCAGATTGGGCTTAAGTTTAG
CCACAGCACTCGCTTAGGTGGACTGAGGATCGAACTGACCTTCAGTTAG

Upstream 100 bases:

>100_bases
ATGTGGTCGAAGTTTATGTGACCCACTTACGTAAAAAATTAGGTAAAACCGCTATCGAAACCCGTCGCGGCCAAGGTTAT
ATCTTCCACGGCATTATTGA

Downstream 100 bases:

>100_bases
TCTCGCTGAACCAGTTAAGTGTAAATGCCCTGTTCAAATGCACTCTTTAATATTTCCTCTTTAAAATACTCATAAAAAAA
ACGCCATCGAATTGATGGCG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MISIRTKLSLWLTGLLVIGTVIGLILFESMLRQAFHDSIINRLEEDLEHIMLATHIHDGDISIDQSQLSSFYKPAYSGRY
FQLNLPNEVIRSRSLWDMQLDIEPLAPNQTRVWQAKGPKNNDMQLLSLGLNSSSANVSATLTVAQDLSIGRRVFSEVYGT
KLGINLAMLVAMIAGIFLILRQSFKPVKHIQHALSRLREGEINALELNNIPPEVQPLAKTYNELLEYTAKQIERSRNNLG
NLSHGLKTPLAVMQQQVEALGLKDPETAIALQQQLDSIHKMVERKLAAARITGDMLPAAQLVIPRDLHSLANTLNKVHRN
KTIECDFELDPNILRLPIHREDGMELLGNLLDNAFKWAQSRVSIQLSRQQERLCLCIDDDGPGVADDELDKLTQRGTRLD
ESVMGHGLGLSIVKEIAEQYQIGLKFSHSTRLGGLRIELTFS

Sequences:

>Translated_442_residues
MISIRTKLSLWLTGLLVIGTVIGLILFESMLRQAFHDSIINRLEEDLEHIMLATHIHDGDISIDQSQLSSFYKPAYSGRY
FQLNLPNEVIRSRSLWDMQLDIEPLAPNQTRVWQAKGPKNNDMQLLSLGLNSSSANVSATLTVAQDLSIGRRVFSEVYGT
KLGINLAMLVAMIAGIFLILRQSFKPVKHIQHALSRLREGEINALELNNIPPEVQPLAKTYNELLEYTAKQIERSRNNLG
NLSHGLKTPLAVMQQQVEALGLKDPETAIALQQQLDSIHKMVERKLAAARITGDMLPAAQLVIPRDLHSLANTLNKVHRN
KTIECDFELDPNILRLPIHREDGMELLGNLLDNAFKWAQSRVSIQLSRQQERLCLCIDDDGPGVADDELDKLTQRGTRLD
ESVMGHGLGLSIVKEIAEQYQIGLKFSHSTRLGGLRIELTFS
>Mature_442_residues
MISIRTKLSLWLTGLLVIGTVIGLILFESMLRQAFHDSIINRLEEDLEHIMLATHIHDGDISIDQSQLSSFYKPAYSGRY
FQLNLPNEVIRSRSLWDMQLDIEPLAPNQTRVWQAKGPKNNDMQLLSLGLNSSSANVSATLTVAQDLSIGRRVFSEVYGT
KLGINLAMLVAMIAGIFLILRQSFKPVKHIQHALSRLREGEINALELNNIPPEVQPLAKTYNELLEYTAKQIERSRNNLG
NLSHGLKTPLAVMQQQVEALGLKDPETAIALQQQLDSIHKMVERKLAAARITGDMLPAAQLVIPRDLHSLANTLNKVHRN
KTIECDFELDPNILRLPIHREDGMELLGNLLDNAFKWAQSRVSIQLSRQQERLCLCIDDDGPGVADDELDKLTQRGTRLD
ESVMGHGLGLSIVKEIAEQYQIGLKFSHSTRLGGLRIELTFS

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=312, Percent_Identity=29.4871794871795, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=27.7372262773723, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789808, Length=276, Percent_Identity=24.2753623188406, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=334, Percent_Identity=25.748502994012, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787894, Length=284, Percent_Identity=23.5915492957746, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=286, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790346, Length=264, Percent_Identity=23.1060606060606, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790551, Length=274, Percent_Identity=22.992700729927, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786600, Length=209, Percent_Identity=25.8373205741627, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49563; Mature: 49563

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISIRTKLSLWLTGLLVIGTVIGLILFESMLRQAFHDSIINRLEEDLEHIMLATHIHDGD
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
ISIDQSQLSSFYKPAYSGRYFQLNLPNEVIRSRSLWDMQLDIEPLAPNQTRVWQAKGPKN
CCCCHHHHHHHHCCCCCCCEEEEECCHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCC
NDMQLLSLGLNSSSANVSATLTVAQDLSIGRRVFSEVYGTKLGINLAMLVAMIAGIFLIL
CCCEEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RQSFKPVKHIQHALSRLREGEINALELNNIPPEVQPLAKTYNELLEYTAKQIERSRNNLG
HHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
NLSHGLKTPLAVMQQQVEALGLKDPETAIALQQQLDSIHKMVERKLAAARITGDMLPAAQ
CHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LVIPRDLHSLANTLNKVHRNKTIECDFELDPNILRLPIHREDGMELLGNLLDNAFKWAQS
HHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
RVSIQLSRQQERLCLCIDDDGPGVADDELDKLTQRGTRLDESVMGHGLGLSIVKEIAEQY
HHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHH
QIGLKFSHSTRLGGLRIELTFS
HHCCEEECCCCCCCEEEEEEEC
>Mature Secondary Structure
MISIRTKLSLWLTGLLVIGTVIGLILFESMLRQAFHDSIINRLEEDLEHIMLATHIHDGD
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
ISIDQSQLSSFYKPAYSGRYFQLNLPNEVIRSRSLWDMQLDIEPLAPNQTRVWQAKGPKN
CCCCHHHHHHHHCCCCCCCEEEEECCHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCC
NDMQLLSLGLNSSSANVSATLTVAQDLSIGRRVFSEVYGTKLGINLAMLVAMIAGIFLIL
CCCEEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RQSFKPVKHIQHALSRLREGEINALELNNIPPEVQPLAKTYNELLEYTAKQIERSRNNLG
HHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
NLSHGLKTPLAVMQQQVEALGLKDPETAIALQQQLDSIHKMVERKLAAARITGDMLPAAQ
CHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LVIPRDLHSLANTLNKVHRNKTIECDFELDPNILRLPIHREDGMELLGNLLDNAFKWAQS
HHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
RVSIQLSRQQERLCLCIDDDGPGVADDELDKLTQRGTRLDESVMGHGLGLSIVKEIAEQY
HHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHH
QIGLKFSHSTRLGGLRIELTFS
HHCCEEECCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]