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The map label for this gene is arcA [H]

Identifier: 160876946

GI number: 160876946

Start: 4524080

End: 4524796

Strand: Direct

Name: arcA [H]

Synonym: Sbal195_3842

Alternate gene names: 160876946

Gene position: 4524080-4524796 (Clockwise)

Preceding gene: 160876942

Following gene: 160876948

Centisome position: 84.61

GC content: 46.86

Gene sequence:

>717_bases
ATGCAAAATCCGCACATTCTGATCGTTGAAGATGAAGCCGTTACCCGTAACACGCTGAGAAGTATTTTCGAGGCAGAAGG
GTATGTGGTAACTGAGGCCAATGATGGCGCAGAAATGCATAAGGCTATGCAGGAAAACAAAATTAACTTGGTCGTTATGG
ACATTAACTTGCCAGGCAAGAATGGCCTGTTGTTGGCACGTGAACTACGTGAAATCAACAACATCGGTCTGATCTTCCTG
ACAGGTCGTGACAACGAAGTCGACAAAATCCTTGGACTTGAAATTGGCGCGGACGATTATATTACCAAGCCGTTCAACCC
ACGTGAATTGACGATTCGTGCTCGTAACCTTCTGACTCGCGTCAACAGCGCTGGTGCCGAAGTCGAAGAAAAGAGCTCAG
TAGAATACTATCGCTTCAACGATTGGAGCTTAGAGATCAACAGCCGTTCATTAGTGAGCCCACAGGGTGAATCCTACAAA
CTGCCACGTAGCGAATTCCGCGCTATGCTGCACTTTGTTGAAAACCCAGGAAAAATTTTGACTCGTGCCGATCTACTGAT
GAAAATGACTGGCCGTGAACTTAAGCCACACGATCGTACTGTAGACGTGACTATCCGTCGTATCCGCAAGCATTTCGAAA
GCTTGCCAGATACGCCAGAAATCATCGCGACTATTCACGGTGAAGGCTATCGCTTTTGCGGTAACTTAGAAGGCTAA

Upstream 100 bases:

>100_bases
AAGCAGTTCAAGGAAGTATCAACGCTTTTATGAATATAAGAGCCCGAAGTAAGTTGCTCTTATTGGTTAGTATAAACTGA
TTAAAATTTAGGTAAATAAT

Downstream 100 bases:

>100_bases
TTGCCCGCTAAGCGACACTCGCATTAGCAACAGGATTGATTCGATAAGCATCAATTCACAAAAAACCAGATCCTATGATC
TGGTTTTTTTATGTCTAAAA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKAMQENKINLVVMDINLPGKNGLLLARELREINNIGLIFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRVNSAGAEVEEKSSVEYYRFNDWSLEINSRSLVSPQGESYK
LPRSEFRAMLHFVENPGKILTRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESLPDTPEIIATIHGEGYRFCGNLEG

Sequences:

>Translated_238_residues
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKAMQENKINLVVMDINLPGKNGLLLARELREINNIGLIFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRVNSAGAEVEEKSSVEYYRFNDWSLEINSRSLVSPQGESYK
LPRSEFRAMLHFVENPGKILTRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESLPDTPEIIATIHGEGYRFCGNLEG
>Mature_238_residues
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKAMQENKINLVVMDINLPGKNGLLLARELREINNIGLIFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRVNSAGAEVEEKSSVEYYRFNDWSLEINSRSLVSPQGESYK
LPRSEFRAMLHFVENPGKILTRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESLPDTPEIIATIHGEGYRFCGNLEG

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=237, Percent_Identity=81.4345991561182, Blast_Score=399, Evalue=1e-113,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=42.9184549356223, Blast_Score=192, Evalue=1e-50,
Organism=Escherichia coli, GI1789809, Length=237, Percent_Identity=35.0210970464135, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=32.1739130434783, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=30.2127659574468, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=32.7433628318584, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.0175438596491, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=30.8695652173913, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=30, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=30.9734513274336, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.4372294372294, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=30.4721030042918, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=27.4336283185841, Blast_Score=82, Evalue=2e-17,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27119; Mature: 27119

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKAMQENKINLVVMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCEEEEEEEEECCCC
NGLLLARELREINNIGLIFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTR
CCEEHHHHHHHHCCCEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHH
VNSAGAEVEEKSSVEYYRFNDWSLEINSRSLVSPQGESYKLPRSEFRAMLHFVENPGKIL
HHCCCCCCCCCCCCEEEEECCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCCHHH
TRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESLPDTPEIIATIHGEGYRFCGNLEG
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCC
>Mature Secondary Structure
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKAMQENKINLVVMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCEEEEEEEEECCCC
NGLLLARELREINNIGLIFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTR
CCEEHHHHHHHHCCCEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHH
VNSAGAEVEEKSSVEYYRFNDWSLEINSRSLVSPQGESYKLPRSEFRAMLHFVENPGKIL
HHCCCCCCCCCCCCEEEEECCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCCHHH
TRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESLPDTPEIIATIHGEGYRFCGNLEG
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]