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The map label for this gene is proA [H]

Identifier: 160876444

GI number: 160876444

Start: 3936981

End: 3938870

Strand: Direct

Name: proA [H]

Synonym: Sbal195_3338

Alternate gene names: 160876444

Gene position: 3936981-3938870 (Clockwise)

Preceding gene: 160876443

Following gene: 160876446

Centisome position: 73.63

GC content: 48.89

Gene sequence:

>1890_bases
ATGCATAAGAAACATTTAATAGCAGTCGCAGTCGCAACTGGACTTGCTTACTTCCCTGTTAACGCTAATGAATACCAAGC
GACTATGGTAAGTGTCCCACAATCTAAAGCCATCAAAGATACTTACATCGTTGTATTCAATACCCCAAGTGTTCTTAATC
TAAGTAATAACAACACCATAGCTGAATTCGCGGTTCAACAAGCCGAGAGTTTAGTCAATCAATATGATGTCAGAGTGATG
AAAAACTTTGGCAATGTGCTCAACGGTGTACTCATCAATGCCAGTGCCCAACAAGTTAAAGCACTGCTTAAAGATCCAAA
CGTGAAGTACGTAGAACAAGATCAAGTGATGTCAGTAACGCCCATGATGGAAGCCAATGCGGACCAACCGAGTCCGACCT
GGGGCATAGACAGAATCGATCAACGCAACTTGCCATTGGATAACAACTATCACACGGATTACGATGGATCAGGTGTGACC
GCCTTTGTTATTGATACTGGGGTGCTAAATACACACAATGAGTTCGGCGGCCGCGCAAGCAGTGGCTATGACTTTATCGA
TAATGATTACGATACGACTGACTGTAACGGTCATGGTACCCATGTGGCGGGGACGATTGGCGGCTCAACCTACGGTGTCG
CGAAAAACGTCAATGTGGTGGGCGTCAGAGTGCTTAACTGTTCAGGTTCTGGCAGTAACTCTGGCGTGATTGCAGGGATA
AACTGGGTGAAAAACAATGCTTCTGGCCCCGCTGTCGCGAACATGAGTTTAGGGGGCGGCGCCTCCCAAGCCACGGATGA
TGCCGTCAATGCCGCTGTTGCCGCAGGGATCACCTTCGTCGTCGCAGCCGGCAATGACAATAGTAATGCCTGTAATTACT
CCCCAGCTCGTGCCGCAGATGCCATCACTGTCGGTTCAACCACCAGTAACGATTCCCGCTCGAGTTTTTCTAACTACGGG
ACTTGCCTTGATATCTATGCGCCCGGTTCGAGCATAACTTCCTCTTGGTATACCTCAAATTCAGCGACTAATACCATTAG
TGGCACCTCAATGGCTTCCCCCCATGTGGCAGGCGTCGCGGCATTATACTTAGATGAAAACCCTAACCTCTCCCCCGCAC
AGGTGACGAACTTACTCAAGACGCGCGCCACTGCGGACAAAGTCACAGATGCTAAGACAGGCTCACCGAATAAGTTACTG
TTTTCAATTGCAAATGATGATGGTGGCTGTGGCAATGATTGCCCCGTTGACGAGACTCAGCTGCAAAATAATGTGGGTAT
TGCGATCAGTGGAGCCACAGGTTCAGCGACTTATTACTATATCGATGTCCCCGCAAATGCGGCAAGTTTAGGCATCAACC
TCGCGGGGGGCTCTGGCGATGCGGATATTTATGTGAGCCAAGGACAAAAACCGACTACGACCAGCTATCAATGCCGCCCA
TATCAAAATGGCAACAATGAGAGCTGTAATTTCACTGCACCTACGGCGGGTCGTTGGTACGTGATGGTTCAAGGCTATAG
CAATTATGCCAACGCCCAGCTGACAGCTAGCTACAACCTCAATGGCGGCGGAAATTGTACCGATGCGAACTGCTTAACCA
ATGGCGTACCCGTCACGAATTTAAGCGGAGCAACGGGAACGGAAGCCCTGTATAAAATCGTCGTCCCAGCGAATAGCCAA
CTCAGTATTACCACCAGTGGAGGGACTGGAGACGTGGATCTGTATGTCAAAGCAGGGACTGTCCCAACGACTACCAGCTA
TGATTGTCGTCCCTATAAAAACGGTAACAATGAAAGCTGTTCGATTACCGTCACTCAAGCTGGAACTTACCATGTGATGT
TACGTGGTTATGCTAATTACTCGGGCGTTCAACTGAGCGCAAGCTACTAG

Upstream 100 bases:

>100_bases
AGGTAAGCCTTAAGCATTAAACTGGGCAGGTTGAAAATACCTTCTACATTGGATTATGTCTCGAAGTCCGTGGAGACATA
AAAAGAAAATGGAGTTCAAC

Downstream 100 bases:

>100_bases
CGAGTAAATCAGCTCAGTGAGTTTTGACTCACACTTAAGCCCACTAAGGTAACAACTTAGTGGGCTTTTTAGTGGTTTAT
TCAGAAGCCAATCCCGCGAA

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MHKKHLIAVAVATGLAYFPVNANEYQATMVSVPQSKAIKDTYIVVFNTPSVLNLSNNNTIAEFAVQQAESLVNQYDVRVM
KNFGNVLNGVLINASAQQVKALLKDPNVKYVEQDQVMSVTPMMEANADQPSPTWGIDRIDQRNLPLDNNYHTDYDGSGVT
AFVIDTGVLNTHNEFGGRASSGYDFIDNDYDTTDCNGHGTHVAGTIGGSTYGVAKNVNVVGVRVLNCSGSGSNSGVIAGI
NWVKNNASGPAVANMSLGGGASQATDDAVNAAVAAGITFVVAAGNDNSNACNYSPARAADAITVGSTTSNDSRSSFSNYG
TCLDIYAPGSSITSSWYTSNSATNTISGTSMASPHVAGVAALYLDENPNLSPAQVTNLLKTRATADKVTDAKTGSPNKLL
FSIANDDGGCGNDCPVDETQLQNNVGIAISGATGSATYYYIDVPANAASLGINLAGGSGDADIYVSQGQKPTTTSYQCRP
YQNGNNESCNFTAPTAGRWYVMVQGYSNYANAQLTASYNLNGGGNCTDANCLTNGVPVTNLSGATGTEALYKIVVPANSQ
LSITTSGGTGDVDLYVKAGTVPTTTSYDCRPYKNGNNESCSITVTQAGTYHVMLRGYANYSGVQLSASY

Sequences:

>Translated_629_residues
MHKKHLIAVAVATGLAYFPVNANEYQATMVSVPQSKAIKDTYIVVFNTPSVLNLSNNNTIAEFAVQQAESLVNQYDVRVM
KNFGNVLNGVLINASAQQVKALLKDPNVKYVEQDQVMSVTPMMEANADQPSPTWGIDRIDQRNLPLDNNYHTDYDGSGVT
AFVIDTGVLNTHNEFGGRASSGYDFIDNDYDTTDCNGHGTHVAGTIGGSTYGVAKNVNVVGVRVLNCSGSGSNSGVIAGI
NWVKNNASGPAVANMSLGGGASQATDDAVNAAVAAGITFVVAAGNDNSNACNYSPARAADAITVGSTTSNDSRSSFSNYG
TCLDIYAPGSSITSSWYTSNSATNTISGTSMASPHVAGVAALYLDENPNLSPAQVTNLLKTRATADKVTDAKTGSPNKLL
FSIANDDGGCGNDCPVDETQLQNNVGIAISGATGSATYYYIDVPANAASLGINLAGGSGDADIYVSQGQKPTTTSYQCRP
YQNGNNESCNFTAPTAGRWYVMVQGYSNYANAQLTASYNLNGGGNCTDANCLTNGVPVTNLSGATGTEALYKIVVPANSQ
LSITTSGGTGDVDLYVKAGTVPTTTSYDCRPYKNGNNESCSITVTQAGTYHVMLRGYANYSGVQLSASY
>Mature_629_residues
MHKKHLIAVAVATGLAYFPVNANEYQATMVSVPQSKAIKDTYIVVFNTPSVLNLSNNNTIAEFAVQQAESLVNQYDVRVM
KNFGNVLNGVLINASAQQVKALLKDPNVKYVEQDQVMSVTPMMEANADQPSPTWGIDRIDQRNLPLDNNYHTDYDGSGVT
AFVIDTGVLNTHNEFGGRASSGYDFIDNDYDTTDCNGHGTHVAGTIGGSTYGVAKNVNVVGVRVLNCSGSGSNSGVIAGI
NWVKNNASGPAVANMSLGGGASQATDDAVNAAVAAGITFVVAAGNDNSNACNYSPARAADAITVGSTTSNDSRSSFSNYG
TCLDIYAPGSSITSSWYTSNSATNTISGTSMASPHVAGVAALYLDENPNLSPAQVTNLLKTRATADKVTDAKTGSPNKLL
FSIANDDGGCGNDCPVDETQLQNNVGIAISGATGSATYYYIDVPANAASLGINLAGGSGDADIYVSQGQKPTTTSYQCRP
YQNGNNESCNFTAPTAGRWYVMVQGYSNYANAQLTASYNLNGGGNCTDANCLTNGVPVTNLSGATGTEALYKIVVPANSQ
LSITTSGGTGDVDLYVKAGTVPTTTSYDCRPYKNGNNESCSITVTQAGTYHVMLRGYANYSGVQLSASY

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI31317307, Length=378, Percent_Identity=30.4232804232804, Blast_Score=165, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320775, Length=346, Percent_Identity=43.6416184971098, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6324576, Length=326, Percent_Identity=40.1840490797546, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319893, Length=426, Percent_Identity=33.5680751173709, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007280
- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR010259 [H]

Pfam domain/function: PF05922 Inhibitor_I9; PF00082 Peptidase_S8; PF04151 PPC [H]

EC number: NA

Molecular weight: Translated: 65518; Mature: 65518

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKKHLIAVAVATGLAYFPVNANEYQATMVSVPQSKAIKDTYIVVFNTPSVLNLSNNNTI
CCCCEEEEEEEECCEEEEECCCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEECCCCCH
AEFAVQQAESLVNQYDVRVMKNFGNVLNGVLINASAQQVKALLKDPNVKYVEQDQVMSVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCCEEEECCCEEEEC
PMMEANADQPSPTWGIDRIDQRNLPLDNNYHTDYDGSGVTAFVIDTGVLNTHNEFGGRAS
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEECCHHCCCCCC
SGYDFIDNDYDTTDCNGHGTHVAGTIGGSTYGVAKNVNVVGVRVLNCSGSGSNSGVIAGI
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCEEEEEEEEEECCCCCCCCEEEEE
NWVKNNASGPAVANMSLGGGASQATDDAVNAAVAAGITFVVAAGNDNSNACNYSPARAAD
EEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCC
AITVGSTTSNDSRSSFSNYGTCLDIYAPGSSITSSWYTSNSATNTISGTSMASPHVAGVA
EEEECCCCCCCCHHHHCCCCCEEEEECCCCCCCCCEEECCCCCCEECCCCCCCCCCCEEE
ALYLDENPNLSPAQVTNLLKTRATADKVTDAKTGSPNKLLFSIANDDGGCGNDCPVDETQ
EEEECCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHH
LQNNVGIAISGATGSATYYYIDVPANAASLGINLAGGSGDADIYVSQGQKPTTTSYQCRP
HCCCCCEEEECCCCCEEEEEEECCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCEEEEC
YQNGNNESCNFTAPTAGRWYVMVQGYSNYANAQLTASYNLNGGGNCTDANCLTNGVPVTN
CCCCCCCCCEEECCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCC
LSGATGTEALYKIVVPANSQLSITTSGGTGDVDLYVKAGTVPTTTSYDCRPYKNGNNESC
CCCCCCCCEEEEEEECCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEE
SITVTQAGTYHVMLRGYANYSGVQLSASY
EEEEEECCEEEEEEEECCCCCCEEEEECC
>Mature Secondary Structure
MHKKHLIAVAVATGLAYFPVNANEYQATMVSVPQSKAIKDTYIVVFNTPSVLNLSNNNTI
CCCCEEEEEEEECCEEEEECCCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEECCCCCH
AEFAVQQAESLVNQYDVRVMKNFGNVLNGVLINASAQQVKALLKDPNVKYVEQDQVMSVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCCEEEECCCEEEEC
PMMEANADQPSPTWGIDRIDQRNLPLDNNYHTDYDGSGVTAFVIDTGVLNTHNEFGGRAS
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEECCHHCCCCCC
SGYDFIDNDYDTTDCNGHGTHVAGTIGGSTYGVAKNVNVVGVRVLNCSGSGSNSGVIAGI
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCEEEEEEEEEECCCCCCCCEEEEE
NWVKNNASGPAVANMSLGGGASQATDDAVNAAVAAGITFVVAAGNDNSNACNYSPARAAD
EEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCC
AITVGSTTSNDSRSSFSNYGTCLDIYAPGSSITSSWYTSNSATNTISGTSMASPHVAGVA
EEEECCCCCCCCHHHHCCCCCEEEEECCCCCCCCCEEECCCCCCEECCCCCCCCCCCEEE
ALYLDENPNLSPAQVTNLLKTRATADKVTDAKTGSPNKLLFSIANDDGGCGNDCPVDETQ
EEEECCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHH
LQNNVGIAISGATGSATYYYIDVPANAASLGINLAGGSGDADIYVSQGQKPTTTSYQCRP
HCCCCCEEEECCCCCEEEEEEECCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCEEEEC
YQNGNNESCNFTAPTAGRWYVMVQGYSNYANAQLTASYNLNGGGNCTDANCLTNGVPVTN
CCCCCCCCCEEECCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCC
LSGATGTEALYKIVVPANSQLSITTSGGTGDVDLYVKAGTVPTTTSYDCRPYKNGNNESC
CCCCCCCCEEEEEEECCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEE
SITVTQAGTYHVMLRGYANYSGVQLSASY
EEEEEECCEEEEEEEECCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2546861 [H]