Click here to switch to the map view.

The map label for this gene is relA [H]

Identifier: 160876395

GI number: 160876395

Start: 3877212

End: 3879422

Strand: Reverse

Name: relA [H]

Synonym: Sbal195_3289

Alternate gene names: 160876395

Gene position: 3879422-3877212 (Counterclockwise)

Preceding gene: 160876396

Following gene: 160876394

Centisome position: 72.55

GC content: 49.48

Gene sequence:

>2211_bases
ATGGTCTCTGTTCGCGAAGCGCACTTTAATGATCCCGATTTTCACTTAGAAGATTGGGTGGCTCGCTATGTCGGTCATGC
CGATGAAGCGCAGATGCTGCTCTCCTTGATAGGGCAGATTGACGCCTTACCCGCCAAGAGTCCTGCGGCGAAGAGAGAAC
TGCTCGAACGTGCTCGAGAGATGATTGAAATCCTCGCACCGCTGAACATGGACATTGAAACCCTGCAAGCGGCGATTCTG
TTTGTGGTGTTCGATGCTGGCTTACTGACCGAAGACGCCATCAAAGAAAAATTTGGTGAGCCGCTGGCGCGTTTAGTGGC
GAGTGTTGTGACCATGAATGCCATCGGCGCCTTAAAAATCAATCCCAACAGCCGCTCCACCGAGCCGCAAATCGACAATA
TCCGCCGCATGTTACTGGCGATGGTTGAAGATGTGCGCGCTGTGGTTATCAAACTTGCTGAGCGTGTGTGTTTGCTGCGG
GCGGTGAAAAATGCCGACGAAGAAACTCGCGTGCTGCTGGCCCGCGAAATTGCCGATATTTACGCGCCGCTGGCTAACCG
TTTAGGGATTGGACAATTGAAGTGGGAGCTGGAAGATATTTCTTTTCGCTACCTGCATCCAGATACCTATAAAGACATTG
CTAAGCAATTAGATGGTAAACGACTGGATCGTGAAGTCTTTATCGACAAGTTTGTCAGTCAGTTACAACAAAGATTAGAT
GAAGACCAAATTCGCGCTAAGGTCTACGGCCGGCCGAAACATATCTACAGTATCTGGCGCAAGATGAAGGGCAAACACCT
CAAATTTGATGAGTTGTTTGACGTGCGCGCCGTGCGTATCGTGACCGATCGTCTGCAGGATTGTTATGGCGCATTAGGCG
TAGTACATACCCTTTGGCACCATATTCCGCGGGAATTTGACGACTATGTCGCTAACCCTAAACCTAACGGTTATCAATCG
ATTCATACCGTAGTGGTAGGGCCTGAGGGCAAAACCGTTGAAATTCAAATCCGTACCCAAGATATGCATGAAGATGCAGA
GCTGGGTGTGGCTGCGCATTGGAAATACAAAGAAGGAAATAATCAATCCGGTAAGCAAAGCGGCTACGAAGAAAAAATTA
ACTGGCTGCGTAAAATTCTGCAATGGCAGGAAGACGTGGTCGAAAGTGGCAACTTGGTCGAAGAAGTGCGCAGCCAAGTG
TTTGAGGATAGAGTGTATGTGTTCACCCCAAGCGGTGAAGTTGTCGACTTGCCACTGGGCTCAACCGTGCTCGACTTTGC
CTATTACATTCACTCCCAAGTGGGACATAAATGTATTGGTGCTAAGGTCGATGGCCGTATTGTGCCGTTCACTTATCAGG
TTGAAACGGGCGAGCGTATCGAGATCATCACCTCGAAACAGCCCAACCCCAAGCGCGATTGGCTTAACCCTAACTTAGGT
TATATCCGTACCTCGCGGGCGCGTTCAAAAATCCAGCATTGGTTTAAGCAGCAGGACAGAGACAAGAATATTGTCGCCGG
CAAAGAAATGCTCGAATCCGAACTGGCGCGGGTGAGCCTTAAAATTAAAGACGCGGCCATCGCGGTCGAGCGCTTTAATA
TGGCGAGCATGGATGACTTACTGGCGGCGATTGGCGGCGGTGATGTGCGTCTGCATCAAGTTGTTAACCATATTCAGAGT
CGTCTGCGACTCGACGAAGTGTCAGAAGAAGATGCCGTCGAAGAATTAGTTAAGAAAGGCCAGCATAAGCCGACCTCCAG
TGGCCGTGGTCAGGTTGAAGTCAACGGTGTGGGTAACTTGCTTAACCATATCGCCCGTTGTTGTCAGCCAGTTCCCGGTG
ATGAAATCTTAGGTTTTATTACTAAAGGCCGTGGCATTTCTGTGCATCGCGCTGATTGTGAACAAGTTAAAGAGTTAATG
CGGGTTCACCCAGAGCGCGGTGTCGATGTGGTCTGGGGCGAAAATTACTCCGGCGGTTATCGCATGCGTCTGCGGGTATT
AGCCCACGATCGCAGCGGTTTATTGCGTGACTTAACCTCAGTGTTGGCTGCCGAAAAATCCAATGTATTAGCCATGAGCT
CGTCATCGGATACTAAAAACCAGACAGCTGCTATTGAGTTGGAACTGGAGCTTTATAATCTCGATGGTTTATCGCGGGTT
TTATCTAAACTGACACAAGTCGATAGCGTGATTGAGGCAAGACGGCTTTAG

Upstream 100 bases:

>100_bases
TTACGTCGGTTGGGTTTGACAAGTTCGCGCCAATGCTGAAGATAGGAGAGCTGAAGTGGTGCCCACTTTCTCTCTGAGCA
CGGATAAGGAAATAAATTAG

Downstream 100 bases:

>100_bases
GTATCATTCACTACAGTAAAAAAGCGGTAGGGCGAATTTCGCCTGCCGCTTTTTTATTTTATGGGGAATTGTGCGGCATG
GTCGTACGCTATTTAAACTA

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 736; Mature: 736

Protein sequence:

>736_residues
MVSVREAHFNDPDFHLEDWVARYVGHADEAQMLLSLIGQIDALPAKSPAAKRELLERAREMIEILAPLNMDIETLQAAIL
FVVFDAGLLTEDAIKEKFGEPLARLVASVVTMNAIGALKINPNSRSTEPQIDNIRRMLLAMVEDVRAVVIKLAERVCLLR
AVKNADEETRVLLAREIADIYAPLANRLGIGQLKWELEDISFRYLHPDTYKDIAKQLDGKRLDREVFIDKFVSQLQQRLD
EDQIRAKVYGRPKHIYSIWRKMKGKHLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWHHIPREFDDYVANPKPNGYQS
IHTVVVGPEGKTVEIQIRTQDMHEDAELGVAAHWKYKEGNNQSGKQSGYEEKINWLRKILQWQEDVVESGNLVEEVRSQV
FEDRVYVFTPSGEVVDLPLGSTVLDFAYYIHSQVGHKCIGAKVDGRIVPFTYQVETGERIEIITSKQPNPKRDWLNPNLG
YIRTSRARSKIQHWFKQQDRDKNIVAGKEMLESELARVSLKIKDAAIAVERFNMASMDDLLAAIGGGDVRLHQVVNHIQS
RLRLDEVSEEDAVEELVKKGQHKPTSSGRGQVEVNGVGNLLNHIARCCQPVPGDEILGFITKGRGISVHRADCEQVKELM
RVHPERGVDVVWGENYSGGYRMRLRVLAHDRSGLLRDLTSVLAAEKSNVLAMSSSSDTKNQTAAIELELELYNLDGLSRV
LSKLTQVDSVIEARRL

Sequences:

>Translated_736_residues
MVSVREAHFNDPDFHLEDWVARYVGHADEAQMLLSLIGQIDALPAKSPAAKRELLERAREMIEILAPLNMDIETLQAAIL
FVVFDAGLLTEDAIKEKFGEPLARLVASVVTMNAIGALKINPNSRSTEPQIDNIRRMLLAMVEDVRAVVIKLAERVCLLR
AVKNADEETRVLLAREIADIYAPLANRLGIGQLKWELEDISFRYLHPDTYKDIAKQLDGKRLDREVFIDKFVSQLQQRLD
EDQIRAKVYGRPKHIYSIWRKMKGKHLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWHHIPREFDDYVANPKPNGYQS
IHTVVVGPEGKTVEIQIRTQDMHEDAELGVAAHWKYKEGNNQSGKQSGYEEKINWLRKILQWQEDVVESGNLVEEVRSQV
FEDRVYVFTPSGEVVDLPLGSTVLDFAYYIHSQVGHKCIGAKVDGRIVPFTYQVETGERIEIITSKQPNPKRDWLNPNLG
YIRTSRARSKIQHWFKQQDRDKNIVAGKEMLESELARVSLKIKDAAIAVERFNMASMDDLLAAIGGGDVRLHQVVNHIQS
RLRLDEVSEEDAVEELVKKGQHKPTSSGRGQVEVNGVGNLLNHIARCCQPVPGDEILGFITKGRGISVHRADCEQVKELM
RVHPERGVDVVWGENYSGGYRMRLRVLAHDRSGLLRDLTSVLAAEKSNVLAMSSSSDTKNQTAAIELELELYNLDGLSRV
LSKLTQVDSVIEARRL
>Mature_736_residues
MVSVREAHFNDPDFHLEDWVARYVGHADEAQMLLSLIGQIDALPAKSPAAKRELLERAREMIEILAPLNMDIETLQAAIL
FVVFDAGLLTEDAIKEKFGEPLARLVASVVTMNAIGALKINPNSRSTEPQIDNIRRMLLAMVEDVRAVVIKLAERVCLLR
AVKNADEETRVLLAREIADIYAPLANRLGIGQLKWELEDISFRYLHPDTYKDIAKQLDGKRLDREVFIDKFVSQLQQRLD
EDQIRAKVYGRPKHIYSIWRKMKGKHLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWHHIPREFDDYVANPKPNGYQS
IHTVVVGPEGKTVEIQIRTQDMHEDAELGVAAHWKYKEGNNQSGKQSGYEEKINWLRKILQWQEDVVESGNLVEEVRSQV
FEDRVYVFTPSGEVVDLPLGSTVLDFAYYIHSQVGHKCIGAKVDGRIVPFTYQVETGERIEIITSKQPNPKRDWLNPNLG
YIRTSRARSKIQHWFKQQDRDKNIVAGKEMLESELARVSLKIKDAAIAVERFNMASMDDLLAAIGGGDVRLHQVVNHIQS
RLRLDEVSEEDAVEELVKKGQHKPTSSGRGQVEVNGVGNLLNHIARCCQPVPGDEILGFITKGRGISVHRADCEQVKELM
RVHPERGVDVVWGENYSGGYRMRLRVLAHDRSGLLRDLTSVLAAEKSNVLAMSSSSDTKNQTAAIELELELYNLDGLSRV
LSKLTQVDSVIEARRL

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=746, Percent_Identity=59.5174262734584, Blast_Score=894, Evalue=0.0,
Organism=Escherichia coli, GI1790082, Length=649, Percent_Identity=34.3605546995378, Blast_Score=410, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83363; Mature: 83363

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVREAHFNDPDFHLEDWVARYVGHADEAQMLLSLIGQIDALPAKSPAAKRELLERARE
CCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MIEILAPLNMDIETLQAAILFVVFDAGLLTEDAIKEKFGEPLARLVASVVTMNAIGALKI
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEEEEE
NPNSRSTEPQIDNIRRMLLAMVEDVRAVVIKLAERVCLLRAVKNADEETRVLLAREIADI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YAPLANRLGIGQLKWELEDISFRYLHPDTYKDIAKQLDGKRLDREVFIDKFVSQLQQRLD
HHHHHHCCCCCCEEEEEECCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
EDQIRAKVYGRPKHIYSIWRKMKGKHLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWH
HHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HIPREFDDYVANPKPNGYQSIHTVVVGPEGKTVEIQIRTQDMHEDAELGVAAHWKYKEGN
HHCHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCHHCCEEEEEEECCCC
NQSGKQSGYEEKINWLRKILQWQEDVVESGNLVEEVRSQVFEDRVYVFTPSGEVVDLPLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCEEECCCC
STVLDFAYYIHSQVGHKCIGAKVDGRIVPFTYQVETGERIEIITSKQPNPKRDWLNPNLG
HHHHHHHHHHHHHHCCHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCC
YIRTSRARSKIQHWFKQQDRDKNIVAGKEMLESELARVSLKIKDAAIAVERFNMASMDDL
CEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHCCCCCHHHH
LAAIGGGDVRLHQVVNHIQSRLRLDEVSEEDAVEELVKKGQHKPTSSGRGQVEVNGVGNL
HHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHH
LNHIARCCQPVPGDEILGFITKGRGISVHRADCEQVKELMRVHPERGVDVVWGENYSGGY
HHHHHHHCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCEEEECCCCCCCE
RMRLRVLAHDRSGLLRDLTSVLAAEKSNVLAMSSSSDTKNQTAAIELELELYNLDGLSRV
EEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEEEECCCHHHHH
LSKLTQVDSVIEARRL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVSVREAHFNDPDFHLEDWVARYVGHADEAQMLLSLIGQIDALPAKSPAAKRELLERARE
CCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MIEILAPLNMDIETLQAAILFVVFDAGLLTEDAIKEKFGEPLARLVASVVTMNAIGALKI
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEEEEE
NPNSRSTEPQIDNIRRMLLAMVEDVRAVVIKLAERVCLLRAVKNADEETRVLLAREIADI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YAPLANRLGIGQLKWELEDISFRYLHPDTYKDIAKQLDGKRLDREVFIDKFVSQLQQRLD
HHHHHHCCCCCCEEEEEECCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
EDQIRAKVYGRPKHIYSIWRKMKGKHLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWH
HHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HIPREFDDYVANPKPNGYQSIHTVVVGPEGKTVEIQIRTQDMHEDAELGVAAHWKYKEGN
HHCHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCHHCCEEEEEEECCCC
NQSGKQSGYEEKINWLRKILQWQEDVVESGNLVEEVRSQVFEDRVYVFTPSGEVVDLPLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCEEECCCC
STVLDFAYYIHSQVGHKCIGAKVDGRIVPFTYQVETGERIEIITSKQPNPKRDWLNPNLG
HHHHHHHHHHHHHHCCHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCC
YIRTSRARSKIQHWFKQQDRDKNIVAGKEMLESELARVSLKIKDAAIAVERFNMASMDDL
CEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHCCCCCHHHH
LAAIGGGDVRLHQVVNHIQSRLRLDEVSEEDAVEELVKKGQHKPTSSGRGQVEVNGVGNL
HHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHH
LNHIARCCQPVPGDEILGFITKGRGISVHRADCEQVKELMRVHPERGVDVVWGENYSGGY
HHHHHHHCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCEEEECCCCCCCE
RMRLRVLAHDRSGLLRDLTSVLAAEKSNVLAMSSSSDTKNQTAAIELELELYNLDGLSRV
EEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEEEECCCHHHHH
LSKLTQVDSVIEARRL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]