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The map label for this gene is pcm [H]

Identifier: 160876379

GI number: 160876379

Start: 3855003

End: 3855638

Strand: Reverse

Name: pcm [H]

Synonym: Sbal195_3273

Alternate gene names: 160876379

Gene position: 3855638-3855003 (Counterclockwise)

Preceding gene: 160876380

Following gene: 160876378

Centisome position: 72.1

GC content: 47.33

Gene sequence:

>636_bases
ATGACTCGAGTTGCCTTAACATCGGCGGTGAACTTAGCTAAAAAGCTTCATGATGCGGGGATCCGTAATCAAGCCGTGTT
AAAGGCGATATCGCATACGCCGCGGGAAATGTTTCTCGATAATGCGCTAGCCCATAAAGCCTATGAAAATACCGCTTTAC
CGATTGGCCAAGGGCAAACCATCTCGCAGCCCTATATCGTCGCCCGTATGACCGAACTCTTACTGCATAAGATGCCCCAG
CGCGTATTAGAAGTGGGTACAGGATCGGGTTATCAGGCGGCAATTTTGGCGCAATTAGTGCCGCAGCTTTGTACTATCGA
GCGAATAAAAGGCTTACAAATTCAAGCGAGACAGCGCTTAAAACGATTAGATTTACATAATGTGTCGTTTAAATATGGTG
ATGGCTGGTTAGGTTGGGCAAATCGTAGCCCGTTCGATGCCATTATGGTGACCGCTGCCGCTTCGACTATACCTGAGGCC
TTACTGTCTCAATTAGCCGAGGGCGGAGTGTTAGTTCTGCCAGTCGGCGAGGATACCCAGCAATTGATGCGAATCACTCG
TACAGGGGAACGTTTTAGTTCGGAAACAATTGAAACGGTTAAATTTGTCCCTTTGATTAATGGAGAGTTAGCTTAA

Upstream 100 bases:

>100_bases
TTCATGCTGTCGCCAATGGCTATGTGTCAATTACGCCTTTGACGGTTGATTTAACTGCCTACGGACAACTAACGGCATTG
CAAAATTGGGTAGATAAAAT

Downstream 100 bases:

>100_bases
CCTTGTGTTGTGCTACTGTCTCCACTGAACAGATTGTCTTGCAACGAGGGCATTGTTTTCTCATCATAAACAGTAATACA
GCCTCACCAAGGAGTTTTTA

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MTRVALTSAVNLAKKLHDAGIRNQAVLKAISHTPREMFLDNALAHKAYENTALPIGQGQTISQPYIVARMTELLLHKMPQ
RVLEVGTGSGYQAAILAQLVPQLCTIERIKGLQIQARQRLKRLDLHNVSFKYGDGWLGWANRSPFDAIMVTAAASTIPEA
LLSQLAEGGVLVLPVGEDTQQLMRITRTGERFSSETIETVKFVPLINGELA

Sequences:

>Translated_211_residues
MTRVALTSAVNLAKKLHDAGIRNQAVLKAISHTPREMFLDNALAHKAYENTALPIGQGQTISQPYIVARMTELLLHKMPQ
RVLEVGTGSGYQAAILAQLVPQLCTIERIKGLQIQARQRLKRLDLHNVSFKYGDGWLGWANRSPFDAIMVTAAASTIPEA
LLSQLAEGGVLVLPVGEDTQQLMRITRTGERFSSETIETVKFVPLINGELA
>Mature_210_residues
TRVALTSAVNLAKKLHDAGIRNQAVLKAISHTPREMFLDNALAHKAYENTALPIGQGQTISQPYIVARMTELLLHKMPQR
VLEVGTGSGYQAAILAQLVPQLCTIERIKGLQIQARQRLKRLDLHNVSFKYGDGWLGWANRSPFDAIMVTAAASTIPEAL
LSQLAEGGVLVLPVGEDTQQLMRITRTGERFSSETIETVKFVPLINGELA

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=193, Percent_Identity=33.160621761658, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1789100, Length=200, Percent_Identity=62.5, Blast_Score=258, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71983477, Length=178, Percent_Identity=32.0224719101124, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193207222, Length=143, Percent_Identity=33.5664335664336, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17981723, Length=216, Percent_Identity=32.4074074074074, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 23151; Mature: 23020

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVALTSAVNLAKKLHDAGIRNQAVLKAISHTPREMFLDNALAHKAYENTALPIGQGQT
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
ISQPYIVARMTELLLHKMPQRVLEVGTGSGYQAAILAQLVPQLCTIERIKGLQIQARQRL
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KRLDLHNVSFKYGDGWLGWANRSPFDAIMVTAAASTIPEALLSQLAEGGVLVLPVGEDTQ
HHHCCCCCEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHH
QLMRITRTGERFSSETIETVKFVPLINGELA
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
>Mature Secondary Structure 
TRVALTSAVNLAKKLHDAGIRNQAVLKAISHTPREMFLDNALAHKAYENTALPIGQGQT
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
ISQPYIVARMTELLLHKMPQRVLEVGTGSGYQAAILAQLVPQLCTIERIKGLQIQARQRL
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KRLDLHNVSFKYGDGWLGWANRSPFDAIMVTAAASTIPEALLSQLAEGGVLVLPVGEDTQ
HHHCCCCCEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHH
QLMRITRTGERFSSETIETVKFVPLINGELA
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA