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The map label for this gene is rmlA2 [H]

Identifier: 160876138

GI number: 160876138

Start: 3597835

End: 3598710

Strand: Reverse

Name: rmlA2 [H]

Synonym: Sbal195_3029

Alternate gene names: 160876138

Gene position: 3598710-3597835 (Counterclockwise)

Preceding gene: 160876139

Following gene: 160876137

Centisome position: 67.3

GC content: 37.33

Gene sequence:

>876_bases
ATGAAAGGAATTATTCTTGCGGGTGGTTCTGGCACACGCCTTTATCCGATAACTAAAGGTGTATCAAAACAGCTATTGCC
TGTTTATGATAAACCCATGATTTATTATCCTATATCAGTATTGATGCTTGCGGGTATACGCGAAATTTTGATTATCACTA
CACCTGGTGACCAATCATCCTTCGAACGCCTTTTAGGTGATGGTAGTTATTTTGGAATTAACATCGAATATGCAGTTCAA
GCAACACCTGATGGCCTAGCGCAAGCTTTTATTATAGGTGAAGAATTTATTGGCAATGATAATGTGTGTTTAGCACTTGG
AGATAATATCTTTTGGGGGCAGGGCTTTTCACCAATACTTAAAAAAGCCGCCGCAAGACCAACTGGTGCATCTGTATTTG
GTTATCAAGTTAAAGATCCTGAGCGTTTTGGTGTGGTGGAATTCGATCAAGATCTAAAAGCTATTTCGATTGAAGAAAAA
CCCCTAAAACCTAAATCTAATTTTGCTGTTACTGGCCTTTATTTTTATGATAACCGAGTCGTTAATATCGCTAAAAATGT
TAAACCCTCAGAACGTGGTGAGTTAGAAATCACTAGTATTAATCAAGCTTATCTTGAAATGGGTGAATTAAATGTTGAAC
TACTAGGTCGTGGTTTTGCTTGGTTAGATACCGGTACCTATGAAAGTCTGTTAGAAGCAGCATCATTTGTTGAAACGATC
GAAAAACGTCAAGGCTATAAAATCGCCTGCTTAGAAGAAATTGCATGGCGTAATAAATGGTTGACTGATGTACAGATAAT
AGCAGCAGCTAATCAGATGGCCAAAAATAGTTATGGGCAATACTTGTTTGATTTATTGGGTAAACAAAATGGATAA

Upstream 100 bases:

>100_bases
AGCGAGAGCGTTTAGGCATTTAATCTCTTTTATTATTTTGTTTTAAAGCTCTGATATTTCTTTAAATCTAGGGCTAATTT
ATCTAGGAGCTTATTTTTTA

Downstream 100 bases:

>100_bases
CATGAGCCTGATTAATATAATTAATTTTCCTGTGTTAGGTGATGGGCGTGGCACTTTAGTCGCGCTAGAAGCAAATCGTC
AGATTCCATTTGAAATTAAG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 2; dTDP-glucose pyrophosphorylase 2; dTDP-glucose synthase 2 [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPISVLMLAGIREILIITTPGDQSSFERLLGDGSYFGINIEYAVQ
ATPDGLAQAFIIGEEFIGNDNVCLALGDNIFWGQGFSPILKKAAARPTGASVFGYQVKDPERFGVVEFDQDLKAISIEEK
PLKPKSNFAVTGLYFYDNRVVNIAKNVKPSERGELEITSINQAYLEMGELNVELLGRGFAWLDTGTYESLLEAASFVETI
EKRQGYKIACLEEIAWRNKWLTDVQIIAAANQMAKNSYGQYLFDLLGKQNG

Sequences:

>Translated_291_residues
MKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPISVLMLAGIREILIITTPGDQSSFERLLGDGSYFGINIEYAVQ
ATPDGLAQAFIIGEEFIGNDNVCLALGDNIFWGQGFSPILKKAAARPTGASVFGYQVKDPERFGVVEFDQDLKAISIEEK
PLKPKSNFAVTGLYFYDNRVVNIAKNVKPSERGELEITSINQAYLEMGELNVELLGRGFAWLDTGTYESLLEAASFVETI
EKRQGYKIACLEEIAWRNKWLTDVQIIAAANQMAKNSYGQYLFDLLGKQNG
>Mature_291_residues
MKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPISVLMLAGIREILIITTPGDQSSFERLLGDGSYFGINIEYAVQ
ATPDGLAQAFIIGEEFIGNDNVCLALGDNIFWGQGFSPILKKAAARPTGASVFGYQVKDPERFGVVEFDQDLKAISIEEK
PLKPKSNFAVTGLYFYDNRVVNIAKNVKPSERGELEITSINQAYLEMGELNVELLGRGFAWLDTGTYESLLEAASFVETI
EKRQGYKIACLEEIAWRNKWLTDVQIIAAANQMAKNSYGQYLFDLLGKQNG

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=256, Percent_Identity=23.4375, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI11761619, Length=256, Percent_Identity=23.4375, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=75.1748251748252, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1788351, Length=289, Percent_Identity=63.6678200692042, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI133931050, Length=241, Percent_Identity=24.896265560166, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=254, Percent_Identity=27.1653543307087, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=20.7171314741036, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=20.7171314741036, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32165; Mature: 32165

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPISVLMLAGIREILIITTPGDQSS
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCHHH
FERLLGDGSYFGINIEYAVQATPDGLAQAFIIGEEFIGNDNVCLALGDNIFWGQGFSPIL
HHHHHCCCCEEEEEEEEEEEECCCHHHEEEEECHHHCCCCCEEEEECCCEEECCCCHHHH
KKAAARPTGASVFGYQVKDPERFGVVEFDQDLKAISIEEKPLKPKSNFAVTGLYFYDNRV
HHHHCCCCCCCEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCEE
VNIAKNVKPSERGELEITSINQAYLEMGELNVELLGRGFAWLDTGTYESLLEAASFVETI
EEEECCCCCCCCCCEEEEECCHHHHHHCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHH
EKRQGYKIACLEEIAWRNKWLTDVQIIAAANQMAKNSYGQYLFDLLGKQNG
HHHCCCEEEHHHHHHHCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPISVLMLAGIREILIITTPGDQSS
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCHHH
FERLLGDGSYFGINIEYAVQATPDGLAQAFIIGEEFIGNDNVCLALGDNIFWGQGFSPIL
HHHHHCCCCEEEEEEEEEEEECCCHHHEEEEECHHHCCCCCEEEEECCCEEECCCCHHHH
KKAAARPTGASVFGYQVKDPERFGVVEFDQDLKAISIEEKPLKPKSNFAVTGLYFYDNRV
HHHHCCCCCCCEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCEE
VNIAKNVKPSERGELEITSINQAYLEMGELNVELLGRGFAWLDTGTYESLLEAASFVETI
EEEECCCCCCCCCCEEEEECCHHHHHHCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHH
EKRQGYKIACLEEIAWRNKWLTDVQIIAAANQMAKNSYGQYLFDLLGKQNG
HHHCCCEEEHHHHHHHCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]