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The map label for this gene is rmlA1 [H]

Identifier: 160876121

GI number: 160876121

Start: 3580683

End: 3581570

Strand: Reverse

Name: rmlA1 [H]

Synonym: Sbal195_3012

Alternate gene names: 160876121

Gene position: 3581570-3580683 (Counterclockwise)

Preceding gene: 160876122

Following gene: 160876120

Centisome position: 66.98

GC content: 47.3

Gene sequence:

>888_bases
ATGAGAAAAGGCATTTTACTGGCGGGCGGTACTGGCTCGCGTCTTTATCCTATGACGCAGGTTGTCTGTAAGCAATTACT
GCCCATTTACGATAAACCTATGATTTATTATCCACTTGTCACCCTAATGCAGGCTGATATTCGGGATATATTGATTATTT
GCACTTCCCACGATTTGCCGCTATTCCATGCATTACTCGGCGATGGCAGTCATTGGGGACTTAAGCTGCAATATGCCGAG
CAAGCCTCTCCGAAGGGATTGGCGCAAGCGCTCATCATTGCTGAGCCATTTTTAGCGGGTGAAGCCTGTGCGCTTATTCT
TGGGGATAATCTATTCTATGGTCAGCATTTAGCGGCAAATTTGCAACATGCTTGGCAAGCCCAAGCTGGGGCGACCGTTT
TTGGTTACCATGTGGCGAATCCTAATGCTTACGGTGTCGTTGAGTTTGATGGTGCAGGTAAGGTGCTTTCTATTGAAGAA
AAACCTCAACATCCACGCTCTCGTTACGCTATGCCTGGGTTGTACTTTTTTGACGGCCGCGCGGCCGCATTTGCAAAAAC
GGTTTTACCTTCGGTAAGGGGCGAGTTAGAGATTGTCGATGTTATCACTCGTTACTTAGCTTTGGGAGAATTGCGAGTCG
ATATTCTTGGGCGGGGGACAGCTTGGTTAGATACTGGCACGCCGGATGCGATGGCCGAGGCGACACAATTTGTTGCTGCC
ATTGAGAAACGACAAGGTCTAAAGATCAATTGCCCTGAAGAGACTGCATTTCGCAGCGGTTGGATCAATGCGCAGCAATT
AGTTGAATTAGCTCAGCCTTTACTCAAAAGTGGTTATGGTGAGTATTTGCTCGGCTTACTCGATAAGCAGGTTTTTGATG
AAATGTAG

Upstream 100 bases:

>100_bases
ATCGACTGACTCATCTGCTGTCATCTGTTCTTCCGGCTCGTCGTCTTTTATATGCTACAATCTGGACACTTCACCTAGCT
TATCAATCTTAAATATTTCA

Downstream 100 bases:

>100_bases
CGCAACTGAGTTAGCCGAAGTGCTGGTGTTTGAACCGCAAGTCTTTGGGGATGAACGCGGTTTCTTTATGGAGACTTTTA
GGCAATCCTATTTTGATGCC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQADIRDILIICTSHDLPLFHALLGDGSHWGLKLQYAE
QASPKGLAQALIIAEPFLAGEACALILGDNLFYGQHLAANLQHAWQAQAGATVFGYHVANPNAYGVVEFDGAGKVLSIEE
KPQHPRSRYAMPGLYFFDGRAAAFAKTVLPSVRGELEIVDVITRYLALGELRVDILGRGTAWLDTGTPDAMAEATQFVAA
IEKRQGLKINCPEETAFRSGWINAQQLVELAQPLLKSGYGEYLLGLLDKQVFDEM

Sequences:

>Translated_295_residues
MRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQADIRDILIICTSHDLPLFHALLGDGSHWGLKLQYAE
QASPKGLAQALIIAEPFLAGEACALILGDNLFYGQHLAANLQHAWQAQAGATVFGYHVANPNAYGVVEFDGAGKVLSIEE
KPQHPRSRYAMPGLYFFDGRAAAFAKTVLPSVRGELEIVDVITRYLALGELRVDILGRGTAWLDTGTPDAMAEATQFVAA
IEKRQGLKINCPEETAFRSGWINAQQLVELAQPLLKSGYGEYLLGLLDKQVFDEM
>Mature_295_residues
MRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQADIRDILIICTSHDLPLFHALLGDGSHWGLKLQYAE
QASPKGLAQALIIAEPFLAGEACALILGDNLFYGQHLAANLQHAWQAQAGATVFGYHVANPNAYGVVEFDGAGKVLSIEE
KPQHPRSRYAMPGLYFFDGRAAAFAKTVLPSVRGELEIVDVITRYLALGELRVDILGRGTAWLDTGTPDAMAEATQFVAA
IEKRQGLKINCPEETAFRSGWINAQQLVELAQPLLKSGYGEYLLGLLDKQVFDEM

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=283, Percent_Identity=60.4240282685512, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=56.8421052631579, Blast_Score=334, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI133931050, Length=183, Percent_Identity=26.775956284153, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=251, Percent_Identity=24.7011952191235, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=23.2931726907631, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=23.2931726907631, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32322; Mature: 32322

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQADIRDILIICTSHDLP
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCH
LFHALLGDGSHWGLKLQYAEQASPKGLAQALIIAEPFLAGEACALILGDNLFYGQHLAAN
HHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCEEECHHHHHH
LQHAWQAQAGATVFGYHVANPNAYGVVEFDGAGKVLSIEEKPQHPRSRYAMPGLYFFDGR
HHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCHHHCCCCCEEEECCC
AAAFAKTVLPSVRGELEIVDVITRYLALGELRVDILGRGTAWLDTGTPDAMAEATQFVAA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEEECCCEEECCCCCHHHHHHHHHHHH
IEKRQGLKINCPEETAFRSGWINAQQLVELAQPLLKSGYGEYLLGLLDKQVFDEM
HHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQADIRDILIICTSHDLP
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCH
LFHALLGDGSHWGLKLQYAEQASPKGLAQALIIAEPFLAGEACALILGDNLFYGQHLAAN
HHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCEEECHHHHHH
LQHAWQAQAGATVFGYHVANPNAYGVVEFDGAGKVLSIEEKPQHPRSRYAMPGLYFFDGR
HHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCHHHCCCCCEEEECCC
AAAFAKTVLPSVRGELEIVDVITRYLALGELRVDILGRGTAWLDTGTPDAMAEATQFVAA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEEECCCEEECCCCCHHHHHHHHHHHH
IEKRQGLKINCPEETAFRSGWINAQQLVELAQPLLKSGYGEYLLGLLDKQVFDEM
HHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]