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The map label for this gene is copA [H]

Identifier: 160875328

GI number: 160875328

Start: 2630203

End: 2632602

Strand: Reverse

Name: copA [H]

Synonym: Sbal195_2215

Alternate gene names: 160875328

Gene position: 2632602-2630203 (Counterclockwise)

Preceding gene: 160875329

Following gene: 160875327

Centisome position: 49.23

GC content: 49.71

Gene sequence:

>2400_bases
ATGACACATCCAAGTTGTTTTCACTGCCAAGAGCCCGTGCTGACGGGCCAGCAGTTTGTGACTCGCATTAATGATCGTGA
TGAACTCATGTGTTGCCCTGGTTGCCAGGCGGTTTCTCAGGCGATTGTGGATGCGGGATTGCTCAGTTACTACAAGTTTC
GCACTGAGCCAGGCAGTAAACAGAACGCCCTCGTCCCCGAAGCCTTAACGCAATTTAGCGCCTATGACTTGCCTGAAGTG
CAGCAAGACTTTGTCCATTCTGAGGACAATATCGAGTCAGTGTCACTTTCTATCGATGGCATCACCTGCGCGGCCTGTGC
TTGGTTAATTGAGCACAAAGTAAAACAACTAACGGGCGTGAGCCAAGTGCTCGTCAACTCGACCACCCAAAGGGCGATGA
TCAGTTGGGATAAACGCACGGTAAAACTCAGCGATATCCTCGGGCAAATTAGCCGTATTGGTTATCAAGCCGCGCCCTAT
CAAGTCGATGAGCAAGAGCTCAACAACAAACTCAATAGCCGTAAGTTTTTATTGCGCTTAGGCTTAGCGGGTTTTGCGAC
CATGCAGGTGATGATGTTCGCCCTCGCCCTCTACACAGGCTACTTCACCGATTTAGATGTGCAGTATCGGGATTATTTCC
GTTGGGTCAGCATGCTTTTTGCCACCCCCGTAGTGCTTTATTCGGCGCAGCCCTTCTATTTCAGTGCTATTCGTACCCTA
CTCAGCGGCAAACTCAATATGGATGTGTCTGTCTCCATTGCGATTGGCGGCGCATACGTTGCCAGTTGTTTTGCCACAGT
AAATGGCACAGGCGAAGTGTATTTTGAATCTGTGTCCATGTTTACCTTCTTCCTGTTACTCGGGCGCTACTTCGAACAAA
AAGCTAGGCAAAAGGCCTCGGTCAGCTCGAGTAATTTGCATAAGTTAGTGCCGCTCACGGCGCACTTAATGAACGACAAT
GGTCAGGAAGAAATTCCCGCCAAAAAATTACGCCTCAATGATGTGATCCTCGTCAAACCGGGGGAAATGATTGCAGCCGA
TGGTGTGGTGATTGAAGGTCACACTAGCATCAATGAAGCTATGCTCACCGGCGAGCAAATGCCAATTGAAAAAACTGTTG
CTAGCCAAGTTTACGCAGGCACAATCAACGTCGACCAGCCCATCAAAGTCAGCGTCACAGCGCTGGGGCAAGACCAACTC
GTGGCTGAGATTATTAGACTGCAGGAGCTTGCATCCAATACTAAACCTGCAATTGCGCTATTAGCCGATAAATTATCGCG
CTATTTCTCGGGCACAATTCTGACCATAGCGACAATCACCTATTTGGTTTGGCATCAAATTTCCCCTGAGGATGCCTTTT
GGGTAACGCTATCGGTTCTAGTTGCTACCTGTCCTTGCGCCTTAGCACTTGCCACACCGACCGCTGTCACCTGCGCGACA
GCTATTTTTACTCGCCTTGGGATTATTACTCGCAAAGCCGGTGTATTTGAAAAACTGCCACAGATCAAACATGTTGTCTT
TGATAAAACCGGCACCCTCACCTGTGGTACCCTCTCTATCGGGCAAACGCAGTGCATGGCCGATTTAACCAATACGCAAG
CCTTAGCCATTGCCGCAGCACTAGAAGCAGGCTCTCGCCACCCGATTGCCGCGGCATTTGCCATGTTTGCCGATAATGCA
CTGGTTGCCGAAGAGGTTCACCATGAAGTTGGCTTTGGCGTTAGAGGCCGTATTGATGGCACTGATTACTTCATTGGCAA
TGCAGTATTTACCGGCGCGAGTATTGATAGTCGTGATCCAACCCAAAAGATTTGGTTAGCACGTTCAGCCAATAATCAGC
TTGAAGTACTGGCAAGCTTTGAAATTCAAGACAATATTCGCCAAGACAGCAAAGCTACAATTGAGATGTTAAAGCAGCAA
GGTTGCCGCATCAGTATTGCCAGCGGCGATAGCTCAGGACACGTACATCAACTGGCAAAAGAGCTGGGGATTGACGATGT
GCACAGCGGCTTAACGCCTGCAGATAAACTTGCCCTCGTGACCCGATTACAACAGCATACAAGGGTTGCCATGTTTGGCG
ATGGCATCAACGATGCGCCTGTGCTTGCGGGCGCCGATTTGTCGGTGGCTATGGGCAGCGGCAGTGCTATCGCGAAAAAC
AGTGCCGATTTAATTTTATTGGGGGATCATCTGTCCCGCTTCACCCAAGCCGTTAGCGTCGCGAAACTGACGACACAGAT
TATCAGACAAAATTTAGCGTGGGCGCTGGGTTACAACGCCCTGATCTTGCCCTTAGCCGTTACCGGCCATGTGGCACCTT
ATATCGCCGCCATTGGCATGTCGGCGAGTTCTTTGATTGTGGTCGGTAATAGCCTGAGATTATTGCGGGTTAAAGTGTGA

Upstream 100 bases:

>100_bases
TGGCAAATGGCGTATTCACCAACGCGTTGAATTAAAAGATCATGTCCAACTTTGGCTGAACTGATTGTGGTTGAATTGAT
TTAGTTAAATAAGAATTGCT

Downstream 100 bases:

>100_bases
TCACAATAAAAGTAAAACCAGAATAGTAAGAGGTCATTATGGAAATTATTTATGTGCTTATCCCCATTGCCATGATCTTT
GTCGCCATCGCTGTAATGGT

Product: heavy metal translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 799; Mature: 798

Protein sequence:

>799_residues
MTHPSCFHCQEPVLTGQQFVTRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGSKQNALVPEALTQFSAYDLPEV
QQDFVHSEDNIESVSLSIDGITCAACAWLIEHKVKQLTGVSQVLVNSTTQRAMISWDKRTVKLSDILGQISRIGYQAAPY
QVDEQELNNKLNSRKFLLRLGLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMLFATPVVLYSAQPFYFSAIRTL
LSGKLNMDVSVSIAIGGAYVASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKASVSSSNLHKLVPLTAHLMNDN
GQEEIPAKKLRLNDVILVKPGEMIAADGVVIEGHTSINEAMLTGEQMPIEKTVASQVYAGTINVDQPIKVSVTALGQDQL
VAEIIRLQELASNTKPAIALLADKLSRYFSGTILTIATITYLVWHQISPEDAFWVTLSVLVATCPCALALATPTAVTCAT
AIFTRLGIITRKAGVFEKLPQIKHVVFDKTGTLTCGTLSIGQTQCMADLTNTQALAIAAALEAGSRHPIAAAFAMFADNA
LVAEEVHHEVGFGVRGRIDGTDYFIGNAVFTGASIDSRDPTQKIWLARSANNQLEVLASFEIQDNIRQDSKATIEMLKQQ
GCRISIASGDSSGHVHQLAKELGIDDVHSGLTPADKLALVTRLQQHTRVAMFGDGINDAPVLAGADLSVAMGSGSAIAKN
SADLILLGDHLSRFTQAVSVAKLTTQIIRQNLAWALGYNALILPLAVTGHVAPYIAAIGMSASSLIVVGNSLRLLRVKV

Sequences:

>Translated_799_residues
MTHPSCFHCQEPVLTGQQFVTRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGSKQNALVPEALTQFSAYDLPEV
QQDFVHSEDNIESVSLSIDGITCAACAWLIEHKVKQLTGVSQVLVNSTTQRAMISWDKRTVKLSDILGQISRIGYQAAPY
QVDEQELNNKLNSRKFLLRLGLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMLFATPVVLYSAQPFYFSAIRTL
LSGKLNMDVSVSIAIGGAYVASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKASVSSSNLHKLVPLTAHLMNDN
GQEEIPAKKLRLNDVILVKPGEMIAADGVVIEGHTSINEAMLTGEQMPIEKTVASQVYAGTINVDQPIKVSVTALGQDQL
VAEIIRLQELASNTKPAIALLADKLSRYFSGTILTIATITYLVWHQISPEDAFWVTLSVLVATCPCALALATPTAVTCAT
AIFTRLGIITRKAGVFEKLPQIKHVVFDKTGTLTCGTLSIGQTQCMADLTNTQALAIAAALEAGSRHPIAAAFAMFADNA
LVAEEVHHEVGFGVRGRIDGTDYFIGNAVFTGASIDSRDPTQKIWLARSANNQLEVLASFEIQDNIRQDSKATIEMLKQQ
GCRISIASGDSSGHVHQLAKELGIDDVHSGLTPADKLALVTRLQQHTRVAMFGDGINDAPVLAGADLSVAMGSGSAIAKN
SADLILLGDHLSRFTQAVSVAKLTTQIIRQNLAWALGYNALILPLAVTGHVAPYIAAIGMSASSLIVVGNSLRLLRVKV
>Mature_798_residues
THPSCFHCQEPVLTGQQFVTRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGSKQNALVPEALTQFSAYDLPEVQ
QDFVHSEDNIESVSLSIDGITCAACAWLIEHKVKQLTGVSQVLVNSTTQRAMISWDKRTVKLSDILGQISRIGYQAAPYQ
VDEQELNNKLNSRKFLLRLGLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMLFATPVVLYSAQPFYFSAIRTLL
SGKLNMDVSVSIAIGGAYVASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKASVSSSNLHKLVPLTAHLMNDNG
QEEIPAKKLRLNDVILVKPGEMIAADGVVIEGHTSINEAMLTGEQMPIEKTVASQVYAGTINVDQPIKVSVTALGQDQLV
AEIIRLQELASNTKPAIALLADKLSRYFSGTILTIATITYLVWHQISPEDAFWVTLSVLVATCPCALALATPTAVTCATA
IFTRLGIITRKAGVFEKLPQIKHVVFDKTGTLTCGTLSIGQTQCMADLTNTQALAIAAALEAGSRHPIAAAFAMFADNAL
VAEEVHHEVGFGVRGRIDGTDYFIGNAVFTGASIDSRDPTQKIWLARSANNQLEVLASFEIQDNIRQDSKATIEMLKQQG
CRISIASGDSSGHVHQLAKELGIDDVHSGLTPADKLALVTRLQQHTRVAMFGDGINDAPVLAGADLSVAMGSGSAIAKNS
ADLILLGDHLSRFTQAVSVAKLTTQIIRQNLAWALGYNALILPLAVTGHVAPYIAAIGMSASSLIVVGNSLRLLRVKV

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=792, Percent_Identity=28.030303030303, Blast_Score=293, Evalue=4e-79,
Organism=Homo sapiens, GI115529486, Length=813, Percent_Identity=27.1832718327183, Blast_Score=277, Evalue=3e-74,
Organism=Homo sapiens, GI55743073, Length=591, Percent_Identity=27.072758037225, Blast_Score=200, Evalue=5e-51,
Organism=Escherichia coli, GI1786691, Length=837, Percent_Identity=29.2712066905615, Blast_Score=308, Evalue=9e-85,
Organism=Escherichia coli, GI1789879, Length=718, Percent_Identity=30.2228412256267, Blast_Score=283, Evalue=3e-77,
Organism=Escherichia coli, GI1786914, Length=543, Percent_Identity=24.8618784530387, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17556548, Length=798, Percent_Identity=26.9423558897243, Blast_Score=227, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI32566766, Length=186, Percent_Identity=26.3440860215054, Blast_Score=70, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17557770, Length=196, Percent_Identity=25.5102040816327, Blast_Score=70, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17557486, Length=186, Percent_Identity=26.3440860215054, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=740, Percent_Identity=27.5675675675676, Blast_Score=274, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6319772, Length=665, Percent_Identity=29.9248120300752, Blast_Score=261, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6321271, Length=316, Percent_Identity=24.0506329113924, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221329854, Length=529, Percent_Identity=29.8676748582231, Blast_Score=205, Evalue=1e-52,
Organism=Drosophila melanogaster, GI17136664, Length=168, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24762455, Length=168, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24762453, Length=168, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24762447, Length=168, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24762457, Length=168, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24762449, Length=168, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24762445, Length=168, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24762451, Length=168, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 86559; Mature: 86427

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPSCFHCQEPVLTGQQFVTRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGSK
CCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEECCCCCC
QNALVPEALTQFSAYDLPEVQQDFVHSEDNIESVSLSIDGITCAACAWLIEHKVKQLTGV
CCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
SQVLVNSTTQRAMISWDKRTVKLSDILGQISRIGYQAAPYQVDEQELNNKLNSRKFLLRL
HHHHHCCCHHHHHEECCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHHHHH
GLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMLFATPVVLYSAQPFYFSAIRTL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHEECCCCHHHHHHHHH
LSGKLNMDVSVSIAIGGAYVASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKAS
HCCCCCCCEEEEEEECHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHC
VSSSNLHKLVPLTAHLMNDNGQEEIPAKKLRLNDVILVKPGEMIAADGVVIEGHTSINEA
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHEEECCEEEECCCCEEEECCEEEECCCCHHHH
MLTGEQMPIEKTVASQVYAGTINVDQPIKVSVTALGQDQLVAEIIRLQELASNTKPAIAL
HHCCCCCCHHHHHHHHHEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCHHHH
LADKLSRYFSGTILTIATITYLVWHQISPEDAFWVTLSVLVATCPCALALATPTAVTCAT
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AIFTRLGIITRKAGVFEKLPQIKHVVFDKTGTLTCGTLSIGQTQCMADLTNTQALAIAAA
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCHHHHHHHH
LEAGSRHPIAAAFAMFADNALVAEEVHHEVGFGVRGRIDGTDYFIGNAVFTGASIDSRDP
HHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCCEEECCEEEECCCCCCCCC
TQKIWLARSANNQLEVLASFEIQDNIRQDSKATIEMLKQQGCRISIASGDSSGHVHQLAK
HHHEEEEECCCCCEEEEEEEEHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
ELGIDDVHSGLTPADKLALVTRLQQHTRVAMFGDGINDAPVLAGADLSVAMGSGSAIAKN
HCCCHHHHCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCCEEECCCCEEEECCCCEEECC
SADLILLGDHLSRFTQAVSVAKLTTQIIRQNLAWALGYNALILPLAVTGHVAPYIAAIGM
CCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCC
SASSLIVVGNSLRLLRVKV
CCCEEEEECCCEEEEEEEC
>Mature Secondary Structure 
THPSCFHCQEPVLTGQQFVTRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGSK
CCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEECCCCCC
QNALVPEALTQFSAYDLPEVQQDFVHSEDNIESVSLSIDGITCAACAWLIEHKVKQLTGV
CCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
SQVLVNSTTQRAMISWDKRTVKLSDILGQISRIGYQAAPYQVDEQELNNKLNSRKFLLRL
HHHHHCCCHHHHHEECCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHHHHH
GLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMLFATPVVLYSAQPFYFSAIRTL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHEECCCCHHHHHHHHH
LSGKLNMDVSVSIAIGGAYVASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKAS
HCCCCCCCEEEEEEECHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHC
VSSSNLHKLVPLTAHLMNDNGQEEIPAKKLRLNDVILVKPGEMIAADGVVIEGHTSINEA
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHEEECCEEEECCCCEEEECCEEEECCCCHHHH
MLTGEQMPIEKTVASQVYAGTINVDQPIKVSVTALGQDQLVAEIIRLQELASNTKPAIAL
HHCCCCCCHHHHHHHHHEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCHHHH
LADKLSRYFSGTILTIATITYLVWHQISPEDAFWVTLSVLVATCPCALALATPTAVTCAT
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AIFTRLGIITRKAGVFEKLPQIKHVVFDKTGTLTCGTLSIGQTQCMADLTNTQALAIAAA
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCHHHHHHHH
LEAGSRHPIAAAFAMFADNALVAEEVHHEVGFGVRGRIDGTDYFIGNAVFTGASIDSRDP
HHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCCEEECCEEEECCCCCCCCC
TQKIWLARSANNQLEVLASFEIQDNIRQDSKATIEMLKQQGCRISIASGDSSGHVHQLAK
HHHEEEEECCCCCEEEEEEEEHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
ELGIDDVHSGLTPADKLALVTRLQQHTRVAMFGDGINDAPVLAGADLSVAMGSGSAIAKN
HCCCHHHHCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCCEEECCCCEEEECCCCEEECC
SADLILLGDHLSRFTQAVSVAKLTTQIIRQNLAWALGYNALILPLAVTGHVAPYIAAIGM
CCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCC
SASSLIVVGNSLRLLRVKV
CCCEEEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA