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The map label for this gene is uraA [H]

Identifier: 160874936

GI number: 160874936

Start: 2185234

End: 2186484

Strand: Reverse

Name: uraA [H]

Synonym: Sbal195_1821

Alternate gene names: 160874936

Gene position: 2186484-2185234 (Counterclockwise)

Preceding gene: 160874939

Following gene: 160874934

Centisome position: 40.89

GC content: 50.44

Gene sequence:

>1251_bases
ATGAGACGACTCGCTATCCCCCTACAGGGCGCACAAATGCTGTTTGTGGCCTTCGGTGCCCTAGTGTTAATGCCGCTGCT
GACAGGACTCGACACTAGTGTGGCATTGTTTACCGCTGGTATCGGTACCCTACTGTTCCAATTGATCACTAAACGCCAAG
TGCCTATCTTCCTTGCCTCATCCTTCGCCTTTATTGCCCCCATACTCTATGGCGTGCAGACTTGGGGCATTCCCTCCACC
ATGGGCGGCATTATGGCCGCGGGCGTGGTCTACGTCATGCTCGGCGCCTTGGTCAAAGTGCGCGGCACCGACTTCATCCA
TAGGCTATTACCGCCTGTGGTAGTGGGTCCAGTGATCATTATCATTGGCCTTGGCCTAGCTCCAGTTGCCGTGAATATGG
CATTGGGGAAAAGTGGCGATGGTAGCTTGACCCTTGTTGACACCAATACTGCGCTATTTATTTCACTCGCGTCACTCTGT
ACCACAATAGCAGTGGCAATTTTTGCCAAGGGCTTACTCAAAGTCATGCCGATTTTAGCGGGGATTATTGTGGGCTACGG
CTTAAGTCTTGCCTTTGGTATTGTTGACTTTGCCGTAGTGACTGCCGCCAGTTGGATTGCGATTCCTAAATTTGTCGCAC
CCGAATTTAACTGGCATGCCATCGCCTTTATGATCCCAGTGGCAATCGCTCCGGCGGTTGAACACATAGGTGATATTTTG
GCGATATCCAATGTTACAGGTAAAGATTTTATGAAAAAACCTGGCCTACACCGCACACTAACGGGAGACGGTGTCGCCAC
AATTGCCGCTGCGGCCTTCGGTGGCCCGCCAAACACGACTTACTCAGAAGTCACTGGTGCTGTAACCCTAACGCGCAATT
TTGATCCAAAAATTATGACTTGGACCGCCATTACCGCCATCACGTTGGCCTTTGTCGGCAAATTAGGTGCGCTGATGCAA
ACCATTCCAGTCCCTGTGATGGGCGGTATTATGTGTTTGTTATTCGGCTCAATAGCAGCCGTTGGTCTCAACACCCTTAT
TCGCAATCATGTGGATTTGTCTGAGCCGCGTAATTTAAGCATTGTCGGTGTCACCTTAGTATTTGGTATCGGCGGCATGG
CATTTGGCATAGGTTCATTCAGTCTGACCGGTATCAGCTTGTGCGGCATTGTCGCGATTACCATGAACTTATTATTACCC
GCGACCAAGCCACACGATAAACACAATGAGTCAGATGTCACCCCTCACTAG

Upstream 100 bases:

>100_bases
ACAGTGATCCGAGTCGGCAAAACGGGCGATTTTCTTCTGCTGAAAATCCAACAAACTGATATCATCTGGCGGTTTACCCT
AAAATTAACGAGAATAATAA

Downstream 100 bases:

>100_bases
TCGTTGTTTGAGGAATCGCCGTTTTATTGAAGTGTTTGTTGTCATGTTTTTTGTAGCGATAGCTCTTTGAAAAACAGCGA
CAAAAAAGCCGCCGTGATAT

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MRRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIMAAGVVYVMLGALVKVRGTDFIHRLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVDTNTALFISLASLC
TTIAVAIFAKGLLKVMPILAGIIVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ATKPHDKHNESDVTPH

Sequences:

>Translated_416_residues
MRRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIMAAGVVYVMLGALVKVRGTDFIHRLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVDTNTALFISLASLC
TTIAVAIFAKGLLKVMPILAGIIVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ATKPHDKHNESDVTPH
>Mature_416_residues
MRRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIMAAGVVYVMLGALVKVRGTDFIHRLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVDTNTALFISLASLC
TTIAVAIFAKGLLKVMPILAGIIVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ATKPHDKHNESDVTPH

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=423, Percent_Identity=25.2955082742317, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI44680143, Length=427, Percent_Identity=24.5901639344262, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI44680148, Length=393, Percent_Identity=24.6819338422392, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI40316845, Length=393, Percent_Identity=24.6819338422392, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1788843, Length=415, Percent_Identity=38.3132530120482, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI87081818, Length=421, Percent_Identity=38.0047505938242, Blast_Score=231, Evalue=9e-62,
Organism=Escherichia coli, GI87082181, Length=381, Percent_Identity=28.8713910761155, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790087, Length=373, Percent_Identity=24.6648793565684, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082178, Length=330, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=180, Percent_Identity=27.2222222222222, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356175, Length=392, Percent_Identity=25, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 43207; Mature: 43207

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLAS
CCCEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
SFAFIAPILYGVQTWGIPSTMGGIMAAGVVYVMLGALVKVRGTDFIHRLLPPVVVGPVII
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHH
IIGLGLAPVAVNMALGKSGDGSLTLVDTNTALFISLASLCTTIAVAIFAKGLLKVMPILA
HHHCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIIVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMT
HCCCCCCHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCCCHHHHCCEEEEEECCCCCEEH
WTAITAITLAFVGKLGALMQTIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
IVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLPATKPHDKHNESDVTPH
EEHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]