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The map label for this gene is gabT [H]

Identifier: 160874324

GI number: 160874324

Start: 1429664

End: 1430941

Strand: Direct

Name: gabT [H]

Synonym: Sbal195_1205

Alternate gene names: 160874324

Gene position: 1429664-1430941 (Clockwise)

Preceding gene: 160874323

Following gene: 160874336

Centisome position: 26.74

GC content: 51.88

Gene sequence:

>1278_bases
ATGACAACAACCAATGATTCATTGATGGCACGTCGCCAAGCCGCAGTTGCGGGTGGTGTCGGGCAAATTCACCCGATCTT
TACCGCGCGCGCCGAAAACGCGACCGTGTGGGATGTTGAAGGTCGCGAGTTTATCGATTTTGCGGGCGGCATTGCTGTGC
TTAATACCGGTCATCTTCACCCTAAAGTGAAGGCGGCGGTTGCGGCTCAGCTGGATAATTTCTCCCACACTTGTTTTATG
GTGCTTGGTTACGAGAGCTATATCCAAGTGTGTGAAAAGCTCAATCAATTGGTGCCAGGGGATTTTGCCAAGAAGACGGC
ATTATTCACTAGTGGTTCAGAAGCGGTTGAAAACGCAGTTAAAGTGGCGCGTGCCTATACCAAACGTGCTGGCGTGATTG
CGTTTACCTCTGGCTACCATGGTCGCACTATCGCAGCCTTGGCACTGACCGGAAAAGTCGCGCCTTACAGTAAAGGTATG
GGGCTGATGTCGGCGAATGTGTTCCGTGCCGAGTTCCCGTGCGAGATGCACGGCGTGTCCGATGATGATGCGATGGCATC
GATTGAACGCATCTTTAAAAATGATGCCGAGCCAAGTGATATTGCCGCCATTATTTTAGAGCCAGTACAGGGCGAGGGTG
GTTTTTATGCTGCATCACCCGCCTTTATGCAGCGGTTGCGCGCATTATGCGATCGTGAAGGCATTATGCTGATCGCCGAT
GAAGTGCAAACGGGCGCTGGCCGTACCGGCACTTTCTTTGCCATGGAGCAAATGGGCGTGAGTGCAGATATCACTACTTT
TGCTAAATCTATCGCGGGTGGGTTCCCACTTTCTGGCATTACTGGCCGCGCGCAAGTGATGGATGCCATTGGTCCGGGTG
GTCTTGGCGGTACGTATGGTGGCAGCCCGTTAGCGTGCGCCGCGGCGCTTGCTGTTATTGAAGTGTTTGAAGAAGAAAAG
CTGTTAGATCGTGCCAATACCATAGGTGAGCGCATTAAGTCTGCATTGAACGTGATGCAGGTCGAACATGCTCAAATCGC
CGATGTGCGTGGTTTAGGCGCGATGATCGCCATTGAATTGATGGAAGATGGCAAACCTGCACCGCACTATTGCGCGCAAG
TATTGAGTGATGCCCGTGACCGTGGATTGATTTTATTATCCTGCGGCACTTACGGTAATGTGCTGCGTATTTTGGTGCCA
TTAACCGCGCCGGATGCACAAATTGATGCAGGCCTTGGTATCCTCAAAGCCAGCTTCGATGCCGTTTTGAAAAGCTAA

Upstream 100 bases:

>100_bases
GCCGCGAAGGTTCTAAGTACGGCATCGAAGAATATTTAGAAATGAAGTACATCTGCATGTCCGTTTAATACGGTCCGATT
TGGCGTGTGAGGAACACTAA

Downstream 100 bases:

>100_bases
TATTGCTTTGATATAAAGCTGTTTTAGATGACAGTTTTACATAATGAAAATCCCGCTTCGGCGGGATTTTTTATGGAAGT
GGCGATTGTTTTGGCGTTTG

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTTTNDSLMARRQAAVAGGVGQIHPIFTARAENATVWDVEGREFIDFAGGIAVLNTGHLHPKVKAAVAAQLDNFSHTCFM
VLGYESYIQVCEKLNQLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRAGVIAFTSGYHGRTIAALALTGKVAPYSKGM
GLMSANVFRAEFPCEMHGVSDDDAMASIERIFKNDAEPSDIAAIILEPVQGEGGFYAASPAFMQRLRALCDREGIMLIAD
EVQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGRAQVMDAIGPGGLGGTYGGSPLACAAALAVIEVFEEEK
LLDRANTIGERIKSALNVMQVEHAQIADVRGLGAMIAIELMEDGKPAPHYCAQVLSDARDRGLILLSCGTYGNVLRILVP
LTAPDAQIDAGLGILKASFDAVLKS

Sequences:

>Translated_425_residues
MTTTNDSLMARRQAAVAGGVGQIHPIFTARAENATVWDVEGREFIDFAGGIAVLNTGHLHPKVKAAVAAQLDNFSHTCFM
VLGYESYIQVCEKLNQLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRAGVIAFTSGYHGRTIAALALTGKVAPYSKGM
GLMSANVFRAEFPCEMHGVSDDDAMASIERIFKNDAEPSDIAAIILEPVQGEGGFYAASPAFMQRLRALCDREGIMLIAD
EVQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGRAQVMDAIGPGGLGGTYGGSPLACAAALAVIEVFEEEK
LLDRANTIGERIKSALNVMQVEHAQIADVRGLGAMIAIELMEDGKPAPHYCAQVLSDARDRGLILLSCGTYGNVLRILVP
LTAPDAQIDAGLGILKASFDAVLKS
>Mature_424_residues
TTTNDSLMARRQAAVAGGVGQIHPIFTARAENATVWDVEGREFIDFAGGIAVLNTGHLHPKVKAAVAAQLDNFSHTCFMV
LGYESYIQVCEKLNQLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRAGVIAFTSGYHGRTIAALALTGKVAPYSKGMG
LMSANVFRAEFPCEMHGVSDDDAMASIERIFKNDAEPSDIAAIILEPVQGEGGFYAASPAFMQRLRALCDREGIMLIADE
VQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGRAQVMDAIGPGGLGGTYGGSPLACAAALAVIEVFEEEKL
LDRANTIGERIKSALNVMQVEHAQIADVRGLGAMIAIELMEDGKPAPHYCAQVLSDARDRGLILLSCGTYGNVLRILVPL
TAPDAQIDAGLGILKASFDAVLKS

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=438, Percent_Identity=29.9086757990868, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI13994255, Length=424, Percent_Identity=30.188679245283, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI37574042, Length=419, Percent_Identity=28.6396181384248, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=29.6636085626911, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI226442705, Length=419, Percent_Identity=28.4009546539379, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI24119277, Length=394, Percent_Identity=28.4263959390863, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=28.9405684754522, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI188536080, Length=403, Percent_Identity=25.8064516129032, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI38679950, Length=403, Percent_Identity=25.8064516129032, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI38679946, Length=403, Percent_Identity=25.8064516129032, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=69.833729216152, Blast_Score=614, Evalue=1e-177,
Organism=Escherichia coli, GI1787560, Length=415, Percent_Identity=52.0481927710843, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1789759, Length=395, Percent_Identity=33.9240506329114, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=34.3434343434343, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI145693181, Length=413, Percent_Identity=33.8983050847458, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1786991, Length=350, Percent_Identity=33.1428571428571, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1786349, Length=320, Percent_Identity=30.9375, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32564660, Length=423, Percent_Identity=31.9148936170213, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=29.4403892944039, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71992977, Length=438, Percent_Identity=28.7671232876712, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25144274, Length=320, Percent_Identity=28.125, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=375, Percent_Identity=25.8666666666667, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=29.1925465838509, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=29.6296296296296, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323470, Length=412, Percent_Identity=29.126213592233, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324386, Length=334, Percent_Identity=25.4491017964072, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321456, Length=246, Percent_Identity=27.6422764227642, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357415, Length=416, Percent_Identity=29.8076923076923, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28574759, Length=419, Percent_Identity=30.0715990453461, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI161085790, Length=437, Percent_Identity=29.2906178489703, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=28.436018957346, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281366494, Length=399, Percent_Identity=25.5639097744361, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24667139, Length=399, Percent_Identity=25.5639097744361, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24667143, Length=399, Percent_Identity=25.5639097744361, Blast_Score=116, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 44757; Mature: 44626

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTNDSLMARRQAAVAGGVGQIHPIFTARAENATVWDVEGREFIDFAGGIAVLNTGHLH
CCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEECCCCHHHHHCCCEEEEECCCCC
PKVKAAVAAQLDNFSHTCFMVLGYESYIQVCEKLNQLVPGDFAKKTALFTSGSEAVENAV
HHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHEEECCCHHHHHHHH
KVARAYTKRAGVIAFTSGYHGRTIAALALTGKVAPYSKGMGLMSANVFRAEFPCEMHGVS
HHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCEEECCEEEEECCCCCCCCC
DDDAMASIERIFKNDAEPSDIAAIILEPVQGEGGFYAASPAFMQRLRALCDREGIMLIAD
CHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEEEEEE
EVQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGRAQVMDAIGPGGLGGTYG
CCCCCCCCCCEEEEHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
GSPLACAAALAVIEVFEEEKLLDRANTIGERIKSALNVMQVEHAQIADVRGLGAMIAIEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEE
MEDGKPAPHYCAQVLSDARDRGLILLSCGTYGNVLRILVPLTAPDAQIDAGLGILKASFD
HHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCHHHCCCHHHHHHHH
AVLKS
HHHCC
>Mature Secondary Structure 
TTTNDSLMARRQAAVAGGVGQIHPIFTARAENATVWDVEGREFIDFAGGIAVLNTGHLH
CCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEECCCCHHHHHCCCEEEEECCCCC
PKVKAAVAAQLDNFSHTCFMVLGYESYIQVCEKLNQLVPGDFAKKTALFTSGSEAVENAV
HHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHEEECCCHHHHHHHH
KVARAYTKRAGVIAFTSGYHGRTIAALALTGKVAPYSKGMGLMSANVFRAEFPCEMHGVS
HHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCEEECCEEEEECCCCCCCCC
DDDAMASIERIFKNDAEPSDIAAIILEPVQGEGGFYAASPAFMQRLRALCDREGIMLIAD
CHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEEEEEE
EVQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGRAQVMDAIGPGGLGGTYG
CCCCCCCCCCEEEEHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
GSPLACAAALAVIEVFEEEKLLDRANTIGERIKSALNVMQVEHAQIADVRGLGAMIAIEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEE
MEDGKPAPHYCAQVLSDARDRGLILLSCGTYGNVLRILVPLTAPDAQIDAGLGILKASFD
HHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCHHHCCCHHHHHHHH
AVLKS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]