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The map label for this gene is modE [H]

Identifier: 160873953

GI number: 160873953

Start: 973190

End: 973969

Strand: Direct

Name: modE [H]

Synonym: Sbal195_0831

Alternate gene names: 160873953

Gene position: 973190-973969 (Clockwise)

Preceding gene: 160873949

Following gene: 160873954

Centisome position: 18.2

GC content: 50.9

Gene sequence:

>780_bases
ATGGATTTACATGCATTACTTACGCTTTCCCTCGGGGACAAGCCCTTCGCCAATCCTAGGCGGATAAGCCTGCTCGAGCA
AGTCGCCAACACAGGCTCGATAAGCCAAGGCGCCAAGCTTGCGGGGATCAGTTATAAAGCGGCGTGGGACGCGATCAATG
AGATGAACACCGCCATGCCCGAACCCGTAGTGTGCAGCGAAAAGGGCGGCAAAGGTGGTGGTGGCGCTAAACTCACCGAA
TTTGGCGAGCGTTTGCTCAAGGTGTATTCCATCACCTCCCAAGTACAAGAAATGGCCTTGGCCGCCTTGCTCGATGAGTC
CGTCGACATGCACAGTTTATTGGATGTGATGGCGCATTTCTCACTCAATACTAGCGCCCGTAATCAGTTAACGGGTCGTA
TCAATGGCATTGAATCATTTGGATTAAATGACAAGATCAGCGTGACCTTAGCGGGCGGGCAACAGATTCAGATTTCAGTG
ACCCATTCGAGCCGCGAACGCTTGCAGTTAGCCATGGATAAATCTGTGTTGTTACTGTTTAAAGCCCCCGCTGTACTGGC
GACGACCCATGCCTGCGAAGTGGATGGGCAAAATTGCCTAAGCGGTCGTTTGCTGAGCGTAACTAAACTTGGCGATAAGG
CCGAATTAGCCATAGATATTGATGGTAAAGATGTTATCTATTCAGTGATGCCACTGACTCAAACGCAGGCGTTGGCTGTC
AGCGAACCATGTTTTACCTGTTTTGATGCCACGCAGGTGATCCTCGCCAGCATGAATTAG

Upstream 100 bases:

>100_bases
AATGGTATTAATCCGCTGAAATATCTCGGCAATCTTATTGGTATCCTCAAGGTGATGAAGGACAATAGGGCTCAAGTCAG
ACTTGGGTGCGGGATAAACG

Downstream 100 bases:

>100_bases
CCGAATGAAGTGATTCATTCGGTTAATCATTGGTCATTCACTGGGGATGGCCAGTGACTTGGCGTTATTTTTTTCGCAAT
GGGTTGGTGGGGAATCTAAT

Product: ModE family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MDLHALLTLSLGDKPFANPRRISLLEQVANTGSISQGAKLAGISYKAAWDAINEMNTAMPEPVVCSEKGGKGGGGAKLTE
FGERLLKVYSITSQVQEMALAALLDESVDMHSLLDVMAHFSLNTSARNQLTGRINGIESFGLNDKISVTLAGGQQIQISV
THSSRERLQLAMDKSVLLLFKAPAVLATTHACEVDGQNCLSGRLLSVTKLGDKAELAIDIDGKDVIYSVMPLTQTQALAV
SEPCFTCFDATQVILASMN

Sequences:

>Translated_259_residues
MDLHALLTLSLGDKPFANPRRISLLEQVANTGSISQGAKLAGISYKAAWDAINEMNTAMPEPVVCSEKGGKGGGGAKLTE
FGERLLKVYSITSQVQEMALAALLDESVDMHSLLDVMAHFSLNTSARNQLTGRINGIESFGLNDKISVTLAGGQQIQISV
THSSRERLQLAMDKSVLLLFKAPAVLATTHACEVDGQNCLSGRLLSVTKLGDKAELAIDIDGKDVIYSVMPLTQTQALAV
SEPCFTCFDATQVILASMN
>Mature_259_residues
MDLHALLTLSLGDKPFANPRRISLLEQVANTGSISQGAKLAGISYKAAWDAINEMNTAMPEPVVCSEKGGKGGGGAKLTE
FGERLLKVYSITSQVQEMALAALLDESVDMHSLLDVMAHFSLNTSARNQLTGRINGIESFGLNDKISVTLAGGQQIQISV
THSSRERLQLAMDKSVLLLFKAPAVLATTHACEVDGQNCLSGRLLSVTKLGDKAELAIDIDGKDVIYSVMPLTQTQALAV
SEPCFTCFDATQVILASMN

Specific function: The modE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA reg

COG id: COG2005

COG function: function code R; N-terminal domain of molybdenum-binding protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the modE family [H]

Homologues:

Organism=Escherichia coli, GI1786976, Length=246, Percent_Identity=39.0243902439024, Blast_Score=146, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR004606
- InterPro:   IPR008995
- InterPro:   IPR003725
- InterPro:   IPR016462
- InterPro:   IPR005116
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03459 TOBE [H]

EC number: NA

Molecular weight: Translated: 27596; Mature: 27596

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLHALLTLSLGDKPFANPRRISLLEQVANTGSISQGAKLAGISYKAAWDAINEMNTAMP
CCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHCCC
EPVVCSEKGGKGGGGAKLTEFGERLLKVYSITSQVQEMALAALLDESVDMHSLLDVMAHF
CCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SLNTSARNQLTGRINGIESFGLNDKISVTLAGGQQIQISVTHSSRERLQLAMDKSVLLLF
CCCCCHHHHHHHEECCCHHCCCCCEEEEEEECCCEEEEEEECCCHHHHHHHHCCCEEEEE
KAPAVLATTHACEVDGQNCLSGRLLSVTKLGDKAELAIDIDGKDVIYSVMPLTQTQALAV
ECCHHHEEEEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCCEEEEEEECCCCCHHEEE
SEPCFTCFDATQVILASMN
CCCHHHHHHHHHHHEECCC
>Mature Secondary Structure
MDLHALLTLSLGDKPFANPRRISLLEQVANTGSISQGAKLAGISYKAAWDAINEMNTAMP
CCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHCCC
EPVVCSEKGGKGGGGAKLTEFGERLLKVYSITSQVQEMALAALLDESVDMHSLLDVMAHF
CCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SLNTSARNQLTGRINGIESFGLNDKISVTLAGGQQIQISVTHSSRERLQLAMDKSVLLLF
CCCCCHHHHHHHEECCCHHCCCCCEEEEEEECCCEEEEEEECCCHHHHHHHHCCCEEEEE
KAPAVLATTHACEVDGQNCLSGRLLSVTKLGDKAELAIDIDGKDVIYSVMPLTQTQALAV
ECCHHHEEEEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCCEEEEEEECCCCCHHEEE
SEPCFTCFDATQVILASMN
CCCHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]