Click here to switch to the map view.

The map label for this gene is desK [H]

Identifier: 160873478

GI number: 160873478

Start: 400157

End: 401236

Strand: Reverse

Name: desK [H]

Synonym: Sbal195_0353

Alternate gene names: 160873478

Gene position: 401236-400157 (Counterclockwise)

Preceding gene: 160873479

Following gene: 160873477

Centisome position: 7.5

GC content: 47.13

Gene sequence:

>1080_bases
ATGACAAGCACGCATCTTCAGCTCGAACGAAAACTCGCTTGGGTGTATTTGATAAACTTAGTGTTTTATCTTATTCCGCT
TACCATCAATGCGTATCCTGCATGGAAAATCGCCCTGAGCTTTGCCGTGCTGATTCCTTTTATTGCCAGTTATTTTTGGG
CCTATAAGTGCACTCAGAATAGCGCCTATCGCCCCATTCTGATGATGGTGGCCATCGCCACAGCAATTACCCCAATTAAC
CCGGGATCTATCTCGTTATTCACCTTTGCCGCTTTTTTCATTGGCTTTTTTTATCCTCTCAGAACCTGTCTGTTGGCTAT
TGCCGCCTTAATCGGCCTGTTGTTTGCCCTCAATGAAATTTACGACTTTAACAGTTACTACTTTCCACTTTACGGCTCAG
GGTTAGTGCTCGGTGTAGGCATGTTTGGCGTAGCCGAACGCAGGCGTCATCAACATAAATTGAAAGAACAGCAAAGCACG
CAAGAAATTAGTACCTTAGCGGCTATGGTTGAGCGAGAACGCATTGCCCGCGATCTACACGACATCATGGGCCACAGCTT
GTCTTCGATTGCGCTTAAGGCGGAACTGGCCGAAAAACTGCTGGCAAAACAAGAATACCAACTGGCCACAATCCAGCTTA
ATGAACTCGGCCAAATTGCCCGCGAGAGCCTCAGCCAAATTCGCCACACCGTATCTGACTACAAACATAAAGGTCTCGCG
GATAGCGTGACACAACTGTGTAAACTATTGAGGGAAAAAGGAGTCAGTGTCGAGCTGACAGGCAATATCCCTAAACTGCC
CGCCAGAATGGAGAGCCAGCTGGGATTAATTGTCACTGAACTGGTGAATAATATTTTACGCCATAGCGGCGCAAGCCAAT
GTATTATCGACTTTATTCAGCAAGCAGATAGGCTAGTCGTTGAGGTCAAAGATAACGGTCCAAGTAAACCTATCGCCGAA
GGCAATGGCCTCACGGGGATACGCGAACGTCTCGACAGCTTAGGCGGCAGCTTGAGCTATAATCTCGAACAGGGATATGC
ATTTACCGTCAGTTTACCTTTGCAGGGAGCAACAGATTAA

Upstream 100 bases:

>100_bases
ACCCCAGCGCCAATCCCTAAACAGATGAATCAACACAGATATCACCTTCGGGCATTCAACGAACAACGATTAACAGTCAA
CGCAGTTTCATAGGGGCATT

Downstream 100 bases:

>100_bases
TGAAGATTTTATTGGCGGAAGACCAAGCCATGGTGCGAGGCGCGCTCGCCGCACTCCTCACGCTTGCGGGAGGCTTTAAT
ATCACCCAAGCGAGTGACGG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTSTHLQLERKLAWVYLINLVFYLIPLTINAYPAWKIALSFAVLIPFIASYFWAYKCTQNSAYRPILMMVAIATAITPIN
PGSISLFTFAAFFIGFFYPLRTCLLAIAALIGLLFALNEIYDFNSYYFPLYGSGLVLGVGMFGVAERRRHQHKLKEQQST
QEISTLAAMVERERIARDLHDIMGHSLSSIALKAELAEKLLAKQEYQLATIQLNELGQIARESLSQIRHTVSDYKHKGLA
DSVTQLCKLLREKGVSVELTGNIPKLPARMESQLGLIVTELVNNILRHSGASQCIIDFIQQADRLVVEVKDNGPSKPIAE
GNGLTGIRERLDSLGGSLSYNLEQGYAFTVSLPLQGATD

Sequences:

>Translated_359_residues
MTSTHLQLERKLAWVYLINLVFYLIPLTINAYPAWKIALSFAVLIPFIASYFWAYKCTQNSAYRPILMMVAIATAITPIN
PGSISLFTFAAFFIGFFYPLRTCLLAIAALIGLLFALNEIYDFNSYYFPLYGSGLVLGVGMFGVAERRRHQHKLKEQQST
QEISTLAAMVERERIARDLHDIMGHSLSSIALKAELAEKLLAKQEYQLATIQLNELGQIARESLSQIRHTVSDYKHKGLA
DSVTQLCKLLREKGVSVELTGNIPKLPARMESQLGLIVTELVNNILRHSGASQCIIDFIQQADRLVVEVKDNGPSKPIAE
GNGLTGIRERLDSLGGSLSYNLEQGYAFTVSLPLQGATD
>Mature_358_residues
TSTHLQLERKLAWVYLINLVFYLIPLTINAYPAWKIALSFAVLIPFIASYFWAYKCTQNSAYRPILMMVAIATAITPINP
GSISLFTFAAFFIGFFYPLRTCLLAIAALIGLLFALNEIYDFNSYYFPLYGSGLVLGVGMFGVAERRRHQHKLKEQQSTQ
EISTLAAMVERERIARDLHDIMGHSLSSIALKAELAEKLLAKQEYQLATIQLNELGQIARESLSQIRHTVSDYKHKGLAD
SVTQLCKLLREKGVSVELTGNIPKLPARMESQLGLIVTELVNNILRHSGASQCIIDFIQQADRLVVEVKDNGPSKPIAEG
NGLTGIRERLDSLGGSLSYNLEQGYAFTVSLPLQGATD

Specific function: Member of the two-component regulatory system desR/desK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates desR by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=234, Percent_Identity=29.0598290598291, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788812, Length=214, Percent_Identity=25.7009345794392, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39934; Mature: 39803

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTHLQLERKLAWVYLINLVFYLIPLTINAYPAWKIALSFAVLIPFIASYFWAYKCTQN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SAYRPILMMVAIATAITPINPGSISLFTFAAFFIGFFYPLRTCLLAIAALIGLLFALNEI
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDFNSYYFPLYGSGLVLGVGMFGVAERRRHQHKLKEQQSTQEISTLAAMVERERIARDLH
HHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIMGHSLSSIALKAELAEKLLAKQEYQLATIQLNELGQIARESLSQIRHTVSDYKHKGLA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DSVTQLCKLLREKGVSVELTGNIPKLPARMESQLGLIVTELVNNILRHSGASQCIIDFIQ
HHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QADRLVVEVKDNGPSKPIAEGNGLTGIRERLDSLGGSLSYNLEQGYAFTVSLPLQGATD
HHCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEEEEEEECCCCCCC
>Mature Secondary Structure 
TSTHLQLERKLAWVYLINLVFYLIPLTINAYPAWKIALSFAVLIPFIASYFWAYKCTQN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SAYRPILMMVAIATAITPINPGSISLFTFAAFFIGFFYPLRTCLLAIAALIGLLFALNEI
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDFNSYYFPLYGSGLVLGVGMFGVAERRRHQHKLKEQQSTQEISTLAAMVERERIARDLH
HHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIMGHSLSSIALKAELAEKLLAKQEYQLATIQLNELGQIARESLSQIRHTVSDYKHKGLA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DSVTQLCKLLREKGVSVELTGNIPKLPARMESQLGLIVTELVNNILRHSGASQCIIDFIQ
HHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QADRLVVEVKDNGPSKPIAEGNGLTGIRERLDSLGGSLSYNLEQGYAFTVSLPLQGATD
HHCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]