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The map label for this gene is htrC

Identifier: 16081088

GI number: 16081088

Start: 4147567

End: 4148769

Strand: Reverse

Name: htrC

Synonym: BSU40360

Alternate gene names: 16081088

Gene position: 4148769-4147567 (Counterclockwise)

Preceding gene: 255767871

Following gene: 16081086

Centisome position: 98.41

GC content: 48.21

Gene sequence:

>1203_bases
ATGGTGGATTACGAACGTGAGGAAGAACATACTACTCCTGAACAGCCAAAGAGAAGCAAAAAAGGATATTTTCTTTCGAG
TCTGATTGGCGTGATTGTCGGTGCCGTATTAATGGCGTTTATCATGCCGTACCTTTCAAATGAAGGGCTGGATACAGGCG
CCTTAGATCAGCAGCAAAACAACAATGGCCGGGAATCAATCAGGACGGTGAATGTCAGTGTCAACAATGCCGTCACCAAG
ATTGTCAGCAATATGTCGCCCGCCGTTGTCGGTGTTGTGAACATCCAAAAATCAGATATTTGGGGAGAGAGCGGCGAGGC
TGGGAGCGGCTCTGGCGTCATCTATAAGAAAAATGACCATTCCGCTTATGTCGTGACCAACCATCATGTCATCGAAGGCG
CTTCCCAAATTGAAATCAGCTTGAAAGACGGCTCACGTGTATCAGCTGATCTTGTCGGCAGCGACCAGCTGATGGACCTT
GCCGTTTTACGGGTGAAAAGCGATAAGATTAAAGCAGTCGCTGATTTCGGAAATTCAGATAAAGTGAAGTCTGGGGAGCC
GGTTATTGCGATCGGGAACCCGTTAGGCCTTGAGTTTGCAGGCTCTGTCACACAAGGCGTCATCTCGGGTACGGAGAGGG
CGATCCCAGTAGATTCAAACGGTGATGGACAGCCTGACTGGAACGCTGAAGTCCTGCAAACAGATGCGGCCATTAACCCT
GGGAACAGCGGCGGCGCTTTGTTAAATATGGATGGGAAGGTCATTGGCATCAATTCAATGAAAATTGCCGAGTCAGCGGT
TGAAGGGATTGGCCTGTCCATTCCGTCTAAGCTCGTGATCCCTGTGATAGAGGATTTAGAGAGATACGGAAAGGTCAAAC
GCCCGTTCCTTGGCATTGAGATGAAATCGCTAAGTGACATCGCAAGCTATCATTGGGATGAAACATTAAAGCTTCCTAAG
AACGTCACCAATGGAGCGGTTGTGATGGGTGTAGACGCCTTTTCACCTGCCGGAAAAGCGGGGCTGAAGGAACTGGATGT
CATCACGGAATTTGACGGATACAAAGTAAATGATATTGTTGACCTGCGAAAACGGCTTTATCAGAAAAAAGTCGGTGACC
GGGTGAAGGTGAAGTTTTATCGCGGCGGAAAAGAAAAATCTGTTGATATCAAGCTGTCCTCCGCAGACCAATTAGGCAGT
TAA

Upstream 100 bases:

>100_bases
TCCGCTTTGCGCTGTATAATTTTTCTATGTAAATCATGACTATTCTAGGAGTTTCTAACCCACAATATAACCATATTAAC
GTTCTTGGAAAGGATGGAAT

Downstream 100 bases:

>100_bases
TAAAAGCAGTCTGGCATCGTTGCCAGGCTGTTTTGATATGCAAAAAAAACTGAACAGGGGTCACGCCCGTTCAGTTGAAA
AAGGATATATCGAATATGAA

Product: membrane serine protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPYLSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTK
IVSNMSPAVVGVVNIQKSDIWGESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL
AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVDSNGDGQPDWNAEVLQTDAAINP
GNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPSKLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPK
NVTNGAVVMGVDAFSPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKLSSADQLGS

Sequences:

>Translated_400_residues
MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPYLSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTK
IVSNMSPAVVGVVNIQKSDIWGESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL
AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVDSNGDGQPDWNAEVLQTDAAINP
GNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPSKLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPK
NVTNGAVVMGVDAFSPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKLSSADQLGS
>Mature_400_residues
MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPYLSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTK
IVSNMSPAVVGVVNIQKSDIWGESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL
AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVDSNGDGQPDWNAEVLQTDAAINP
GNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPSKLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPK
NVTNGAVVMGVDAFSPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKLSSADQLGS

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain

Homologues:

Organism=Homo sapiens, GI4506141, Length=298, Percent_Identity=32.8859060402685, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI22129776, Length=297, Percent_Identity=28.956228956229, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24308541, Length=306, Percent_Identity=31.0457516339869, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI7019477, Length=315, Percent_Identity=29.5238095238095, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1789629, Length=289, Percent_Identity=38.4083044982699, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1786356, Length=293, Percent_Identity=35.8361774744027, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1789630, Length=376, Percent_Identity=32.9787234042553, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646839, Length=302, Percent_Identity=34.1059602649007, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YYXA_BACSU (P39668)

Other databases:

- EMBL:   D78193
- EMBL:   AL009126
- EMBL:   L22006
- PIR:   B70092
- RefSeq:   NP_391916.1
- ProteinModelPortal:   P39668
- SMR:   P39668
- MEROPS:   S01.364
- EnsemblBacteria:   EBBACT00000002325
- GeneID:   937779
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU40360
- NMPDR:   fig|224308.1.peg.4042
- GenoList:   BSU40360
- GeneTree:   EBGT00050000001145
- HOGENOM:   HBG585708
- OMA:   HKGIVIS
- ProtClustDB:   CLSK888188
- BioCyc:   BSUB:BSU40360-MONOMER
- GO:   GO:0006508
- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940
- PRINTS:   PR00834
- SMART:   SM00228

Pfam domain/function: PF00089 Trypsin; SSF50156 PDZ; SSF50494 Pept_Ser_Cys

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42789; Mature: 42789

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50106 PDZ

Important sites: ACT_SITE 129-129 ACT_SITE 159-159 ACT_SITE 243-243

Signals:

None

Transmembrane regions:

HASH(0x13480e10)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPYLSNEGLDTGALDQQQN
CCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWGESGEAGSGSGVIYKKNDH
CCCCCEEEEEEEEHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEECCC
SAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDLAVLRVKSDKIKAVADFGNSD
CEEEEECCEEECCCCEEEEEECCCCEEEEEECCCCHHHEEEHEEECCCCEEEEECCCCCC
KVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVDSNGDGQPDWNAEVLQTDAAINP
CCCCCCCEEEECCCCCCEECCHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEECCCCCC
GNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPSKLVIPVIEDLERYGKVKRPFLGIE
CCCCCEEEECCCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECEE
MKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAFSPAGKAGLKELDVITEFDGYKVNDIV
HHHHHHHHHHCCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHEEECCCCEEHHHHH
DLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKLSSADQLGS
HHHHHHHHHHCCCEEEEEEEECCCCCEEEEEECCCCCCCH
>Mature Secondary Structure
MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPYLSNEGLDTGALDQQQN
CCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWGESGEAGSGSGVIYKKNDH
CCCCCEEEEEEEEHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEECCC
SAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDLAVLRVKSDKIKAVADFGNSD
CEEEEECCEEECCCCEEEEEECCCCEEEEEECCCCHHHEEEHEEECCCCEEEEECCCCCC
KVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVDSNGDGQPDWNAEVLQTDAAINP
CCCCCCCEEEECCCCCCEECCHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEECCCCCC
GNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPSKLVIPVIEDLERYGKVKRPFLGIE
CCCCCEEEECCCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECEE
MKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAFSPAGKAGLKELDVITEFDGYKVNDIV
HHHHHHHHHHCCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHEEECCCCEEHHHHH
DLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKLSSADQLGS
HHHHHHHHHHCCCEEEEEEEECCCCCEEEEEECCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8113162