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The map label for this gene is rocD

Identifier: 16081086

GI number: 16081086

Start: 4144301

End: 4145506

Strand: Reverse

Name: rocD

Synonym: BSU40340

Alternate gene names: 16081086

Gene position: 4145506-4144301 (Counterclockwise)

Preceding gene: 16081088

Following gene: 16081085

Centisome position: 98.34

GC content: 49.09

Gene sequence:

>1206_bases
ATGACAGCTTTATCTAAATCCAAAGAAATTATTGATCAGACGTCTCATTACGGAGCCAACAATTATCACCCGCTCCCGAT
TGTTATTTCTGAAGCGCTGGGTGCTTGGGTAAAGGACCCGGAAGGCAATGAATATATGGATATGCTGAGTGCTTACTCTG
CGGTAAACCAGGGGCACAGACACCCGAAAATCATTCAGGCATTAAAGGATCAGGCTGATAAAATCACCCTCACGTCACGC
GCGTTTCATAACGATCAGCTTGGGCCGTTTTACGAAAAAACAGCTAAACTGACAGGCAAAGAGATGATTCTGCCGATGAA
TACAGGAGCCGAAGCGGTTGAATCCGCGGTGAAAGCGGCGAGACGCTGGGCGTATGAAGTGAAGGGCGTAGCTGACAATC
AAGCGGAAATTATCGCATGTGTCGGGAACTTCCACGGCCGCACGATGCTGGCGGTATCTCTTTCTTCTGAAGAGGAATAT
AAACGAGGATTCGGCCCGATGCTTCCAGGAATCAAACTCATTCCTTACGGCGATGTGGAAGCGCTTCGACAGGCCATTAC
GCCGAATACAGCGGCATTCTTGTTTGAACCGATTCAAGGCGAAGCGGGCATTGTGATTCCGCCTGAAGGATTTTTACAGG
AAGCGGCGGCGATTTGTAAGGAAGAGAATGTCTTGTTTATTGCGGATGAAATTCAGACGGGTCTCGGACGTACAGGCAAG
ACGTTTGCCTGTGACTGGGACGGCATTGTTCCGGATATGTATATCTTGGGCAAAGCGCTTGGCGGCGGTGTGTTCCCGAT
CTCTTGCATTGCGGCGGACCGCGAGATCCTAGGCGTGTTTAACCCTGGCTCACACGGCTCAACATTTGGTGGAAACCCGC
TTGCATGTGCAGTGTCTATCGCTTCATTAGAAGTGCTGGAGGATGAAAAGCTGGCGGATCGTTCTCTTGAACTTGGTGAA
TACTTTAAAAGCGAGCTTGAGAGTATTGACAGCCCTGTCATTAAAGAAGTCCGCGGCAGAGGGCTGTTTATCGGTGTGGA
ATTGACTGAAGCGGCACGTCCGTATTGTGAGCGTTTGAAGGAAGAGGGACTTTTATGCAAGGAAACGCATGATACAGTCA
TTCGTTTTGCACCGCCATTAATCATTTCCAAAGAGGACTTGGATTGGGCGATAGAGAAAATTAAGCACGTGCTGCGAAAC
GCATAA

Upstream 100 bases:

>100_bases
GTAGAAAACACACGAATTCTTGATTTGGCACAGAACTTGCATTTATATAAAGGGAAAGCAGGATAACATGTTGAAACAGA
AAACAAGGGGGAATTCAAAT

Downstream 100 bases:

>100_bases
ATCCGCACCATGGCGGGATATTCACTTCGTTTGTATAAATTTACAACAGAAAAATCAGCACTCCCTATTTGCTCAGCTAC
AGTATTTTAGTATAATGTAT

Product: ornithine--oxo-acid transaminase

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNEYMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSR
AFHNDQLGPFYEKTAKLTGKEMILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY
KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAICKEENVLFIADEIQTGLGRTGK
TFACDWDGIVPDMYILGKALGGGVFPISCIAADREILGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGE
YFKSELESIDSPVIKEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIEKIKHVLRN
A

Sequences:

>Translated_401_residues
MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNEYMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSR
AFHNDQLGPFYEKTAKLTGKEMILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY
KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAICKEENVLFIADEIQTGLGRTGK
TFACDWDGIVPDMYILGKALGGGVFPISCIAADREILGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGE
YFKSELESIDSPVIKEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIEKIKHVLRN
A
>Mature_400_residues
TALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNEYMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRA
FHNDQLGPFYEKTAKLTGKEMILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEYK
RGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAICKEENVLFIADEIQTGLGRTGKT
FACDWDGIVPDMYILGKALGGGVFPISCIAADREILGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEY
FKSELESIDSPVIKEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIEKIKHVLRNA

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde. Controls arginine catabolism

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=397, Percent_Identity=49.6221662468514, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI284507298, Length=298, Percent_Identity=48.6577181208054, Blast_Score=295, Evalue=7e-80,
Organism=Homo sapiens, GI13994255, Length=434, Percent_Identity=29.4930875576037, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=28.8782816229117, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI37574042, Length=416, Percent_Identity=26.6826923076923, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI226442709, Length=384, Percent_Identity=26.0416666666667, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI226442705, Length=416, Percent_Identity=25.9615384615385, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1789759, Length=383, Percent_Identity=34.9869451697128, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI145693181, Length=377, Percent_Identity=33.6870026525199, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1788044, Length=379, Percent_Identity=33.509234828496, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1787560, Length=406, Percent_Identity=32.512315270936, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789016, Length=439, Percent_Identity=30.751708428246, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1786991, Length=397, Percent_Identity=30.4785894206549, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=27.7936962750716, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=391, Percent_Identity=48.5933503836317, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI25144274, Length=270, Percent_Identity=45.5555555555556, Blast_Score=255, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71981843, Length=177, Percent_Identity=49.1525423728814, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32564660, Length=441, Percent_Identity=30.6122448979592, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71992977, Length=435, Percent_Identity=27.816091954023, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17541228, Length=452, Percent_Identity=23.4513274336283, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323470, Length=410, Percent_Identity=49.2682926829268, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324432, Length=365, Percent_Identity=31.5068493150685, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324386, Length=431, Percent_Identity=25.5220417633411, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6321456, Length=373, Percent_Identity=24.1286863270777, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21357415, Length=397, Percent_Identity=48.1108312342569, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI161085790, Length=435, Percent_Identity=31.0344827586207, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28574759, Length=424, Percent_Identity=30.8962264150943, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21356575, Length=433, Percent_Identity=26.3279445727483, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI281366494, Length=431, Percent_Identity=24.3619489559165, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24667139, Length=431, Percent_Identity=24.3619489559165, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24667143, Length=431, Percent_Identity=24.3619489559165, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): OAT_BACSU (P38021)

Other databases:

- EMBL:   X81802
- EMBL:   D78193
- EMBL:   AL009126
- EMBL:   L22006
- PIR:   S55793
- RefSeq:   NP_391914.1
- ProteinModelPortal:   P38021
- SMR:   P38021
- EnsemblBacteria:   EBBACT00000001804
- GeneID:   937755
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU40340
- NMPDR:   fig|224308.1.peg.4040
- GenoList:   BSU40340
- GeneTree:   EBGT00070000031861
- HOGENOM:   HBG725944
- OMA:   VRRWAYD
- PhylomeDB:   P38021
- ProtClustDB:   PRK04073
- BioCyc:   BSUB:BSU40340-MONOMER
- BRENDA:   2.6.1.13
- GO:   GO:0005737
- HAMAP:   MF_01689
- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF18
- TIGRFAMs:   TIGR01885

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.13

Molecular weight: Translated: 43762; Mature: 43631

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNEYMDMLSAYSAVNQGHR
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
HPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEMILPMNTGAEAVESAVKAA
CHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
RRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEYKRGFGPMLPGIKLIPYGDVE
HHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEECCHHHHHHCCCCCCCCCEEECCCCHH
ALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAICKEENVLFIADEIQTGLGRTGK
HHHHHHCCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCC
TFACDWDGIVPDMYILGKALGGGVFPISCIAADREILGVFNPGSHGSTFGGNPLACAVSI
EEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEEH
ASLEVLEDEKLADRSLELGEYFKSELESIDSPVIKEVRGRGLFIGVELTEAARPYCERLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEEEEHHHHHHHHHHHH
EEGLLCKETHDTVIRFAPPLIISKEDLDWAIEKIKHVLRNA
HCCCEEECCCCCCEEECCCEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNEYMDMLSAYSAVNQGHR
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
HPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEMILPMNTGAEAVESAVKAA
CHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
RRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEYKRGFGPMLPGIKLIPYGDVE
HHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEECCHHHHHHCCCCCCCCCEEECCCCHH
ALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAICKEENVLFIADEIQTGLGRTGK
HHHHHHCCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCC
TFACDWDGIVPDMYILGKALGGGVFPISCIAADREILGVFNPGSHGSTFGGNPLACAVSI
EEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEEH
ASLEVLEDEKLADRSLELGEYFKSELESIDSPVIKEVRGRGLFIGVELTEAARPYCERLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEEEEHHHHHHHHHHHH
EEGLLCKETHDTVIRFAPPLIISKEDLDWAIEKIKHVLRNA
HCCCEEECCCCCCEEECCCEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7540694; 9384377; 8113162