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The map label for this gene is ahpC

Identifier: 16081061

GI number: 16081061

Start: 4118950

End: 4119513

Strand: Direct

Name: ahpC

Synonym: BSU40090

Alternate gene names: 16081061

Gene position: 4118950-4119513 (Clockwise)

Preceding gene: 16081060

Following gene: 16081062

Centisome position: 97.71

GC content: 43.09

Gene sequence:

>564_bases
ATGTCTTTAATCGGTAAAGAAGTACTTCCATTCGAAGCAAAAGCATTCAAAAACGGTGAATTCATCGATGTAACAAACGA
AGATTTGAAAGGCCAATGGAGCGTATTCTGCTTCTACCCAGCAGATTTCTCTTTCGTATGCCCAACTGAGCTTGAAGATC
TTCAAGAACAATATGCTGCACTTAAAGAATTAGGTGTTGAAGTATACTCTGTTTCTACAGATACTCACTTCGTACACAAA
GGCTGGCATGACAGCTCTGAAAAAATCAGCAAAATCACTTACGCAATGATCGGTGACCCATCTCAAACGATCTCTCGCAA
CTTCGATGTTCTTGACGAAGAAACTGGCCTTGCTGACCGCGGAACATTCATCATCGATCCAGACGGCGTTATCCAAACTG
TTGAAATCAATGCAGGCGGTATCGGCCGTGACGCAAGCAACCTTGTAAACAAAGTAAAAGCAGCTCAATACGTTCGTCAA
AACCCAGGTGAAGTTTGCCCGGCTAAATGGGAAGAAGGCGGCGAAACTCTTACACCTAGCCTTGATCTAGTAGGTAAAAT
CTAA

Upstream 100 bases:

>100_bases
CTTGACAAAAAATATATATTAATTAATAATTCATATATAATTAGAATTATTATTGAAAGCGATTATGCTTTCTAATACAT
TTTTAGGAGGAATATACATT

Downstream 100 bases:

>100_bases
GGAGTGCATTCAATTGGTACTTGATGCAAATATCAAAGCACAATTAAATCAATATATGCAGCTAATTGAGAATGACATTG
TTCTCAAAGTTAGCGCAGGC

Product: alkyl hydroperoxide reductase small subunit

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; General stress protein 22; Peroxiredoxin; Thioredoxin peroxidase

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFSFVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHK
GWHDSSEKISKITYAMIGDPSQTISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ
NPGEVCPAKWEEGGETLTPSLDLVGKI

Sequences:

>Translated_187_residues
MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFSFVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHK
GWHDSSEKISKITYAMIGDPSQTISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ
NPGEVCPAKWEEGGETLTPSLDLVGKI
>Mature_186_residues
SLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFSFVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKG
WHDSSEKISKITYAMIGDPSQTISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQN
PGEVCPAKWEEGGETLTPSLDLVGKI

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI5802974, Length=173, Percent_Identity=41.6184971098266, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI32483377, Length=173, Percent_Identity=41.6184971098266, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI32189392, Length=182, Percent_Identity=36.8131868131868, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI4505591, Length=182, Percent_Identity=35.1648351648352, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI32455266, Length=182, Percent_Identity=35.1648351648352, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI32455264, Length=182, Percent_Identity=35.1648351648352, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI5453549, Length=187, Percent_Identity=34.2245989304813, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI33188454, Length=85, Percent_Identity=41.1764705882353, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI1786822, Length=187, Percent_Identity=65.24064171123, Blast_Score=274, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI193204376, Length=183, Percent_Identity=37.1584699453552, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32565831, Length=183, Percent_Identity=37.1584699453552, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17554494, Length=180, Percent_Identity=36.1111111111111, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323613, Length=185, Percent_Identity=33.5135135135135, Blast_Score=115, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320661, Length=181, Percent_Identity=32.0441988950276, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319407, Length=162, Percent_Identity=24.6913580246914, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21357347, Length=185, Percent_Identity=37.2972972972973, Blast_Score=136, Evalue=9e-33,
Organism=Drosophila melanogaster, GI17738015, Length=171, Percent_Identity=37.4269005847953, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17157991, Length=180, Percent_Identity=36.6666666666667, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24641739, Length=180, Percent_Identity=36.6666666666667, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24656348, Length=182, Percent_Identity=35.1648351648352, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI17864676, Length=182, Percent_Identity=35.1648351648352, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24581278, Length=158, Percent_Identity=25.9493670886076, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): AHPC_BACSU (P80239)

Other databases:

- EMBL:   D78193
- EMBL:   AL009126
- PIR:   F69583
- RefSeq:   NP_391889.1
- ProteinModelPortal:   P80239
- SMR:   P80239
- PeroxiBase:   4904
- EnsemblBacteria:   EBBACT00000000483
- GeneID:   938147
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU40090
- NMPDR:   fig|224308.1.peg.4015
- GenoList:   BSU40090
- GeneTree:   EBGT00050000000759
- HOGENOM:   HBG493509
- OMA:   GDLADHY
- PhylomeDB:   P80239
- ProtClustDB:   CLSK888184
- BioCyc:   BSUB:BSU40090-MONOMER
- BRENDA:   1.11.1.15
- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- TIGRFAMs:   TIGR03137

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA; SSF52833 Thiordxn-like_fd

EC number: =1.11.1.15

Molecular weight: Translated: 20627; Mature: 20496

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: PS51352 THIOREDOXIN_2

Important sites: ACT_SITE 47-47

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFSFVCPTELEDLQEQYAA
CCCCCCCCCCCCHHHCCCCCEEEECCCCCCCEEEEEEEECCCCCEECCHHHHHHHHHHHH
LKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQTISRNFDVLDEETGLADR
HHHCCCEEEEECCCCEEEECCCCCCHHHHHHEEEEEECCCHHHHHCCCCCCCCCCCCCCC
GTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQNPGEVCPAKWEEGGETLTPS
CEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCC
LDLVGKI
HHEEECC
>Mature Secondary Structure 
SLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFSFVCPTELEDLQEQYAA
CCCCCCCCCCCHHHCCCCCEEEECCCCCCCEEEEEEEECCCCCEECCHHHHHHHHHHHH
LKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQTISRNFDVLDEETGLADR
HHHCCCEEEEECCCCEEEECCCCCCHHHHHHEEEEEECCCHHHHHCCCCCCCCCCCCCCC
GTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQNPGEVCPAKWEEGGETLTPS
CEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCC
LDLVGKI
HHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8180695; 8012595