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The map label for this gene is gntZ

Identifier: 16081060

GI number: 16081060

Start: 4117080

End: 4118486

Strand: Direct

Name: gntZ

Synonym: BSU40080

Alternate gene names: 16081060

Gene position: 4117080-4118486 (Clockwise)

Preceding gene: 16081059

Following gene: 16081061

Centisome position: 97.66

GC content: 47.62

Gene sequence:

>1407_bases
ATGTTCAATTCGATTGGTGTCATAGGCTTAGGCGTAATGGGAAGCAACATCGCCTTAAACATGGCAAATAAAGGCGAAAA
CGTCGCTGTCTATAATTACACCAGAGATTTAACGGACCAGCTTATCCAAAAGCTGGATGGACAATCTCTCAGCCCGTATT
ACGAGCTTGAGGACTTTGTTCAATCGTTAGAAAAACCAAGAAAAATCTTTTTGATGGTCACAGCGGGAAAACCCGTAGAT
TCCGTCATCCAATCATTAAAGCCTTTGCTTGAAGAAGGCGACGTCATCATGGACGGAGGAAACTCCCACTATGAAGACAC
AGAAAGAAGATATGACGAGCTGAAGGAAAAAGGGATCGGCTACCTGGGAGTCGGCATTTCCGGCGGTGAAGTCGGTGCGT
TAACAGGGCCTTCCATCATGCCGGGCGGAGATCGCGACGTCTATGAGAAAGCCGCTCCTATCCTGACGAAAATCGCAGCC
CAAGTCGGAGATGACCCTTGCTGTGTCTATATCGGACCAAAAGGGGCAGGGCACTTTACAAAAATGGTGCACAACGGCAT
TGAATATGCCGACATGCAGCTGATTGCAGAAGCTTATACGTTTCTAAGAGAAACGCTTCGTCTGCCGCTAGATGAAATTG
CATCTATTTTTGAAACATGGAATCAAGGTGAGCTGAAAAGCTATTTAATAGAGATTACAGCTGAGATTTTACGCAAAAAA
GACGAAAAAACAGGACAGCCTCTGATCGATGTCATCCTTGATAAAACCGGCCAAAAAGGCACCGGAAAATGGACGAGCAT
GCAGGCGATTGATAACGGCATCCCGTCCACGATCATCACAGAGTCCTTGTTCGCCCGCTACTTGTCATCTTTAAAAGAAG
AACGGATGGCAGCTCAAGATGTATTAGCAGGCCCGGAAGCCGAAGAAAAACACTTGGATAAAGACACTTGGATTGAATAC
GTCAGACAGGCTCTTTACATGGGGAAAGTATGCGCCTATGCACAAGGCTTTGCCCAATATAAGATGTCATCTGAGCTTTA
CGGCTGGAATCTGCCGCTCAAAGACATCGCCTTGATTTTCCGAGGCGGCTGCATCATCCGCGCTGATTTCCTAAACGTGA
TCAGCGAAGCATTCAGTGAGCAGCCAAATCTGGCTAACCTGCTGATCGCGCCTTATTTCACAGATAAGCTCCATGCCTAT
CAAACAGGCCTGCGAAAAGTCGTTTGCGAGGGTATCAGCACCGGAATCTCTTTCCCATGCTTAACTACCGCGCTCTCTTA
TTACGACGGCTACCGCACAGGGCGTTCCAATGCGAACCTCTTGCAGGCACAGCGCGATTACTTTGGCGCTCACACGTACG
AACGGACTGATATGGACGGCGTCTTCCATACGAATTGGTCTGAATAA

Upstream 100 bases:

>100_bases
GCCACATGGACATTGCTGGAAACCATTATTTCCGTTGCTGGACTGGGATTCATTTTATTGTTAAGTTTAGTTGTATGAAA
TTAAGAAGGAGCTGTAACAC

Downstream 100 bases:

>100_bases
CCTGTATTAAAAACACGGTCAGTTTCAACTGAACCGTGTTTTTTTCTTCTATCCCAAACAACAGAAGACATAAGTTATGT
TTTAAATATCATAAACAGTG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQKLDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVD
SVIQSLKPLLEEGDVIMDGGNSHYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA
QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFETWNQGELKSYLIEITAEILRKK
DEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPSTIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEY
VRQALYMGKVCAYAQGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPYFTDKLHAY
QTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDMDGVFHTNWSE

Sequences:

>Translated_468_residues
MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQKLDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVD
SVIQSLKPLLEEGDVIMDGGNSHYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA
QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFETWNQGELKSYLIEITAEILRKK
DEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPSTIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEY
VRQALYMGKVCAYAQGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPYFTDKLHAY
QTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDMDGVFHTNWSE
>Mature_468_residues
MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQKLDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVD
SVIQSLKPLLEEGDVIMDGGNSHYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA
QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFETWNQGELKSYLIEITAEILRKK
DEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPSTIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEY
VRQALYMGKVCAYAQGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPYFTDKLHAY
QTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDMDGVFHTNWSE

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI40068518, Length=466, Percent_Identity=49.3562231759657, Blast_Score=435, Evalue=1e-122,
Organism=Escherichia coli, GI1788341, Length=463, Percent_Identity=55.7235421166307, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1786719, Length=290, Percent_Identity=26.8965517241379, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17542558, Length=467, Percent_Identity=47.1092077087794, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6321695, Length=473, Percent_Identity=46.723044397463, Blast_Score=451, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321977, Length=477, Percent_Identity=47.7987421383648, Blast_Score=446, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24639279, Length=465, Percent_Identity=48.3870967741936, Blast_Score=415, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGD_BACSU (P12013)

Other databases:

- EMBL:   J02584
- EMBL:   AB005554
- EMBL:   AL009126
- EMBL:   D78193
- PIR:   D26190
- RefSeq:   NP_391888.1
- ProteinModelPortal:   P12013
- SMR:   P12013
- EnsemblBacteria:   EBBACT00000002726
- GeneID:   937716
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU40080
- NMPDR:   fig|224308.1.peg.4014
- GenoList:   BSU40080
- GeneTree:   EBGT00050000001992
- HOGENOM:   HBG286913
- OMA:   HYEDTER
- PhylomeDB:   P12013
- ProtClustDB:   PRK09287
- BioCyc:   BSUB:BSU40080-MONOMER
- BRENDA:   1.1.1.44
- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183
- Gene3D:   G3DSA:1.20.5.320
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PIRSF:   PIRSF000109
- PRINTS:   PR00076
- TIGRFAMs:   TIGR00873

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2; SSF48179 6DGDH_C_like

EC number: =1.1.1.44

Molecular weight: Translated: 51984; Mature: 51984

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00461 6PGD

Important sites: ACT_SITE 181-181 ACT_SITE 188-188 BINDING 101-101 BINDING 101-101 BINDING 189-189 BINDING 259-259 BINDING 286-286 BINDING 445-445 BINDING 451-451

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQKLDGQSLSPYYELEDFV
CCCCCCEEEEEEECCCEEEEECCCCCCEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHH
QSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNSHYEDTERRYDELKEKGIG
HHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCC
YLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAAQVGDDPCCVYIGPKGAGHFT
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
KMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFETWNQGELKSYLIEITAEILRKK
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
DEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPSTIITESLFARYLSSLKEERMAAQD
HCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYAQGFAQYKMSSELYGWNLPLKDIALIF
HHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RGGCIIRADFLNVISEAFSEQPNLANLLIAPYFTDKLHAYQTGLRKVVCEGISTGISFPC
HCCCEEEHHHHHHHHHHHHCCCCHHHEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LTTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDMDGVFHTNWSE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQKLDGQSLSPYYELEDFV
CCCCCCEEEEEEECCCEEEEECCCCCCEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHH
QSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNSHYEDTERRYDELKEKGIG
HHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCC
YLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAAQVGDDPCCVYIGPKGAGHFT
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
KMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFETWNQGELKSYLIEITAEILRKK
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
DEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPSTIITESLFARYLSSLKEERMAAQD
HCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYAQGFAQYKMSSELYGWNLPLKDIALIF
HHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RGGCIIRADFLNVISEAFSEQPNLANLLIAPYFTDKLHAYQTGLRKVVCEGISTGISFPC
HCCCEEEHHHHHHHHHHHHCCCCHHHEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LTTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDMDGVFHTNWSE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3020045; 7584049; 9384377; 1659648