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The map label for this gene is ywlC

Identifier: 16080748

GI number: 16080748

Start: 3792969

End: 3794009

Strand: Reverse

Name: ywlC

Synonym: BSU36950

Alternate gene names: 16080748

Gene position: 3794009-3792969 (Counterclockwise)

Preceding gene: 16080749

Following gene: 16080747

Centisome position: 90.0

GC content: 51.49

Gene sequence:

>1041_bases
ATGAAAACGAAAAGATGGTTTGTGGATGTAACTGACGAGTTATCCACAAATGATCCACAAATTGCACAAGCAGCCGCTTT
GCTCCGAGAAAATGAGGTCGTTGCCTTTCCGACAGAAACAGTATATGGCCTAGGCGCAAACGCAAAAAATACGGATGCCG
TCAAAAAAATATATGAGGCGAAAGGGCGGCCGAGCGATAATCCCCTGATTGTCCACATTGCGGATATCAGCCAGCTTGAG
GATTTAACGGGCCCGGCGCCGGAAAAGGCGAAAACATTGATGAAACGGTTTTGGCCGGGAGCACTTACGCTCATTCTGCC
TTGCAAACCTGATGCGCTTTCACCTCGTGTAACGGCAGGTCTTGAAACGGTTGCCATTAGAATGCCGGATCATCCGCTTG
CCCTTGCATTGATTCGCGAATCGGGACTGCCGATTGCAGCACCGAGCGCCAATCTATCAGGCAAGCCAAGTCCCACAAAA
GCGGAGCATGTGGCTCACGACTTGGATGGCCGCATAGCCGGTATTGTGGATGGAGGCCCTACCGGAATCGGGGTCGAATC
AACTGTGCTTTCATGTGCGGACGACATCCCTGTTCTCTTGCGTCCTGGCGGCATTACGAAGGAACAAATTGAAGCGGTGA
TCGGGCCGATCCATGTGGATAAAGGGCTCAGCGACCAAAACGAGAAGCCGATTTCTCCAGGGATGAAATATACACATTAT
GCGCCGACAGCGCCTCTTGCCATTTGCGAAGGCAGCCCAGAGCGCATTCAGCACCTCATTCAAGAATATCAACAGGGTGG
AAGACGGGTCGGTGTCCTGACGACAGAAGAAAAAGCGGGCGTTTATTCCGCTGATTATGTGAAGAGCTGCGGAAGACGGG
CTCAGCTTGAGACTGTTGCGGCAGGGCTGTATGATGCTTTGCGCAGCTTTGATGAGAATAAGGTGGATTTCATTATAGCG
GAATCCTTTCCGGATACAGGTGTCGGTCTTGCTATTATGAACAGGCTGATGAAAGCCGCCGGAGGAAGAGTGATTCGCTG
A

Upstream 100 bases:

>100_bases
GATAACGCTTGTTTTATTACAGGACATCTTTTATACTTTCAAAAGGATTACACGCGTAAAACAATCGTTTTATTGTTGTG
AATAAGGAGTTTGGTCAGAA

Downstream 100 bases:

>100_bases
AAGCAGTCAGATGTTCTAACCCTTTTTGGACACGCATAGGCTAAAAAAGCGGGGCGTGTCCAAGGGGGTTATTTATGTAT
GTCGGATTTGTTTATAGGCG

Product: ribosome maturation factor; RNA binding protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGLGANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLE
DLTGPAPEKAKTLMKRFWPGALTLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK
AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIHVDKGLSDQNEKPISPGMKYTHY
APTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTEEKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIA
ESFPDTGVGLAIMNRLMKAAGGRVIR

Sequences:

>Translated_346_residues
MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGLGANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLE
DLTGPAPEKAKTLMKRFWPGALTLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK
AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIHVDKGLSDQNEKPISPGMKYTHY
APTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTEEKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIA
ESFPDTGVGLAIMNRLMKAAGGRVIR
>Mature_346_residues
MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGLGANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLE
DLTGPAPEKAKTLMKRFWPGALTLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK
AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIHVDKGLSDQNEKPISPGMKYTHY
APTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTEEKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIA
ESFPDTGVGLAIMNRLMKAAGGRVIR

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable)

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain

Homologues:

Organism=Homo sapiens, GI58761510, Length=190, Percent_Identity=32.6315789473684, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI2367210, Length=140, Percent_Identity=39.2857142857143, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI87081864, Length=191, Percent_Identity=27.7486910994764, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17537239, Length=172, Percent_Identity=30.2325581395349, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321269, Length=374, Percent_Identity=40.1069518716578, Blast_Score=227, Evalue=2e-60,
Organism=Drosophila melanogaster, GI78707274, Length=169, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YWLC_BACSU (P39153)

Other databases:

- EMBL:   Z38002
- EMBL:   AL009126
- PIR:   I40476
- RefSeq:   NP_391576.1
- ProteinModelPortal:   P39153
- SMR:   P39153
- EnsemblBacteria:   EBBACT00000000402
- GeneID:   937023
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU36950
- NMPDR:   fig|224308.1.peg.3702
- GenoList:   BSU36950
- GeneTree:   EBGT00050000002177
- HOGENOM:   HBG738264
- OMA:   YRHYAPS
- PhylomeDB:   P39153
- ProtClustDB:   CLSK888046
- BioCyc:   BSUB:BSU36950-MONOMER
- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923
- Gene3D:   G3DSA:3.90.870.10
- PIRSF:   PIRSF004930
- TIGRFAMs:   TIGR00057

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC; SSF55821 DHBP_synth_RibB-like_a/b_dom

EC number: NA

Molecular weight: Translated: 37008; Mature: 37008

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGLGANAKNTDAVKKIYEA
CCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCHHEEECCCCCCCHHHHHHHHHH
KGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGALTLILPCKPDALSPRVTAG
CCCCCCCCEEEEECCHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHCC
LETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTKAEHVAHDLDGRIAGIVDGGP
CEEEEEECCCCCEEEEEEHHCCCCEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCC
TGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIHVDKGLSDQNEKPISPGMKYTHY
CCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCEEEC
APTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTEEKAGVYSADYVKSCGRRAQLETVA
CCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHCCCHHHHHHHH
AGLYDALRSFDENKVDFIIAESFPDTGVGLAIMNRLMKAAGGRVIR
HHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGLGANAKNTDAVKKIYEA
CCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCHHEEECCCCCCCHHHHHHHHHH
KGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGALTLILPCKPDALSPRVTAG
CCCCCCCCEEEEECCHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHCC
LETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTKAEHVAHDLDGRIAGIVDGGP
CEEEEEECCCCCEEEEEEHHCCCCEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCC
TGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIHVDKGLSDQNEKPISPGMKYTHY
CCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCEEEC
APTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTEEKAGVYSADYVKSCGRRAQLETVA
CCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHCCCHHHHHHHH
AGLYDALRSFDENKVDFIIAESFPDTGVGLAIMNRLMKAAGGRVIR
HHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377