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The map label for this gene is hisG

Identifier: 16080545

GI number: 16080545

Start: 3587551

End: 3588192

Strand: Reverse

Name: hisG

Synonym: BSU34920

Alternate gene names: 16080545

Gene position: 3588192-3587551 (Counterclockwise)

Preceding gene: 16080546

Following gene: 16080544

Centisome position: 85.12

GC content: 49.53

Gene sequence:

>642_bases
ATGGGTAAGTTACTCACAATGGCGATGCCAAAGGGCCGGATATTTGAAGAAGCGGCAGGGCTGCTGAGGCAGGCAGGCTA
CAGGCTCCCTGAGGAGTTTGAAGATTCGAGAAAACTGATCATCGATGTGCCGGAGGAAAATCTTCGGTTTATATTAGCGA
AGCCGATGGACGTAACCACGTATGTGGAGCATGGCGTGGCAGACGTCGGAATTGCGGGCAAGGATGTCATGCTGGAGGAG
GAACGCGATGTGTATGAGGTACTGGATTTAAACATCAGCAAATGCCACTTAGCTGTCGCCGGACTTCCGAATACAGACTG
GAGCGGAGTAGCGCCAAGAATCGCGACAAAGTATCCGAATGTGGCTTCCAGTTATTTCAGAGAGCAGGGAGAACAAGTCG
AGATTATTAAGCTCAACGGTTCAATTGAACTGGCTCCGCTCATTGGGCTTGCAGATCGGATAGTGGACATTGTTTCCACA
GGACAGACGCTGAAAGAAAATGGGCTTGTTGAAACGGAGCACATTTGTGACATTACCTCTCGCTTTATTGTCAACCCGGT
AAGCTATCGCATGAAAGACGATGTGATTGACGAAATGGCATCCCGCCTATCTCTCGTTGTGGAAGGAGAGACGGCAAAAT
GA

Upstream 100 bases:

>100_bases
GTGGTTCTTCAAGATTTATCGGGAATAGAAAATATCGACCAGATGACAAAATCTTTTGCAAACGTCACTTATTTTATCGG
TGCCAGAAAGGAAGAGCAAA

Downstream 100 bases:

>100_bases
AGATCAAAACCATCAGCGGAGCGGAACGGCTTTCTCTCAAGCGTTCCATCGATGCCGGAACGGAAGAGCAAAGAAAGACG
GTCCGGTCCATTATTGAAGA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVPEENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEE
ERDVYEVLDLNISKCHLAVAGLPNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST
GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK

Sequences:

>Translated_213_residues
MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVPEENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEE
ERDVYEVLDLNISKCHLAVAGLPNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST
GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK
>Mature_212_residues
GKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVPEENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEE
RDVYEVLDLNISKCHLAVAGLPNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVSTG
QTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=224, Percent_Identity=30.8035714285714, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=218, Percent_Identity=27.0642201834862, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23621; Mature: 23490

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVPEENLRFILAKPMDVTT
CCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCCCCEEEEECCCCHHH
YVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGLPNTDWSGVAPRIATKYPN
HHHCCCHHCCCCCCCEEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCC
VASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVSTGQTLKENGLVETEHICDITS
HHHHHHHHCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHH
RFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK
HHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCC
>Mature Secondary Structure 
GKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVPEENLRFILAKPMDVTT
CCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCCCCEEEEECCCCHHH
YVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGLPNTDWSGVAPRIATKYPN
HHHCCCHHCCCCCCCEEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCC
VASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVSTGQTLKENGLVETEHICDITS
HHHHHHHHCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHH
RFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK
HHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA