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The map label for this gene is yvbW

Identifier: 16080454

GI number: 16080454

Start: 3489910

End: 3491253

Strand: Reverse

Name: yvbW

Synonym: BSU34010

Alternate gene names: 16080454

Gene position: 3491253-3489910 (Counterclockwise)

Preceding gene: 16080455

Following gene: 16080452

Centisome position: 82.82

GC content: 45.46

Gene sequence:

>1344_bases
ATGAAAAACGACAATCAAACGTTAAAACGCACGATGACGTCCCGCCATATTATGATGATGGCGCTGGGCGGAGCAATCGG
CGCAGGTTTATTTAAGGGGAGCAGCTCAGCGATCGATGTGGCAGGGCCATCTGTCATTATCGCATACCTGCTCGGCGGGA
TTATTTTGCTGTTTATTATGCAGGGGCTGGCGGAAATGGCTGTTCGAAACCGTAACGCCAGAACCTTCCGTGATCTTGTC
CAGCAGGTATTGGGAAATTACGCTGCTTACTTTTTGGACTGGATCTACTGGAAAATGTGGGTGCTTAACATTGCGGCTGA
AGCTGTTGTAGCTGCGATTTTCATTCAATATTGGCTGCCGGGCTGCCCGATCTGGGTGTTGGCATTAGGAATTTCTCTTA
TCGTCACGATTGTAAACTTGCTTTCTGTTAAAATCTTCGCCGAAACTGAATATTGGCTGGCAATGATCAAGATTACCGTT
ATTATTATCTTTATTATTCTGGGATTGCTGCTCTTATTTGTATCATTCGGTGATCATACAGCATCCGGATTTTCCAACCT
GACAGACCACGGCGGATTTTTCCCGCACGGCGGCACAGGGCTGATCACGGCGATGCTTGTCGTCATCTACTCTTACGGCG
GTACAGAAATTATCGGTGTAACGCTTGCAGAGACAAAAAATCCGGAAAAGGTTGTCCCGAAAGCTGTCCGCAGCACACTG
ACACGGATTGTCGCGTTTTACCTGCTGCCGTTTTTCATCATCGTCAGCCTGATTCCATGGAACCAAGTCAATTCCGTTCC
GGAAAGTCCTTTCGTGATGGTCTTTAAAATGGTAGGCATTCCGGGCGCGGATCATATCATGAATGCAGTCATCCTGCTGG
CGATCATTTCTTCTATGAATTCAGGTTTATACGGATCATCACGCATTTTGTATACACAGGCAAGTGACGGAAGGCTTCCA
AAGGTCTTCTCGAAGCTTTCATCGAAAAACGTACCGATGTTTGCGATTCTGATGTGCACTTCTTCTCTCTATATTGGCGT
ATTGATTTCTCTGTTCGCAGGAAGCCAAACATTTAATTATTTAATGGGATCATTGGGATATACCGTTTTATTCATTTGGC
TGATCATCGGATTCGCTCATTTAAAATCGAGAAAACAGCAAACGGAAACACCGGCCTATTATGTAAAATGGTTCCCGTAC
ACGACATGGTTTGCGATTGTGGCATTACTCGCCATTCTGATCGGGGTCATCATGACAACATCAATTGTCATTACCGGCAT
TACTGCGGCGATCTACCTTTTGATTACAGTTGCATATTTGGTCAAAGGACGCAAGCATCAGTAA

Upstream 100 bases:

>100_bases
CCGCGGTCAGCCGAAGGCTCGTCGTCTCTTTATCTATTAGATTAGGTAGGAGACGGCGGGCTTTTTTGTTTTTGAAAACG
AGAAGGAGAGGTAGAAGAGG

Downstream 100 bases:

>100_bases
ATAAGAAACCCTCTTGCCGCATCCGGCAAGAGGGTTTTTATTATTGTGCAGCTTTCTCGTTTATACCAATCGCCGCAGCT
TTCTGCGCTTTTGATTTTGT

Product: amino acid permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPSVIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLV
QQVLGNYAAYFLDWIYWKMWVLNIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV
IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEIIGVTLAETKNPEKVVPKAVRSTL
TRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFKMVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLP
KVFSKLSSKNVPMFAILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPAYYVKWFPY
TTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ

Sequences:

>Translated_447_residues
MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPSVIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLV
QQVLGNYAAYFLDWIYWKMWVLNIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV
IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEIIGVTLAETKNPEKVVPKAVRSTL
TRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFKMVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLP
KVFSKLSSKNVPMFAILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPAYYVKWFPY
TTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ
>Mature_447_residues
MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPSVIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLV
QQVLGNYAAYFLDWIYWKMWVLNIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV
IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEIIGVTLAETKNPEKVVPKAVRSTL
TRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFKMVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLP
KVFSKLSSKNVPMFAILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPAYYVKWFPY
TTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ

Specific function: Transporter For Gaba. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Homo sapiens, GI110347453, Length=354, Percent_Identity=22.8813559322034, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI181337167, Length=359, Percent_Identity=23.9554317548747, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI115648063, Length=451, Percent_Identity=21.2860310421286, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI115648022, Length=451, Percent_Identity=21.2860310421286, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI7657683, Length=345, Percent_Identity=23.4782608695652, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI258614005, Length=148, Percent_Identity=27.7027027027027, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI258645169, Length=147, Percent_Identity=27.2108843537415, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI258614003, Length=148, Percent_Identity=27.7027027027027, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1789017, Length=451, Percent_Identity=36.3636363636364, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1786302, Length=453, Percent_Identity=35.3200883002208, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1790653, Length=388, Percent_Identity=38.1443298969072, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI1786789, Length=436, Percent_Identity=36.4678899082569, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87081708, Length=424, Percent_Identity=35.1415094339623, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI48994972, Length=459, Percent_Identity=34.2047930283224, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1786602, Length=387, Percent_Identity=37.7260981912145, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1788480, Length=422, Percent_Identity=34.3601895734597, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87081915, Length=412, Percent_Identity=33.0097087378641, Blast_Score=245, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17532491, Length=363, Percent_Identity=23.9669421487603, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540018, Length=392, Percent_Identity=25, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17533459, Length=359, Percent_Identity=23.1197771587744, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=149, Percent_Identity=28.1879194630872, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=426, Percent_Identity=30.9859154929577, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320772, Length=451, Percent_Identity=31.2638580931264, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6321629, Length=443, Percent_Identity=29.7968397291196, Blast_Score=180, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6324553, Length=389, Percent_Identity=32.133676092545, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6324990, Length=411, Percent_Identity=31.1435523114355, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6319824, Length=410, Percent_Identity=29.5121951219512, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324924, Length=455, Percent_Identity=29.2307692307692, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324059, Length=438, Percent_Identity=29.2237442922374, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321053, Length=429, Percent_Identity=28.2051282051282, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=394, Percent_Identity=29.9492385786802, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=27.027027027027, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320251, Length=408, Percent_Identity=27.6960784313726, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319543, Length=397, Percent_Identity=28.2115869017632, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=27.7227722772277, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322967, Length=394, Percent_Identity=28.1725888324873, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=394, Percent_Identity=25.3807106598985, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324981, Length=395, Percent_Identity=26.8354430379747, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320364, Length=493, Percent_Identity=22.920892494929, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24666159, Length=382, Percent_Identity=22.5130890052356, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221512776, Length=382, Percent_Identity=22.5130890052356, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24667468, Length=348, Percent_Identity=22.4137931034483, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI161077963, Length=222, Percent_Identity=22.972972972973, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YVBW_BACSU (O32257)

Other databases:

- EMBL:   AL009126
- PIR:   G70030
- RefSeq:   NP_391281.1
- ProteinModelPortal:   O32257
- EnsemblBacteria:   EBBACT00000003159
- GeneID:   936289
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU34010
- NMPDR:   fig|224308.1.peg.3407
- GenoList:   BSU34010
- GeneTree:   EBGT00070000031736
- HOGENOM:   HBG492579
- OMA:   GRIISFY
- PhylomeDB:   O32257
- ProtClustDB:   CLSK887896
- BioCyc:   BSUB:BSU34010-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 49179; Mature: 49179

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1; PS00962 RIBOSOMAL_S2_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x118bd7c4)-; HASH(0x40c08434)-; HASH(0x40c077d4)-; HASH(0x40c06c58)-; HASH(0x11989f6c)-; HASH(0x40c08d64)-; HASH(0x40c08038)-; HASH(0x40c07ffc)-; HASH(0x123be6c8)-; HASH(0x12243318)-; HASH(0x11c50ba0)-; HASH(0x1270a358)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPSVIIAYLLGGIILLFIM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHH
QGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVLNIAAEAVVAAIFIQYWLP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITVIIIFIILGLLLLFVSFGDHT
CCHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEIIGVTLAETKNPEKVVPKAVRSTL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHH
TRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFKMVGIPGADHIMNAVILLAIISSMN
HHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
SGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMFAILMCTSSLYIGVLISLFAGSQTFNY
CCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LMGSLGYTVLFIWLIIGFAHLKSRKQQTETPAYYVKWFPYTTWFAIVALLAILIGVIMTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
SIVITGITAAIYLLITVAYLVKGRKHQ
HHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure
MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPSVIIAYLLGGIILLFIM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHH
QGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVLNIAAEAVVAAIFIQYWLP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITVIIIFIILGLLLLFVSFGDHT
CCHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEIIGVTLAETKNPEKVVPKAVRSTL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHH
TRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFKMVGIPGADHIMNAVILLAIISSMN
HHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
SGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMFAILMCTSSLYIGVLISLFAGSQTFNY
CCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LMGSLGYTVLFIWLIIGFAHLKSRKQQTETPAYYVKWFPYTTWFAIVALLAILIGVIMTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
SIVITGITAAIYLLITVAYLVKGRKHQ
HHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377