Click here to switch to the map view.

The map label for this gene is yvaK

Identifier: 16080415

GI number: 16080415

Start: 3454221

End: 3454967

Strand: Reverse

Name: yvaK

Synonym: BSU33620

Alternate gene names: 16080415

Gene position: 3454967-3454221 (Counterclockwise)

Preceding gene: 16080416

Following gene: 16080414

Centisome position: 81.96

GC content: 44.44

Gene sequence:

>747_bases
ATGAGCATGAAAGTTGTGACACCAAAACCATTTACATTTAAAGGCGGAGACAAAGCGGTGCTTTTGCTGCATGGCTTTAC
AGGAAATACAGCGGATGTAAGGATGCTGGGACGATATTTGAATGAACGCGGCTATACGTGCCACGCGCCTCAATATGAAG
GACATGGCGTCCCGCCTGAAGAACTTGTACATACGGGGCCCGAAGACTGGTGGAAAAACGTAATGGATGGCTATGAATAT
TTAAAATCTGAAGGTTATGAGAGCATTGCTGCCTGCGGACTGTCGCTTGGCGGGGTTTTTTCGCTGAAATTGGGTTACAC
TGTACCCATAAAGGGAATTGTCCCAATGTGCGCACCGATGCATATTAAGAGTGAAGAGGTCATGTATCAAGGCGTTCTTT
CATACGCTCGCAATTACAAAAAGTTTGAGGGGAAAAGCCCGGAGCAAATTGAAGAGGAAATGAAAGAATTCGAAAAAACG
CCGATGAATACCCTCAAGGCGCTGCAAGACTTAATTGCTGATGTGCGGAATAATGTCGATATGATTTATTCACCGACATT
TGTGGTGCAGGCCCGTCATGACCACATGATTAATACCGAAAGCGCCAATATTATTTACAACGAAGTGGAAACTGATGATA
AACAGCTGAAATGGTACGAGGAATCAGGGCATGTCATTACACTCGACAAAGAACGTGACCTCGTCCATCAGGATGTGTAT
GAATTTTTAGAGAAGCTCGATTGGTAA

Upstream 100 bases:

>100_bases
TGAAGTCAGGCCTTTTTCACGTTTCTGGATGATATTCAAAACGTTTTTTTCTGATTAAACTGTGGAAAACTAAAATGATC
GTGCAGATAGAAAGGGAGAC

Downstream 100 bases:

>100_bases
TCAACAGGAGGTCGGATAATGGAAAAAGAAGCATTTATGGAAAAGCTTCTCTCGTTTATGAAGGAAGAGGCGTACAAACC
TCTGACCGTTCAGGAACTTG

Product: carboxylesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MSMKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYTCHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEY
LKSEGYESIAACGLSLGGVFSLKLGYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKT
PMNTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYEESGHVITLDKERDLVHQDVY
EFLEKLDW

Sequences:

>Translated_248_residues
MSMKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYTCHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEY
LKSEGYESIAACGLSLGGVFSLKLGYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKT
PMNTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYEESGHVITLDKERDLVHQDVY
EFLEKLDW
>Mature_247_residues
SMKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYTCHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYL
KSEGYESIAACGLSLGGVFSLKLGYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTP
MNTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYEESGHVITLDKERDLVHQDVYE
FLEKLDW

Specific function: Involved in the detoxification of xenobiotics. Shows maximal activity with C6 substrates, with gradually decreasing activity from C8 to C12 substrates. No activity for higher chain length substrates acids rather than long-chain ones [H]

COG id: COG1647

COG function: function code R; Esterase/lipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipase/esterase LIP3/BchO family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019149
- InterPro:   IPR012354 [H]

Pfam domain/function: PF09752 DUF2048 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 28412; Mature: 28280

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYTCHAPQYEGHGVPPE
CCCEECCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCHH
ELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKLGYTVPIKGIVPMCAPM
HHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCEECCCCCHHHCCCC
HIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPMNTLKALQDLIADVRNNVD
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCE
MIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYEESGHVITLDKERDLVHQDVY
EEECCEEEEEECCCCEECCCCCCEEEECCCCCHHHHEEEECCCCEEEECCCHHHHHHHHH
EFLEKLDW
HHHHHHCC
>Mature Secondary Structure 
SMKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYTCHAPQYEGHGVPPE
CCEECCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCHH
ELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKLGYTVPIKGIVPMCAPM
HHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCEECCCCCHHHCCCC
HIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPMNTLKALQDLIADVRNNVD
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCE
MIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYEESGHVITLDKERDLVHQDVY
EEECCEEEEEECCCCEECCCCCCEEEECCCCCHHHHEEEECCCCEEEECCCHHHHHHHHH
EFLEKLDW
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]