Click here to switch to the map view.

The map label for this gene is rnr

Identifier: 16080414

GI number: 16080414

Start: 3451863

End: 3454202

Strand: Reverse

Name: rnr

Synonym: BSU33610

Alternate gene names: 16080414

Gene position: 3454202-3451863 (Counterclockwise)

Preceding gene: 16080415

Following gene: 16080413

Centisome position: 81.94

GC content: 47.52

Gene sequence:

>2340_bases
ATGGAAAAAGAAGCATTTATGGAAAAGCTTCTCTCGTTTATGAAGGAAGAGGCGTACAAACCTCTGACCGTTCAGGAACT
TGAGGAGATGTTAAATATTACGGAAGCCGAGGAGTTTAAAGAGCTCGTCAAAGCGTTAGTCGCCTTGGAAGAAAAAGGGC
TTATCGTACGGACGAGAAGCGACCGCTACGGCATTCCGGAGAAGATGAATTTAATAAAAGGAAAGATTTCAGCCCATGCG
AAAGGATTCGCCTTTTTGCTGCCTGAGGATACGTCGTTAAGTGATGTGTTTATTCCGCCTAATGAGCTAAATACGGCAAT
GAACGGCGATATCGTCATGGTGCGTCTGAACTCACAATCAAGCGGCTCCAGGCAGGAAGGAACCGTCATACGGATTTTAG
AAAGAGCGATTCAGCGGGTTGTCGGCACGTATACAGAAACGAGAAACTTCGGCTTTGTCATTCCGGACGACAAAAAAATC
ACGAGTGACATCTTCATTCCGAAAAATGGGAAAAATGGAGCTGCGGAAGGGCATAAGGTTGTTGTCAAGCTGACGAGCTA
TCCTGAAGGCCGCATGAACGCAGAGGGTGAGGTTGAAACCATTCTCGGCCACAAAAACGACCCGGGCATTGATATTTTAT
CGGTCATTCATAAGCACGGCCTGCCGGGAGAATTTCCAGCTGACGCGATGGAACAGGCATCAAGTACGCCTGACACGATT
GATGAAAAAGATCTGAAAGACCGCCGTGATCTCCGTGACCAGGTGATTGTCACCATTGATGGTGCGGATGCGAAGGATTT
GGATGATGCAGTTACCGTGACGAAGCTTGATGATGGAAGCTACAAGCTTGGCGTTCACATAGCTGATGTCAGCCATTACG
TAACCGAAAACTCGCCGATTGACAAAGAAGCGCTTGAAAGAGGGACAAGTGTGTATCTGGTTGACCGTGTCATCCCGATG
ATTCCGCACAGATTGTCAAACGGCATCTGCTCCTTAAATCCAAAGGTTGACCGCCTGACGCTTTCTTGTGAAATGACAAT
TAACAGTCAGGGACAGGTGACAGAGCACGAGATCTTCCAAAGTGTCATCAAAACAACGGAAAGAATGACATATTCAGATG
TGAATAAAATTCTTGTTGATGATGATGAAGAGCTGAAACAAAAATACGAGCCTCTTGTTCCGATGTTCAAAGACATGGAG
CGTCTGGCTCAAATTCTGCGCGATAAGCGGATGGACCGCGGCGCCGTTGACTTTGATTTCAAAGAAGCAAAGGTGCTTGT
TGATGACGAAGGAGCGGTTAAAGACGTTGTGATCAGAGAACGCTCTGTCGCCGAGAAGCTGATTGAAGAATTTATGCTTG
TAGCAAACGAAACAGTTGCGGAGCATTTCCATTGGATGAATGTCCCGTTTATATACCGGATTCACGAAGAGCCGAATGCT
GAAAAGCTGCAAAAGTTTTTAGAATTTGTGACGACATTTGGCTATGTGGTGAAAGGAACGGCGGGGAATATTCATCCGCG
CGCGCTGCAAAGCATTCTGGACGCTGTGCGTGACAGACCAGAGGAAACGGTTATATCTACTGTTATGCTCCGTTCGATGA
AACAGGCGAAATACGACCCGCAAAGCTTGGGGCACTTCGGTCTGTCAACGGAATTCTATACGCATTTCACATCACCGATC
CGCCGTTACCCGGACTTAATCGTTCACCGTCTGATCCGAACGTATTTGATCAACGGCAAGGTCGATGAAGCGACACAGGA
AAAGTGGGCTGAACGCCTGCCGGATATCGCCGAACATACATCATCTATGGAGCGCCGTGCAGTTGACGCCGAGCGTGAGA
CGGATGATCTGAAAAAAGCGGAATACATGCTTGATAAAATCGGTGAAGAGTTTGACGGCATGATCAGCTCTGTGACAAAC
TTCGGAATGTTCGTCGAGCTGCCGAATACAATTGAAGGACTCGTCCATGTCAGCTTTATGACAGATGACTACTACCGCTT
TGACGAACAGCATTTCGCAATGATTGGCGAGCGGACAGGCAACGTCTTCCGCATCGGGGATGAAATCACAGTCAAGGTTG
TCGATGTCAATAAAGATGAGCGCAATATCGACTTTGAAATTGTCGGCATGAAAGGCACTCCGCGGCGTCCGAGAGAATTG
GACAGCAGCCGGAGCAGAAAACGCGGAAAGCCTGCCAGAAAACGTGTTCAAAGCACCAATACACCTGTTTCTCCAGCTCC
GTCTGAGGAAAAAGGGGAGTGGTTCACTAAGCCGAAGAAGAAAAAGAAAAAACGCGGCTTCCAGAATGCTCCGAAACAGA
AACGGAAAAAGAAGAAATAG

Upstream 100 bases:

>100_bases
AGGGCATGTCATTACACTCGACAAAGAACGTGACCTCGTCCATCAGGATGTGTATGAATTTTTAGAGAAGCTCGATTGGT
AATCAACAGGAGGTCGGATA

Downstream 100 bases:

>100_bases
CAGCTCAACCAGCAAATAGGGCCGCAGCGCTCTATTTGCTTTCTTTCGGAAACAGCTTTTCATTGTAGCGGTACGTGACA
TTTGGTAAAATAGAGCGTAT

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVKALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHA
KGFAFLLPEDTSLSDVFIPPNELNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI
TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHKHGLPGEFPADAMEQASSTPDTI
DEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKLDDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPM
IPHRLSNGICSLNPKVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPLVPMFKDME
RLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEEFMLVANETVAEHFHWMNVPFIYRIHEEPNA
EKLQKFLEFVTTFGYVVKGTAGNIHPRALQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPI
RRYPDLIVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYMLDKIGEEFDGMISSVTN
FGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNVFRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPREL
DSSRSRKRGKPARKRVQSTNTPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK

Sequences:

>Translated_779_residues
MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVKALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHA
KGFAFLLPEDTSLSDVFIPPNELNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI
TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHKHGLPGEFPADAMEQASSTPDTI
DEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKLDDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPM
IPHRLSNGICSLNPKVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPLVPMFKDME
RLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEEFMLVANETVAEHFHWMNVPFIYRIHEEPNA
EKLQKFLEFVTTFGYVVKGTAGNIHPRALQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPI
RRYPDLIVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYMLDKIGEEFDGMISSVTN
FGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNVFRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPREL
DSSRSRKRGKPARKRVQSTNTPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK
>Mature_779_residues
MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVKALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHA
KGFAFLLPEDTSLSDVFIPPNELNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI
TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHKHGLPGEFPADAMEQASSTPDTI
DEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKLDDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPM
IPHRLSNGICSLNPKVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPLVPMFKDME
RLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEEFMLVANETVAEHFHWMNVPFIYRIHEEPNA
EKLQKFLEFVTTFGYVVKGTAGNIHPRALQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPI
RRYPDLIVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYMLDKIGEEFDGMISSVTN
FGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNVFRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPREL
DSSRSRKRGKPARKRVQSTNTPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain

Homologues:

Organism=Homo sapiens, GI134288890, Length=418, Percent_Identity=32.5358851674641, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI190014625, Length=466, Percent_Identity=29.3991416309013, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI190014623, Length=466, Percent_Identity=29.3991416309013, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI219521928, Length=619, Percent_Identity=26.3327948303716, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI19115966, Length=511, Percent_Identity=28.1800391389432, Blast_Score=177, Evalue=5e-44,
Organism=Homo sapiens, GI156105695, Length=133, Percent_Identity=30.8270676691729, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI156105693, Length=133, Percent_Identity=30.8270676691729, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI87082383, Length=704, Percent_Identity=39.2045454545455, Blast_Score=523, Evalue=1e-149,
Organism=Escherichia coli, GI1787542, Length=651, Percent_Identity=26.7281105990783, Blast_Score=163, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17553506, Length=492, Percent_Identity=30.4878048780488, Blast_Score=197, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI212645896, Length=621, Percent_Identity=26.4090177133655, Blast_Score=184, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324552, Length=445, Percent_Identity=30.561797752809, Blast_Score=185, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320499, Length=420, Percent_Identity=23.5714285714286, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323943, Length=479, Percent_Identity=26.0960334029228, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24649634, Length=489, Percent_Identity=30.2658486707566, Blast_Score=216, Evalue=7e-56,
Organism=Drosophila melanogaster, GI19922976, Length=370, Percent_Identity=32.972972972973, Blast_Score=192, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24654597, Length=370, Percent_Identity=32.972972972973, Blast_Score=192, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24654592, Length=370, Percent_Identity=32.972972972973, Blast_Score=192, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNR_BACSU (O32231)

Other databases:

- EMBL:   AL009126
- PIR:   G70027
- RefSeq:   NP_391241.1
- ProteinModelPortal:   O32231
- SMR:   O32231
- EnsemblBacteria:   EBBACT00000000893
- GeneID:   938644
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU33610
- NMPDR:   fig|224308.1.peg.3367
- GenoList:   BSU33610
- GeneTree:   EBGT00050000001822
- HOGENOM:   HBG690243
- OMA:   GHRDGFG
- PhylomeDB:   O32231
- ProtClustDB:   CLSK873641
- BioCyc:   BSUB:BSU33610-MONOMER
- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR23355:SF9
- SMART:   SM00357
- SMART:   SM00955
- SMART:   SM00316
- TIGRFAMs:   TIGR00358
- TIGRFAMs:   TIGR02063

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1; SSF50249 Nucleic_acid_OB

EC number: 3.1.-.- [C]

Molecular weight: Translated: 88751; Mature: 88751

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS01175 RIBONUCLEASE_II; PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVKALVALEEKGLIVRTRS
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECC
DRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNELNTAMNGDIVMVRLNSQS
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCHHHCCCCCCCEEEEEECCCC
SGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKITSDIFIPKNGKNGAAEGHKV
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCCCCCCEE
VVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHKHGLPGEFPADAMEQASSTPDTI
EEEEECCCCCCCCCCCCCHHEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCC
DEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKLDDGSYKLGVHIADVSHYVTENSPI
CHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEEEEHHHHHHCCCCCC
DKEALERGTSVYLVDRVIPMIPHRLSNGICSLNPKVDRLTLSCEMTINSQGQVTEHEIFQ
CHHHHHCCCEEEEHHHHHHHHHHHHCCCEEECCCCCEEEEEEEEEEECCCCCCHHHHHHH
SVIKTTERMTYSDVNKILVDDDEELKQKYEPLVPMFKDMERLAQILRDKRMDRGAVDFDF
HHHHHHHHCCHHHHHHEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
KEAKVLVDDEGAVKDVVIRERSVAEKLIEEFMLVANETVAEHFHWMNVPFIYRIHEEPNA
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
EKLQKFLEFVTTFGYVVKGTAGNIHPRALQSILDAVRDRPEETVISTVMLRSMKQAKYDP
HHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCH
QSLGHFGLSTEFYTHFTSPIRRYPDLIVHRLIRTYLINGKVDEATQEKWAERLPDIAEHT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHH
SSMERRAVDAERETDDLKKAEYMLDKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFM
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHCCCEEEEEE
TDDYYRFDEQHFAMIGERTGNVFRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPREL
CCCHHHHCHHHHHHHHHCCCCEEEECCEEEEEEEECCCCCCCCCEEEEECCCCCCCCHHH
DSSRSRKRGKPARKRVQSTNTPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK
HHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHCCC
>Mature Secondary Structure
MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVKALVALEEKGLIVRTRS
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECC
DRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNELNTAMNGDIVMVRLNSQS
CCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCHHHCCCCCCCEEEEEECCCC
SGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKITSDIFIPKNGKNGAAEGHKV
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCCCCCCEE
VVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHKHGLPGEFPADAMEQASSTPDTI
EEEEECCCCCCCCCCCCCHHEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCC
DEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKLDDGSYKLGVHIADVSHYVTENSPI
CHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEEEEHHHHHHCCCCCC
DKEALERGTSVYLVDRVIPMIPHRLSNGICSLNPKVDRLTLSCEMTINSQGQVTEHEIFQ
CHHHHHCCCEEEEHHHHHHHHHHHHCCCEEECCCCCEEEEEEEEEEECCCCCCHHHHHHH
SVIKTTERMTYSDVNKILVDDDEELKQKYEPLVPMFKDMERLAQILRDKRMDRGAVDFDF
HHHHHHHHCCHHHHHHEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
KEAKVLVDDEGAVKDVVIRERSVAEKLIEEFMLVANETVAEHFHWMNVPFIYRIHEEPNA
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
EKLQKFLEFVTTFGYVVKGTAGNIHPRALQSILDAVRDRPEETVISTVMLRSMKQAKYDP
HHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCH
QSLGHFGLSTEFYTHFTSPIRRYPDLIVHRLIRTYLINGKVDEATQEKWAERLPDIAEHT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHH
SSMERRAVDAERETDDLKKAEYMLDKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFM
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHCCCEEEEEE
TDDYYRFDEQHFAMIGERTGNVFRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPREL
CCCHHHHCHHHHHHHHHCCCCEEEECCEEEEEEEECCCCCCCCCEEEEECCCCCCCCHHH
DSSRSRKRGKPARKRVQSTNTPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK
HHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377