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The map label for this gene is ytnA

Identifier: 16080105

GI number: 16080105

Start: 3124250

End: 3125641

Strand: Reverse

Name: ytnA

Synonym: BSU30530

Alternate gene names: 16080105

Gene position: 3125641-3124250 (Counterclockwise)

Preceding gene: 16080106

Following gene: 16080103

Centisome position: 74.14

GC content: 45.04

Gene sequence:

>1392_bases
ATGCAAAAACAAAAACAAGAGCTGCACCGCGGACTCGAAGAAAGGCATATTTCTTTAATGTCTTTAGGAGCTGCTATAGG
AGTAGGGTTGTTCCTCGGCTCCGCATCAGCTATTCAATTAGCAGGGCCTGGTATTTTGGTAGCGTATGCCGCAAGCGGCC
TGGTCATGTTTTTTATTATGAGAGCGCTTGGGGAAATGGCCATTCAAAAACCGGTCGCAGGCTCCTTCAGCAGGTATGCG
CGTGATTATTTGGGACCGCTTGCAGGCTATTTAACAGGTTGGAACTACTGGTTTTTATGGGTTGTCACCTGTATGGCCGA
AATCACTGCTGTCGGCATCTATATGGGGTTCTGGTTTCCGGACGTGCCAAACTGGATTTGGGCGTTATCGGCACTGGTCA
TTATGACGGGTGTTAATTTCCTGGCTGTCAAAGCTTACGGCGAGCTGGAATTTTGGTTCGCATTGATTAAAATTGTTGCA
ATCTTATCCATGATTGCTGTCGGTTTATTGATGATTATTGCAGGAGTCGGCAATGGGGGCATTGCAACCGGAATCAGCAA
TTTGTGGAACAACGGAGGATTTTTCCCTCATGGATTAAAAGGGGTTTTATTGTCTCTTCAAATGGTCATGTTCGCCTATT
TAGGGATTGAAATGATCGGGGTGACGGCTGGCGAAGTAAAAAACCCGCAAAAATCGTTAGCCAAAGCAATCGATACAGTA
TTTTGGCGGATTTTGATTTTTTATGTAGGCGCTTTATTTGTCATTATGTCTATTTATCCGTGGCAGGAAATTGGCTCTCA
AGGAAGTCCATTTGTTCTCACATTTCAAAAAGTGGGCATTCCATCGGCCGCAGGTATCATTAACTTTGTCGTGTTGACAG
CCGCGCTGTCTTCATGCAACAGTGGTATTTTCAGCACAGGGCGGATGCTGTTTAACTTGGCGGAACAGAAAGAGGCGCCA
CAAGCATATGGTCAGCTGACGAAAGGCGGCATCCCGGGTAAAGCTGTTCTGGCTTCAGCGGGCGCTTTATTAGTCGGAGT
GCTGTTAAACTATGTTGTCCCTGCGAAGGTATTTACTTGGGTTACAAGTATTGCGACGTTCGGAGCGATTTGGACGTGGG
CAATCATTTTGCTTTCTCAAATAAAATACAGGAAAAGTTTGAAGCCGGAAGAAAAGAAACAATTAAAGTACAAAATGCCT
TTATTTCCGTTTACGTCTTATGTGTCATTGGCATTTCTAGCATTCGTCGTCATTCTTATGGCTTACAGCCCTGATACAAG
AGTAGCCGTGATTATCGGGCCGATATGGTTTCTCATCTTGCTGGCTGTGTACTATGGAAAAGGGTTTCATAAAAAAAATG
CGGCTGCTGCCAGCGAACGAAATATCAGCTGA

Upstream 100 bases:

>100_bases
TTGTTATCCTTTTATTTCTCCATCATCATTGATTTACCCAATCCGTACGGAATATTCAGAAAAATGATATAATGATATTT
TTTTCTAGGGGAGAAGAAGC

Downstream 100 bases:

>100_bases
CAAAAAGAGCTCCCAGTGGGCTCTTTTTGTGTGTGCTCATAGAAAATAGAGAACAGGAAAGAATAGGTATGTGTTTTTGC
AGAGGCTGTTTATAGTTTTG

Product: amino acid permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPGILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYA
RDYLGPLAGYLTGWNYWFLWVVTCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA
ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEMIGVTAGEVKNPQKSLAKAIDTV
FWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQKVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAP
QAYGQLTKGGIPGKAVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEKKQLKYKMP
LFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFHKKNAAAASERNIS

Sequences:

>Translated_463_residues
MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPGILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYA
RDYLGPLAGYLTGWNYWFLWVVTCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA
ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEMIGVTAGEVKNPQKSLAKAIDTV
FWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQKVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAP
QAYGQLTKGGIPGKAVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEKKQLKYKMP
LFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFHKKNAAAASERNIS
>Mature_463_residues
MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPGILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYA
RDYLGPLAGYLTGWNYWFLWVVTCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA
ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEMIGVTAGEVKNPQKSLAKAIDTV
FWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQKVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAP
QAYGQLTKGGIPGKAVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEKKQLKYKMP
LFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFHKKNAAAASERNIS

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Homo sapiens, GI258614003, Length=428, Percent_Identity=22.6635514018692, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI258614005, Length=428, Percent_Identity=22.6635514018692, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI258645169, Length=427, Percent_Identity=22.0140515222482, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786602, Length=453, Percent_Identity=54.083885209713, Blast_Score=470, Evalue=1e-134,
Organism=Escherichia coli, GI48994972, Length=462, Percent_Identity=49.5670995670996, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1786789, Length=451, Percent_Identity=43.4589800443459, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1790653, Length=439, Percent_Identity=47.1526195899772, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1786302, Length=459, Percent_Identity=42.9193899782135, Blast_Score=407, Evalue=1e-114,
Organism=Escherichia coli, GI87081915, Length=449, Percent_Identity=41.4253897550111, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI87081708, Length=465, Percent_Identity=36.1290322580645, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=36.6589327146172, Blast_Score=307, Evalue=9e-85,
Organism=Escherichia coli, GI1788480, Length=407, Percent_Identity=36.3636363636364, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI87081869, Length=417, Percent_Identity=21.1031175059952, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324061, Length=465, Percent_Identity=32.258064516129, Blast_Score=243, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6320772, Length=442, Percent_Identity=32.8054298642534, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6324924, Length=449, Percent_Identity=31.4031180400891, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6324059, Length=442, Percent_Identity=31.9004524886878, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6322892, Length=434, Percent_Identity=29.4930875576037, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324990, Length=449, Percent_Identity=28.7305122494432, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6320717, Length=403, Percent_Identity=28.7841191066998, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6319824, Length=401, Percent_Identity=28.1795511221945, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=413, Percent_Identity=29.5399515738499, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324553, Length=396, Percent_Identity=30.050505050505, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321629, Length=484, Percent_Identity=26.4462809917355, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6319542, Length=415, Percent_Identity=27.710843373494, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322967, Length=415, Percent_Identity=25.7831325301205, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319543, Length=410, Percent_Identity=26.8292682926829, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321053, Length=425, Percent_Identity=25.4117647058824, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6319608, Length=424, Percent_Identity=25.9433962264151, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324981, Length=471, Percent_Identity=23.5668789808917, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320364, Length=506, Percent_Identity=24.901185770751, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161077963, Length=389, Percent_Identity=23.9074550128535, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666159, Length=418, Percent_Identity=19.8564593301435, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221512776, Length=418, Percent_Identity=19.8564593301435, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YTNA_BACSU (O34618)

Other databases:

- EMBL:   AF008220
- EMBL:   AL009126
- PIR:   C69997
- RefSeq:   NP_390931.1
- ProteinModelPortal:   O34618
- EnsemblBacteria:   EBBACT00000004051
- GeneID:   938118
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU30530
- NMPDR:   fig|224308.1.peg.3056
- GenoList:   BSU30530
- GeneTree:   EBGT00070000031860
- HOGENOM:   HBG492579
- OMA:   VYYYASQ
- PhylomeDB:   O34618
- ProtClustDB:   CLSK2752484
- BioCyc:   BSUB:BSU30530-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 50329; Mature: 50329

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1161aac0)-; HASH(0x10ee62f0)-; HASH(0x11d676c4)-; HASH(0x11d4fa3c)-; HASH(0x10ada79c)-; HASH(0x117bc438)-; HASH(0x1212391c)-; HASH(0x11d29484)-; HASH(0x11bf6cc4)-; HASH(0x11d52b98)-; HASH(0x11d76994)-; HASH(0x11d400e8)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPGILVAYAASGLVMFFIM
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHH
RALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVVTCMAEITAVGIYMGFWFP
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVAILSMIAVGLLMIIAGVGNGG
CCCHHHHHHHHHHHHHCCHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
IATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEMIGVTAGEVKNPQKSLAKAIDTV
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHH
FWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQKVGIPSAAGIINFVVLTAALSSCN
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHC
SGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGKAVLASAGALLVGVLLNYVVPAKVFTW
CCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSIATFGAIWTWAIILLSQIKYRKSLKPEEKKQLKYKMPLFPFTSYVSLAFLAFVVILM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AYSPDTRVAVIIGPIWFLILLAVYYGKGFHKKNAAAASERNIS
HCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCH
>Mature Secondary Structure
MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPGILVAYAASGLVMFFIM
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHH
RALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVVTCMAEITAVGIYMGFWFP
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVAILSMIAVGLLMIIAGVGNGG
CCCHHHHHHHHHHHHHCCHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
IATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEMIGVTAGEVKNPQKSLAKAIDTV
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHH
FWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQKVGIPSAAGIINFVVLTAALSSCN
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHC
SGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGKAVLASAGALLVGVLLNYVVPAKVFTW
CCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSIATFGAIWTWAIILLSQIKYRKSLKPEEKKQLKYKMPLFPFTSYVSLAFLAFVVILM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AYSPDTRVAVIIGPIWFLILLAVYYGKGFHKKNAAAASERNIS
HCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377