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The map label for this gene is hemD

Identifier: 16079866

GI number: 16079866

Start: 2875173

End: 2875961

Strand: Reverse

Name: hemD

Synonym: BSU28140

Alternate gene names: 16079866

Gene position: 2875961-2875173 (Counterclockwise)

Preceding gene: 16079867

Following gene: 16079865

Centisome position: 68.22

GC content: 45.12

Gene sequence:

>789_bases
ATGGAAAATGATTTTCCGTTGAAAGGAAAAACAGTGCTTGTCACCCGGAATAAGGCACAGGCAGCATCATTTCAGCAAAA
AGTGGAGGCGCTTGGCGGTAAAGCGGTTTTAACCTCTTTGATTACGTTTCGCCGCGCTTTGCCGAATGATGTTGCGGAAC
AGGTAAGAGAGGATCTTGCCGCGCCAGGCTGGCTTGTTTTTACAAGTGTGAACGGGGCAGACTTCTTTTTTTCTTATCTG
AAGGAAAATCAGCTTATTCTCCCTGCGCATAAAAAAATTGCAGCCGTCGGTGAAAAAACCGCGCGCCGTTTAAAAATGCA
TAACGTATCGGTTGATGTGATGCCACAGGAGTATATTGCTGAACAATTGGCTGACGCTCTTAAGCAGCATGCTGAACCGG
GGGAGACCATTACCGTGATGAAAGGGAATTTGTCACGTGATGTGATAAAACAAGAGCTTGTCCCGCTCGGTTTTGAAGTA
AAGGAATGGGTTCTCTACGAAACGATTCCGGATGAAGAAGGCATTGAGGCATTGAAAGACGCTGCGGGTCAATATTCCTT
TGACTATGTAACATTTACGAGTTCATCAACCGTACATACGTTTATGCATGTCTTGGGAGAAGAATTAAAAAAGTGGAAGG
CGAATGGGACGGCCTGTATCAGCATTGGGCCTTTAACAAATGATGCCCTTCTGACGTACGGCATCACATCGCATACGCCT
GATACATTTACAATAGATGGCATGCTTGAGTTAATGTGCAGCATGTCAAGAGAGGAAGAGAGAATATGA

Upstream 100 bases:

>100_bases
GGAAACGATCCGGAGGAAGTAGGAAAGCGCTGTGCCGCTCTTATGGCTGACAAAGGAGCAAAAGATTTAATTGATCGTGT
AAAACGGGAGCTTGACGAGG

Downstream 100 bases:

>100_bases
GTCAATCATTTAATAGACACCGCCGCCTGCGGACATCAAAAGCAATGAGAGAAATGGTAAAGGAAACACGTTTGCATCCA
TCAGATTTTATATATCCGAT

Product: uroporphyrinogen III cosynthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYL
KENQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV
KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTACISIGPLTNDALLTYGITSHTP
DTFTIDGMLELMCSMSREEERI

Sequences:

>Translated_262_residues
MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYL
KENQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV
KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTACISIGPLTNDALLTYGITSHTP
DTFTIDGMLELMCSMSREEERI
>Mature_262_residues
MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYL
KENQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV
KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTACISIGPLTNDALLTYGITSHTP
DTFTIDGMLELMCSMSREEERI

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM4_BACSU (P21248)

Other databases:

- EMBL:   M57676
- EMBL:   AL009126
- PIR:   B42728
- RefSeq:   NP_390692.1
- ProteinModelPortal:   P21248
- EnsemblBacteria:   EBBACT00000002114
- GeneID:   937287
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU28140
- NMPDR:   fig|224308.1.peg.2817
- GenoList:   BSU28140
- GeneTree:   EBGT00050000001271
- HOGENOM:   HBG700564
- OMA:   GMLELMC
- ProtClustDB:   CLSK887687
- BioCyc:   BSUB:BSU28140-MONOMER
- BRENDA:   4.2.1.75
- InterPro:   IPR003754

Pfam domain/function: PF02602 HEM4; SSF69618 HEM4_synth

EC number: =4.2.1.75

Molecular weight: Translated: 29115; Mature: 29115

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLA
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHC
APGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQEYIA
CCCEEEEEECCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHH
EQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEVKEWVLYETIPDEEGIEALKD
HHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHEEEEECCCCHHHHHHHHH
AAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTACISIGPLTNDALLTYGITSHTP
HCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCCCC
DTFTIDGMLELMCSMSREEERI
CCEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLA
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHC
APGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQEYIA
CCCEEEEEECCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHH
EQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEVKEWVLYETIPDEEGIEALKD
HHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHEEEEECCCCHHHHHHHHH
AAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTACISIGPLTNDALLTYGITSHTP
HCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCCCC
DTFTIDGMLELMCSMSREEERI
CCEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377; 2110138