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The map label for this gene is czcD

Identifier: 16079718

GI number: 16079718

Start: 2723892

End: 2724827

Strand: Reverse

Name: czcD

Synonym: BSU26650

Alternate gene names: 16079718

Gene position: 2724827-2723892 (Counterclockwise)

Preceding gene: 16079719

Following gene: 16079717

Centisome position: 64.64

GC content: 38.25

Gene sequence:

>936_bases
ATGGGTCACAATCATAATGAAGGAGCAAATAAAAAGGTTTTATTGATCTCTTTTATCATGATTACAGGTTATATGATTAT
AGAAGCTATAGGTGGATTTTTAACAAATAGCCTGGCGCTTTTATCTGATGCAGGCCATATGCTGAGTGATTCAATTTCAT
TAATGGTTGCCCTGATTGCTTTTACATTAGCTGAAAAAAAGGCAAATCACAATAAGACATTCGGCTATAAACGATTTGAG
ATTCTTGCAGCTGTGATAAACGGTGCTGCCTTAATTCTTATTTCTCTTTATATCATTTATGAAGCAATCGAACGCTTCTC
TAATCCACCAAAAGTAGCAACAACCGGCATGCTTACAATTAGTATCATCGGGTTAGTTGTGAATCTATTGGTCGCTTGGA
TTATGATGAGTGGCGGAGATACAAAGAATAATCTGAATATAAGAGGAGCTTATTTACATGTAATAAGCGATATGCTCGGC
TCTGTAGGTGCCATTTTAGCTGCCATACTTATCATCTTCTTTGGATGGGGCTGGGCAGATCCATTGGCTAGTATCATTGT
GGCTATTCTTGTTCTAAGAAGCGGTTACAATGTGACTAAAGATTCCATTCACATCTTAATGGAAGGAACTCCAGAAAATA
TCGATGTCTCTGATATCATTCGTACAATTGAAGGGACAGAGGGAATTCAAAACATTCATGATTTACACATATGGTCTATC
ACAAGCGGATTGAATGCTCTTTCTTGCCACGCAGTTGTTGACGATCAACTGACCATTTCAGAAAGTGAAAATATTTTACG
CAAAATTGAACATGAACTTGAGCATAAAGGCATTACGCACGTAACCATTCAAATGGAAACCGAAGCGCATAACCACGACA
ATGCGATCCTTTGTCAGCCCAAAATGGAGAAGCAGCGTGACCACCATCACCATTAA

Upstream 100 bases:

>100_bases
CATATATAAATATTATTTGTATCATGTTAGAATGCTTCATAACAGATTTGAAATAATAAATACATATGTATTAAAAACTT
TAGGTAAGGAGGAGTTTTTT

Downstream 100 bases:

>100_bases
ATTTTTTATCTAACTTTATAGTGAGGAGATCAACTAGGATTTTGCAGATTCTGTCTACTGACAATTTGAAATTGGCGGGG
TGATAATGTGTACGACACTA

Product: potassium/proton-divalent cation antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDAGHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFE
ILAAVINGAALILISLYIIYEAIERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG
SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSDIIRTIEGTEGIQNIHDLHIWSI
TSGLNALSCHAVVDDQLTISESENILRKIEHELEHKGITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH

Sequences:

>Translated_311_residues
MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDAGHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFE
ILAAVINGAALILISLYIIYEAIERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG
SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSDIIRTIEGTEGIQNIHDLHIWSI
TSGLNALSCHAVVDDQLTISESENILRKIEHELEHKGITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH
>Mature_310_residues
GHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDAGHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEI
LAAVINGAALILISLYIIYEAIERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLGS
VGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSDIIRTIEGTEGIQNIHDLHIWSIT
SGLNALSCHAVVDDQLTISESENILRKIEHELEHKGITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily

Homologues:

Organism=Homo sapiens, GI52352805, Length=308, Percent_Identity=27.9220779220779, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI20070323, Length=307, Percent_Identity=30.2931596091205, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI21361112, Length=309, Percent_Identity=27.831715210356, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI289803013, Length=305, Percent_Identity=30.1639344262295, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI289803009, Length=305, Percent_Identity=30.1639344262295, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI289803007, Length=305, Percent_Identity=30.1639344262295, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI289803003, Length=305, Percent_Identity=30.1639344262295, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI64762489, Length=305, Percent_Identity=30.1639344262295, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI21359890, Length=319, Percent_Identity=28.2131661442006, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI14210520, Length=232, Percent_Identity=27.5862068965517, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI52351208, Length=163, Percent_Identity=30.0613496932515, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI222080086, Length=107, Percent_Identity=36.4485981308411, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40255009, Length=107, Percent_Identity=36.4485981308411, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI21687224, Length=291, Percent_Identity=22.680412371134, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI301898545, Length=298, Percent_Identity=22.4832214765101, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI52352803, Length=125, Percent_Identity=37.6, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786966, Length=285, Percent_Identity=41.0526315789474, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17555794, Length=325, Percent_Identity=29.8461538461538, Blast_Score=160, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI193210990, Length=322, Percent_Identity=29.1925465838509, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17555796, Length=312, Percent_Identity=29.8076923076923, Blast_Score=157, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI32564488, Length=302, Percent_Identity=33.112582781457, Blast_Score=153, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6320411, Length=238, Percent_Identity=34.0336134453782, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=149, Percent_Identity=32.8859060402685, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=123, Percent_Identity=39.0243902439024, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24583858, Length=334, Percent_Identity=26.0479041916168, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24656728, Length=337, Percent_Identity=27.299703264095, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24656724, Length=337, Percent_Identity=27.299703264095, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24656720, Length=337, Percent_Identity=27.299703264095, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24656715, Length=337, Percent_Identity=27.299703264095, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21357035, Length=337, Percent_Identity=27.299703264095, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24584409, Length=165, Percent_Identity=30.3030303030303, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574430, Length=165, Percent_Identity=30.3030303030303, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24645863, Length=157, Percent_Identity=31.8471337579618, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585900, Length=126, Percent_Identity=31.7460317460317, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585898, Length=126, Percent_Identity=31.7460317460317, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585896, Length=126, Percent_Identity=31.7460317460317, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19921672, Length=126, Percent_Identity=31.7460317460317, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CZCD_BACSU (O07084)

Other databases:

- EMBL:   U93876
- EMBL:   AL009126
- EMBL:   U62055
- PIR:   C69612
- RefSeq:   NP_390542.1
- ProteinModelPortal:   O07084
- SMR:   O07084
- EnsemblBacteria:   EBBACT00000001517
- GeneID:   937630
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU26650
- NMPDR:   fig|224308.1.peg.2667
- GenoList:   BSU26650
- GeneTree:   EBGT00050000001463
- HOGENOM:   HBG317426
- OMA:   KESINIR
- PhylomeDB:   O07084
- ProtClustDB:   CLSK887635
- BioCyc:   BSUB:BSU26650-MONOMER
- InterPro:   IPR002524
- PANTHER:   PTHR11562
- TIGRFAMs:   TIGR01297

Pfam domain/function: PF01545 Cation_efflux

EC number: NA

Molecular weight: Translated: 34163; Mature: 34032

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10a4355c)-; HASH(0x10f86854)-; HASH(0x113303b0)-; HASH(0x1131a7cc)-; HASH(0x11329c90)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDAGHMLSDSISLMVALIA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEAIERFSNPPKVATTGMLTI
HHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLGSVGAILAAILIIFFGWGWAD
HHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
PLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSDIIRTIEGTEGIQNIHDLHIWSI
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHEEEEH
TSGLNALSCHAVVDDQLTISESENILRKIEHELEHKGITHVTIQMETEAHNHDNAILCQP
HCCCCCEEEHEEECCCEEECHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEECC
KMEKQRDHHHH
CHHHHHCCCCH
>Mature Secondary Structure 
GHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDAGHMLSDSISLMVALIA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEAIERFSNPPKVATTGMLTI
HHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLGSVGAILAAILIIFFGWGWAD
HHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
PLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSDIIRTIEGTEGIQNIHDLHIWSI
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHEEEEH
TSGLNALSCHAVVDDQLTISESENILRKIEHELEHKGITHVTIQMETEAHNHDNAILCQP
HCCCCCEEEHEEECCCEEECHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEECC
KMEKQRDHHHH
CHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864