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The map label for this gene is pbuX

Identifier: 16079264

GI number: 16079264

Start: 2318127

End: 2319443

Strand: Reverse

Name: pbuX

Synonym: BSU22060

Alternate gene names: 16079264

Gene position: 2319443-2318127 (Counterclockwise)

Preceding gene: 16079265

Following gene: 16079263

Centisome position: 55.02

GC content: 44.8

Gene sequence:

>1317_bases
ATGAGAAATGGATTCGGCAAAACGCTGTCTTTAGGGATTCAGCATGTTCTTGCCATGTATGCCGGCGCCATTGTCGTTCC
TCTGATTGTCGGAAAAGCAATGGGACTGACTGTCGAGCAGCTGACTTACTTAGTATCGATTGATATTTTTATGTGCGGTG
TGGCTACACTTCTGCAAGTGTGGAGCAACCGATTTTTTGGGATCGGGCTTCCGGTAGTGCTTGGCTGTACCTTTACAGCT
GTATCGCCGATGATAGCGATTGGATCTGAATATGGGGTTTCAACAGTTTACGGCAGCATTATCGCTTCAGGCATTCTTGT
CATTCTTATTTCATTTTTCTTTGGAAAGCTCGTATCGTTTTTTCCGCCGGTCGTGACAGGCTCTGTTGTTACGATTATCG
GTATTACACTGATGCCGGTTGCCATGAATAACATGGCCGGCGGAGAAGGAAGTGCAGATTTCGGAGATCTCTCCAATCTT
GCACTTGCTTTTACCGTGTTGAGTATCATTGTGCTTCTATACCGTTTTACAAAAGGCTTTATCAAGTCCGTCTCGATTTT
GATCGGTATTTTGATTGGCACCTTCATCGCATATTTTATGGGAAAAGTTCAATTTGATAATGTTTCGGACGCGGCAGTTG
TTCAAATGATTCAGCCATTTTACTTCGGAGCGCCGTCTTTTCACGCAGCGCCTATCATTACGATGTCCATCGTTGCAATT
GTCAGCCTTGTGGAGTCAACTGGTGTTTACTTTGCTTTAGGTGACCTGACAAACCGCCGTTTGACAGAGATAGATTTGTC
TAAAGGCTATCGAGCTGAAGGACTGGCTGTGCTTCTGGGCGGTATTTTTAACGCTTTTCCTTACACGGCATTCTCTCAAA
ATGTCGGGCTTGTTCAGCTCACAGGGATCAAAAAAAATGCCGTCATTGTGGTCACAGGTGTGATCCTAATGGCATTTGGG
CTGTTTCCAAAGATCGCTGCTTTCACGACTATTATTCCATCCGCTGTTTTGGGCGGTGCAATGGTGGCGATGTTTGGAAT
GGTGATTGCTTACGGAATTAAAATGCTCAGCCGCATTGATTTTGCGAAACAGGAAAATCTGCTGATTGTTGCTTGCTCAG
TGGGATTGGGGCTCGGTGTGACCGTTGTGCCGGATATTTTCAAACAGCTTCCGAGTGCCTTAACGCTGCTTACAACGAAT
GGCATTGTGGCGGGCAGCTTTACTGCAGTCGTCTTAAATATTGTATATAACGTTTTTTCTAAAGCTAAAAAAATAGAACA
AGAAGCTGACCTCGCTGAACAAAAAACAGCAGTCTAA

Upstream 100 bases:

>100_bases
GAAGAGATGAACTTGTAAAACTGGGCTACCGAGTGGAATCTTTGGCAAGAATTCAGTCTTTAGAAGAAGGAAAAGTGTCC
TTCGTACAGGAGGTTCATTC

Downstream 100 bases:

>100_bases
CTCCGCCGCGGCGGAGTTTTTTTTGCATATAAAAAAGATTGTTGCGGCACAATGTATGCAAAGAGGTGATCGCATGGCGT
TTATTTTATCCATTGGAACA

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYLVSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTA
VSPMIAIGSEYGVSTVYGSIIASGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL
ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQPFYFGAPSFHAAPIITMSIVAI
VSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLAVLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFG
LFPKIAAFTTIIPSAVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPSALTLLTTN
GIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV

Sequences:

>Translated_438_residues
MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYLVSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTA
VSPMIAIGSEYGVSTVYGSIIASGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL
ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQPFYFGAPSFHAAPIITMSIVAI
VSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLAVLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFG
LFPKIAAFTTIIPSAVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPSALTLLTTN
GIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV
>Mature_438_residues
MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYLVSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTA
VSPMIAIGSEYGVSTVYGSIIASGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL
ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQPFYFGAPSFHAAPIITMSIVAI
VSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLAVLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFG
LFPKIAAFTTIIPSAVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPSALTLLTTN
GIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV

Specific function: Transport of xanthine in the cell

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily

Homologues:

Organism=Homo sapiens, GI44680148, Length=476, Percent_Identity=24.3697478991597, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI40316845, Length=476, Percent_Identity=24.3697478991597, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI44680145, Length=498, Percent_Identity=22.4899598393574, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI44680143, Length=503, Percent_Identity=22.2664015904573, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87082181, Length=436, Percent_Identity=41.5137614678899, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1790087, Length=432, Percent_Identity=31.0185185185185, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87082178, Length=431, Percent_Identity=32.9466357308585, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87081818, Length=437, Percent_Identity=30.6636155606407, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788843, Length=380, Percent_Identity=26.8421052631579, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17542262, Length=464, Percent_Identity=22.6293103448276, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=186, Percent_Identity=27.4193548387097, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71993493, Length=222, Percent_Identity=23.8738738738739, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17542260, Length=186, Percent_Identity=25.2688172043011, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17541904, Length=423, Percent_Identity=21.2765957446809, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356175, Length=416, Percent_Identity=23.7980769230769, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PBUX_BACSU (P42086)

Other databases:

- EMBL:   X83878
- EMBL:   L77246
- EMBL:   AL009126
- PIR:   S51310
- RefSeq:   NP_390088.1
- ProteinModelPortal:   P42086
- EnsemblBacteria:   EBBACT00000003179
- GeneID:   939068
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU22060
- NMPDR:   fig|224308.1.peg.2211
- GenoList:   BSU22060
- GeneTree:   EBGT00050000001001
- HOGENOM:   HBG470187
- OMA:   CFLLWRA
- PhylomeDB:   P42086
- ProtClustDB:   CLSK887478
- BioCyc:   BSUB:BSU22060-MONOMER
- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043
- PANTHER:   PTHR11119:SF3
- PANTHER:   PTHR11119
- TIGRFAMs:   TIGR00801
- TIGRFAMs:   TIGR03173

Pfam domain/function: PF00860 Xan_ur_permease

EC number: NA

Molecular weight: Translated: 46239; Mature: 46239

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfd44c50)-; HASH(0xf9ecdbc)-; HASH(0x1039dd10)-; HASH(0xf9e1408)-; HASH(0x1024eef8)-; HASH(0x1068f3a8)-; HASH(0xfe26e10)-; HASH(0x1067bea8)-; HASH(0x10688bdc)-; HASH(0x100c2ec8)-; HASH(0xe32c6d8)-; HASH(0xfab4afc)-; HASH(0xec31b64)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCH
>Mature Secondary Structure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HHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377