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The map label for this gene is tkt

Identifier: 16078852

GI number: 16078852

Start: 1919861

End: 1921864

Strand: Direct

Name: tkt

Synonym: BSU17890

Alternate gene names: 16078852

Gene position: 1919861-1921864 (Clockwise)

Preceding gene: 16078851

Following gene: 16078853

Centisome position: 45.54

GC content: 45.26

Gene sequence:

>2004_bases
ATGGATACAATTGAAAAGAAATCAGTTGCTACCATTCGCACACTGTCAATAGACGCTATTGAAAAAGCAAATTCTGGTCA
CCCAGGGATGCCGATGGGAGCCGCTCCAATGGCATACACGCTGTGGACAAAATTTATGAACGTAAGTCCGGCAAACCCTG
GCTGGTTTAACCGTGACCGTTTTGTTTTATCTGCTGGACACGGGTCAGCACTATTATACAGCATGCTTCATTTAAGCGGG
TTTGATCTTAGTATTGAAGATCTTAAGGGATTCCGCCAGTGGGGCAGCAAAACACCAGGACATCCGGAATTCGGACATAC
TGCCGGTGTTGATGCTACAACAGGTCCGCTTGGCCAAGGAATTGCCATGGCAGTCGGTATGGCAATTGCTGAACGCCATT
TAGCGGAAACATACAACCGCGATTCATTTAACGTAGTCGATCATTATACATACAGTATTTGCGGTGATGGTGATTTAATG
GAAGGTATTTCTTCTGAAGCCGCTTCACTCGCAGGCCATCTTCAGCTTGGCCGTCTGATCGTACTATACGATTCTAATGA
CATCTCTCTTGATGGAGACCTCGACCGTTCATTCTCTGAAAACGTGAAACAGCGTTTTGAAGCAATGAATTGGGAAGTTC
TTTATGTTGAGGATGGAAACAATATTGAAGAATTAACAGCGGCTATCGAAAAAGCACGCCAAAATGAAAAGAAACCTACA
TTAATTGAAGTGAAAACGACAATCGGATTCGGTTCACCTAACCGTGCCGGTACATCCGGTGTTCACGGTGCGCCGCTTGG
TAAAGAAGAAAGCAAATTAACAAAAGAAGCTTACGCGTGGACATATGAAGAAGACTTCTACGTTCCGTCAGAAGTTTATG
AGCATTTCGCTGTAGCTGTTAAAGAATCAGGTGAGAAAAAAGAACAAGAATGGAATGCTCAATTCGCTAAATATAAAGAA
GTTTATCCTGAACTTGCTGAACAGCTTGAACTGGCAATCAAAGGAGAGCTTCCGAAGGACTGGGATCAAGAGGTTCCTGT
GTATGAAAAAGGAAGCAGTTTGGCATCCCGTGCATCTTCCGGTGAAGTTCTCAACGGACTTGCGAAAAAAATTCCTTTCT
TTGTCGGAGGTTCTGCTGACCTAGCGGGATCGAACAAAACGACTATTAAAAATGCCGGTGATTTTACAGCGGTTGATTAC
TCAGGCAAAAACTTCTGGTTTGGTGTACGTGAATTTGCGATGGGTGCGGCCTTAAACGGTATGGCGCTTCATGGCGGTCT
TCGTGTATTCGGCGGAACTTTCTTTGTCTTCTCTGATTACCTGCGTCCTGCGATTCGCCTTGCAGCGTTAATGGGCCTTC
CTGTGACATATGTCTTCACACATGACAGTATTGCGGTTGGTGAAGACGGTCCGACGCACGAGCCTGTTGAACAGCTTGCT
TCACTCCGTGCGATGCCTAACCTTTCTTTGATCCGTCCAGCAGACGGCAATGAGACAGCAGCAGCATGGAAGCTTGCAGT
GCAAAGCACTGACCACCCAACAGCGCTAGTGCTTACACGTCAAAACCTTCCTACCATCGATCAAACATCTGAAGAAGCAT
TGGCAGGAGTAGAAAAAGGTGCATATGTCGTTTCTAAATCTAAAAACGAAACACCTGACGCTCTTCTCATCGCTTCCGGA
TCAGAGGTAGGTCTTGCAATTGAAGCGCAGGCTGAATTGGCAAAAGAAAATATCGATGTTTCTGTTGTCAGCATGCCTTC
AATGGACCGTTTTGAGAAACAATCTGATGAATACAAAAACGAAGTCCTTCCTGCAGATGTGAAAAAACGTCTTGCAATTG
AAATGGGCTCATCATTTGGATGGGGCAAATACACGGGGCTTGAAGGTGACGTTCTCGGCATAGACCGATTCGGTGCATCT
GCTCCTGGTGAAACCATCATTAACGAATACGGCTTCTCAGTTCCGAACGTAGTGAATCGAGTTAAGGCATTAATCAATAA
GTAA

Upstream 100 bases:

>100_bases
AAATTCAACAAGTTTCTCTCAAATTTAAGCTGAAACAGTTGAGAAAAAGTCGTCAGACATTTATGATGTAAGGGTACAAC
ACATAAGGAAGGGGATTTTT

Downstream 100 bases:

>100_bases
GCTTTTGAAAGAGGATGAGTCAAATCATCCTCTTTTTCTTGTTTATCCGACAAAAATAGTATTGGCTGTTTAACAGTAAT
AGACAATTCTTTCTTTTCTT

Product: transketolase

Products: NA

Alternate protein names: TK

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTKFMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSG
FDLSIEDLKGFRQWGSKTPGHPEFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM
EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVEDGNNIEELTAAIEKARQNEKKPT
LIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKEAYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKE
VYPELAEQLELAIKGELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNAGDFTAVDY
SGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAALMGLPVTYVFTHDSIAVGEDGPTHEPVEQLA
SLRAMPNLSLIRPADGNETAAAWKLAVQSTDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASG
SEVGLAIEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKYTGLEGDVLGIDRFGAS
APGETIINEYGFSVPNVVNRVKALINK

Sequences:

>Translated_667_residues
MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTKFMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSG
FDLSIEDLKGFRQWGSKTPGHPEFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM
EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVEDGNNIEELTAAIEKARQNEKKPT
LIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKEAYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKE
VYPELAEQLELAIKGELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNAGDFTAVDY
SGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAALMGLPVTYVFTHDSIAVGEDGPTHEPVEQLA
SLRAMPNLSLIRPADGNETAAAWKLAVQSTDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASG
SEVGLAIEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKYTGLEGDVLGIDRFGAS
APGETIINEYGFSVPNVVNRVKALINK
>Mature_667_residues
MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTKFMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSG
FDLSIEDLKGFRQWGSKTPGHPEFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM
EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVEDGNNIEELTAAIEKARQNEKKPT
LIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKEAYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKE
VYPELAEQLELAIKGELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNAGDFTAVDY
SGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAALMGLPVTYVFTHDSIAVGEDGPTHEPVEQLA
SLRAMPNLSLIRPADGNETAAAWKLAVQSTDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASG
SEVGLAIEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKYTGLEGDVLGIDRFGAS
APGETIINEYGFSVPNVVNRVKALINK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family

Homologues:

Organism=Homo sapiens, GI205277463, Length=596, Percent_Identity=26.6778523489933, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI4507521, Length=596, Percent_Identity=26.6778523489933, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI133778974, Length=581, Percent_Identity=25.6454388984509, Blast_Score=130, Evalue=6e-30,
Organism=Homo sapiens, GI225637459, Length=583, Percent_Identity=22.6415094339623, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI225637463, Length=507, Percent_Identity=23.4714003944773, Blast_Score=107, Evalue=5e-23,
Organism=Homo sapiens, GI225637461, Length=507, Percent_Identity=23.4714003944773, Blast_Score=106, Evalue=9e-23,
Organism=Escherichia coli, GI48994911, Length=665, Percent_Identity=49.3233082706767, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=668, Percent_Identity=47.1556886227545, Blast_Score=620, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17539652, Length=667, Percent_Identity=27.2863568215892, Blast_Score=155, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=670, Percent_Identity=48.3582089552239, Blast_Score=625, Evalue=1e-180,
Organism=Saccharomyces cerevisiae, GI6319593, Length=673, Percent_Identity=47.1025260029718, Blast_Score=601, Evalue=1e-172,
Organism=Drosophila melanogaster, GI45551847, Length=579, Percent_Identity=27.4611398963731, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45550715, Length=579, Percent_Identity=27.4611398963731, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24666278, Length=575, Percent_Identity=26.2608695652174, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24645119, Length=551, Percent_Identity=27.2232304900181, Blast_Score=150, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TKT_BACSU (P45694)

Other databases:

- EMBL:   Z73234
- EMBL:   AL009126
- EMBL:   X87845
- PIR:   G69723
- RefSeq:   NP_389672.1
- ProteinModelPortal:   P45694
- SMR:   P45694
- EnsemblBacteria:   EBBACT00000001446
- GeneID:   937377
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU17890
- NMPDR:   fig|224308.1.peg.1793
- GenoList:   BSU17890
- GeneTree:   EBGT00070000031844
- HOGENOM:   HBG565885
- OMA:   ELANEFQ
- PhylomeDB:   P45694
- ProtClustDB:   CLSK887352
- BioCyc:   BSUB:BSU17890-MONOMER
- BRENDA:   2.2.1.1
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- PANTHER:   PTHR11624:SF1
- SMART:   SM00861
- TIGRFAMs:   TIGR00232

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.1

Molecular weight: Translated: 72345; Mature: 72345

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2; PS00037 MYB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTKFMNVSPANPGWFNRDR
CCCCCCCCCEEEEEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCE
FVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHPEFGHTAGVDATTGPLGQG
EEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
IAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLMEGISSEAASLAGHLQLGRLI
HHHHHHHHHHHHHHHHHHCCCCCEEEECEEEEEECCCHHHHHHHHHHHHHHHHEEECEEE
VLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVEDGNNIEELTAAIEKARQNEKKPT
EEECCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCC
LIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKEAYAWTYEEDFYVPSEVYEHFAVAV
EEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCHHHHHHHHHHHH
KESGEKKEQEWNAQFAKYKEVYPELAEQLELAIKGELPKDWDQEVPVYEKGSSLASRASS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCEECCCHHHHHCCC
GEVLNGLAKKIPFFVGGSADLAGSNKTTIKNAGDFTAVDYSGKNFWFGVREFAMGAALNG
CHHHHHHHHHCCEEECCCCCCCCCCCCEECCCCCEEEEEECCCCEEHHHHHHHHHHHCCC
MALHGGLRVFGGTFFVFSDYLRPAIRLAALMGLPVTYVFTHDSIAVGEDGPTHEPVEQLA
EEEECCEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
SLRAMPNLSLIRPADGNETAAAWKLAVQSTDHPTALVLTRQNLPTIDQTSEEALAGVEKG
HHHCCCCCEEEECCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHCC
AYVVSKSKNETPDALLIASGSEVGLAIEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKN
CEEEECCCCCCCCEEEEECCCCCEEEEECHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
EVLPADVKKRLAIEMGSSFGWGKYTGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNR
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHCCCHHHHHHH
VKALINK
HHHHHCC
>Mature Secondary Structure
MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTKFMNVSPANPGWFNRDR
CCCCCCCCCEEEEEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCE
FVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHPEFGHTAGVDATTGPLGQG
EEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
IAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLMEGISSEAASLAGHLQLGRLI
HHHHHHHHHHHHHHHHHHCCCCCEEEECEEEEEECCCHHHHHHHHHHHHHHHHEEECEEE
VLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVEDGNNIEELTAAIEKARQNEKKPT
EEECCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCC
LIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKEAYAWTYEEDFYVPSEVYEHFAVAV
EEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCHHHHHHHHHHHH
KESGEKKEQEWNAQFAKYKEVYPELAEQLELAIKGELPKDWDQEVPVYEKGSSLASRASS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCEECCCHHHHHCCC
GEVLNGLAKKIPFFVGGSADLAGSNKTTIKNAGDFTAVDYSGKNFWFGVREFAMGAALNG
CHHHHHHHHHCCEEECCCCCCCCCCCCEECCCCCEEEEEECCCCEEHHHHHHHHHHHCCC
MALHGGLRVFGGTFFVFSDYLRPAIRLAALMGLPVTYVFTHDSIAVGEDGPTHEPVEQLA
EEEECCEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
SLRAMPNLSLIRPADGNETAAAWKLAVQSTDHPTALVLTRQNLPTIDQTSEEALAGVEKG
HHHCCCCCEEEECCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHCC
AYVVSKSKNETPDALLIASGSEVGLAIEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKN
CEEEECCCCCCCCEEEEECCCCCEEEEECHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
EVLPADVKKRLAIEMGSSFGWGKYTGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNR
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHCCCHHHHHHH
VKALINK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642