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The map label for this gene is prpC

Identifier: 16078639

GI number: 16078639

Start: 1650384

End: 1651148

Strand: Direct

Name: prpC

Synonym: BSU15760

Alternate gene names: 16078639

Gene position: 1650384-1651148 (Clockwise)

Preceding gene: 16078638

Following gene: 16078640

Centisome position: 39.15

GC content: 45.36

Gene sequence:

>765_bases
TTGTTAACAGCCTTAAAAACAGATACAGGAAAAATCCGCCAGCATAATGAAGATGATGCGGGGATATTCAAGGGGAAAGA
TGAATTTATATTAGCGGTTGTCGCTGATGGCATGGGCGGCCATCTTGCTGGAGATGTTGCGAGCAAGATGGCTGTGAAAG
CCATGGGGGAGAAATGGAATGAAGCAGAGACGATTCCAACTGCGCCCTCGGAATGTGAAAAATGGCTCATTGAACAGATT
CTATCGGTAAACAGCAAAATATACGATCACGCTCAAGCCCACGAAGAATGCCAAGGCATGGGGACGACGATTGTATGTGC
ACTTTTTACGGGGAAAACGGTTTCTGTTGCCCATATCGGAGACAGCAGATGCTATTTGCTTCAGGACGATGATTTCGTTC
AAGTGACAGAAGACCATTCGCTTGTAAATGAACTGGTTCGCACTGGAGAGATTTCCAGAGAAGACGCTGAACATCATCCG
CGAAAAAATGTGTTGACGAAGGCGCTTGGAACAGACCAGTTAGTCAGTATTGACACCCGTTCCTTTGATATAGAACCCGG
AGACAAACTGCTTCTATGTTCTGACGGACTGACAAATAAAGTGGAAGGCACTGAGTTAAAAGACATCCTGCAAAGCGATT
CAGCTCCTCAGGAAAAAGTAAACCTGCTTGTGGACAAAGCCAATCAGAATGGCGGAGAAGACAACATTACAGCAGTTTTG
CTTGAGCTTGCTTTACAAGTTGAAGAGGGTGAAGATCAGTGCTAA

Upstream 100 bases:

>100_bases
AGTAAATGTCACAATCCGAAGAGAGCAAGGACATGACATTGACGCAGCCTGCGGTCAGCTTCGCGCGAAGGAGCGTCAAG
ACGAGACGAGGTGATGAGGG

Downstream 100 bases:

>100_bases
TCGGCAAGCGGATCAGCGGGCGTTACCAAATTCTCCGCGTCATAGGCGGCGGGGGAATGGCCAACGTGTATTTAGCTGAG
GATATCATTCTAGACCGTGA

Product: phosphorylated protein phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAGDVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQI
LSVNSKIYDHAQAHEECQGMGTTIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP
RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQEKVNLLVDKANQNGGEDNITAVL
LELALQVEEGEDQC

Sequences:

>Translated_254_residues
MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAGDVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQI
LSVNSKIYDHAQAHEECQGMGTTIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP
RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQEKVNLLVDKANQNGGEDNITAVL
LELALQVEEGEDQC
>Mature_254_residues
MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAGDVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQI
LSVNSKIYDHAQAHEECQGMGTTIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP
RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQEKVNLLVDKANQNGGEDNITAVL
LELALQVEEGEDQC

Specific function: Protein phosphatase that dephosphorylates prkC and fusA (elongation factor G). PrpC and prkC are cotranscribed, which suggests that they form a functional couple in vivo, prpC's primary role being possibly to counter the action of prkC. May be involved in

COG id: COG0631

COG function: function code T; Serine/threonine protein phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRPC_BACSU (O34779)

Other databases:

- EMBL:   Y13937
- EMBL:   AL009126
- PIR:   G69878
- RefSeq:   NP_389458.1
- ProteinModelPortal:   O34779
- SMR:   O34779
- PptaseDB:   P3D040488
- EnsemblBacteria:   EBBACT00000003827
- GeneID:   935931
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU15760
- NMPDR:   fig|224308.1.peg.1578
- GenoList:   BSU15760
- GeneTree:   EBGT00050000002710
- HOGENOM:   HBG688775
- OMA:   VKMGQIT
- ProtClustDB:   CLSK887289
- BioCyc:   BSUB:BSU15760-MONOMER
- BRENDA:   3.1.3.16
- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045
- Gene3D:   G3DSA:3.60.40.10
- PANTHER:   PTHR13832
- SMART:   SM00331
- SMART:   SM00332

Pfam domain/function: PF00481 PP2C; SSF81606 PP2C-related

EC number: =3.1.3.16

Molecular weight: Translated: 27674; Mature: 27674

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAGDVASKMAVKAMGEKWN
CCCEECCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCC
EAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGTTIVCALFTGKTVSVAHIG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEC
DSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHPRKNVLTKALGTDQLVSIDTR
CCEEEEECCCCEEEEECHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHCCCCCEEEECCC
SFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQEKVNLLVDKANQNGGEDNITAVL
EEECCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHEECCCCCCCCHHHHHHH
LELALQVEEGEDQC
HHHHHHHCCCCCCC
>Mature Secondary Structure
MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAGDVASKMAVKAMGEKWN
CCCEECCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCC
EAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGTTIVCALFTGKTVSVAHIG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEC
DSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHPRKNVLTKALGTDQLVSIDTR
CCEEEEECCCCEEEEECHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHCCCCCEEEECCC
SFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQEKVNLLVDKANQNGGEDNITAVL
EEECCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHEECCCCCCCCHHHHHHH
LELALQVEEGEDQC
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377