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The map label for this gene is sirC

Identifier: 16078627

GI number: 16078627

Start: 1635603

End: 1636091

Strand: Direct

Name: sirC

Synonym: BSU15630

Alternate gene names: 16078627

Gene position: 1635603-1636091 (Clockwise)

Preceding gene: 16078626

Following gene: 16078629

Centisome position: 38.8

GC content: 45.4

Gene sequence:

>489_bases
ATGCTTCCGCTGCACATTAGCCTGGAAAAGAAGAAGGTTGTGATTGCGGGGGGCGGAAGCATCGCTCTCAGAAGGCTGAA
AACGGTGATTTCTGAGGGAGCTGATATAACGCTTGTCAGTCCGGATGTGGAACCGGAAATCAAGCAAATGGCAGAAGAGC
GGCGTATCAAATGGGAAAAACGGACAATTGAAAAAGAAGATTATCTCAATGCTTTCTTCATTATTGCTGCGACGGATAAT
GCGGCAGTGAACAAAGAAATTGCCCAATCCGCTTCGCCTTTTCAGCTTGTCAATTGTGTCAGTGACGCTGAGCTTGGCAA
TGTATATATGCCGAAAATCGTAAAAAGAGGGCATGTCACTGTGTCTGTTTCTACAAGCGGAGCCAGTCCAAAGCACACGA
AAGAGCTTGCTGAAAACGTGGATAAGCTGATTGACGGCGATTTTGTTGCTGAAGTGAACAGGCTTTATCAGATGAGAAGA
AAGAAATAA

Upstream 100 bases:

>100_bases
TATATCGGTTTTCATCCTCATGTGAAAAACGCATTTTTGAACCGTGTGAGAGAAACTGCGGCAAATTCTGAGGGACAATT
TGATTTTGATGGAGGTTCAT

Downstream 100 bases:

>100_bases
GCCAGAGCATACAAATGCTCTGGCTTTTCTTTATGCGGCTCAGCTTTTTTTGAGCTTGATGACAGTATCAGCATCAGGCG
TGACAAAGACGGTATGCTGG

Product: Precorrin-2 dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVEPEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDN
AAVNKEIAQSASPFQLVNCVSDAELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR
KK

Sequences:

>Translated_162_residues
MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVEPEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDN
AAVNKEIAQSASPFQLVNCVSDAELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR
KK
>Mature_162_residues
MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVEPEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDN
AAVNKEIAQSASPFQLVNCVSDAELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR
KK

Specific function: Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin used as precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis (Probable)

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789768, Length=144, Percent_Identity=26.3888888888889, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SIRC_BACSU (O34813)

Other databases:

- EMBL:   AJ000974
- EMBL:   AL009126
- PIR:   F69877
- RefSeq:   NP_389446.1
- HSSP:   P15807
- ProteinModelPortal:   O34813
- SMR:   O34813
- EnsemblBacteria:   EBBACT00000002901
- GeneID:   938048
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU15630
- NMPDR:   fig|224308.1.peg.1565
- GenoList:   BSU15630
- GeneTree:   EBGT00050000001868
- HOGENOM:   HBG730212
- OMA:   RIMISSD
- ProtClustDB:   CLSK887286
- BioCyc:   BSUB:BSU15630-MONOMER
- GO:   GO:0005488
- InterPro:   IPR016040
- InterPro:   IPR006367
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01470

Pfam domain/function: NA

EC number: =1.3.1.76

Molecular weight: Translated: 18004; Mature: 18004

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVEPEIKQMAEERRIKWEK
CCCEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
RTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSDAELGNVYMPKIVKRGHVT
HHCCHHHCCCEEEEEEECCCCHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHCCEEE
VSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRRKK
EEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVEPEIKQMAEERRIKWEK
CCCEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
RTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSDAELGNVYMPKIVKRGHVT
HHCCHHHCCCEEEEEEECCCCHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHCCEEE
VSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRRKK
EEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 10217486