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The map label for this gene is cysC

Identifier: 16078624

GI number: 16078624

Start: 1633369

End: 1633962

Strand: Direct

Name: cysC

Synonym: BSU15600

Alternate gene names: 16078624

Gene position: 1633369-1633962 (Clockwise)

Preceding gene: 16078623

Following gene: 16078625

Centisome position: 38.75

GC content: 44.78

Gene sequence:

>594_bases
GTGACAAATCGCGATATTGTATGGCATGAAGCCTCTATCACAAAAGAAGAGTATCAGCAAAAAAACAAGCATAAAAGCTC
CATTCTCTGGCTGACAGGGTTAAGCGGCTCAGGCAAATCAACCATTGCCAACGCCGCTGCGAGAGAATTGTTTGAGCAAG
GCTACCAAGTCATTGTGCTGGACGGGGATAATATCCGTCACGGCCTAAATAGGGATCTTGGTTTTTCTGATGAAGACCGA
AAAGAAAACATCCGCCGGATCGGAGAGGTGGCGAAGCTTTTTGTTCAGCAGGGAACCATTGTGATTACTGCTTTTATCTC
TCCTTTCCGCGAGGACAGACAACAGGTTCGCGAGCTTGTGGAAGCGGGCGAATTTAATGAAGTCTACATTAAATGCGACC
TTGATATTTGTGAACAAAGAGATCCGAAAGGGCTTTACAAAAAAGCAAGAAACGGCGAGATTCCGTTCTTTACAGGAATT
GATTCTCCTTATGAAGAACCGGAAGCTCCAGAGCTCGTTCTTGATTCAGGACAGCATGACCGTGAAGCGTGTAAAAATCA
GCTGATCGAGTTTGTTAAACAAAAATTGAGCTGA

Upstream 100 bases:

>100_bases
GCTGCCGCCTGCTGAATTCAGTCGAAAAGAAGTAGTAGAAGTGTTAATCAAAGGGATGAAGAAAAAAGAAGAAGTAGGCG
TATCTTAAGGAGGACTGGCA

Downstream 100 bases:

>100_bases
ATATGATCTGCTGCGTTCTTCTCAGATGCCGGAATGCAAGCGAGAACATCATCACAGCGAATCTTCTGGAAGAACTCGAA
TAGATCGGGGGAAATACGAT

Product: adenylylsulfate kinase

Products: NA

Alternate protein names: APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIANAAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDR
KENIRRIGEVAKLFVQQGTIVITAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI
DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS

Sequences:

>Translated_197_residues
MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIANAAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDR
KENIRRIGEVAKLFVQQGTIVITAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI
DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS
>Mature_196_residues
TNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIANAAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRK
ENIRRIGEVAKLFVQQGTIVITAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGID
SPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS

Specific function: Catalyzes the synthesis of activated sulfate

COG id: COG0529

COG function: function code P; Adenylylsulfate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the APS kinase family

Homologues:

Organism=Homo sapiens, GI46094058, Length=173, Percent_Identity=53.1791907514451, Blast_Score=189, Evalue=1e-48,
Organism=Homo sapiens, GI34447231, Length=173, Percent_Identity=51.4450867052023, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI62912492, Length=173, Percent_Identity=51.4450867052023, Blast_Score=182, Evalue=1e-46,
Organism=Escherichia coli, GI1789107, Length=194, Percent_Identity=52.5773195876289, Blast_Score=211, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17542422, Length=197, Percent_Identity=48.7309644670051, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6322852, Length=190, Percent_Identity=52.6315789473684, Blast_Score=191, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24667032, Length=173, Percent_Identity=47.3988439306358, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24667028, Length=173, Percent_Identity=47.3988439306358, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24667036, Length=173, Percent_Identity=47.3988439306358, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24667040, Length=173, Percent_Identity=47.3988439306358, Blast_Score=167, Evalue=6e-42,
Organism=Drosophila melanogaster, GI116007838, Length=173, Percent_Identity=47.3988439306358, Blast_Score=166, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24667044, Length=173, Percent_Identity=47.3988439306358, Blast_Score=166, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSC1_BACSU (O34577)

Other databases:

- EMBL:   AJ000974
- EMBL:   AL009126
- PIR:   C69877
- RefSeq:   NP_389443.1
- ProteinModelPortal:   O34577
- SMR:   O34577
- EnsemblBacteria:   EBBACT00000000583
- GeneID:   937102
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU15600
- NMPDR:   fig|224308.1.peg.1562
- GenoList:   BSU15600
- GeneTree:   EBGT00050000001911
- HOGENOM:   HBG309946
- OMA:   DFIEIYC
- PhylomeDB:   O34577
- ProtClustDB:   CLSK887283
- BioCyc:   BSUB:BSU15600-MONOMER
- BRENDA:   2.7.1.25
- HAMAP:   MF_00065
- InterPro:   IPR002891
- TIGRFAMs:   TIGR00455

Pfam domain/function: PF01583 APS_kinase

EC number: =2.7.1.25

Molecular weight: Translated: 22545; Mature: 22413

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIANAAARELFEQGYQVIVL
CCCCCEEEECHHCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEE
DGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVITAFISPFREDRQQVRELV
CCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHH
EAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGIDSPYEEPEAPELVLDSGQHD
HCCCCCEEEEEECCHHHCCCCCHHHHHHCCCCCCCEEECCCCCCCCCCCCHHEECCCCCH
REACKNQLIEFVKQKLS
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIANAAARELFEQGYQVIVL
CCCCEEEECHHCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEE
DGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVITAFISPFREDRQQVRELV
CCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHH
EAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGIDSPYEEPEAPELVLDSGQHD
HCCCCCEEEEEECCHHHCCCCCHHHHHHCCCCCCCEEECCCCCCCCCCCCHHEECCCCCH
REACKNQLIEFVKQKLS
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377