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The map label for this gene is ylbQ

Identifier: 16078575

GI number: 16078575

Start: 1577409

End: 1578305

Strand: Direct

Name: ylbQ

Synonym: BSU15110

Alternate gene names: 16078575

Gene position: 1577409-1578305 (Clockwise)

Preceding gene: 16078573

Following gene: 255767345

Centisome position: 37.42

GC content: 45.93

Gene sequence:

>897_bases
ATGAAAATTGGAATTATCGGCGGAGGCTCCGTTGGTCTTTTATGCGCCTATTATTTGTCACTTTATCACGACGTGACTGT
TGTGACGAGGCGGCAAGAACAGGCTGCGGCCATTCAGTCTGAAGGAATCCGGCTTTATAAAGGCGGGGAGGAATTCAGGG
CTGATTGCAGTGCGGACACGAGTATCAATTCGGACTTTGACCTGCTTGTCGTGACAGTGAAGCAGCATCAGCTTCAATCT
GTTTTTTCGTCGCTTGAACGAATCGGGAAGACGAATATATTATTTTTGCAAAACGGCATGGGGCATATCCACGACCTAAA
AGACTGGCACGTTGGCCATTCCATTTATGTTGGAATCGTTGAGCACGGAGCTGTAAGAAAATCGGATACAGCTGTTGATC
ATACAGGCCTAGGTGCGATAAAATGGAGCGCGTTCGACGATGCTGAACCAGACCGGCTGAACATCTTGTTTCAGCATAAC
CATTCGGATTTTCCGATTTATTATGAGACGGATTGGTACCGTCTGCTGACGGGCAAGCTGATTGTAAATGCGTGTATTAA
TCCTTTAACTGCGTTATTGCAAGTGAAAAATGGAGAACTGCTGACAACGCCAGCTTATCTGGCTTTTATGAAGCTGGTAT
TTCAGGAGGCATGCCGCATTTTAAAACTTGAAAATGAAGAAAAGGCTTGGGAGCGGGTTCAGGCCGTTTGTGGGCAAACG
AAAGAGAATCGTTCATCAATGCTGGTTGACGTCATTGGAGGCCGGCAGACGGAAGCTGACGCCATTATCGGATACTTATT
GAAGGAAGCAAGTCTTCAAGGTCTTGATGCCGTCCACCTAGAGTTTTTATATGGCAGCATCAAAGCATTGGAGCGAAATA
CAAACAAAGTCTTTTGA

Upstream 100 bases:

>100_bases
AATATTTAAACTTTAATTTTAAGCACATGGGATCTTTGAGAAGTAATTTCTTCTTACTTCTGCTATGATAATACGTAAAT
GCTAAATTGGGTGTGACATC

Downstream 100 bases:

>100_bases
GCTTTTTCGGTAACATGCTATACTCATTTCGGATCACTAACTATTTATTGGAGAAAGGAAGTTCTAGAAGATGCAGCTAA
CTGAACTTTCCATCAAAAAT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIRLYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQS
VFSSLERIGKTNILFLQNGMGHIHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN
HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEACRILKLENEEKAWERVQAVCGQT
KENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLDAVHLEFLYGSIKALERNTNKVF

Sequences:

>Translated_298_residues
MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIRLYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQS
VFSSLERIGKTNILFLQNGMGHIHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN
HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEACRILKLENEEKAWERVQAVCGQT
KENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLDAVHLEFLYGSIKALERNTNKVF
>Mature_298_residues
MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIRLYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQS
VFSSLERIGKTNILFLQNGMGHIHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN
HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEACRILKLENEEKAWERVQAVCGQT
KENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLDAVHLEFLYGSIKALERNTNKVF

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family

Homologues:

Organism=Escherichia coli, GI1786627, Length=306, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANE_BACSU (O34661)

Other databases:

- EMBL:   Z98682
- EMBL:   AL009126
- PIR:   F69875
- RefSeq:   NP_389394.1
- PDB:   3EGO
- PDBsum:   3EGO
- ProteinModelPortal:   O34661
- SMR:   O34661
- EnsemblBacteria:   EBBACT00000002137
- GeneID:   936782
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU15110
- NMPDR:   fig|224308.1.peg.1513
- GenoList:   BSU15110
- GeneTree:   EBGT00050000001655
- HOGENOM:   HBG668370
- OMA:   ELKNIHI
- PhylomeDB:   O34661
- ProtClustDB:   PRK06522
- BioCyc:   BSUB:BSU15110-MONOMER
- BRENDA:   1.1.1.169
- GO:   GO:0005737
- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21708:SF21
- TIGRFAMs:   TIGR00745

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.169

Molecular weight: Translated: 33287; Mature: 33287

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: ACT_SITE 179-179 BINDING 98-98 BINDING 98-98 BINDING 183-183 BINDING 187-187 BINDING 246-246 BINDING 258-258

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIRLYKGGEEFRADCSADT
CEEEEECCCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCEEEEECCHHHHCCCCCCC
SINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGHIHDLKDWHVGHSIYVGIV
CCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHCCCCEEEEEEE
EHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHNHSDFPIYYETDWYRLLTGKL
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCEEEECCHHHHHHHHH
IVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEACRILKLENEEKAWERVQAVCGQT
HHHHHHHHHHHHHEECCCCEEECHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCC
KENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLDAVHLEFLYGSIKALERNTNKVF
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIRLYKGGEEFRADCSADT
CEEEEECCCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCEEEEECCHHHHCCCCCCC
SINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGHIHDLKDWHVGHSIYVGIV
CCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHCCCCEEEEEEE
EHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHNHSDFPIYYETDWYRLLTGKL
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCEEEECCHHHHHHHHH
IVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEACRILKLENEEKAWERVQAVCGQT
HHHHHHHHHHHHHEECCCCEEECHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCC
KENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLDAVHLEFLYGSIKALERNTNKVF
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377