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The map label for this gene is ykbA

Identifier: 16078351

GI number: 16078351

Start: 1351375

End: 1352691

Strand: Reverse

Name: ykbA

Synonym: BSU12860

Alternate gene names: 16078351

Gene position: 1352691-1351375 (Counterclockwise)

Preceding gene: 255767300

Following gene: 16078350

Centisome position: 32.09

GC content: 45.48

Gene sequence:

>1317_bases
ATGCATACTGAAGACAACGGTTTGAAAAAAGAGATAGGCCTCTTGTTTGCCCTTACTCTTGTCATCGGAACCATTATCGG
TTCTGGTGTTTTTATGAAGCCCGGCGCTGTGCTTGCTTATTCAGGTGATTCAAAAATGGCGCTTTTCGCCTGGCTGTTAG
GCGGTATTTTAACACTGGCGGGCGGTTTGACAATCGCGGAAATCGGAACGCAGATTCCAAAAACCGGCGGGCTTTATACG
TACCTTGAAGAAGTGTACGGCGAGTTTTGGGGATTTTTGTGCGGCTGGGTGCAGATTATCATTTACGGCCCGGCGATTAT
TGGCGCGCTGGGTTTATATTTTGGATCTTTAATGGCGAATCTTTTCGGCTGGGGATCTGGACTATCAAAAGTCATTGGAA
TTATAGCAGTTCTCTTTTTATGCGTCATTAATATTATCGGTACAAAATACGGCGGTTTTGTCCAAACGCTGACAACGATC
GGAAAACTGATTCCGATTGCCTGCATCATCGTCTTTGGCCTTTGGAAAGGCGATCAGCACATCTTCACAGCAGTAAACGA
AAGCATTTCTGATATGAACTTCGGGGCGGCTATTTTAGCTACGTTGTTTGCTTATGACGGATGGATTCTCCTTGCCGCTC
TCGGCGGAGAAATGAAAAATCCCGAAAAGCTGCTGCCACGCGCTATGACGGGCGGATTATTAATTGTAACGGCGATCTAT
ATTTTCATTAATTTTGCATTGCTTCACATCCTGTCAGCGAACGAAATTGTCACGCTTGGTGAAAATGCGACAAGCACCGC
TGCAACCATGCTGTTCGGTTCAATTGGCGGAAAGCTGATCAGTGTAGGGATTATCGTCAGCATCTTTGGGTGCTTAAATG
GAAAGGTGCTTTCTTTCCCGCGTGTTTCATTTGCAATGGCGGAACGCAAACAGCTTCCATTTGCTGAAAAACTGTCACAT
GTACACCCGTCGTTCCGCACACCATGGATTGCGATTTCTTTTCAAATTGCTTTGGCTTTGATTATGATGCTGATCAGCAA
CCCTGATAAGCTCTCAGAAATCTCCATTTTCATGATCTACATTTTTTATGTGATGGCCTTTTTTGCAGTGTTTATTCTCC
GCAAGCGAGCAAAGGGAGAAAAGCGCGCCTACAGTGTTCCGCTTTATCCATTTATGCCAATTCTGGCAATCGCGGGCTCC
TTCTTTGTGTTAGGCAGCACACTCATTACAGATACAATGAGCTGCGGATTATCCATCCTCATCGGCCTTGCCGGACTGCC
TGTTTATTACGGGATGAAAAAACGAAAAGCAAGCTGA

Upstream 100 bases:

>100_bases
TCAGAAAATTTATTTTATTTCACTTTTCTAAAATAGGGTTTACAATATGAAAAAATAGATTCTTCAACATGAAGCTTCAA
CATCATAGGAGGTTAAGGAC

Downstream 100 bases:

>100_bases
TAAAACGGTTCCCTTGTTTAGGGAACCGTTTTTTGGTGAAACAGAAGATAAAAGTTGACAGGAAAAACACAACTTTTGAT
ATACTTTTTACGTTAAGCAG

Product: amino acid permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDSKMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYT
YLEEVYGEFWGFLCGWVQIIIYGPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI
GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEMKNPEKLLPRAMTGGLLIVTAIY
IFINFALLHILSANEIVTLGENATSTAATMLFGSIGGKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSH
VHPSFRTPWIAISFQIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFMPILAIAGS
FFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS

Sequences:

>Translated_438_residues
MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDSKMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYT
YLEEVYGEFWGFLCGWVQIIIYGPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI
GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEMKNPEKLLPRAMTGGLLIVTAIY
IFINFALLHILSANEIVTLGENATSTAATMLFGSIGGKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSH
VHPSFRTPWIAISFQIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFMPILAIAGS
FFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS
>Mature_438_residues
MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDSKMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYT
YLEEVYGEFWGFLCGWVQIIIYGPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI
GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEMKNPEKLLPRAMTGGLLIVTAIY
IFINFALLHILSANEIVTLGENATSTAATMLFGSIGGKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSH
VHPSFRTPWIAISFQIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFMPILAIAGS
FFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS

Specific function: Exhibits an obligate exchange activity for serine, threonine and aromatic amino acids

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family

Homologues:

Organism=Homo sapiens, GI115648063, Length=437, Percent_Identity=31.5789473684211, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI115648022, Length=437, Percent_Identity=31.5789473684211, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI186910308, Length=436, Percent_Identity=29.5871559633028, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI186910306, Length=436, Percent_Identity=29.5871559633028, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI186910304, Length=436, Percent_Identity=29.5871559633028, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI33286428, Length=436, Percent_Identity=31.4220183486239, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI7657683, Length=438, Percent_Identity=31.2785388127854, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI187423910, Length=437, Percent_Identity=28.604118993135, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI7657591, Length=437, Percent_Identity=28.604118993135, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI9790235, Length=441, Percent_Identity=31.2925170068027, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI71979932, Length=444, Percent_Identity=30.6306306306306, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI71999149, Length=407, Percent_Identity=24.3243243243243, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI33286430, Length=247, Percent_Identity=28.7449392712551, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI258614005, Length=417, Percent_Identity=24.220623501199, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI258614003, Length=415, Percent_Identity=24.3373493975904, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4507047, Length=426, Percent_Identity=23.4741784037559, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI258645169, Length=372, Percent_Identity=23.9247311827957, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI114326544, Length=427, Percent_Identity=23.8875878220141, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI114326550, Length=427, Percent_Identity=23.8875878220141, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI110347453, Length=349, Percent_Identity=23.4957020057307, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI87082250, Length=437, Percent_Identity=27.2311212814645, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786694, Length=395, Percent_Identity=24.3037974683544, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI2367353, Length=321, Percent_Identity=27.4143302180685, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1787890, Length=402, Percent_Identity=23.3830845771144, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790584, Length=323, Percent_Identity=26.3157894736842, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081708, Length=429, Percent_Identity=21.4452214452214, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=444, Percent_Identity=27.7027027027027, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17568033, Length=449, Percent_Identity=27.6169265033408, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71993915, Length=401, Percent_Identity=27.1820448877805, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71995382, Length=402, Percent_Identity=26.865671641791, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71995388, Length=402, Percent_Identity=26.865671641791, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI32566699, Length=352, Percent_Identity=30.3977272727273, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71990446, Length=445, Percent_Identity=25.8426966292135, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI32566695, Length=428, Percent_Identity=25, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI193208714, Length=428, Percent_Identity=25, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71982612, Length=441, Percent_Identity=27.2108843537415, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71982608, Length=448, Percent_Identity=25.8928571428571, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17532491, Length=445, Percent_Identity=26.5168539325843, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17531343, Length=378, Percent_Identity=24.8677248677249, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982623, Length=270, Percent_Identity=28.8888888888889, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17533459, Length=332, Percent_Identity=24.6987951807229, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321751, Length=394, Percent_Identity=27.1573604060914, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321492, Length=363, Percent_Identity=23.4159779614325, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24651635, Length=430, Percent_Identity=29.5348837209302, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24651633, Length=430, Percent_Identity=29.5348837209302, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI221331183, Length=450, Percent_Identity=29.1111111111111, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17647653, Length=450, Percent_Identity=29.1111111111111, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24664379, Length=450, Percent_Identity=29.1111111111111, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24641993, Length=386, Percent_Identity=29.5336787564767, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24641995, Length=386, Percent_Identity=29.5336787564767, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI21357367, Length=437, Percent_Identity=28.3752860411899, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI45550968, Length=446, Percent_Identity=29.5964125560538, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI19921172, Length=446, Percent_Identity=29.5964125560538, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24667468, Length=399, Percent_Identity=25.062656641604, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24668806, Length=404, Percent_Identity=24.2574257425743, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356285, Length=404, Percent_Identity=24.2574257425743, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24668802, Length=404, Percent_Identity=24.2574257425743, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI221512776, Length=414, Percent_Identity=24.8792270531401, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666159, Length=414, Percent_Identity=24.8792270531401, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): STET_BACSU (O34739)

Other databases:

- EMBL:   AJ002571
- EMBL:   AL009126
- PIR:   B69855
- RefSeq:   NP_389169.1
- ProteinModelPortal:   O34739
- EnsemblBacteria:   EBBACT00000003293
- GeneID:   936518
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU12860
- NMPDR:   fig|224308.1.peg.1288
- GenoList:   BSU12860
- GeneTree:   EBGT00050000000869
- HOGENOM:   HBG714539
- OMA:   MALCYCE
- PhylomeDB:   O34739
- ProtClustDB:   CLSK2393379
- BioCyc:   BSUB:BSU12860-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 47149; Mature: 47149

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe54a5e8)-; HASH(0xe3eb280)-; HASH(0xe93c4e8)-; HASH(0xe840dd4)-; HASH(0xd9e3130)-; HASH(0xe941cec)-; HASH(0xe8e6e50)-; HASH(0xe6d0eb8)-; HASH(0xcaf186c)-; HASH(0xe2da5ec)-; HASH(0xe929234)-; HASH(0xe191044)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDSKMALFAWLLGGILTLA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHH
GGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIYGPAIIGALGLYFGSLMAN
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTIGKLIPIACIIVFGLWKGDQH
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEMKNPEKLLPRAMTGGLLIVTAIY
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHH
IFINFALLHILSANEIVTLGENATSTAATMLFGSIGGKLISVGIIVSIFGCLNGKVLSFP
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEECCC
RVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISFQIALALIMMLISNPDKLSEISIFMIY
HHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IFYVMAFFAVFILRKRAKGEKRAYSVPLYPFMPILAIAGSFFVLGSTLITDTMSCGLSIL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLAGLPVYYGMKKRKAS
HHHHCCHHHHCCHHHCCH
>Mature Secondary Structure
MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDSKMALFAWLLGGILTLA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHH
GGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIYGPAIIGALGLYFGSLMAN
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTIGKLIPIACIIVFGLWKGDQH
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEMKNPEKLLPRAMTGGLLIVTAIY
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHH
IFINFALLHILSANEIVTLGENATSTAATMLFGSIGGKLISVGIIVSIFGCLNGKVLSFP
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEECCC
RVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISFQIALALIMMLISNPDKLSEISIFMIY
HHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IFYVMAFFAVFILRKRAKGEKRAYSVPLYPFMPILAIAGSFFVLGSTLITDTMSCGLSIL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLAGLPVYYGMKKRKAS
HHHHCCHHHHCCHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377