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The map label for this gene is hemD

Identifier: 16078288

GI number: 16078288

Start: 1294138

End: 1294950

Strand: Direct

Name: hemD

Synonym: BSU12230

Alternate gene names: 16078288

Gene position: 1294138-1294950 (Clockwise)

Preceding gene: 16078287

Following gene: 16078292

Centisome position: 30.7

GC content: 50.31

Gene sequence:

>813_bases
ATGGGAAAAGGGTTACTTGGAAAACGCGTGGCAATCGGTGGCTCACGAAAAACGGAAGAAATTAGTACAATCATTGAAAA
ACAGGGCGGAATACCTGTCATCCGGCCTCTCCAAGGTACAGTTTACTTAGCAGAGAAGCAGGTGGAGCCGGATTTGCGGA
CGTTTGCGGAAGAAAAAGCTGACTGGGTCATTTTCACGACAGGCATCGGGTTGGAGACTCTTGTCGATATGGCAGAGAAA
ATTGGACTGAAAGATGAGTTTCTGCAGGCCATTCGCCAAGCGAAAGCGGCATGCCGGGGATACAAAACGCTGTCTGCGCT
GAAAAAGCTTGGAATCACACCGGAAGCTTCGGATGAAGACGGGACAACAAGAGGCTTAATCCGTTCCTTGGAGCCTCACG
ACTTTTCAGGAAAAACAGTCATGGTGCAGCTTCATGGCGAAAAAGCGCCGGCTCTCATGGCATTTCTTGAAGAAAAAGGC
GCGTCTGTCCTGCCGATTCTGCCTTATCAGCACATCCCGCCGGAGGAGGAAACGGTGGAGCGGTTATGCCGAGAGCTGAT
GAACGATGAGGTCGATGCCGTTTGTTTTACAACGGCCATTCAGGTTCGTTCCCTGTTTGATTTTGCCAAGGGGCGAGGTT
ATATCAATGAAGTGAAGAAGGTATTCGAAGAACGCGCCATCGCAGCTGCTGTCGGAAAAGTGACTGCTGAAGCACTGCGG
GAAGAGGGCATTACGAGACTGCTTGCGCCAGAGATTGAGCGGATGGGTGCGATGATTGTTGAGCTGGCCAAGTATTATGA
AGAAAAGGAATAA

Upstream 100 bases:

>100_bases
GAGGTTGGGTTTATCTTGATTTCTCCCTTGGTTTGCGCCAAAATAGCTTTATTAAGCTTATATACATAAAAAGCCTATGC
AAAGAGGAGAGGAAACGGGT

Downstream 100 bases:

>100_bases
CAAGTACAAAAAGCCGCTTTTCCCTCGGAAAGCGGCTTTTGTCTGTCATTCATTTTGCTTCAGCTGCTGATGAACGGTGA
ATAATGATGGGTATGTCAGC

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLAEKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEK
IGLKDEFLQAIRQAKAACRGYKTLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG
ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEVKKVFEERAIAAAVGKVTAEALR
EEGITRLLAPEIERMGAMIVELAKYYEEKE

Sequences:

>Translated_270_residues
MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLAEKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEK
IGLKDEFLQAIRQAKAACRGYKTLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG
ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEVKKVFEERAIAAAVGKVTAEALR
EEGITRLLAPEIERMGAMIVELAKYYEEKE
>Mature_269_residues
GKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLAEKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKI
GLKDEFLQAIRQAKAACRGYKTLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKGA
SVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEVKKVFEERAIAAAVGKVTAEALRE
EGITRLLAPEIERMGAMIVELAKYYEEKE

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YJJA_BACSU (O34394)

Other databases:

- EMBL:   AF015825
- EMBL:   AL009126
- PIR:   D69851
- RefSeq:   NP_389105.1
- HSSP:   Q5SKH2
- ProteinModelPortal:   O34394
- SMR:   O34394
- EnsemblBacteria:   EBBACT00000000474
- GeneID:   939823
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU12230
- NMPDR:   fig|224308.1.peg.1224
- GenoList:   BSU12230
- GeneTree:   EBGT00050000001272
- HOGENOM:   HBG313549
- OMA:   IGFRGWV
- ProtClustDB:   PRK05928
- BioCyc:   BSUB:BSU12230-MONOMER
- InterPro:   IPR003754

Pfam domain/function: PF02602 HEM4; SSF69618 HEM4_synth

EC number: NA

Molecular weight: Translated: 29837; Mature: 29706

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLAEKQVEPDLRTFAEEKA
CCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCEEECCCCEEEEECCCCCHHHHHHHHHCC
DWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYKTLSALKKLGITPEASDED
CEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKGASVLPILPYQHIPPEEETVE
CHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCHHHHH
RLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEVKKVFEERAIAAAVGKVTAEALR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEGITRLLAPEIERMGAMIVELAKYYEEKE
HHCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLAEKQVEPDLRTFAEEKA
CCCCCCCEEECCCCCCHHHHHHHHHHCCCCCEEECCCCEEEEECCCCCHHHHHHHHHCC
DWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYKTLSALKKLGITPEASDED
CEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKGASVLPILPYQHIPPEEETVE
CHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCHHHHH
RLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEVKKVFEERAIAAAVGKVTAEALR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEGITRLLAPEIERMGAMIVELAKYYEEKE
HHCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377