BacMap

Definition	Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome.
Accession	NC_000964
Length	4,215,606

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The map label for this gene is fabL

Identifier: 16077931

GI number: 16077931

Start: 937079

End: 937831

Strand: Direct

Name: fabL

Synonym: BSU08650

Alternate gene names: 16077931

Gene position: 937079-937831 (Clockwise)

Preceding gene: 16077929

Following gene: 16077932

Centisome position: 22.23

GC content: 46.35

Gene sequence:

>753_bases
ATGGAACAAAATAAATGTGCACTCGTAACAGGAAGCAGCCGCGGTGTCGGAAAAGCGGCCGCGATCAGACTTGCTGAGAA
CGGCTATAACATCGTCATTAACTATGCACGCAGCAAAAAAGCAGCATTAGAAACAGCGGAAGAAATCGAAAAGCTTGGCG
TTAAAGTGCTTGTCGTAAAAGCAAACGTAGGACAGCCTGCAAAAATCAAAGAAATGTTTCAGCAAATTGATGAAACGTTC
GGCAGACTTGATGTTTTTGTCAATAATGCCGCTTCAGGAGTACTAAGACCTGTCATGGAATTAGAAGAAACACACTGGGA
CTGGACGATGAACATTAATGCGAAAGCATTGCTTTTCTGCGCTCAGGAAGCTGCCAAGCTAATGGAGAAGAACGGTGGCG
GGCATATTGTCAGCATTAGTTCATTAGGCTCTATCCGCTATCTTGAAAACTACACCACGGTCGGTGTATCAAAAGCAGCG
TTAGAGGCTTTAACCCGTTATCTTGCCGTTGAGCTTTCACCAAAACAAATTATCGTCAATGCTGTTTCAGGCGGAGCGAT
CGACACAGATGCGCTGAAGCACTTCCCGAATAGAGAAGATCTGCTTGAGGATGCGCGCCAAAATACGCCGGCGGGACGCA
TGGTCGAAATTAAAGACATGGTTGATACTGTGGAGTTTCTAGTGTCTTCCAAGGCTGACATGATCCGCGGACAGACAATT
ATCGTTGACGGCGGACGCTCACTGCTCGTTTAA

Upstream 100 bases:

>100_bases
TATCACGTCCGACATACATAACAGAAGACCCCCTTTAAAGTTCTTGCCATTATTGTTTGTGGAAATAAAAGAACTATACG
CTACAAGGAGATGAGGAAAA

Downstream 100 bases:

>100_bases
AAATTTTTAAAAAAGAGGAATAGCTATACGATCACCTGCACATTCTAATGACCGTGGAGGTGATAACAATGGCTAACTCA
AATAACTTCAGCAAAACAAA

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETF
GRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA
LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIKDMVDTVEFLVSSKADMIRGQTI
IVDGGRSLLV

Sequences:

>Translated_250_residues
MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETF
GRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA
LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIKDMVDTVEFLVSSKADMIRGQTI
IVDGGRSLLV
>Mature_250_residues
MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETF
GRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA
LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIKDMVDTVEFLVSSKADMIRGQTI
IVDGGRSLLV

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

Homologues:

Organism=Homo sapiens, GI32483357, Length=243, Percent_Identity=32.0987654320988, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI126723750, Length=246, Percent_Identity=28.8617886178862, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI209862901, Length=206, Percent_Identity=33.495145631068, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI19923983, Length=206, Percent_Identity=33.495145631068, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI5031737, Length=242, Percent_Identity=30.9917355371901, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI19923817, Length=255, Percent_Identity=28.2352941176471, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI7705925, Length=239, Percent_Identity=28.8702928870293, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=28.1124497991968, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI126723191, Length=180, Percent_Identity=32.2222222222222, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI10190704, Length=245, Percent_Identity=27.3469387755102, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI33667109, Length=188, Percent_Identity=31.3829787234043, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI15277342, Length=250, Percent_Identity=28.4, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI66933014, Length=184, Percent_Identity=27.1739130434783, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI31542939, Length=233, Percent_Identity=26.1802575107296, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI40254986, Length=194, Percent_Identity=28.8659793814433, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI109715829, Length=242, Percent_Identity=28.099173553719, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI302344755, Length=103, Percent_Identity=36.8932038834951, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI4503301, Length=213, Percent_Identity=25.3521126760563, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4503817, Length=201, Percent_Identity=27.363184079602, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=31.4285714285714, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=33.8645418326693, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790717, Length=241, Percent_Identity=29.045643153527, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787905, Length=241, Percent_Identity=31.9502074688797, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=33.7349397590361, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082160, Length=243, Percent_Identity=30.4526748971193, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=30.6122448979592, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=28.2945736434109, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787545, Length=198, Percent_Identity=29.2929292929293, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI2367365, Length=242, Percent_Identity=30.1652892561983, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786812, Length=255, Percent_Identity=27.0588235294118, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=26.6129032258064, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=23.9382239382239, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=32.4427480916031, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI115534694, Length=245, Percent_Identity=32.6530612244898, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=31.2977099236641, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=29.4339622641509, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17560220, Length=267, Percent_Identity=32.2097378277154, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=31.9548872180451, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=30.9160305343511, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=30.3149606299213, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17555612, Length=203, Percent_Identity=33.9901477832512, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=30.4511278195489, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=30.8270676691729, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=27.2357723577236, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=28.6792452830189, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=27.5590551181102, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=251, Percent_Identity=29.0836653386454, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=30.0380228136882, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI86565303, Length=212, Percent_Identity=33.0188679245283, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17536025, Length=250, Percent_Identity=30, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71997099, Length=206, Percent_Identity=28.6407766990291, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=26.5384615384615, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=272, Percent_Identity=29.7794117647059, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=259, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565030, Length=269, Percent_Identity=29.7397769516729, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=250, Percent_Identity=28.8, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=26.9961977186312, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=260, Percent_Identity=27.3076923076923, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=270, Percent_Identity=28.1481481481481, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71982365, Length=186, Percent_Identity=27.4193548387097, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=249, Percent_Identity=27.3092369477912, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=24.3346007604563, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=25.9109311740891, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=250, Percent_Identity=27.6, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=137, Percent_Identity=27.7372262773723, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=181, Percent_Identity=27.0718232044199, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=252, Percent_Identity=28.968253968254, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=215, Percent_Identity=26.5116279069767, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355319, Length=242, Percent_Identity=35.1239669421488, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=31.2, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=31.3253012048193, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24643142, Length=256, Percent_Identity=30.46875, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=28.90625, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24644337, Length=208, Percent_Identity=28.3653846153846, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=28, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21357673, Length=183, Percent_Identity=25.1366120218579, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641388, Length=251, Percent_Identity=27.4900398406374, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24641232, Length=262, Percent_Identity=27.0992366412214, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859837, Length=188, Percent_Identity=28.1914893617021, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABL_BACSU (P71079)

Other databases:

- EMBL:   D85082
- EMBL:   Z82044
- EMBL:   AL009126
- PIR:   B69802
- RefSeq:   NP_388745.1
- HSSP:   Q01782
- ProteinModelPortal:   P71079
- SMR:   P71079
- EnsemblBacteria:   EBBACT00000003189
- GeneID:   939223
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU08650
- NMPDR:   fig|224308.1.peg.864
- GenoList:   BSU08650
- GeneTree:   EBGT00070000031994
- HOGENOM:   HBG750976
- OMA:   NYARSKK
- PhylomeDB:   P71079
- ProtClustDB:   PRK08063
- BioCyc:   BSUB:BSU08650-MONOMER
- GO:   GO:0005488
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PRINTS:   PR00081
- PRINTS:   PR00080

Pfam domain/function: PF00106 adh_short

EC number: =1.3.1.10

Molecular weight: Translated: 27179; Mature: 27179

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00061 ADH_SHORT

Important sites: ACT_SITE 151-151 BINDING 141-141

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVK
CCCCCEEEEECCCCCCCHHHEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEE
ANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFC
ECCCCCHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCEEEEE
AQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAALEALTRYLAVELSPKQIIVN
HHHHHHHHHCCCCCCEEEEECCCCEEEHHCCCCCCHHHHHHHHHHHHHHEECCCHHEEEE
AVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIKDMVDTVEFLVSSKADMIRGQTI
ECCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCHHHHCCCEE
IVDGGRSLLV
EEECCCEECC
>Mature Secondary Structure
MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVK
CCCCCEEEEECCCCCCCHHHEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEE
ANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFC
ECCCCCHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCEEEEE
AQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAALEALTRYLAVELSPKQIIVN
HHHHHHHHHCCCCCCEEEEECCCCEEEHHCCCCCCHHHHHHHHHHHHHHEECCCHHEEEE
AVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIKDMVDTVEFLVSSKADMIRGQTI
ECCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCHHHHCCCEE
IVDGGRSLLV
EEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377