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The map label for this gene is mntH

Identifier: 16077503

GI number: 16077503

Start: 491147

End: 492424

Strand: Reverse

Name: mntH

Synonym: BSU04360

Alternate gene names: 16077503

Gene position: 492424-491147 (Counterclockwise)

Preceding gene: 16077504

Following gene: 255767135

Centisome position: 11.68

GC content: 48.28

Gene sequence:

>1278_bases
ATGATGAACAAGGACATCACAGCACAATCTCCCCGTTCCAAAGCCGTCCAAGATGCGCTTGACGGGAAAATCAGAGGATT
CAGAGGGCTGCTCCCTTTTCTCGGCCCTGCATTTATAGCAGCCATTGCCTATATTGATCCCGGCAACTTCGCAACGAATA
TTTCGGCGGGTTCTAAATACGGATATATGCTCTTATGGGTGATCTTATTTTCCAATATCATGGCGCTTTTAATTCAATCC
CTATCCGCCAAACTCGGTATTGCGACAGGCAAAAATCTGCCTGAGGTTGCCCGTGAAGAATTCCCGAAGCCTGTCTCGAT
CGGATTATGGATTCAGGGCGAGTTGGTCATTATCGCAACTGATCTGGCGGAATTTATCGGAGCGGCTCTGGGACTGTATT
TGCTGTTCGGCATTCCGATGCTTGAAGCGTCTATTATTGCGGCGATCGGTTCTTTCGCGATATTGGAGCTTCAGCGCCGT
GGTTATCGCTCACTTGAAGCAGGTATTGCCGGTATGCTGTTTGTGGTCGTGATCGCCTTTGCGTTGCAGACCTTTTTCGC
AAAGCCTGATGCCGTGTCAGTGATGAAGGGCCTTTTTGTCCCGGCGTTTCATGGCACCGACAGTGTGCTTCTTGCAGCGG
GTATTCTTGGCGCAACTGTTATGCCGCACGCCATTTATTTACACTCTGCCCTTACACAGCGGCGGGTGGTTGGCAAAACT
GATGCAGAACGGAAAAAAATCTTTAGGTTTGAATTTATTGATATTTTAATAGCGATGCTGATTGCAGGGGCTATTAATGC
AAGTATGCTGATTGTGGCTGCCGCATTATTCTTCAAAAACGGCCTGTTTGTTGAGGATCTCGACGTCGCATTTCAGCAAT
TCGGACATCTTGTCAGCCCTATGTCTGCGGCTTTGTTCGGGATCGGGCTGCTCGTTGCCGGTCTATCCAGTTCGTCTGTC
GGCACACTTTCAGGCGACGTGATTATGCAAGGATTTATCAACTACCGCATTCCGCTGTATGTACGGCGTTTTATCACGAT
CATTCCGCCGATCTTGATCATCGCGTCAGGTGTTAATCCGACGACCGCTCTCGTACTGAGCCAGGTCGTGCTGTCCTTCG
GGATCGCCTTTGCCCTCATTCCGCTTATTATGTTTACAAGCAATAAACGGATCATGGGATCTCTGATCAACGCCAAATGG
ATCACAGTGGTGTCTTGGCTGATTGCTGTATTGATCGTTGCTTTGAATGTGTTTTTAATTGTAGATACGTTTCGATAA

Upstream 100 bases:

>100_bases
GTTGACAAGAAACCGGGATGGTCATATGATGTAGATAAAATAATTTGCCTTAAGGAAACTCTTTGTTGTACGGCAAAAAC
AAACAGAATTCAGGTGAGAC

Downstream 100 bases:

>100_bases
AAAAACCGGCTTCTAAAGCCGGTTTTTATTTTTCCGCAAAAGCTCATTGATACCCTTTTTGACAGAAATTTGTTATGATA
GAAGAAAAATCGGAGTTTTG

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAYIDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQS
LSAKLGIATGKNLPEVAREEFPKPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR
GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGATVMPHAIYLHSALTQRRVVGKT
DAERKKIFRFEFIDILIAMLIAGAINASMLIVAAALFFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSV
GTLSGDVIMQGFINYRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIMGSLINAKW
ITVVSWLIAVLIVALNVFLIVDTFR

Sequences:

>Translated_425_residues
MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAYIDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQS
LSAKLGIATGKNLPEVAREEFPKPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR
GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGATVMPHAIYLHSALTQRRVVGKT
DAERKKIFRFEFIDILIAMLIAGAINASMLIVAAALFFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSV
GTLSGDVIMQGFINYRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIMGSLINAKW
ITVVSWLIAVLIVALNVFLIVDTFR
>Mature_425_residues
MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAYIDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQS
LSAKLGIATGKNLPEVAREEFPKPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR
GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGATVMPHAIYLHSALTQRRVVGKT
DAERKKIFRFEFIDILIAMLIAGAINASMLIVAAALFFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSV
GTLSGDVIMQGFINYRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIMGSLINAKW
ITVVSWLIAVLIVALNVFLIVDTFR

Specific function: H(+)-stimulated, highly selective, manganese uptake system. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI109255241, Length=436, Percent_Identity=31.1926605504587, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI295293167, Length=430, Percent_Identity=32.7906976744186, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI295293178, Length=430, Percent_Identity=32.7906976744186, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI295293171, Length=430, Percent_Identity=32.7906976744186, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI295293169, Length=430, Percent_Identity=32.7906976744186, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI295293175, Length=430, Percent_Identity=32.7906976744186, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI295293173, Length=430, Percent_Identity=32.7906976744186, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI10835169, Length=430, Percent_Identity=32.7906976744186, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1788736, Length=394, Percent_Identity=50.761421319797, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI193210616, Length=462, Percent_Identity=30.3030303030303, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17569473, Length=396, Percent_Identity=33.8383838383838, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI71999499, Length=446, Percent_Identity=31.1659192825112, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71993856, Length=426, Percent_Identity=26.7605633802817, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323062, Length=393, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6321841, Length=436, Percent_Identity=32.3394495412844, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324450, Length=426, Percent_Identity=31.4553990610329, Blast_Score=176, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24648607, Length=435, Percent_Identity=30.5747126436782, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI281362176, Length=435, Percent_Identity=30.5747126436782, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24648609, Length=435, Percent_Identity=30.5747126436782, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI45553443, Length=411, Percent_Identity=31.1435523114355, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_BACSU (P96593)

Other databases:

- EMBL:   AB001488
- EMBL:   AL009126
- PIR:   A69770
- RefSeq:   NP_388317.1
- ProteinModelPortal:   P96593
- EnsemblBacteria:   EBBACT00000003634
- GeneID:   938241
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU04360
- NMPDR:   fig|224308.1.peg.436
- GenoList:   BSU04360
- GeneTree:   EBGT00050000002420
- HOGENOM:   HBG312498
- OMA:   ICKSEYP
- PhylomeDB:   P96593
- ProtClustDB:   PRK00701
- BioCyc:   BSUB:BSU04360-MONOMER
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447
- TIGRFAMs:   TIGR01197

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 45686; Mature: 45686

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd031998)-; HASH(0xc968f30)-; HASH(0xc917700)-; HASH(0xcb923bc)-; HASH(0xcbc6abc)-; HASH(0xb1517c8)-; HASH(0xb2a6b84)-; HASH(0xc5156d8)-; HASH(0xd3cd95c)-; HASH(0xc398110)-; HASH(0xb3d5ed4)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAYIDPGNFATNISAGSKY
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCH
GYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFPKPVSIGLWIQGELVIIAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCEEEEEH
DLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRRGYRSLEAGIAGMLFVVVIAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
ALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGATVMPHAIYLHSALTQRRVVGKT
HHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DAERKKIFRFEFIDILIAMLIAGAINASMLIVAAALFFKNGLFVEDLDVAFQQFGHLVSP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
MSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFINYRIPLYVRRFITIIPPILIIASGVNP
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCCH
TTALVLSQVVLSFGIAFALIPLIMFTSNKRIMGSLINAKWITVVSWLIAVLIVALNVFLI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDTFR
HCCCH
>Mature Secondary Structure
MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAYIDPGNFATNISAGSKY
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCH
GYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFPKPVSIGLWIQGELVIIAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCEEEEEH
DLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRRGYRSLEAGIAGMLFVVVIAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
ALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGATVMPHAIYLHSALTQRRVVGKT
HHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DAERKKIFRFEFIDILIAMLIAGAINASMLIVAAALFFKNGLFVEDLDVAFQQFGHLVSP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
MSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFINYRIPLYVRRFITIIPPILIIASGVNP
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCCH
TTALVLSQVVLSFGIAFALIPLIMFTSNKRIMGSLINAKWITVVSWLIAVLIVALNVFLI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDTFR
HCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10760146