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The map label for this gene is hisB [H]

Identifier: 159901179

GI number: 159901179

Start: 5964496

End: 5965086

Strand: Direct

Name: hisB [H]

Synonym: Haur_4667

Alternate gene names: 159901179

Gene position: 5964496-5965086 (Clockwise)

Preceding gene: 159901176

Following gene: 159901182

Centisome position: 93.98

GC content: 51.44

Gene sequence:

>591_bases
ATGGCTCGGATTGCAACGATCGAACGTAACACCCGTGAAACCCAAATTAAGCTCACGCTCAATCTCGATGGCTCTGGTCA
AGTGGCGATCAATACGGGCATCGGGATGTATAACCATATGTTGGAGAGTTTCGCTCGCCACGGTCAATTTGATTTAGCAG
TGACCTGCAATGGCGATTTACATATCGACGACCATCATTCGGTCGAAGATGTGGCAATTTGCTTGGGCATGGCGATTGAT
CGGGCGCTGGGCGATAAGGCTGGTATCACCCGCACCGCCCATGCTTATGTGCCGATGGATGAGGCGCTGGCGTTTGTTGC
GCTTGATCTGAGTGGCCGACCGTTTCATGTGCTCAACTTTAGCTGGACAAACCCTAGTATCGGTGGCTTGACCTGCGATT
TGGTTGAGCATGTGTTTGAAAGTATTGCGATTCATGCCCGCATGAATTTGCATGCGAAAATCGAATATGGCCGCAACGAC
CACCACAAGGCCGAAGCCTTATTCAAAGCTTTGGCGAGGGCACTCGATAGCGCCACCAAACATGATCCACGTTTGGGCGA
TGCGATTCCCAGCACCAAAGGCGTGATTTGA

Upstream 100 bases:

>100_bases
ATGGCGATGAGCTATCAGCGTGAAATCGTTATCAAGACTGGTTGGCAAAAATCGCCAGAGCAGGTACGATCAGGCAGCTT
TAGCGAAAGGATGCATAAGT

Downstream 100 bases:

>100_bases
TCGTTCCCCCCTCATTATAAGGGTAGGTTTTAATGATAATTGGGTGTAATTTGCCGTCGATTGACCTGCCCTCACCCCCT
GCCCCCTCTCCCGCCGAGCG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MARIATIERNTRETQIKLTLNLDGSGQVAINTGIGMYNHMLESFARHGQFDLAVTCNGDLHIDDHHSVEDVAICLGMAID
RALGDKAGITRTAHAYVPMDEALAFVALDLSGRPFHVLNFSWTNPSIGGLTCDLVEHVFESIAIHARMNLHAKIEYGRND
HHKAEALFKALARALDSATKHDPRLGDAIPSTKGVI

Sequences:

>Translated_196_residues
MARIATIERNTRETQIKLTLNLDGSGQVAINTGIGMYNHMLESFARHGQFDLAVTCNGDLHIDDHHSVEDVAICLGMAID
RALGDKAGITRTAHAYVPMDEALAFVALDLSGRPFHVLNFSWTNPSIGGLTCDLVEHVFESIAIHARMNLHAKIEYGRND
HHKAEALFKALARALDSATKHDPRLGDAIPSTKGVI
>Mature_195_residues
ARIATIERNTRETQIKLTLNLDGSGQVAINTGIGMYNHMLESFARHGQFDLAVTCNGDLHIDDHHSVEDVAICLGMAIDR
ALGDKAGITRTAHAYVPMDEALAFVALDLSGRPFHVLNFSWTNPSIGGLTCDLVEHVFESIAIHARMNLHAKIEYGRNDH
HKAEALFKALARALDSATKHDPRLGDAIPSTKGVI

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=45.8762886597938, Blast_Score=173, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=37.962962962963, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21402; Mature: 21270

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIATIERNTRETQIKLTLNLDGSGQVAINTGIGMYNHMLESFARHGQFDLAVTCNGDL
CCEEEEEECCCCEEEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCE
HIDDHHSVEDVAICLGMAIDRALGDKAGITRTAHAYVPMDEALAFVALDLSGRPFHVLNF
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHCEEEEEEECCCCCEEEEEE
SWTNPSIGGLTCDLVEHVFESIAIHARMNLHAKIEYGRNDHHKAEALFKALARALDSATK
EECCCCCCCEEHHHHHHHHHHHEEHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHC
HDPRLGDAIPSTKGVI
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARIATIERNTRETQIKLTLNLDGSGQVAINTGIGMYNHMLESFARHGQFDLAVTCNGDL
CEEEEEECCCCEEEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCE
HIDDHHSVEDVAICLGMAIDRALGDKAGITRTAHAYVPMDEALAFVALDLSGRPFHVLNF
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHCEEEEEEECCCCCEEEEEE
SWTNPSIGGLTCDLVEHVFESIAIHARMNLHAKIEYGRNDHHKAEALFKALARALDSATK
EECCCCCCCEEHHHHHHHHHHHEEHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHC
HDPRLGDAIPSTKGVI
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA