Click here to switch to the map view.

The map label for this gene is phoR [H]

Identifier: 159901176

GI number: 159901176

Start: 5961370

End: 5962611

Strand: Direct

Name: phoR [H]

Synonym: Haur_4664

Alternate gene names: 159901176

Gene position: 5961370-5962611 (Clockwise)

Preceding gene: 159901175

Following gene: 159901179

Centisome position: 93.93

GC content: 53.06

Gene sequence:

>1242_bases
ATGAGACGTTTTTTGCATCAATCGAGCCTTTTGTTGTTGACCTTGGCGATTGCTCTGGGCTTGGTAAGTTTGGTCGGTCA
CTTTGGCTTGATGCTGCCAATGAGCGAATTAGAAGGCATCATCAAGCTGTTTGGCTCGCTGGGCTTTGGTGCTGGCATCG
TGGCAATCGTCGCCTTACAAAGCCGGATGCTCTCGCTGTTGCGTAGTTTGCGAGCGCAAATTATTGCCGCGATTGGCCTT
GGTGGAATTTTGGTTGCGGCCTTGTTGCAAGGCGTAGCGCGGGCCATGTTCATCAGTACCGACCACGATTTGCCCTTGCT
CTTATTGGTTTTGATTTTTATGTTGGTGCTGGCTTTGGGGTTTAGCATTGCGGTTGGTAATGTCTTGGTGGCGCGTTTGG
CCGAGGTTCGCGCAGGAGCCGCTGCGCTGGCCAAGGGCGATTTGGCTTTGCGAATTCCTGAACATGGTAATGATGAAGTC
AGTATTTTGGCCGCCGATTTTAACCAAATGGCCGATGCTTTAGCCCAAAGTGCTGAGCGCCAGCACGAGCTTGAACAATC
GCGCCGCGATTTGATTGCGGCGATCTCGCACGATTTGCGTACCCCGTTGACGGCGGTGCGGGCGATGATCGAGGCCTTAG
CTGATGGTGTGGTAACTGAGCCAGCCATGCAGCAGCGCTACCTCAATTCGGCCAATTCTCAATTGACTAACCTAAGCACC
TTAGTTGATGATTTATTTGAGATGGCCCAACTTGATGCTGGAGTGTTGCGTTTGGAACTAGAACGCGCCTCGCTCGGCGA
TTTAATCTCTGATACGCTGAGCAACTTGCAGCCGCATGCCGCAGCCCATGGCGTGCAATTGCGTGGTAGCGTCGCGCCCG
AAGCCGATTTGGTGCTGATGAATGCGCCCAAATTGCAACGAGTGTTGTATAACTTGATTAGCAATGCGCTGCGCCACACG
CCGAGCGATGGCACAATCGCGATTCAGGCCCAAACGATCAACCAAACCGTGCATGTCGAAGTTAGCGACACTGGCGAAGG
CATTCAGCCCGACGATTTACCACATATTTTCGAGCGTACCTATCGCGGCGAAAAATCGCGTTCGCGTGATTATGGCGGGG
CAGGTTTGGGCTTGGCGATTGTACGGGCGATTGTTGAGGCCCATGGTGGCAACGTTTGGGTTGAAAGCCAGCCTCAGCAT
GGCGCACGCTTTGTCTTTACCCTGCAAACTCCAGTTAACTAA

Upstream 100 bases:

>100_bases
ATATTCGGCGCTTGCGCGAAAAAATCGAAGACGATCCGACTGCCCCGCGTTATTTGCAAACAGTTTGGGGCGTGGGCTAC
AAACTCAGCGCAGGCGAACA

Downstream 100 bases:

>100_bases
TAGGCTAGGGGGAACCACGAAACCAAAAGCCCCTCGCCCGCCGCAGTGGGAGAGGGGTTGGGGTGAGGGTATTAATCAAG
CACGCGCCGATAAACTGCCA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MRRFLHQSSLLLLTLAIALGLVSLVGHFGLMLPMSELEGIIKLFGSLGFGAGIVAIVALQSRMLSLLRSLRAQIIAAIGL
GGILVAALLQGVARAMFISTDHDLPLLLLVLIFMLVLALGFSIAVGNVLVARLAEVRAGAAALAKGDLALRIPEHGNDEV
SILAADFNQMADALAQSAERQHELEQSRRDLIAAISHDLRTPLTAVRAMIEALADGVVTEPAMQQRYLNSANSQLTNLST
LVDDLFEMAQLDAGVLRLELERASLGDLISDTLSNLQPHAAAHGVQLRGSVAPEADLVLMNAPKLQRVLYNLISNALRHT
PSDGTIAIQAQTINQTVHVEVSDTGEGIQPDDLPHIFERTYRGEKSRSRDYGGAGLGLAIVRAIVEAHGGNVWVESQPQH
GARFVFTLQTPVN

Sequences:

>Translated_413_residues
MRRFLHQSSLLLLTLAIALGLVSLVGHFGLMLPMSELEGIIKLFGSLGFGAGIVAIVALQSRMLSLLRSLRAQIIAAIGL
GGILVAALLQGVARAMFISTDHDLPLLLLVLIFMLVLALGFSIAVGNVLVARLAEVRAGAAALAKGDLALRIPEHGNDEV
SILAADFNQMADALAQSAERQHELEQSRRDLIAAISHDLRTPLTAVRAMIEALADGVVTEPAMQQRYLNSANSQLTNLST
LVDDLFEMAQLDAGVLRLELERASLGDLISDTLSNLQPHAAAHGVQLRGSVAPEADLVLMNAPKLQRVLYNLISNALRHT
PSDGTIAIQAQTINQTVHVEVSDTGEGIQPDDLPHIFERTYRGEKSRSRDYGGAGLGLAIVRAIVEAHGGNVWVESQPQH
GARFVFTLQTPVN
>Mature_413_residues
MRRFLHQSSLLLLTLAIALGLVSLVGHFGLMLPMSELEGIIKLFGSLGFGAGIVAIVALQSRMLSLLRSLRAQIIAAIGL
GGILVAALLQGVARAMFISTDHDLPLLLLVLIFMLVLALGFSIAVGNVLVARLAEVRAGAAALAKGDLALRIPEHGNDEV
SILAADFNQMADALAQSAERQHELEQSRRDLIAAISHDLRTPLTAVRAMIEALADGVVTEPAMQQRYLNSANSQLTNLST
LVDDLFEMAQLDAGVLRLELERASLGDLISDTLSNLQPHAAAHGVQLRGSVAPEADLVLMNAPKLQRVLYNLISNALRHT
PSDGTIAIQAQTINQTVHVEVSDTGEGIQPDDLPHIFERTYRGEKSRSRDYGGAGLGLAIVRAIVEAHGGNVWVESQPQH
GARFVFTLQTPVN

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=35.9848484848485, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1786783, Length=269, Percent_Identity=34.5724907063197, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=33.0508474576271, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1786600, Length=270, Percent_Identity=30, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787894, Length=353, Percent_Identity=30.3116147308782, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789149, Length=243, Percent_Identity=28.3950617283951, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=29.4354838709677, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=29.4545454545455, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=25.3061224489796, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789808, Length=287, Percent_Identity=27.1777003484321, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI87081816, Length=228, Percent_Identity=30.2631578947368, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=29.1479820627803, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788549, Length=250, Percent_Identity=29.2, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788279, Length=262, Percent_Identity=29.3893129770992, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=25.3275109170306, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790861, Length=245, Percent_Identity=28.9795918367347, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789403, Length=266, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44201; Mature: 44201

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRFLHQSSLLLLTLAIALGLVSLVGHFGLMLPMSELEGIIKLFGSLGFGAGIVAIVALQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
SRMLSLLRSLRAQIIAAIGLGGILVAALLQGVARAMFISTDHDLPLLLLVLIFMLVLALG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FSIAVGNVLVARLAEVRAGAAALAKGDLALRIPEHGNDEVSILAADFNQMADALAQSAER
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHH
QHELEQSRRDLIAAISHDLRTPLTAVRAMIEALADGVVTEPAMQQRYLNSANSQLTNLST
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LVDDLFEMAQLDAGVLRLELERASLGDLISDTLSNLQPHAAAHGVQLRGSVAPEADLVLM
HHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHCCCCHHHHCCCEEECCCCCCCCEEEE
NAPKLQRVLYNLISNALRHTPSDGTIAIQAQTINQTVHVEVSDTGEGIQPDDLPHIFERT
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEEEEECCCCCCCCCCCHHHHHHHH
YRGEKSRSRDYGGAGLGLAIVRAIVEAHGGNVWVESQPQHGARFVFTLQTPVN
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MRRFLHQSSLLLLTLAIALGLVSLVGHFGLMLPMSELEGIIKLFGSLGFGAGIVAIVALQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
SRMLSLLRSLRAQIIAAIGLGGILVAALLQGVARAMFISTDHDLPLLLLVLIFMLVLALG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FSIAVGNVLVARLAEVRAGAAALAKGDLALRIPEHGNDEVSILAADFNQMADALAQSAER
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHH
QHELEQSRRDLIAAISHDLRTPLTAVRAMIEALADGVVTEPAMQQRYLNSANSQLTNLST
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LVDDLFEMAQLDAGVLRLELERASLGDLISDTLSNLQPHAAAHGVQLRGSVAPEADLVLM
HHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHCCCCHHHHCCCEEECCCCCCCCEEEE
NAPKLQRVLYNLISNALRHTPSDGTIAIQAQTINQTVHVEVSDTGEGIQPDDLPHIFERT
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEEEEECCCCCCCCCCCHHHHHHHH
YRGEKSRSRDYGGAGLGLAIVRAIVEAHGGNVWVESQPQHGARFVFTLQTPVN
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]