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The map label for this gene is hemY [H]

Identifier: 159901171

GI number: 159901171

Start: 5955196

End: 5956626

Strand: Direct

Name: hemY [H]

Synonym: Haur_4659

Alternate gene names: 159901171

Gene position: 5955196-5956626 (Clockwise)

Preceding gene: 159901170

Following gene: 159901174

Centisome position: 93.83

GC content: 53.39

Gene sequence:

>1431_bases
ATGGATGTTGCTGATCAGCCACGCATTGCCATTATTGGCGGTGGTATCGCTGGCCTTAGTACAGCATGGTATTTACAACA
ACAAGGTCTCACGAATATTCAGCTTTTTGAACGTGATCAACGGCTGGGCGGCAAATTGCGCACCAGCCATGTTGCCTTGC
CCGATGGCGCTGGCGAATTGCTGGTCGAAGCTGGCCCCGATGCCTTTATCAGCCAAAAGCCTTGGGGCTTGCAATTGGCG
CGTGAGTTGGGCTTGGAAGATCAGTTAATTTCAACTGAGCCAGCTCGCCATAAGGTGTTTGTGTTGCATCGTGGCAAGCC
CGAACCCTTGCCTGATGGCATTAACTTGGTTGTCCCAACTGAGTTTTGGCCGTTGCTGCGCACGCCGATTCTCTCGCTGC
CAGGCAAATTGCGTATGTTGCTCGATTTGGTCTTGCCTGCCCGCCAAAGTAATACTGATGAATCGCTGGCCGATTTTGTG
CGCCGCCGATTTGGGGCCGAAGCGCTGGATAAATTGGCCGAGCCGTTGATGGCAGGCATTCACAATGCAGAATCGGATCG
CCAAAGCCTCGAAGCCACCTTTCCACGCTTTATCGAGGCCGAACGCAGCCATGGCAGTGTGATTCGTGGGATTCTGGCGG
CTAAACTTAAAGCAGGCAAGCCCAAAGGTCAGCAACTTAGCCCATTTATTAGCTTACGCGGCGGGATCGAGCAATTAATT
ACCGCGCTGGTTGAGCAGCTCAACGTTGAAATTCGGACAAATTGTGGGGTTCAAGCGCTGCGCTACGACCCAACCAACGC
CTCAGCCTATCAACTGACCCTCGATGATGGCACGAAGATTGATGCTGATGCAGTGGTGTTGGCAGTGCCTAGTTTTGTGG
CCGCTGAGTTGGTCGCACCTTGGGCTGAAGCCTTGGCCGAGCGCTTGAAGGCGATTCGTTATGTCAGCACTGGCACAGTT
TCGTTGGCATTTCGGCGTAGCGAAACCAACATGGCCTTCGATAGTTATGGCTTGGTGATTCCGCGCAGCGAATATCGGCT
GATTAATGCTGTAACGATCAACTCACGCAAATTTGCTGGGCGTGCTCCCGCCGATTATATGCTGTTGCGGGCCTTTGTGG
GCGGCTCGAAACATCCCGAAGTGCTGCGCTTGGATGATCAGGCATTAACTCAATTGGTGCGTGATCAGCTTAAATCGATT
TTTGGCCTGACCGCCGAGCCAATTTGGAGCGGGGTTGCCCGTTGGAACGAGGCTAATCCCCAATACGATGTTGGTCATTT
CCAACGTATGGATCAGCTTGAGGCCTTGTGTCCAGAAGGCTTGTTGTTGTGTGGCAGCGGCTTTCGGGGCGTGGGCATTC
CCGATTGTGTGCGCCAAGGCCAAGCAACCGCTCAGGCCATTAGCCAATTGTTCGCTTTGGCTAACGCTTAA

Upstream 100 bases:

>100_bases
TAACGTTGCCTAATCTCCACCAGATCCATTCAATAACCGATTGACAGAATCCGCCAACCCTTGCAAACTAAGCCTAGTTT
TCACTACGATGAGGTTTGCA

Downstream 100 bases:

>100_bases
TTTAAAAAGCCCACGGCATTTAGCTTTGCCGTGGGCTTGCTATTTTAGACGTTTTTGGTTTGGCTGATAAAGGCTTCGAG
GTCGCTTTTTAGCTCAGCCA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MDVADQPRIAIIGGGIAGLSTAWYLQQQGLTNIQLFERDQRLGGKLRTSHVALPDGAGELLVEAGPDAFISQKPWGLQLA
RELGLEDQLISTEPARHKVFVLHRGKPEPLPDGINLVVPTEFWPLLRTPILSLPGKLRMLLDLVLPARQSNTDESLADFV
RRRFGAEALDKLAEPLMAGIHNAESDRQSLEATFPRFIEAERSHGSVIRGILAAKLKAGKPKGQQLSPFISLRGGIEQLI
TALVEQLNVEIRTNCGVQALRYDPTNASAYQLTLDDGTKIDADAVVLAVPSFVAAELVAPWAEALAERLKAIRYVSTGTV
SLAFRRSETNMAFDSYGLVIPRSEYRLINAVTINSRKFAGRAPADYMLLRAFVGGSKHPEVLRLDDQALTQLVRDQLKSI
FGLTAEPIWSGVARWNEANPQYDVGHFQRMDQLEALCPEGLLLCGSGFRGVGIPDCVRQGQATAQAISQLFALANA

Sequences:

>Translated_476_residues
MDVADQPRIAIIGGGIAGLSTAWYLQQQGLTNIQLFERDQRLGGKLRTSHVALPDGAGELLVEAGPDAFISQKPWGLQLA
RELGLEDQLISTEPARHKVFVLHRGKPEPLPDGINLVVPTEFWPLLRTPILSLPGKLRMLLDLVLPARQSNTDESLADFV
RRRFGAEALDKLAEPLMAGIHNAESDRQSLEATFPRFIEAERSHGSVIRGILAAKLKAGKPKGQQLSPFISLRGGIEQLI
TALVEQLNVEIRTNCGVQALRYDPTNASAYQLTLDDGTKIDADAVVLAVPSFVAAELVAPWAEALAERLKAIRYVSTGTV
SLAFRRSETNMAFDSYGLVIPRSEYRLINAVTINSRKFAGRAPADYMLLRAFVGGSKHPEVLRLDDQALTQLVRDQLKSI
FGLTAEPIWSGVARWNEANPQYDVGHFQRMDQLEALCPEGLLLCGSGFRGVGIPDCVRQGQATAQAISQLFALANA
>Mature_476_residues
MDVADQPRIAIIGGGIAGLSTAWYLQQQGLTNIQLFERDQRLGGKLRTSHVALPDGAGELLVEAGPDAFISQKPWGLQLA
RELGLEDQLISTEPARHKVFVLHRGKPEPLPDGINLVVPTEFWPLLRTPILSLPGKLRMLLDLVLPARQSNTDESLADFV
RRRFGAEALDKLAEPLMAGIHNAESDRQSLEATFPRFIEAERSHGSVIRGILAAKLKAGKPKGQQLSPFISLRGGIEQLI
TALVEQLNVEIRTNCGVQALRYDPTNASAYQLTLDDGTKIDADAVVLAVPSFVAAELVAPWAEALAERLKAIRYVSTGTV
SLAFRRSETNMAFDSYGLVIPRSEYRLINAVTINSRKFAGRAPADYMLLRAFVGGSKHPEVLRLDDQALTQLVRDQLKSI
FGLTAEPIWSGVARWNEANPQYDVGHFQRMDQLEALCPEGLLLCGSGFRGVGIPDCVRQGQATAQAISQLFALANA

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=490, Percent_Identity=27.1428571428571, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4506001, Length=490, Percent_Identity=27.1428571428571, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24649745, Length=485, Percent_Identity=23.5051546391753, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 51992; Mature: 51992

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVADQPRIAIIGGGIAGLSTAWYLQQQGLTNIQLFERDQRLGGKLRTSHVALPDGAGEL
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEECEEECCCCCCCE
LVEAGPDAFISQKPWGLQLARELGLEDQLISTEPARHKVFVLHRGKPEPLPDGINLVVPT
EEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECC
EFWPLLRTPILSLPGKLRMLLDLVLPARQSNTDESLADFVRRRFGAEALDKLAEPLMAGI
CHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
HNAESDRQSLEATFPRFIEAERSHGSVIRGILAAKLKAGKPKGQQLSPFISLRGGIEQLI
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHH
TALVEQLNVEIRTNCGVQALRYDPTNASAYQLTLDDGTKIDADAVVLAVPSFVAAELVAP
HHHHHHCCCEEECCCCEEEEEECCCCCCEEEEEECCCCEECCCEEEEEHHHHHHHHHHHH
WAEALAERLKAIRYVSTGTVSLAFRRSETNMAFDSYGLVIPRSEYRLINAVTINSRKFAG
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEECCCCEEEECCCCEEEEEEEECCCCCCC
RAPADYMLLRAFVGGSKHPEVLRLDDQALTQLVRDQLKSIFGLTAEPIWSGVARWNEANP
CCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
QYDVGHFQRMDQLEALCPEGLLLCGSGFRGVGIPDCVRQGQATAQAISQLFALANA
CCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDVADQPRIAIIGGGIAGLSTAWYLQQQGLTNIQLFERDQRLGGKLRTSHVALPDGAGEL
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEECEEECCCCCCCE
LVEAGPDAFISQKPWGLQLARELGLEDQLISTEPARHKVFVLHRGKPEPLPDGINLVVPT
EEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECC
EFWPLLRTPILSLPGKLRMLLDLVLPARQSNTDESLADFVRRRFGAEALDKLAEPLMAGI
CHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
HNAESDRQSLEATFPRFIEAERSHGSVIRGILAAKLKAGKPKGQQLSPFISLRGGIEQLI
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHH
TALVEQLNVEIRTNCGVQALRYDPTNASAYQLTLDDGTKIDADAVVLAVPSFVAAELVAP
HHHHHHCCCEEECCCCEEEEEECCCCCCEEEEEECCCCEECCCEEEEEHHHHHHHHHHHH
WAEALAERLKAIRYVSTGTVSLAFRRSETNMAFDSYGLVIPRSEYRLINAVTINSRKFAG
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEECCCCEEEECCCCEEEEEEEECCCCCCC
RAPADYMLLRAFVGGSKHPEVLRLDDQALTQLVRDQLKSIFGLTAEPIWSGVARWNEANP
CCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
QYDVGHFQRMDQLEALCPEGLLLCGSGFRGVGIPDCVRQGQATAQAISQLFALANA
CCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]