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The map label for this gene is ffh [H]

Identifier: 159901134

GI number: 159901134

Start: 5907070

End: 5908419

Strand: Reverse

Name: ffh [H]

Synonym: Haur_4622

Alternate gene names: 159901134

Gene position: 5908419-5907070 (Counterclockwise)

Preceding gene: 159901137

Following gene: 159901133

Centisome position: 93.1

GC content: 50.67

Gene sequence:

>1350_bases
ATGTTTGAGAATCTATCCGACCGCTTAACCGATGTTTTCAACCGGTTGGGCAGCAAAGGCCGCCTAACTGAATCTGATGT
TGATGCGGGCTTGCGCGAAGTGCGTTTGGCCTTGTTGGAAGCAGACGTTAACTTCAAAGTCGTCAAAGATTTTGTGGCGC
GGGTGCGCGAACAAGCGATTGGCGAAGAAGTCACCAAGAGTTTGACTCCTGGTCAACAAGTGATCAAAATCGTTCACGAC
GAGTTGGTGCACTTGCTTGGTGATGCCAATGTGCCGATCAACGAATCGAAAAACCGCGAGCAACCGACGATTGTGATGTT
GGTCGGGTTACAAGGTGCTGGTAAAACAACCATGGCTGCCAAATTGGCGCTGTATATGCGCAAAAAAGGCAAAACGCCAT
TGTTGGTTGCCGCCGACATCTACCGACCCGCCGCGATCAAGCAGTTGGAAACGCTCGGCAAGCAATTGAATATTCCGGTT
TATAGCGAAGGTACTGAGGTTGCGCCGCCCGATATCGCTGAGCACGCCTTGCGCCAAGCGCGAATCAATGGCAACAACTT
TGTGATCGTCGATACCGCCGGACGCTTGCAAATCGACGAACGCTTGATGACCGAATTACAACAAGTCGTCGAACGCATTG
GCCCAACCGAAATTATGTTGGTCGTCGATGCCATGATCGGTCAAGAATCAGTCAAAGTGGCCGAGGCCTTCCATGCCAAA
GTACCATTAACTGGCTTGATTATGACCAAGATCGACGGCGATGCCCGTGGTGGGGCGGCGCTCTCGATGCGCGAAGTCAC
TGGAGTGCCAATTAAGTTCCTTGGGACGGGCGAAAAAACCGATGCCATCGAACCATTCCACCCCGATCGTCTAGCCCAAC
GAATTTTGGGCATGGGCGATGTGATGACCTTGATCGAGCGAGCTGAGCAAGTTTATGATAAAGATGAAGCCAAGAAAATG
CAAAAGAAGATGCGCAAAGGCACCTTCGACTTTGAAGATTTCCTTGGCGCAATGAATTCAATGCGTAAACTTGGCCCAAT
CCAACAAATCTTGGGCATGATTCCTGGGCTAGGCAAGCAAATGCGCCAAATGAAAGAGCTTGATGAAGCCCTTGATGATC
GCGAAATGAAACGGATCGAAGCAATTATTCAATCGATGACGATCAAAGAGCGCCGTAACCCCGACTTGCTCAAAGATCCC
AGCCGCAAGCGCCGGATCTCAGTTGGTAGTGGTACACGGATCGAAGATGTCAATGCATTGGTTAAGCAGTTCCGCGAAAT
GCAACGCATGATGAAACGCTTCAGCAAGGGCGGCCAAAACCCGCGCGACCTGATGCGCATGTTCAAATAA

Upstream 100 bases:

>100_bases
TGTGTAATCAACTACAATGCGACAAAATGCTGACAGGAAACTCTCCACGCTAGGGCGTGCCAAGTTTCTGCCAGTTTTTT
CTGTTGCGGTGAGGTGTATG

Downstream 100 bases:

>100_bases
TTATTCATAGAACATAGAGCATAGAACATAGAACATAGAATGTTTGTGGCCTATAAATCGTGTTCTAGCTTTACTTTTCA
ATTTTGGAGGAAACACTCGA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFENLSDRLTDVFNRLGSKGRLTESDVDAGLREVRLALLEADVNFKVVKDFVARVREQAIGEEVTKSLTPGQQVIKIVHD
ELVHLLGDANVPINESKNREQPTIVMLVGLQGAGKTTMAAKLALYMRKKGKTPLLVAADIYRPAAIKQLETLGKQLNIPV
YSEGTEVAPPDIAEHALRQARINGNNFVIVDTAGRLQIDERLMTELQQVVERIGPTEIMLVVDAMIGQESVKVAEAFHAK
VPLTGLIMTKIDGDARGGAALSMREVTGVPIKFLGTGEKTDAIEPFHPDRLAQRILGMGDVMTLIERAEQVYDKDEAKKM
QKKMRKGTFDFEDFLGAMNSMRKLGPIQQILGMIPGLGKQMRQMKELDEALDDREMKRIEAIIQSMTIKERRNPDLLKDP
SRKRRISVGSGTRIEDVNALVKQFREMQRMMKRFSKGGQNPRDLMRMFK

Sequences:

>Translated_449_residues
MFENLSDRLTDVFNRLGSKGRLTESDVDAGLREVRLALLEADVNFKVVKDFVARVREQAIGEEVTKSLTPGQQVIKIVHD
ELVHLLGDANVPINESKNREQPTIVMLVGLQGAGKTTMAAKLALYMRKKGKTPLLVAADIYRPAAIKQLETLGKQLNIPV
YSEGTEVAPPDIAEHALRQARINGNNFVIVDTAGRLQIDERLMTELQQVVERIGPTEIMLVVDAMIGQESVKVAEAFHAK
VPLTGLIMTKIDGDARGGAALSMREVTGVPIKFLGTGEKTDAIEPFHPDRLAQRILGMGDVMTLIERAEQVYDKDEAKKM
QKKMRKGTFDFEDFLGAMNSMRKLGPIQQILGMIPGLGKQMRQMKELDEALDDREMKRIEAIIQSMTIKERRNPDLLKDP
SRKRRISVGSGTRIEDVNALVKQFREMQRMMKRFSKGGQNPRDLMRMFK
>Mature_449_residues
MFENLSDRLTDVFNRLGSKGRLTESDVDAGLREVRLALLEADVNFKVVKDFVARVREQAIGEEVTKSLTPGQQVIKIVHD
ELVHLLGDANVPINESKNREQPTIVMLVGLQGAGKTTMAAKLALYMRKKGKTPLLVAADIYRPAAIKQLETLGKQLNIPV
YSEGTEVAPPDIAEHALRQARINGNNFVIVDTAGRLQIDERLMTELQQVVERIGPTEIMLVVDAMIGQESVKVAEAFHAK
VPLTGLIMTKIDGDARGGAALSMREVTGVPIKFLGTGEKTDAIEPFHPDRLAQRILGMGDVMTLIERAEQVYDKDEAKKM
QKKMRKGTFDFEDFLGAMNSMRKLGPIQQILGMIPGLGKQMRQMKELDEALDDREMKRIEAIIQSMTIKERRNPDLLKDP
SRKRRISVGSGTRIEDVNALVKQFREMQRMMKRFSKGGQNPRDLMRMFK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=435, Percent_Identity=35.4022988505747, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI226371618, Length=377, Percent_Identity=35.5437665782493, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI89061728, Length=164, Percent_Identity=39.0243902439024, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI23308697, Length=292, Percent_Identity=28.4246575342466, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI295424842, Length=292, Percent_Identity=28.4246575342466, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1788963, Length=431, Percent_Identity=50.5800464037123, Blast_Score=433, Evalue=1e-123,
Organism=Escherichia coli, GI1789874, Length=267, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=434, Percent_Identity=32.7188940092166, Blast_Score=251, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI193206261, Length=253, Percent_Identity=32.0158102766798, Blast_Score=101, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=419, Percent_Identity=35.0835322195704, Blast_Score=242, Evalue=7e-65,
Organism=Drosophila melanogaster, GI17647949, Length=434, Percent_Identity=32.7188940092166, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24641198, Length=253, Percent_Identity=29.2490118577075, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50315; Mature: 50315

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLSDRLTDVFNRLGSKGRLTESDVDAGLREVRLALLEADVNFKVVKDFVARVREQAI
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVTKSLTPGQQVIKIVHDELVHLLGDANVPINESKNREQPTIVMLVGLQGAGKTTMAA
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHH
KLALYMRKKGKTPLLVAADIYRPAAIKQLETLGKQLNIPVYSEGTEVAPPDIAEHALRQA
HHHHHHHHCCCCCEEEEHHHHCHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHH
RINGNNFVIVDTAGRLQIDERLMTELQQVVERIGPTEIMLVVDAMIGQESVKVAEAFHAK
HCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHCC
VPLTGLIMTKIDGDARGGAALSMREVTGVPIKFLGTGEKTDAIEPFHPDRLAQRILGMGD
CCCCEEEEEEECCCCCCCCEEEHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCHH
VMTLIERAEQVYDKDEAKKMQKKMRKGTFDFEDFLGAMNSMRKLGPIQQILGMIPGLGKQ
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHH
MRQMKELDEALDDREMKRIEAIIQSMTIKERRNPDLLKDPSRKRRISVGSGTRIEDVNAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCEEECCCCCCHHHHHHH
VKQFREMQRMMKRFSKGGQNPRDLMRMFK
HHHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure
MFENLSDRLTDVFNRLGSKGRLTESDVDAGLREVRLALLEADVNFKVVKDFVARVREQAI
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVTKSLTPGQQVIKIVHDELVHLLGDANVPINESKNREQPTIVMLVGLQGAGKTTMAA
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHH
KLALYMRKKGKTPLLVAADIYRPAAIKQLETLGKQLNIPVYSEGTEVAPPDIAEHALRQA
HHHHHHHHCCCCCEEEEHHHHCHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHH
RINGNNFVIVDTAGRLQIDERLMTELQQVVERIGPTEIMLVVDAMIGQESVKVAEAFHAK
HCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHCC
VPLTGLIMTKIDGDARGGAALSMREVTGVPIKFLGTGEKTDAIEPFHPDRLAQRILGMGD
CCCCEEEEEEECCCCCCCCEEEHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCHH
VMTLIERAEQVYDKDEAKKMQKKMRKGTFDFEDFLGAMNSMRKLGPIQQILGMIPGLGKQ
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHH
MRQMKELDEALDDREMKRIEAIIQSMTIKERRNPDLLKDPSRKRRISVGSGTRIEDVNAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCEEECCCCCCHHHHHHH
VKQFREMQRMMKRFSKGGQNPRDLMRMFK
HHHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]