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The map label for this gene is relA [H]

Identifier: 159900988

GI number: 159900988

Start: 5721417

End: 5723672

Strand: Reverse

Name: relA [H]

Synonym: Haur_4475

Alternate gene names: 159900988

Gene position: 5723672-5721417 (Counterclockwise)

Preceding gene: 159900997

Following gene: 159900987

Centisome position: 90.19

GC content: 50.49

Gene sequence:

>2256_bases
ATGGACCTCGCACCTCATATGCCTAGTTCTTTTAATGATGATGCAACCCATAGCGAGAGCACAAAATACATCACTGCGAC
TCCCGCTAGTTCGCCGCTAGTTCATGAAAGTGAAGCGCTGATCAGCCGCATGCGTACCTATTGGCCGCTTGATGAATTTC
AATTAATCGAGCGAGCTTGGGATGTAGCCAAGGTCGCCCATGCTCCCCAAATTCGTAAATCGGGGGAGCCTTATTTTCTG
CATCCAGTGCAAGTGGCCCATATTTTAGTCGATATGAAGCTCGACCCCGAATCGGTCGCGGCGGCGCTATTGCACGATGT
GGTTGAAGATACGCCGATTACTTTGGAGCAAATTCGTGCCGATTTTGGCCGCGAAGTCGCCCATATCGTCGATGGCGTGA
CCAAATTAAGTAAGTTGGAAGCCAAAAGCATCGAAGAAGCCCAAGCGATTACCTATCGCAAGATGTTTATTGCGATGGCC
GATGACCCGCGCGTGGTGCTGATCAAGCTGGCCGACCGCTTGCATAATATGCGCACGCTTGGCGCAATGCGCCCCGATAA
ACAGCAACGCATCGCCCGCGAAACCCTCGAAGTTTATGCACCACTCGCCCATCGCCTCGGGATTTGGCAATTCAAGTGGG
AGCTAGAAGACCTTTCGTTTCGCTATATCAACCCCGAAAAGTATAGCGAAATTGGTCGTCAGCTCAACTTGCGCCGCGAA
ACCCGTGAGCGGATCGTGCAACGGGTCATTGCCCGCCTCAAACAGATTCTCGACCGCGATAATATTAAAGCTGAAGTAAC
AGGCCGCCCGAAACATATCTATTCAATCGCCCGCAAAATGGAGCGCAAGAGTGTAAGCCTTGATCAAATTTATGATCAAT
TGGCAGTACGGGTTATGGTCAATAGCGTTGATGAATGTTATCGTGTGCTGGGTTTGGTGCACTCAACTTGGATTCCAATT
ATGAGCGAATTCGACGATTATATTGCTGTCCCCAAGGAAAGCATGTATCGTTCGCTGCATACAACTGTGGTGATTCCAGG
TGAGCAACCCTGCGAAGTTCAAATTCGCACCTACGAAATGCACGAAGTTTCTGAATATGGGATTGCCGCACACTGGCGCT
ATAAAGAAGGCTTTGGCAACAAACACGATCAATCGTTTGAAACCAAATTAGCGTGGCTACGCTCAGCAATCAACGGCCAG
CGCGACCTTGATCCGACCGAGTTTTTCGAGACGGTCAAGGAAGATGTGCTGCGCGATCAGGTGTTTGTGCTCACTCCCAA
GGGCAAAATCATTGATCTGCCCAAAGGCTCGACCCCGATCGATTTTGCCTATCGCATTCACTCAGAGGTTGGCAATCGCT
GTATTGGGGCGCGGGTCAACAACAAACCAGTGCCGTTGTATTATCAACTACAACATGGCGAAATTGTCGATGTCGTAACC
AGCAAAGTGCCGCGCGGCCCTTCGCGCGACTGGCTGGAATATGTTAAATCGAACGGCGCACGCACCCATATCAAACGCTG
GTTCCGTCGCCAAGAGAACGATGTTAATATTTCAGCGGGCCGCGAATTAATTGATAAAGAACTTAAACGTTTGGGTGTAC
GCCCAACCATGGAAGAGTTGATTCGCGCCAATGCCATGAAAAATAGCGAGGATTTTCTGGCAGCGATTGGCAATGGAGAT
CTTTCGCCGCGCCAAGCAATTCAGCGTGTCATCAGCGATAAAGGTGCTGAGGAAGAGCCATTGGCGGCAATTCCTACGAT
TGCACCGCCTTCCAAGCCAGTCAAACCAGGCACAATTATCGTGCGCGGCGAGACCGATGTCTATACTCGCATCGCCCACT
GCTGTAATCCGGTTTATCCTGAGGCAGTGATTGGCTATACCACTCGTGGCCATGGCATCACTGTTCACCGCATGGATTGC
CATAACGTTTTGCATGAACGCAATCGCGAACGTTTGATCGATGTTGATTGGGGTGGGACAACCGAAAAACAATCCTATCC
TGTACCAATTCGGATCGAAGCATGGGATCGGGTCGGGCTTTGGCGTGATGTGACCAATGCAATCGCTGATGGCAATATCA
ACATTCAAGCGGTGCAGCAATTGGACAATAAACATCATGGCCGCGCCACCTTGCTTGCGACCATCCGCATCGAGAGCATC
GATCAACTTAGTCGCATTTTGGATAAACTCAATCGCGTCAAGGATGTCATCGAGGCTCGCCGCGAAAATACGGTCGCTGG
CACGATGATTGGCTAG

Upstream 100 bases:

>100_bases
TGCTTGACATGTGTATAGCGGCGTGTTAATCTGTTCGCTACAATCAGCAGAAAATGTATCGCGACACAACAGCGCAATGA
CGCTAGAAACGAGGGTCATT

Downstream 100 bases:

>100_bases
CCCAAGAACATAGAGCATAGAACATAGGGCATAGATTATGCTTGGTTCTATGCTCTATTTAGTTTAAGCAATATCCTTCT
GATTGTAGGAGTTGTTTTAT

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 751; Mature: 751

Protein sequence:

>751_residues
MDLAPHMPSSFNDDATHSESTKYITATPASSPLVHESEALISRMRTYWPLDEFQLIERAWDVAKVAHAPQIRKSGEPYFL
HPVQVAHILVDMKLDPESVAAALLHDVVEDTPITLEQIRADFGREVAHIVDGVTKLSKLEAKSIEEAQAITYRKMFIAMA
DDPRVVLIKLADRLHNMRTLGAMRPDKQQRIARETLEVYAPLAHRLGIWQFKWELEDLSFRYINPEKYSEIGRQLNLRRE
TRERIVQRVIARLKQILDRDNIKAEVTGRPKHIYSIARKMERKSVSLDQIYDQLAVRVMVNSVDECYRVLGLVHSTWIPI
MSEFDDYIAVPKESMYRSLHTTVVIPGEQPCEVQIRTYEMHEVSEYGIAAHWRYKEGFGNKHDQSFETKLAWLRSAINGQ
RDLDPTEFFETVKEDVLRDQVFVLTPKGKIIDLPKGSTPIDFAYRIHSEVGNRCIGARVNNKPVPLYYQLQHGEIVDVVT
SKVPRGPSRDWLEYVKSNGARTHIKRWFRRQENDVNISAGRELIDKELKRLGVRPTMEELIRANAMKNSEDFLAAIGNGD
LSPRQAIQRVISDKGAEEEPLAAIPTIAPPSKPVKPGTIIVRGETDVYTRIAHCCNPVYPEAVIGYTTRGHGITVHRMDC
HNVLHERNRERLIDVDWGGTTEKQSYPVPIRIEAWDRVGLWRDVTNAIADGNINIQAVQQLDNKHHGRATLLATIRIESI
DQLSRILDKLNRVKDVIEARRENTVAGTMIG

Sequences:

>Translated_751_residues
MDLAPHMPSSFNDDATHSESTKYITATPASSPLVHESEALISRMRTYWPLDEFQLIERAWDVAKVAHAPQIRKSGEPYFL
HPVQVAHILVDMKLDPESVAAALLHDVVEDTPITLEQIRADFGREVAHIVDGVTKLSKLEAKSIEEAQAITYRKMFIAMA
DDPRVVLIKLADRLHNMRTLGAMRPDKQQRIARETLEVYAPLAHRLGIWQFKWELEDLSFRYINPEKYSEIGRQLNLRRE
TRERIVQRVIARLKQILDRDNIKAEVTGRPKHIYSIARKMERKSVSLDQIYDQLAVRVMVNSVDECYRVLGLVHSTWIPI
MSEFDDYIAVPKESMYRSLHTTVVIPGEQPCEVQIRTYEMHEVSEYGIAAHWRYKEGFGNKHDQSFETKLAWLRSAINGQ
RDLDPTEFFETVKEDVLRDQVFVLTPKGKIIDLPKGSTPIDFAYRIHSEVGNRCIGARVNNKPVPLYYQLQHGEIVDVVT
SKVPRGPSRDWLEYVKSNGARTHIKRWFRRQENDVNISAGRELIDKELKRLGVRPTMEELIRANAMKNSEDFLAAIGNGD
LSPRQAIQRVISDKGAEEEPLAAIPTIAPPSKPVKPGTIIVRGETDVYTRIAHCCNPVYPEAVIGYTTRGHGITVHRMDC
HNVLHERNRERLIDVDWGGTTEKQSYPVPIRIEAWDRVGLWRDVTNAIADGNINIQAVQQLDNKHHGRATLLATIRIESI
DQLSRILDKLNRVKDVIEARRENTVAGTMIG
>Mature_751_residues
MDLAPHMPSSFNDDATHSESTKYITATPASSPLVHESEALISRMRTYWPLDEFQLIERAWDVAKVAHAPQIRKSGEPYFL
HPVQVAHILVDMKLDPESVAAALLHDVVEDTPITLEQIRADFGREVAHIVDGVTKLSKLEAKSIEEAQAITYRKMFIAMA
DDPRVVLIKLADRLHNMRTLGAMRPDKQQRIARETLEVYAPLAHRLGIWQFKWELEDLSFRYINPEKYSEIGRQLNLRRE
TRERIVQRVIARLKQILDRDNIKAEVTGRPKHIYSIARKMERKSVSLDQIYDQLAVRVMVNSVDECYRVLGLVHSTWIPI
MSEFDDYIAVPKESMYRSLHTTVVIPGEQPCEVQIRTYEMHEVSEYGIAAHWRYKEGFGNKHDQSFETKLAWLRSAINGQ
RDLDPTEFFETVKEDVLRDQVFVLTPKGKIIDLPKGSTPIDFAYRIHSEVGNRCIGARVNNKPVPLYYQLQHGEIVDVVT
SKVPRGPSRDWLEYVKSNGARTHIKRWFRRQENDVNISAGRELIDKELKRLGVRPTMEELIRANAMKNSEDFLAAIGNGD
LSPRQAIQRVISDKGAEEEPLAAIPTIAPPSKPVKPGTIIVRGETDVYTRIAHCCNPVYPEAVIGYTTRGHGITVHRMDC
HNVLHERNRERLIDVDWGGTTEKQSYPVPIRIEAWDRVGLWRDVTNAIADGNINIQAVQQLDNKHHGRATLLATIRIESI
DQLSRILDKLNRVKDVIEARRENTVAGTMIG

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=140, Percent_Identity=40, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1789147, Length=683, Percent_Identity=39.0922401171303, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1790082, Length=714, Percent_Identity=39.2156862745098, Blast_Score=497, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI25143118, Length=139, Percent_Identity=36.6906474820144, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 85868; Mature: 85868

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLAPHMPSSFNDDATHSESTKYITATPASSPLVHESEALISRMRTYWPLDEFQLIERAW
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
DVAKVAHAPQIRKSGEPYFLHPVQVAHILVDMKLDPESVAAALLHDVVEDTPITLEQIRA
HHHHHHCCCHHHCCCCCEEECHHHEEHHHEECCCCHHHHHHHHHHHHHCCCCCHHHHHHH
DFGREVAHIVDGVTKLSKLEAKSIEEAQAITYRKMFIAMADDPRVVLIKLADRLHNMRTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEHHHHHHHHHHHHHH
GAMRPDKQQRIARETLEVYAPLAHRLGIWQFKWELEDLSFRYINPEKYSEIGRQLNLRRE
CCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECHHHHHHHHHHHCCHHH
TRERIVQRVIARLKQILDRDNIKAEVTGRPKHIYSIARKMERKSVSLDQIYDQLAVRVMV
HHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
NSVDECYRVLGLVHSTWIPIMSEFDDYIAVPKESMYRSLHTTVVIPGEQPCEVQIRTYEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEECCCCCCEEEEEEEEH
HEVSEYGIAAHWRYKEGFGNKHDQSFETKLAWLRSAINGQRDLDPTEFFETVKEDVLRDQ
HHHHHCCCEEEEEEHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
VFVLTPKGKIIDLPKGSTPIDFAYRIHSEVGNRCIGARVNNKPVPLYYQLQHGEIVDVVT
EEEECCCCCEEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCHHHHH
SKVPRGPSRDWLEYVKSNGARTHIKRWFRRQENDVNISAGRELIDKELKRLGVRPTMEEL
HCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
IRANAMKNSEDFLAAIGNGDLSPRQAIQRVISDKGAEEEPLAAIPTIAPPSKPVKPGTII
HHHHCCCCCCHHEEEECCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCEEE
VRGETDVYTRIAHCCNPVYPEAVIGYTTRGHGITVHRMDCHNVLHERNRERLIDVDWGGT
EECCHHHHHHHHHHCCCCCCCHHEEEEECCCCEEEEECHHHHHHHHCCCCEEEEECCCCC
TEKQSYPVPIRIEAWDRVGLWRDVTNAIADGNINIQAVQQLDNKHHGRATLLATIRIESI
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEEEHHHH
DQLSRILDKLNRVKDVIEARRENTVAGTMIG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDLAPHMPSSFNDDATHSESTKYITATPASSPLVHESEALISRMRTYWPLDEFQLIERAW
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
DVAKVAHAPQIRKSGEPYFLHPVQVAHILVDMKLDPESVAAALLHDVVEDTPITLEQIRA
HHHHHHCCCHHHCCCCCEEECHHHEEHHHEECCCCHHHHHHHHHHHHHCCCCCHHHHHHH
DFGREVAHIVDGVTKLSKLEAKSIEEAQAITYRKMFIAMADDPRVVLIKLADRLHNMRTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEHHHHHHHHHHHHHH
GAMRPDKQQRIARETLEVYAPLAHRLGIWQFKWELEDLSFRYINPEKYSEIGRQLNLRRE
CCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECHHHHHHHHHHHCCHHH
TRERIVQRVIARLKQILDRDNIKAEVTGRPKHIYSIARKMERKSVSLDQIYDQLAVRVMV
HHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
NSVDECYRVLGLVHSTWIPIMSEFDDYIAVPKESMYRSLHTTVVIPGEQPCEVQIRTYEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEECCCCCCEEEEEEEEH
HEVSEYGIAAHWRYKEGFGNKHDQSFETKLAWLRSAINGQRDLDPTEFFETVKEDVLRDQ
HHHHHCCCEEEEEEHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
VFVLTPKGKIIDLPKGSTPIDFAYRIHSEVGNRCIGARVNNKPVPLYYQLQHGEIVDVVT
EEEECCCCCEEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCHHHHH
SKVPRGPSRDWLEYVKSNGARTHIKRWFRRQENDVNISAGRELIDKELKRLGVRPTMEEL
HCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
IRANAMKNSEDFLAAIGNGDLSPRQAIQRVISDKGAEEEPLAAIPTIAPPSKPVKPGTII
HHHHCCCCCCHHEEEECCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCEEE
VRGETDVYTRIAHCCNPVYPEAVIGYTTRGHGITVHRMDCHNVLHERNRERLIDVDWGGT
EECCHHHHHHHHHHCCCCCCCHHEEEEECCCCEEEEECHHHHHHHHCCCCEEEEECCCCC
TEKQSYPVPIRIEAWDRVGLWRDVTNAIADGNINIQAVQQLDNKHHGRATLLATIRIESI
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEEEHHHH
DQLSRILDKLNRVKDVIEARRENTVAGTMIG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]